Access the full text.
Sign up today, get DeepDyve free for 14 days.
O. Nakamura, T. Ishii, H. Mankyu, S. Tsubakimoto, T. Nomura, K. Tokuyama (2002)
Contribution of vitamin D receptor genotypes to bone mineral density in young male athletes with different impact loadingEuropean Journal of Sport Science, 2
G. Paxinos, Charles Watson (1983)
The Rat Brain in Stereotaxic Coordinates
M. Piacentini, R. Meeusen, L. Buyse, G. Schutter, K. Meirleir (2002)
No Effect of a Selective Serotonergic/Noradrenergic Reuptake Inhibitor on Endurance PerformanceEuropean Journal of Sport Science, 2
D. Kiem, I. Barna, J. Koenig, G. Makara (1995)
Adrenocorticotropin, prolactin and beta-endorphin stimulatory actions of alpha-2-adrenoceptor antagonists.Neuroendocrinology, 61 2
R. Meeusen, M. Piacentini, S. Eynde, L. Magnus, K. Meirleir (2001)
Exercise Performance is not Influenced by a 5-HT Reuptake InhibitorInternational Journal of Sports Medicine, 22
S. Lupien, M. Lepage (2001)
Stress, memory, and the hippocampus: can't live with it, can't live without itBehavioural Brain Research, 127
R. Ferris, Cooper Br, R. Maxwell (1983)
Studies of bupropion's mechanism of antidepressant activity.The Journal of clinical psychiatry, 44 5 Pt 2
J. Ascher, J. Cole, J. Colin, J. Feighner, R. Ferris, H. Fibiger, R. Golden, P. Martin, W. Potter, E. Richelson (1995)
Bupropion: a review of its mechanism of antidepressant activity.The Journal of clinical psychiatry, 56 9
B. McEwen (2001)
Plasticity of the Hippocampus: Adaptation to Chronic Stress and Allostatic LoadAnnals of the New York Academy of Sciences, 933
(1993)
Mechanisms of antidepressant activity of bupropion
'. R.Meeusen, J. Roeykens, '. I.Mognus, K. H.Keizer2., '. DeMeirleir, R. Meemen, H. Magnus, Meirleir, Intramural Sports, O. Ceorg, Thieme Verlag, Stungart York (1997)
Endurance Performance in Humans: The Effect of a Dopamine Precursor or a Specific Serotonin (5-HT2A/2C) AntagonistInternational Journal of Sports Medicine, 18
Warren Stern, J. Rogers, V. Fang, H. Meltzer (1979)
Influence of bupropion HCl (Wellbatrin), a novel antidepressant, on plasma levels of prolactin and growth hormone in man and rat.Life sciences, 25 20
S. Sarre, K. Thorré, llse Smolders, Y. Michotte (1997)
Microbore liquid chromatography analysis of monoamine transmitters.Methods in molecular biology, 72
G. Nomikos, G. Damsma, D. Wenkstern, H. Fibiger (1989)
Acute effects of bupropion on extracellular dopamine concentrations in rat striatum and nucleus accumbens studied by in vivo microdialysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2 4
Ike Smolders, S. Sarre, G. Ebinger, Y. Michotte (1997)
Microbore liquid chromatography analysis of amino acid transmitters.Methods in molecular biology, 72
S. Checkley (1980)
Neuroendocrine tests of monoamine function in man: a review of basic theory and its application to the study of depressive illnessPsychological Medicine, 10
M. Piacentini, R. Meeusen, L. Buyse, G. Schutter, K. Meirleir (2004)
Hormonal responses during prolonged exercise are influenced by a selective DA/NA reuptake inhibitorBritish Journal of Sports Medicine, 38
Jeffrey Davis, S. Bailey (1997)
Possible mechanisms of central nervous system fatigue during exercise.Medicine and science in sports and exercise, 29 1
M. Piacentini, R. Meeusen, L. Buyse, G. Schutter, F. Kempenaers, Joeri Nijvel, K. Meirleir (2002)
No effect of a noradrenergic reuptake inhibitor on performance in trained cyclists.Medicine and science in sports and exercise, 34 7
C. Gilbert (1995)
Optimal physical performance in athletes: key roles of dopamine in a specific neurotransmitter/hormonal mechanismMechanisms of Ageing and Development, 84
G. Laakmann, N. Hoffmann, E. Hofschuster (1982)
The lack of effect of bupropion HCL (Wellbatrin) on the secretion of growth hormone and prolactin in humans.Life sciences, 30 20
M. Santiago, E. Matarredona, A. Machado, J. Cano (1998)
Influence of serotoninergic drugs on in vivo dopamine extracellular output in rat striatumJournal of Neuroscience Research, 52
B. Cooper, Ching Wang, R. Cox, R. Norton, V. Shea, R. Ferris (1994)
Evidence that the Acute Behavioral and Electrophysiological Effects of Bupropion (Wellbutrin®) Are Mediated by a Noradrenergic MechanismNeuropsychopharmacology, 11
R. Lathe (2001)
Hormones and the hippocampus.The Journal of endocrinology, 169 2
P. Terry, J. Katz (1997)
Dopaminergic mediation of the discriminative stimulus effects of bupropion in ratsPsychopharmacology, 134
The purpose of the present study was to administer an acute dose of the dual dopamine norepinephrine reuptake blocker bupropion in freely moving rats and to monitor the extracellular neurotransmitter concentrations in the hippocampus via in vivo microdialysis and the peripheral hormonal concentrations via catheterization. A microdialysis probe was inserted in the hippocampus, and samples for serotonin, dopamine, and norepinephrine were collected every 20 min before and after the injection of 17 mg/kg of bupropion, for a total sampling time of 180 min. A catheter was placed in the vena femoralis of the second group of rats, and blood samples were collected before and after bupropion injection for quantification of growth hormone, prolactin, corticosterone, adrenocorticotropin hormone, and -endorphins. All neurotransmitter levels (dopamine, norepinephrine, and serotonin) significantly increased after bupropion injection. This was accompanied by a significant decrease in prolactin concentrations, whereas the other hormones showed no statistically significant variation. It can, therefore, be concluded that, although bupropion has dual reuptake proprieties, the observed effects both at the central and at the peripheral level seem to be ruled by the dopaminergic system. dopamine and norepinephrine reuptake inhibitor; hippocampus; hypothalamic-pituitary-adrenal axis; microdialysis; neurotransmitters. Address for reprint requests and other correspondence: R. Meeusen, Dept. of Human Physiology and Sportsmedicine, Free Univ. Brussel, Pleinlaan 2, 1050 Brussels, Belgium (E-mail: rmeeusen@vub.ac.be ).
Journal of Applied Physiology – The American Physiological Society
Published: Aug 1, 2003
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.