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Adaptation of the Exocrine Pancreas to Diet

Adaptation of the Exocrine Pancreas to Diet Since the report of Pavlov (66) in the early 1900s, the adaptation of the exocrine pancreas to dietary changes in various species, including the rat (29, 34, 74), dog (4), pig (15, 26), and chicken (41), has been described. The content in both pancreatic tissue and its secretions (5, 7) of the major digestive enzymes, proteases, amylase, and lipase, changes in proportion to the dietary content of their respective substrates, protein, carbohydrate, and fat (29, 34, 0199-9885/90/0715-0085$02.00 BRANNON 35, 74). Pancreatic adaptation occurs through changes in the synthetic rates 07, 75, 76, 99) and mRNA levels (30, 3 1 , 10 1 , 1 02). Cholecystokinin (CCK), through the negative feedback regulation of its secretion by dietary protein and peptides, appears to be the mediator of the adaptation of the proteases. Various hormones and metabolites are proposed mediators of the adaptation of pancreatic amylase and lipase, but the mechanisms by which dietary carbohydrate and fat regulate these enzymes are not yet known. The physiologic significance of pancreatic adaptation to diet is unclear. Teleologically, the coordinate regulation of a digestive enzyme by its dietary substrate would optimize digestion and utilization of that substrate, but the pancreas normally synthesizes and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Nutrition Annual Reviews

Adaptation of the Exocrine Pancreas to Diet

Brannon, P. M.
Annual Review of Nutrition , Volume 10 (1) – Jul 1, 1990
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References (44)

Publisher
Annual Reviews
Copyright
Copyright 1990 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0199-9885
eISSN
1545-4312
DOI
10.1146/annurev.nu.10.070190.000505
pmid
2200477
Publisher site
See Article on Publisher Site

Abstract

Since the report of Pavlov (66) in the early 1900s, the adaptation of the exocrine pancreas to dietary changes in various species, including the rat (29, 34, 74), dog (4), pig (15, 26), and chicken (41), has been described. The content in both pancreatic tissue and its secretions (5, 7) of the major digestive enzymes, proteases, amylase, and lipase, changes in proportion to the dietary content of their respective substrates, protein, carbohydrate, and fat (29, 34, 0199-9885/90/0715-0085$02.00 BRANNON 35, 74). Pancreatic adaptation occurs through changes in the synthetic rates 07, 75, 76, 99) and mRNA levels (30, 3 1 , 10 1 , 1 02). Cholecystokinin (CCK), through the negative feedback regulation of its secretion by dietary protein and peptides, appears to be the mediator of the adaptation of the proteases. Various hormones and metabolites are proposed mediators of the adaptation of pancreatic amylase and lipase, but the mechanisms by which dietary carbohydrate and fat regulate these enzymes are not yet known. The physiologic significance of pancreatic adaptation to diet is unclear. Teleologically, the coordinate regulation of a digestive enzyme by its dietary substrate would optimize digestion and utilization of that substrate, but the pancreas normally synthesizes and

Journal

Annual Review of Nutrition – Annual Reviews

Published: Jul 1, 1990

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