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H. Law, R. Fleming, M. Gilmore, I. McCarthy, S. Hughes (1986)
In vitro measurement and computer modelling of the diffusion of antibiotic in bone cement.Journal of biomedical engineering, 8 2
R. Elson, A. Jephcott, D. McGechie, D. Verettas (1977)
Antibiotic-loaded acrylic cement.The Journal of bone and joint surgery. British volume, 59 2
Carl Norden, Elizabeth Kennedy (1971)
Experimental osteomyelitis. II. Therapeutic trials and measurement of antibiotic levels in bone.The Journal of infectious diseases, 124 6
K. Marks, C. Nelson, E. Lautenschlager (1976)
Antibiotic-impregnated acrylic bone cement.The Journal of bone and joint surgery. American volume, 58 3
F. Waldvogel, P. Papageorgiou (1980)
Osteomyelitis: the past decade.The New England journal of medicine, 303 7
H. Wahlig, E. Dingeldein (1980)
Antibiotics and bone cements. Experimental and clinical long-term observations.Acta orthopaedica Scandinavica, 51 1
Laboratory evaluation of new antibiotics in vitro and in experimental animal infections
B. Cunha, H. Gossling, H. Pasternak, C. Nightingale, R. Quintiliani (1977)
The penetration characteristics of cefazolin, cephalothin, and cephradine into bone in patients undergoing total hip replacement.The Journal of bone and joint surgery. American volume, 59 7
S. Henry, D. Seligson, P. Mangino, G. Popham (1991)
Antibiotic-impregnated beads. Part I: Bead implantation versus systemic therapy.Orthopaedic review, 20 3
B. Picknell, L. Mizen, R. Sutherland (1977)
Antibacterial activity of antibiotics in acrylic bone cement.The Journal of bone and joint surgery. British volume, 59 3
D. Schurman, C. Trindade, H. Hirshman, K. Moser, G. Kajiyama, P. Stevens (1978)
Antibiotic-acrylic bone cement composites. Studies of gentamicin and Palacos.The Journal of bone and joint surgery. American volume, 60 7
D. Kuechle, G. Landon, D. Musher, P. Noble (1991)
Elution of vancomycin, daptomycin, and amikacin from acrylic bone cement.Clinical orthopaedics and related research, 264
D. Kirkpatrick, L. Trachtenberg, P. Mangino, J. Fraunhofer, D. Seligson (1985)
In vitro characteristics of tobramycin-PMMA beads: compressive strength and leaching.Orthopedics, 8 9
A. Flick, J. Herbert, J. Goodell, T. Kristiansen (1987)
Noncommercial fabrication of antibiotic-impregnated polymethylmethacrylate beads. Technical note.Clinical orthopaedics and related research, 223
R. Fitzgerald, P. Kelly, R. Snyder, J. Washington (1978)
Penetration of Methicillin, Oxacillin, and Cephalothin into Bone and Synovial TissuesAntimicrobial Agents and Chemotherapy, 14
H. Wahlig, E. Dingeldein, R. Bergmann, K. Reuss (1978)
The release of gentamicin from polymethylmethacrylate beads. An experimental and pharmacokinetic study.The Journal of bone and joint surgery. British volume, 60-B 2
T. Gerhart, R. Roux, G. Horowitz, Richard Miller, P. Hanff, W. Hayes (1988)
Antibiotic release from an experimental biodegradable bone cementJournal of Orthopaedic Research, 6
(1976)
Treatment of chronic bone infections with gentamicin - PMMA chains and beads
Jason Calhoun, Jon Mader (1989)
Antibiotic beads in the management of surgical infections.American journal of surgery, 157 4
J. Hill, L. Klenerman, S. Trustey, R. Blowers (1977)
Diffusion of antibiotics from acrylic bone-cement in vitro.The Journal of bone and joint surgery. British volume, 59 2
A. Baker, L. Greenham (1988)
Release of gentamicin from acrylic bone cement. Elution and diffusion studies.The Journal of bone and joint surgery. American volume, 70 10
Buchholz Hw, H. Engelbrecht (1970)
[Depot effects of various antibiotics mixed with Palacos resins].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 41 11
G. Popham, P. Mangino, D. Seligson, S. Henry (1991)
Antibiotic-impregnated beads. Part II: Factors in antibiotic selection.Orthopaedic review, 20 4
(1986)
The measurement of antibiotics in human body fluids: techniques and significance
F. Waldvogel, G. Medoff, M. Swartz (1970)
Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects.The New England journal of medicine, 282 4
The rates of elution of tobramycin in vitro were compared for polymethylmethacrylate beads impregnated with the powder form and an alternative biodegradable substance, sponge collagen. The impregnated polymethylmethacrylate beads initially had a lower zone of inhibition, but the rate of release was slow in comparison with that of the impregnated sponge collagen. The sponge collagen delivered a higher dose faster and with a shorter duration than the polymethylmethacrylate beads with the same antibiotic concentration in vitro, but the beads delivered a therapeutic concentration for longer periods. Because it deteriorates rapidly, sponge collagen may be unsatisfactory as an agent of antibiotic delivery in patients who have chronic osteomyelitis; however, it may be useful for patients who have acute trauma with highly contaminated bone or soft tissue, or during hemiarthroplasty revision, to deliver a high local concentration of antibiotic for a short period of time.
Journal of Orthopaedic Research – Wiley
Published: Sep 1, 1994
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