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E. Richelson, M. Pfenning (1984)
Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: most antidepressants selectively block norepinephrine uptake.European journal of pharmacology, 104 3-4
D. Nutt, P. Glue (1989)
Clinical pharmacology of anxiolytics and antidepressants: A psychopharmacological perspectivePharmacology & Therapeutics, 44
K. Njung'e, Sheila Handley (1991)
Effects of 5‐HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; a putative test for anxiolytic agentsBritish Journal of Pharmacology, 104
C. Broekkamp, H. Berendsen, F. Jenck, A. Delft (1989)
Animal models for anxiety and response to serotonergic drugs.Psychopathology, 22 Suppl 1
C. Gottfries (1989)
Pharmacological Treatment Strategies in Dementia DisordersPharmacopsychiatry, 22
R. Bolles (1970)
Species-specific defense reactions and avoidance learning.Psychological Review, 77
A. Tsuda, Masatoshi Tanaka, Y. Ida, S. Tsujimaru, I. Ushijima, N. Nagasaki (1986)
Effects of preshock experience on enhancement of rat brain noradrenaline turnover induced by psychological stressPharmacology Biochemistry and Behavior, 24
J. Herman, D. Guillonneau, R. Dantzer, B. Scatton, L. Semerdjian-Rouquier, M. Moal (1982)
Differential effects of inescapable footshocks and of stimuli previously paired with inescapable footshocks on dopamine turnover in cortical and limbic areas of the rat.Life sciences, 30 25
M. Fanselow (1980)
Conditional and unconditional components of post-shock freezingThe Pavlovian Journal of Biological Science : Official Journal of the Pavlovian, 15
J. Sherman, N. Kalin (1988)
ICV-CRH alters stress-induced freezing behavior without affecting pain sensitivityPharmacology Biochemistry and Behavior, 30
P. Rittenhouse, E. Bakkum, Patricia O'Connor, M. Carnes, C. Bethea, L. Kar (1992)
Comparison of neuroendocrine and behavioral effects of ipsapirone, a 5-HT1A agonist, in three stress paradigms: immobilization, forced swim and conditioned fearBrain Research, 580
P. Andersen (1989)
The dopamine uptake inhibitor GBR 12909: selectivity and molecular mechanism of actionEuropean Journal of Pharmacology, 166
E. Hård, J. Engel, K. Larsson, B. Musi (2004)
Effect of Diazepam, Apomorphine and Haloperidol on the audiogenic immobility reaction and on the open field behaviorPsychopharmacology, 85
Takeshi Inoue, K. Tsuchiya, T. Koyama (1994)
Regional changes in dopamine and serotonin activation with various intensity of physical and psychological stress in the rat brainPharmacology Biochemistry and Behavior, 49
Takeshi Inoue, T. Koyama, I. Yamashita (1993)
Effect of conditioned fear stress on serotonin metabolism in the rat brainPharmacology Biochemistry and Behavior, 44
N. Kalin, J. Sherman, L. Takahashi (1988)
Antagonism of endogenous CRH systems attenuates stress-induced freezing behavior in ratsBrain Research, 457
E. Eriksson, M. Humble (1990)
Serotonin in Psychiatric Pathophysiology, 3
C. Moret, M. Charvéron, J. Finberg, J. Couzinier, M. Briley (1985)
Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drugNeuropharmacology, 24
T. Ohmori, T. Abekawa, A. Muraki, T. Koyama (1994)
Competitive and noncompetitive NMDA antagonists block sensitization to methamphetaminePharmacology Biochemistry and Behavior, 48
Boyer Wf (1992)
Potential Indications for the Selective Serotonin Reuptake InhibitorsInternational Clinical Psychopharmacology, 6
Y. Claustre, J. Rivy, T. Dennis, B. Scatton (1986)
Pharmacological studies on stress-induced increase in frontal cortical dopamine metabolism in the rat.The Journal of pharmacology and experimental therapeutics, 238 2
K. Rickels, R. Downing, E. Schweizer, Howard Hassman (1993)
Antidepressants for the treatment of generalized anxiety disorder. A placebo-controlled comparison of imipramine, trazodone, and diazepam.Archives of general psychiatry, 50 11
R. Bolles, A. Collier (1976)
The effect of predictive cues on freezing in ratsAnimal Learning & Behavior, 4
A. Deutch, S. Tam, R. Roth (1985)
Footshock and conditioned stress increase 3, 4-dihydroxyphenylacetic acid (DOPAC) in the ventral tegmental area but not substantia nigraBrain Research, 333
M. Bouton, R. Bolles (1980)
Conditioned fear assessed by freezing and by the suppression of three different baselinesAnimal Learning & Behavior, 8
L. Conti, C. Maciver, J. Ferkany, M. Abreu (2005)
Footshock-induced freezing behavior in rats as a model for assessing anxiolyticsPsychopharmacology, 102
R. Blanchard, D. Blanchard (1969)
Crouching as an index of fear.Journal of comparative and physiological psychology, 67 3
R. Kahn, D. Mcnair, R. Lipman, R. Lipman, L. Covi, K. Rickels, R. Downing, S. Fisher, S. Fisher, L. Frankenthaler (1986)
Imipramine and chlordiazepoxide in depressive and anxiety disorders. II. Efficacy in anxious outpatients.Archives of general psychiatry, 43 1
M. Fanselow, F. Helmstetter (1988)
Conditional analgesia, defensive freezing, and benzodiazepines.Behavioral neuroscience, 102 2
G. Griebel, J. Moreau, F. Jenck, R. Misslin, James Martin (2005)
Acute and chronic treatment with 5-HT reuptake inhibitors differentially modulate emotional responses in anxiety models in rodentsPsychopharmacology, 113
S. Bodnoff, B. Suranyi-Cadotte, R. Quirion, M. Meaney (2004)
A comparison of the effects of diazepam versus several typical and atypical anti-depressant drugs in an animal model of anxietyPsychopharmacology, 97
213 123 123 2 2 S. Hashimoto T. Inoue T. Koyama Department of Psychiatry Hokkaidko University School of Medicine North 15 West 7, Kita-ku 060 Sapporo Japan Abstract Conditioned fear stress (CFS)-induced freezing behavior has been proposed as an animal model of anxiety. In the present study, freezing was used to determine the anxiolytic activity of selective serotonin reuptake inhibitors (SSRIs), which are reported to be clinically effective in anxiety disorders. The duration of freezing behavior was reduced by acute treatment with the SSRIs citalopram (1–10 mg/kg) and fluvoxamine (3–30 mg/kg). Acute treatment with the serotonin (5-HT)/noradrenaline (NA) mixed reuptake inhibitor milnacipran (3–30 mg/kg) also attenuated CFS-induced freezing, while acute treatment with the NA reuptake inhibitors maprotiline and ORG4428, and the dopamine (DA) reuptake inhibitor GBR12909 failed to alter CFS-induced freezing. These results indicate that facilitation of 5-HT availability in the brain produced by 5-HT reuptake inhibition reduces CFS-induced freezing behavior. CFS may be a useful model for detecting the anxiolytic potential of 5-HT reuptake inhibitors.
Psychopharmacology – Springer Journals
Published: Jan 1, 1996
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