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Age‐Related Alterations of the Growth Hormone/Insulin‐Like‐Growth‐Factor I Axis

Age‐Related Alterations of the Growth Hormone/Insulin‐Like‐Growth‐Factor I Axis T he decline of growth hormone (GH) secretion with aging and its impact on physiological functions are currently subjects of considerable interest. In addition to promoting growth, GH has anabolic and lipolytic effects and actions on various metabolic and physiologic functions. 1 It has recently been shown that in adults (18 to 51 years old) with GH deficiency, GH replacement increases lean body and reduces fat mass, increases muscle mass, lowers plasma cholesterol, and improves renal function. 2 , 3 The onset of age‐related alterations of GH secretion occurs prior to other manifestations of aging. The blunted secretion of GH in adult and aging humans, the actions of GH, and similarities in manifestations of aging and of GH deficiency have prompted the hypothesis that age‐associated GH deficiency contributes to the aging process. Table 1 summarizes the possible relationship of GH to the aging process. EFFECTS OF AGING AND OF GH ON SELECTED PARAMETERS OF BODY COMPOSITION AND FUNCTION Aging GH * Nitrogen balance ↓ ↑ Body content of protein ↓ ↑ Muscle mass as percentage of body weight ↓ ↑ Body content of K ↓ ↑ Bone mass ↓ ↑ Body content of H 2 O ↓ ↑ http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of American Geriatrics Society Wiley

Age‐Related Alterations of the Growth Hormone/Insulin‐Like‐Growth‐Factor I Axis

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References (168)

Publisher
Wiley
Copyright
© The American Geriatrics Society
ISSN
0002-8614
eISSN
1532-5415
DOI
10.1111/j.1532-5415.1991.tb01654.x
Publisher site
See Article on Publisher Site

Abstract

T he decline of growth hormone (GH) secretion with aging and its impact on physiological functions are currently subjects of considerable interest. In addition to promoting growth, GH has anabolic and lipolytic effects and actions on various metabolic and physiologic functions. 1 It has recently been shown that in adults (18 to 51 years old) with GH deficiency, GH replacement increases lean body and reduces fat mass, increases muscle mass, lowers plasma cholesterol, and improves renal function. 2 , 3 The onset of age‐related alterations of GH secretion occurs prior to other manifestations of aging. The blunted secretion of GH in adult and aging humans, the actions of GH, and similarities in manifestations of aging and of GH deficiency have prompted the hypothesis that age‐associated GH deficiency contributes to the aging process. Table 1 summarizes the possible relationship of GH to the aging process. EFFECTS OF AGING AND OF GH ON SELECTED PARAMETERS OF BODY COMPOSITION AND FUNCTION Aging GH * Nitrogen balance ↓ ↑ Body content of protein ↓ ↑ Muscle mass as percentage of body weight ↓ ↑ Body content of K ↓ ↑ Bone mass ↓ ↑ Body content of H 2 O ↓ ↑

Journal

Journal of American Geriatrics SocietyWiley

Published: Mar 1, 1991

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