Access the full text.
Sign up today, get DeepDyve free for 14 days.
(1985)
reotaxic administration to rats: implication for the mechanism of MPTP toxicity
G. Davis, Adrian Williams, S. Markey, M. Ebert, E. Caine, Cheryl Reichert, I. Kopin (1979)
Chronic parkinsonism secondary to intravenous injection of meperidine analoguesPsychiatry Research, 1
Nicklas Nicklas, Vyas Vyas, Heikkila Heikkila (1985)
Inhibition of NADH‐linked oxidation in brain mitochondria by MPP + , a metabolite of the neurotoxin MPTPLife Sci, 36
Salach Salach, Singer Singer, Castagnoli Castagnoli, Trevor Trevor (1984)
Oxidation of the neurotoxic amine MPTP by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTPBiochem Biophys Res Commun, 125
A. Schapira, J. Cooper, D. Dexter, P. Jenner, J. Clark, C. Marsden (1989)
MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASEThe Lancet, 333
Hansen Van, Zandt Law, W. Briles, Longen-Ecker Pazderka, J. Gavora, R Spencer, Ruth, W Brilei, R Stone, Science, W Droege, Miggieno Hala, Ziegler, D. Ewert, W Gilmour, M Vilhelmovb, J Maggiano, K. Pink, J Hkla, Eiiv Hartmanovi, M Simonsen, In Hkla, A. Benedict, Plenum, I. Doherty, R. Zinkernagle (1983)
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis.Science, 219 4587
W. Nicklas, I. Vyas, R. Heikkila (1985)
Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.Life sciences, 36 26
E. Southern (1975)
Detection of specific sequences among DNA fragments separated by gel electrophoresis.Journal of molecular biology, 98 3
G. Singh, M. Lott, D. Wallace (1989)
A mitochondrial DNA mutation as a cause of Leber's hereditary optic neuropathy.The New England journal of medicine, 320 20
J. Javitch, R. D'Amato, S. Strittmatter, S. Snyder (1985)
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.Proceedings of the National Academy of Sciences of the United States of America, 82 7
(1986)
Energy driven uptake of MPP+ by brain mitochondria mediates the neurotoxocity of MPTP
Denton Denton, Howard Howard (1987)
A dopaminergic cell line variant resistant to the neurotoxin MPTPJ Neurochem, 49
A. Schapira, J. Morgan-Hughes, M. Cleeter, J. Cooper, Salil Patel, C. Ragan, J. Clark (1988)
MOLECULAR BASIS OF MITOCHONDRIAL MYOPATHIES: POLYPEPTIDE ANALYSIS IN COMPLEX-1 DEFICIENCYThe Lancet, 331
Functional assignment of the unidentified reading frames of human mitochondrial DNA
R. Ramsay, T. Singer (1986)
Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria.The Journal of biological chemistry, 261 17
L. Golbe, G. Iorio, V. Bonavita, Douglas Miller, R. Duvoisin (1990)
A large kindred with autosomal dominant Parkinson's diseaseAnnals of Neurology, 27
D. Davies, P. Elwood (1974)
Milk antibodies and myocardial infarction [Letter]
S. Anderson, A. Bankier, B. Barrell, M. Bruijn, A. Coulson, J. Drouin, J. Drouin, I. Eperon, D. Nierlich, D. Nierlich, B. Roe, B. Roe, F. Sanger, P. Schreier, A. Smith, R. Staden, I. Young, I. Young (1981)
Sequence and organization of the human mitochondrial genomeNature, 290
W. Johnson, S. Hodge, R. Duvoisin (1990)
Twin studies and the genetics of Parkinson's disease—a reappraisalMovement Disorders, 5
Vyas 1, Duvoisin RC. Dopamicontent in postmortem Parkinsonian brain. Lance; 1987;2: nergic toxicity of rotenone and the MPP ion after their ste
R. Heikkila, W. Nicklas, I. Vyas, R. Duvoisin (1985)
Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicityNeuroscience Letters, 62
A. Feinberg, B. Vogelstein (1983)
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.Analytical biochemistry, 132 1
Holt Holt, Harding Harding, Morgan‐Hughes Morgan‐Hughes (1988)
Mitochondrial DNA polymorphism in mitochondrial myopathyHum Genet, 79
D. Dexter, C. Carter, F. Wells, F. Javoy‐Agid, Y. Agid, A. Lees, P. Jenner, C. Marsden (1989)
Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's DiseaseJournal of Neurochemistry, 52
R. Cann, M. Stoneking, A. Wilson (1987)
Mitochondrial DNA and human evolutionNature, 325
I. Holt, A. Harding, J. Morgan-Hughes (1988)
Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathiesNature, 331
D. Brahams (1983)
Medicine and the LawThe Lancet, 321
Carpenter Wt (1974)
A new setting for informed consent.The Lancet, 1
F. Earley, Salil Patel, C. Ragan, G. Attardi (1987)
Photolabelling of a mitochondrially encoded subunit of NADH dehydrogenase with [3H]dihydrorotenoneFEBS Letters, 219
Javitch Javitch, D'Amato D'Amato, Strittmatter Strittmatter, Snyder Snyder (1985)
Parkinsonism‐inducing toxin MPTP: uptake of the metabolite MPP + by dopamine neurons explains selective toxicityProc Natl Acad Sci USA, 82
Heikkila Heikkila, Nicklas Nicklas, Vyas Vyas, Duvoisin Duvoisin (1985)
Dopaminergic toxicity of rotenone and the MPP ion after their stereotaxic administration to rats: implication for the mechanism of MPTP toxicityNeurosci Lett, 62
J. Salach, J. Salach, T. Singer, T. Singer, N. Castagnoli, Anthony Trevor (1984)
Oxidation of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTP.Biochemical and biophysical research communications, 125 2
DE Mycosides, C’ Formes, Simplifiees Mycoside, Dans Bacteries, Isolees Bovins, Atteints Farcin, G. Lanéelle, et Asselineau (1971)
Presence de mycosides C′ (formes simplifiees de mycoside C) dans les bacteries isolees de bovins atteints du farcinFEBS Letters, 19
Holt Holt, Harding Harding, Morgan‐Hughes Morgan‐Hughes (1988)
Deletions of mitochondrial DNA in patients with mitochondrial myopathyNature, 331
T. Denton, B. Howard (1987)
A Dopaminergic Cell Line Variant Resistant to the Neurotoxin 1‐Methyl‐4‐Phenyl‐1,2,3,6‐TetrahydropyridineJournal of Neurochemistry, 49
Dexter Dexter, Wells Wells, Agid Agid (1987)
Increased nigral iron content in postmortem Parkinsonian brainLancet, 2
The reduced form of nicotinamide adenine dinucleotide coenzyme Q reductase (complex I) activity has recently been shown to be deficient in the substantia nigra of patients dying with Parkinson's disease. This biochemical defect is identical to that produced by the neurotoxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP), which also produces parkinsonism in humans. Complex I comprises 25 polypeptides, seven of which are encoded by mitochondrial DNA. Restriction fragment analysis of substantia nigra DNA from six patients with Parkinson's disease did not show any major deletion. In two cases, there were different novel polymorphisms that were not observed in control brain (n = 6) or blood (n = 34) samples.
Movement Disorders – Wiley
Published: Jan 1, 1990
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.