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J. Drapier, Jr Hibbs (1988)
Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.Journal of immunology, 140 8
W. Sessa (1994)
The nitric oxide synthase family of proteins.Journal of vascular research, 31 3
L. Ignarro, J. Fukuto, Jeannete Griscavage, N. Rogers, R. Byrns (1993)
Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine.Proceedings of the National Academy of Sciences of the United States of America, 90 17
P. Bush, N. Gonzalez, J. Griscavage, L. Ignarro (1992)
Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine.Biochemical and biophysical research communications, 185 3
J. Merrill, L. Ignarro, M. Sherman, J. Melinek, T. Lane (1993)
Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.Journal of immunology, 151 4
E. Galea, D. Reis, D. Feinstein (1994)
Cloning and expression of inducible nitric oxide synthase from rat astrocytesJournal of Neuroscience Research, 37
Koka Koka, He He, Zack Zack, Kitchen Kitchen, Peacock Peacock, Fried Fried, Tran Tran, Yashar Yashar, Merrill Merrill (1995)
HIV‐1 envelope proteins induce IL1, TNFα, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brainJ Exp Med, 182
S. Murphy, M. Simmons, L. Agulló, Agustina Garcı́a, D. Feinstein, E. Galea, D. Reis, D. Minc‐Golomb, J. Schwartz (1993)
Synthesis of nitric oxide in CNS glial cellsTrends in Neurosciences, 16
V. Mollace, M. Colasanti, P. Rodinò, R. Massoud, Giuliana Lauro, G. Nisticó (1993)
Cytokine-induced nitric oxide generation by cultured astrocytoma cells involves Ca(++)-calmodulin-independent NO-synthase.Biochemical and biophysical research communications, 191 2
E. Galea, D. Feinstein, D. Reis (1992)
Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures.Proceedings of the National Academy of Sciences of the United States of America, 89 22
O. Bagasra, F. Michaels, Yong Zheng, L. Bobroski, S. Spitsin, Z. Fu, R. Tawadros, H. Koprowski (1995)
Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America, 92 26
A. Nussler, T. Billiar (1993)
Inflammation, immunoregulation, and inducible nitric oxide synthaseJournal of Leukocyte Biology, 54
Y. Vodovotz, C. Bogdan, J. Paik, Q. Xie, C. Nathan (1993)
Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor betaThe Journal of Experimental Medicine, 178
V. Mollace, M. Colasanti, T. Persichini, G. Bagetta, Giuliana Lauro, G. Nisticó (1993)
HIV gp120 glycoprotein stimulates the inducible isoform of no synthase in human cultured astrocytoma cells.Biochemical and biophysical research communications, 194 1
Sunhee Lee, D. Dickson, Wei Liu, C. Brosnan (1993)
Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-γJournal of Neuroimmunology, 46
Branislava Mitrovic, Louis Ignarro, H. Vinters, Mari-Anne Akers, Ingrid Schmid, Christel Uittenbogaart, Jean Merrill (1995)
Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytesNeuroscience, 65
J. Stadler, T. Billiar, R. Curran, D. Stuehr, Juan Ochoa, Richard Simmons (1991)
Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes.The American journal of physiology, 260 5 Pt 1
Branislava Mitrovic, L. Ignarro, S. Montestruque, A. Smoll, Jean Merrill (1994)
Nitric oxide as a potential pathological mechanism in demyelination: Its differential effects on primary glial cellsin vitroNeuroscience, 61
C. Lowenstein, Charles Glatt, D. Bredt, S. Snyder (1992)
Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.Proceedings of the National Academy of Sciences of the United States of America, 89 15
Q. Xie, H. Cho, J. Calaycay, R. Mumford, K. Swiderek, Terry Lee, A. Ding, Tiffany Troso, C. Nathan (1992)
Cloning and characterization of inducible nitric oxide synthase from mouse macrophages.Science, 256 5054
H. Rubbo, R. Radi, M. Trujillo, R. Telleri, B. Kalyanaraman, S. Barnes, Marion Kirk, B. Freeman (1994)
Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives.The Journal of biological chemistry, 269 42
Prasad Koka, Kongyuan He, Jerome, Zack, Scott Kitchen, Warwick Peacock, Itzhak Fried, Thanh Tran, S. Yashar, J Merrill (1995)
Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor alpha, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brainThe Journal of Experimental Medicine, 182
D. Bredt, S. Snyder (1990)
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.Proceedings of the National Academy of Sciences of the United States of America, 87 2
Rubbo Rubbo, Radi Radi, Trujillo Trujillo, Telleri Telleri, Kalyanaraman Kalyanaraman, Barnes Barnes, Kirk Kirk, Freeman Freeman (1994)
Nitric oxide regulation of superoxide and peroxynitrite‐dependent lipid peroxidationJ Biol Chem, 269
Juan Bolaños, S. Peuchen, S. Heales, John Land, JB Clark (1994)
Nitric Oxide‐Mediated Inhibition of the Mitochondrial Respiratory Chain in Cultured AstrocytesJournal of Neurochemistry, 63
Jürgen Zielasek, Maria Tausch, K. Toyka, H. Hartung (1992)
Production of nitrite by neonatal rat microglial cells/brain macrophages.Cellular immunology, 141 1
L. Ignarro (1990)
Biosynthesis and metabolism of endothelium-derived nitric oxide.Annual review of pharmacology and toxicology, 30
L. Bö, T. Dawson, S. Wesselingh, Sverre Möurk, Steven Choi, P. Kong, D. Hanley, B. Trapp (1994)
Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brainsAnnals of Neurology, 36
J. Griscavage, N. Rogers, Michael Sherman, L. Ignarro (1993)
Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide.Journal of immunology, 151 11
S. Murphy, D. Grzybicki, M. Simmons (1995)
Glial Cells as Nitric Oxide Sources and Targets
H. Hartung, Stefan Jung, G. Stoll, J. Zielasek, B. Schmidt, J. Archelos, K. Toyka (1992)
Inflammatory mediators in demyelinating disorders of the CNS and PNSJournal of Neuroimmunology, 40
M. Simmons, Sean Murphy (1992)
Induction of Nitric Oxide Synthase in Glial CellsJournal of Neurochemistry, 59
A. Boullerne, K. Petry, M. Meynard, M. Geffard (1995)
Indirect evidence for nitric oxide involvement in multiple sclerosis by characterization of circulating antibodies directed against conjugated S-nitrosocysteineJournal of Neuroimmunology, 60
A. Johnson, J. Land, E. Thompson, J. Bolaños, J. Clark, S. Heales (1995)
Evidence for increased nitric oxide production in multiple sclerosis.Journal of Neurology, Neurosurgery & Psychiatry, 58
Ted Dawson, V. Dawson (1994)
gp120 neurotoxicity in primary cortical cultures.Advances in neuroimmunology, 4 3
C. Lowenstein, S. Hill, A. Lafond-Walker, Jean Wu, Greg Allen, M. Landavere, N. Rose, A. Herskowitz (1996)
Nitric oxide inhibits viral replication in murine myocarditis.The Journal of clinical investigation, 97 8
A. MacKenzie-Graham, B. Mitrovic, A. Smoll, J. Merrill (1994)
Differential sensitivity to nitric oxide in immortalized, cloned murine oligodendrocyte cell lines.Developmental neuroscience, 16 3-4
R. Gold, J. Zielasek, R. Kiefer, K. Toyka, H. Hartung (1996)
Secretion of nitrite by Schwann cells and its effect on T-cell activation in vitro.Cellular immunology, 168 1
It has been previously demonstrated that microglia and astrocytes produce micromolar amounts of nitric oxide in vitro. In this study, we demonstrate that primary rat oligodendrocytes can be stimulated to produce iNOS mRNA as detected by Northern blot and in situ hybridization analysis and a 131‐kDa iNOS protein by Western blot analysis; protein was also detected in cells by single‐ and double‐label immunohistochemistry for iNOS and the oligodendrocyte‐specific marker CNPase. NO/NOS are produced as a consequence of activation of the gene encoding the inducible nitric oxide synthase as determined by inhibition with actinomycin D and cyclohexamide. The iNOS is functional, leading to calcium/calmodulin‐independent NO production in these in vitro cultures. J. Neurosci. Res. 48:372–384, 1997. © 1997 Wiley‐Liss, Inc.
Journal of Neuroscience Research – Wiley
Published: May 15, 1997
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