Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Parkinson plus syndrome: diagnosis using high field MR imaging of brain iron.

Parkinson plus syndrome: diagnosis using high field MR imaging of brain iron. The distribution of iron in the brain was analyzed using high field strength (1.5 T) magnetic resonance (MR) imaging in 14 healthy control individuals and six patients with Parkinson plus syndromes (multisystem atrophy and progressive supranuclear palsy) who were unresponsive to antiparkinsonian therapy. The normal topographic distribution of iron in the brain as indicated by high field MR images coincided precisely with the distribution of iron in the brain as determined by Perls staining for ferric iron. In Parkinson plus syndromes, there were abnormally increased concentrations of iron (decreased T2 relaxation times) in the putamen, and less prominent increases in the caudate nucleus and lateral pars compacta of the substantia nigra. In high field strength MR images of normal patients, the decreased signal intensity in the globus pallidus is more prominent than that of the putamen. In MR images of patients with Parkinson plus syndromes, the decreased signal intensity of the putamen is more prominent than that of the globus pallidus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Radiology Radiological Society of North America, Inc.

Parkinson plus syndrome: diagnosis using high field MR imaging of brain iron.

Radiology , Volume 159 (2): 493 – May 1, 1986

Loading next page...
 
/lp/radiological-society-of-north-america-inc/parkinson-plus-syndrome-diagnosis-using-high-field-mr-imaging-of-brain-u7yLvRIARS

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Radiological Society of North America, Inc.
Copyright
Copyright © 1986 by Radiological Society of North America
ISSN
1527-1315
eISSN
0033-8419
Publisher site
See Article on Publisher Site

Abstract

The distribution of iron in the brain was analyzed using high field strength (1.5 T) magnetic resonance (MR) imaging in 14 healthy control individuals and six patients with Parkinson plus syndromes (multisystem atrophy and progressive supranuclear palsy) who were unresponsive to antiparkinsonian therapy. The normal topographic distribution of iron in the brain as indicated by high field MR images coincided precisely with the distribution of iron in the brain as determined by Perls staining for ferric iron. In Parkinson plus syndromes, there were abnormally increased concentrations of iron (decreased T2 relaxation times) in the putamen, and less prominent increases in the caudate nucleus and lateral pars compacta of the substantia nigra. In high field strength MR images of normal patients, the decreased signal intensity in the globus pallidus is more prominent than that of the putamen. In MR images of patients with Parkinson plus syndromes, the decreased signal intensity of the putamen is more prominent than that of the globus pallidus.

Journal

RadiologyRadiological Society of North America, Inc.

Published: May 1, 1986

There are no references for this article.