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Physiological and pharmacological basis of GABA and glycine action on neurons of mudpuppy retina. II. Amacrine and ganglion cells

Physiological and pharmacological basis of GABA and glycine action on neurons of mudpuppy retina.... U.S.A. ROBERT RAM F. F. THOMAS E. MALCOLM AND Departmentsof Ophthalmology, Physiology, and Biophysics, Washgt University School of Medice, St. Louis, Missouri 631IO; and Department of Psychology, QueensCollege, Flushg, New York 1I367 SUMMARY AND CCLUSIS I. tracellular recordgs were obtaed from amacre and ngli cells the perfused reta-eyecup preparati of the mudpuppy. y-Amobutyric acid () and () were added to the bathg medium and the / antagists strychne (Strych), picrotox (Picro), and bicuculle methiodide (BCC) were also applied. 2. / caused a large decrease put resistance (IR) both amacre and ngli cells. The decreased IR was often more than 100 MQ and cstituted a large fracti of the put resistance of the cell. 3. The /-mediated change IR was not associated with a shift membrane potential amacres, but caused a hyperpolarizati ngli cells. 4. / acti amacre and ngli cells was verted to a depolarizati by tracellular jectis of Cl- usg KCl-filled micropipettes. This suggests that chloride is volved mediatg / acti both amacre and ngli cells. 5. A comparis of selective versus sensitivity of ngli cells showed a small populati of cells that were exclusively sensitive .and a small populati of off cells that were exclusively sensitive. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurophysiology The American Physiological Society

Physiological and pharmacological basis of GABA and glycine action on neurons of mudpuppy retina. II. Amacrine and ganglion cells

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Publisher
The American Physiological Society
Copyright
Copyright © 1981 the American Physiological Society
ISSN
0022-3077
eISSN
1522-1598
Publisher site
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Abstract

U.S.A. ROBERT RAM F. F. THOMAS E. MALCOLM AND Departmentsof Ophthalmology, Physiology, and Biophysics, Washgt University School of Medice, St. Louis, Missouri 631IO; and Department of Psychology, QueensCollege, Flushg, New York 1I367 SUMMARY AND CCLUSIS I. tracellular recordgs were obtaed from amacre and ngli cells the perfused reta-eyecup preparati of the mudpuppy. y-Amobutyric acid () and () were added to the bathg medium and the / antagists strychne (Strych), picrotox (Picro), and bicuculle methiodide (BCC) were also applied. 2. / caused a large decrease put resistance (IR) both amacre and ngli cells. The decreased IR was often more than 100 MQ and cstituted a large fracti of the put resistance of the cell. 3. The /-mediated change IR was not associated with a shift membrane potential amacres, but caused a hyperpolarizati ngli cells. 4. / acti amacre and ngli cells was verted to a depolarizati by tracellular jectis of Cl- usg KCl-filled micropipettes. This suggests that chloride is volved mediatg / acti both amacre and ngli cells. 5. A comparis of selective versus sensitivity of ngli cells showed a small populati of cells that were exclusively sensitive .and a small populati of off cells that were exclusively sensitive.

Journal

Journal of Neurophysiology – The American Physiological Society

Published: Apr 1, 1981

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