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Insulin secretion and carbohydrate metabolism during pregnancy in the mare

Insulin secretion and carbohydrate metabolism during pregnancy in the mare ABIGAIL L. FOWDEN, R. S. COMLINE and MARIAN SILVER Physiological Laboratory, Downing Street, Cambridge CB2 3EG Introduction DURING pregnancy, the mother must supply not only its own metabolic requirements but also those of the developing foetus. This challenge t o the maternal homeostatic mechanisms increases with gestational age as the nutritional demands of the growing foetus increase (Van Assche, Hoet and Jack 1976). In humans, a number of metabolic adaptations occur to ensure that the nutritional needs of the foetus are met (Freinkel 1980). There are changes in fat, amino acid and carbohydrate metabolism as well as in the functioning of endocrine glands such as the pancreas, which control metabolite uptake and utilisation by the peripheral tissues (Kalkhoff, Kissebah and Kim 1978). However, relatively little is known about the metabolic changes that occur during pregnancy in domestic species (Freinkel, Phelps and Metzger 1979). The foetal foal, for example, appears to have a rate of glucose utilisation similar t o that of the human foetus in utero (Silver and Comline 1975; Morris, Makowski, Meschia and Battaglia 1975), but how the pregnant mare copes with this extra demand for glucose is not known. In the present study, the effects of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Equine Veterinary Journal Wiley

Insulin secretion and carbohydrate metabolism during pregnancy in the mare

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References (32)

Publisher
Wiley
Copyright
© 1984 EVJ Ltd
ISSN
0425-1644
eISSN
2042-3306
DOI
10.1111/j.2042-3306.1984.tb01919.x
Publisher site
See Article on Publisher Site

Abstract

ABIGAIL L. FOWDEN, R. S. COMLINE and MARIAN SILVER Physiological Laboratory, Downing Street, Cambridge CB2 3EG Introduction DURING pregnancy, the mother must supply not only its own metabolic requirements but also those of the developing foetus. This challenge t o the maternal homeostatic mechanisms increases with gestational age as the nutritional demands of the growing foetus increase (Van Assche, Hoet and Jack 1976). In humans, a number of metabolic adaptations occur to ensure that the nutritional needs of the foetus are met (Freinkel 1980). There are changes in fat, amino acid and carbohydrate metabolism as well as in the functioning of endocrine glands such as the pancreas, which control metabolite uptake and utilisation by the peripheral tissues (Kalkhoff, Kissebah and Kim 1978). However, relatively little is known about the metabolic changes that occur during pregnancy in domestic species (Freinkel, Phelps and Metzger 1979). The foetal foal, for example, appears to have a rate of glucose utilisation similar t o that of the human foetus in utero (Silver and Comline 1975; Morris, Makowski, Meschia and Battaglia 1975), but how the pregnant mare copes with this extra demand for glucose is not known. In the present study, the effects of

Journal

Equine Veterinary JournalWiley

Published: Jul 1, 1984

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