Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Effect of anti‐inflammatory and antioxidant drugs on the long‐term repair of severely injured mouse skeletal muscle

Effect of anti‐inflammatory and antioxidant drugs on the long‐term repair of severely injured... Non‐steroidal anti‐inflammatory drugs are frequently prescribed after skeletal muscle injury. It is not known whether this type of medication can interfere with muscle repair, although inflammatory response is thought to play an important role in this process. Tibialis anterior muscles of mice were injured by myotoxic agent (snake venom) or crushed. Then, animals were treated daily for 10–14 days with different types of non‐steroidal anti‐inflammatory and antioxidant drugs. The long‐term repair was studied 10–42 days after injury by analysing the recovery of in situ muscle force production, size of regenerating muscle cells and expression of myosin heavy chain. Our results show that diclofenac, diferuloylmethane (curcumin), dimethylthiourea or pyrrolidine dithiocarbamate treatment did not significantly affect muscle recovery after myotoxic injury (P > 0.05). Similarly, diferuloylmethane, dimethyl sulphoxide or indomethacin administration did not markedly change muscle repair after crush injury. However, we noted that high doses (> 2 mg kg−1) of diferuloylmethane or indomethacin increased lethality and reduced muscle repair after crush injury. In conclusion, non‐steroidal anti‐inflammatory and antioxidant drugs did not exhibit long‐term detrimental effects on muscle recovery after injury, except at lethal doses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Physiology Wiley

Effect of anti‐inflammatory and antioxidant drugs on the long‐term repair of severely injured mouse skeletal muscle

Loading next page...
 
/lp/wiley/effect-of-anti-inflammatory-and-antioxidant-drugs-on-the-long-term-w6rJ5OOhm0

References (47)

Publisher
Wiley
Copyright
Copyright © 2005 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0958-0670
eISSN
1469-445X
DOI
10.1113/expphysiol.2005.029835
pmid
15728135
Publisher site
See Article on Publisher Site

Abstract

Non‐steroidal anti‐inflammatory drugs are frequently prescribed after skeletal muscle injury. It is not known whether this type of medication can interfere with muscle repair, although inflammatory response is thought to play an important role in this process. Tibialis anterior muscles of mice were injured by myotoxic agent (snake venom) or crushed. Then, animals were treated daily for 10–14 days with different types of non‐steroidal anti‐inflammatory and antioxidant drugs. The long‐term repair was studied 10–42 days after injury by analysing the recovery of in situ muscle force production, size of regenerating muscle cells and expression of myosin heavy chain. Our results show that diclofenac, diferuloylmethane (curcumin), dimethylthiourea or pyrrolidine dithiocarbamate treatment did not significantly affect muscle recovery after myotoxic injury (P > 0.05). Similarly, diferuloylmethane, dimethyl sulphoxide or indomethacin administration did not markedly change muscle repair after crush injury. However, we noted that high doses (> 2 mg kg−1) of diferuloylmethane or indomethacin increased lethality and reduced muscle repair after crush injury. In conclusion, non‐steroidal anti‐inflammatory and antioxidant drugs did not exhibit long‐term detrimental effects on muscle recovery after injury, except at lethal doses.

Journal

Experimental PhysiologyWiley

Published: Jul 1, 2005

There are no references for this article.