Access the full text.
Sign up today, get DeepDyve free for 14 days.
K. Park, F. Cozier, O. Ong, J. Caprioli (2001)
Induction of heat shock protein 72 protects retinal ganglion cells in a rat glaucoma model.Investigative ophthalmology & visual science, 42 7
S. Namura, K. Iihara, S. Takami, Izumi Nagata, H. Kikuchi, Koji Matsushita, M. Moskowitz, J. Bonventre, A. Alessandrini (2001)
Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemiaProceedings of the National Academy of Sciences of the United States of America, 98
A. Brunet, A. Bonni, M. Zigmond, Michael Lin, P. Juo, Linda Hu, M. Anderson, K. Arden, J. Blenis, M. Greenberg (1999)
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription FactorCell, 96
G. Borasio, A. Markus, A. Wittinghofer, Y. Barde, R. Heumann (1993)
Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neuronsThe Journal of Cell Biology, 121
I. Nir, Changdong Liu, Rong Wen (1999)
Light treatment enhances photoreceptor survival in dystrophic retinas of Royal College of Surgeons rats.Investigative ophthalmology & visual science, 40 10
K. Kuida, T. Zheng, S. Na, C. Kuan, Di Yang, H. Karasuyama, P. Rakic, R. Flavell (1996)
Decreased apoptosis in the brain and premature lethality in CPP32-deficient miceNature, 384
Rong Wen, Tong Cheng, Ying Song, M. Matthes, D. Yasumura, M. Lavail, ROY Steinberg (1998)
Continuous exposure to bright light upregulates bFGF and CNTF expression in the rat retina.Current eye research, 17 5
T. Allsopp, S. Wyatt, H. Paterson, A. Davies (1993)
The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosisCell, 73
Li-ming Cheng, P. Sapieha, P. Kittlerová, W. Hauswirth, A. Polo (2002)
TrkB Gene Transfer Protects Retinal Ganglion Cells from Axotomy-Induced Death In VivoThe Journal of Neuroscience, 22
A. Alessandrini, S. Namura, M. Moskowitz, J. Bonventre (1999)
MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia.Proceedings of the National Academy of Sciences of the United States of America, 96 22
Hua Gao, Xiaoxi Qiao, Franz Hefti, Joe Hollyfield, B. Knusel (1997)
Elevated mRNA expression of brain-derived neurotrophic factor in retinal ganglion cell layer after optic nerve injury.Investigative ophthalmology & visual science, 38 9
L. Désiré, Y. Courtois, J. Jeanny (2000)
Endogenous and Exogenous Fibroblast Growth Factor 2 Support Survival of Chick Retinal Neurons by Control of Neuronal Neuronal bcl‐xL and bcl‐2 Expression Through a Fibroblast Berowth Factor Receptor 1‐ and Erk‐Dependent PathwayJournal of Neurochemistry, 75
G. Seigel, L. Liu (1997)
Inducible apoptosis-promoting activity in retinal cell-conditioned medium.Molecular vision, 3
N. Ogata, Lin Wang, N. Jo, J. Tombran-Tink, Kanji Takahashi, D. Mrazek, M. Matsumura (2001)
Pigment epithelium derived factor as a neuroprotective agent against ischemic retinal injuryCurrent Eye Research, 22
Lothar Schweigerer, B. Malerstein, G. Neufeld, D. Gospodarowicz (1987)
Basic fibroblast growth factor is synthesized in cultured retinal pigment epithelial cells.Biochemical and biophysical research communications, 143 3
Ruben Adler (1996)
Mechanisms of photoreceptor death in retinal degenerations. From the cell biology of the 1990s to the ophthalmology of the 21st century?Archives of ophthalmology, 114 1
R. Ali, G. Sarra, C. Stephens, M. Alwis, J. Bainbridge, P. Munro, S. Fauser, M. Reichel, C. Kinnon, D. Hunt, S. Bhattacharya, A. Thrasher (2000)
Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapyNature Genetics, 25
Madalina Stanciu, Ying Wang, Ruth Kentor, N. Burke, Simon Watkins, G. Kress, I. Reynolds, E. Klann, Maria Angiolieri, Jon Johnson, D. DeFranco (2000)
Persistent Activation of ERK Contributes to Glutamate-induced Oxidative Toxicity in a Neuronal Cell Line and Primary Cortical Neuron Cultures*The Journal of Biological Chemistry, 275
R. Joseph, T. Li (1996)
Overexpression of Bcl-2 or Bcl-XL transgenes and photoreceptor degeneration.Investigative ophthalmology & visual science, 37 12
R Adler (1996)
Mechanisms of photoreceptor death in retinal degenerations, 114
K. Wahlin, P. Campochiaro, D. Zack, R. Adler (2000)
Neurotrophic factors cause activation of intracellular signaling pathways in Müller cells and other cells of the inner retina, but not photoreceptors.Investigative ophthalmology & visual science, 41 3
V. Fontaine, N. Kinkl, J. Sahel, H. Dreyfus, D. Hicks (1998)
Survival of Purified Rat Photoreceptors In Vitro Is Stimulated Directly by Fibroblast Growth Factor-2The Journal of Neuroscience, 18
G. Putcha, Charles Harris, K. Moulder, R. Easton, C. Thompson, E. Johnson (2002)
Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice
J. Pastorino, M. Tafani, J. Farber (1999)
Tumor Necrosis Factor Induces Phosphorylation and Translocation of BAD through a Phosphatidylinositide-3-OH Kinase-dependent Pathway*The Journal of Biological Chemistry, 274
S. Datta, H. Dudek, Xu Tao, S. Masters, H. Fu, Y. Gotoh, M. Greenberg (1997)
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death MachineryCell, 91
A. Caffé, A. Söderpalm, T. Veen (1993)
Photoreceptor-specific protein expression of mouse retina in organ culture and retardation of rd degeneration in vitro by a combination of basic fibroblast and nerve growth factors.Current eye research, 12 8
Y. Uteza, J. Rouillot, A. Kobetz, D. Marchant, S. Pecqueur, E. Arnaud, H. Prats, J. Honiger, J. Dufier, M. Abitbol, M. Neuner‐Jehle (1999)
Intravitreous transplantation of encapsulated fibroblasts secreting the human fibroblast growth factor 2 delays photoreceptor cell degeneration in Royal College of Surgeons rats.Proceedings of the National Academy of Sciences of the United States of America, 96 6
E. Yoles, Shir Muller, M. Schwartz (1997)
NMDA-receptor antagonist protects neurons from secondary degeneration after partial optic nerve crush.Journal of neurotrauma, 14 9
R. Oppenheim (1991)
Cell death during development of the nervous system.Annual review of neuroscience, 14
K. Philpott, M. McCarthy, A. Klippel, L. Rubin (1997)
Activated Phosphatidylinositol 3-Kinase and Akt Kinase Promote Survival of Superior Cervical NeuronsThe Journal of Cell Biology, 139
C. Portera-Cailliau, C. Sung, J. Nathans, R. Adler (1994)
Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa.Proceedings of the National Academy of Sciences of the United States of America, 91
Rong Wen, Ying Song, T. Cheng, M. Matthes, D. Yasumura, M. Lavail, Roy Steinbergi (1995)
Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina.The Journal of neuroscience : the official journal of the Society for Neuroscience, 15 11
N. Mata, J. Weng, G. Travis (2000)
Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration.Proceedings of the National Academy of Sciences of the United States of America, 97 13
C. Marshall (2000)
Signal transduction takes centre stageNature Cell Biology, 2
Patricia D’Cruz, D. Yasumura, Jessica Weir, M. Matthes, H. Abderrahim, M. Lavail, D. Vollrath (2000)
Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat.Human molecular genetics, 9 4
S. Pugazhenthi, Elisa Miller, C. Sable, P. Young, K. Heidenreich, L. Boxer, J. Reusch (1999)
Insulin-like Growth Factor-I Induces bcl-2 Promoter through the Transcription Factor cAMP-Response Element-binding Protein*The Journal of Biological Chemistry, 274
T Redmond, Shirley Yu, Eric Lee, D. Bok, D. Hamasaki, N. Chen, P. Goletz, Jian-xing Ma, R. Crouch, K. Pfeifer (1998)
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycleNature Genetics, 20
P. Heinrich, I. Behrmann, G. Müller-Newen, F. Schaper, L. Graeve (1998)
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.The Biochemical journal, 334 ( Pt 2)
A. Meyer‐Franke, Miriam Kaplan, Frank Pfieger, B. Barres (1995)
Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in cultureNeuron, 15
K. Shinoda, Yu Nakamura, K. Matsushita, K. Shimoda, H. Okita, M. Fukuma, Taketo Yamada, H. Ohde, Y. Oguchi, J. Hata, A. Umezawa (2001)
Light induced apoptosis is accelerated in transgenic retina overexpressing human EAT/mcl-1, an anti-apoptotic bcl-2 related geneBritish Journal of Ophthalmology, 85
A. Wenzel, C. Grimm, A. Marti, N. Kueng-Hitz, F. Hafezi, G. Niemeyer, C. Remé (2000)
c-fos Controls the “Private Pathway” of Light-Induced Apoptosis of Retinal PhotoreceptorsThe Journal of Neuroscience, 20
Charles Harris, M. Deshmukh, Brian Tsui-Pierchala, A. Maroney, Eugene Johnson (2002)
Inhibition of the c-Jun N-Terminal Kinase Signaling Pathway by the Mixed Lineage Kinase Inhibitor CEP-1347 (KT7515) Preserves Metabolism and Growth of Trophic Factor-Deprived NeuronsThe Journal of Neuroscience, 22
M. Xiao, S. Sastry, Z. Li, D. Possin, Jean Chang, I. Klock, A. Milam (1998)
Effects of retinal laser photocoagulation on photoreceptor basic fibroblast growth factor and survival.Investigative ophthalmology & visual science, 39 3
SK Kostyk, P. D’Amore, IM Herman, J. Wagner (1994)
Optic nerve injury alters basic fibroblast growth factor localization in the retina and optic tract, 14
G. Tezel, M. Wax (1999)
Inhibition of caspase activity in retinal cell apoptosis induced by various stimuli in vitro.Investigative ophthalmology & visual science, 40 11
PA Campochiaro, M. Chang, M. Ohsato, S. Vinores, Z. Nie, L. Hjelmeland, A. Mansukhani, C. Basilico, D. Zack (1996)
Retinal degeneration in transgenic mice with photoreceptor-specific expression of a dominant-negative fibroblast growth factor receptor, 16
R. Bush, T. Williams (1991)
The effect of unilateral optic nerve section on retinal light damage in rats.Experimental eye research, 52 2
Gordon Fain, John Lisman (1993)
Photoreceptor degeneration in vitamin A deprivation and retinitis pigmentosa: the equivalent light hypothesis.Experimental eye research, 57 3
G. Chang, Y. Hao, F. Wong (1993)
Apoptosis: Final common pathway of photoreceptor death in rd, rds, and mutant miceNeuron, 11
J. Lisman, G. Fain (1995)
Support for the equivalent light hypothesis for RPNature Medicine, 1
T. Jelsma, Hana Friedman, Michelle Berkelaar, G. Bray, A. Aguayo (1993)
Different forms of the neurotrophin receptor trkB mRNA predominate in rat retina and optic nerve.Journal of neurobiology, 24 9
Jun-Sub Choi, Jeong-a Kim, Dong-Hwan Kim, Myung-Hun Chun, B. Gwag, S. Yoon, C. Joo (2000)
Failure to activate NF-κB promotes apoptosis of retinal ganglion cells following optic nerve transectionBrain Research, 883
M. Hetman, K. Kanning, Jane Cavanaugh, Z. Xia (1999)
Neuroprotection by Brain-derived Neurotrophic Factor Is Mediated by Extracellular Signal-regulated Kinase and Phosphatidylinositol 3-Kinase*The Journal of Biological Chemistry, 274
Jeffrey Bennett, Steven Zeiler, Kevin Jones (1999)
Patterned expression of BDNF and NT-3 in the retina and anterior segment of the developing mammalian eye.Investigative ophthalmology & visual science, 40 12
M. McLaren, G. Inana (1997)
Inherited retinal degeneration: basic FGF induces phagocytic competence in cultured RPE cells from RCS ratsFEBS Letters, 412
Ka-Man Lai, Tony Pawson (2000)
The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo.Genes & development, 14 9
C. Grimm, A. Wenzel, F. Hafezi, C. Remé (2000)
Gene expression in the mouse retina: the effect of damaging light.Molecular vision, 6
P. Simon, C. Vorwerk, S. Mansukani, S. Chen, J. Wilson, D. Zurakowski, J. Bennett, E. Dreyer (1999)
bcl-2 gene therapy exacerbates excitotoxicity.Human gene therapy, 10 10
Y. Izumi, K. Shimamoto, A. Benz, S. Hammerman, J. Olney, C. Zorumski (2002)
Glutamate transporters and retinal excitotoxicityGlia, 39
P. Kermer, R. Ankerhold, N. Klöcker, S. Krajewski, John Reed, M. Bähr (2000)
Caspase-9: involvement in secondary death of axotomized rat retinal ganglion cells in vivo.Brain research. Molecular brain research, 85 1-2
A. Kauffmann-Zeh, P. Rodriguez-Viciana, E. Ulrich, C. Gilbert, P. Coffer, J. Downward, G. Evan (1997)
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKBNature, 385
F. Davidson, H. Steller (1998)
Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutantsNature, 391
Dana Lau, Laura Mcgee, Shangzhen Zhou, Katherine Rendahl, William Manning, Jaime Escobedo, John Flannery (2000)
Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2.Investigative ophthalmology & visual science, 41 11
Ching-Kang Chen, Marie Burns, Maribeth Spencer, G. Niemi, Jeannie Chen, James Hurley, Denis Baylor, Melvin Simon (1999)
Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase.Proceedings of the National Academy of Sciences of the United States of America, 96 7
D. Bok, D. Yasumura, M. Matthes, A. Ruiz, J. Duncan, A. Chappelow, Sergei Zolutukhin, W. Hauswirth, M. Lavail (2002)
Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation.Experimental eye research, 74 6
J. Johnson, Y. Barde, M. Schwab, H. Thoenen (1986)
Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells, 6
R. Katso, K. Okkenhaug, K. Ahmadi, S. White, J. Timms, M. Waterfield (2001)
Cellular function of phosphoinositide 3-kinases: Implications for development, immunity, homeostasis, and cancerAnnual Review of Cell and Developmental Biology, 17
M. Dubois‐Dauphin, H. Frankowski, Y. Tsujimoto, J. Huarte, J. Martinou (1994)
Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death.Proceedings of the National Academy of Sciences of the United States of America, 91
Atsushi Hayashi, B. Koroma, Kazuyuki Imai, Eugene dejuan (1996)
Increase of protein tyrosine phosphorylation in rat retina after ischemia-reperfusion injury.Investigative ophthalmology & visual science, 37 11
Masayuki Akimoto, Shin-ichi Miyatake, J. Kogishi, Masanori Hangai, K. Okazaki, Jun Takabashi, Masaaki Saiki, Masayoshi Iwaki, Yoshihito Honda (1999)
Adenovirally expressed basic fibroblast growth factor rescues photoreceptor cells in RCS rats.Investigative ophthalmology & visual science, 40 2
R. Katso, K. Okkenhaug, K. Ahmadi, S. White, J. Timms, M. Waterfield (2001)
Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.Annual review of cell and developmental biology, 17
S. Mansour-Robaey, D. Clarke, Y. Wang, G. Bray, A. Aguayo (1994)
Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells.Proceedings of the National Academy of Sciences of the United States of America, 91
R. Yao, G. Cooper (1995)
Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor.Science, 267 5206
E. Faktorovich, R. Steinberg, D. Yasumura, M. Matthes, M. Lavail (1992)
Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat, 12
Q. Cui, Louisa Tang, Bing Hu, K. So, H. Yip (2002)
Expression of trkA, trkB, and trkC in injured and regenerating retinal ganglion cells of adult rats.Investigative ophthalmology & visual science, 43 6
N. Kinkl, J. Sahel, D. Hicks (2001)
Alternate FGF2-ERK1/2 Signaling Pathways in Retinal Photoreceptor and Glial Cells in Vitro *The Journal of Biological Chemistry, 276
R. Lolley, Hongmei Rong, C. Craft (1994)
Linkage of photoreceptor degeneration by apoptosis with inherited defect in phototransduction.Investigative ophthalmology & visual science, 35 2
F. Wein, L. Levin (2002)
Current understanding of neuroprotection in glaucomaCurrent Opinion in Ophthalmology, 13
A. Cellerino, K. Kohler (1997)
Brain‐derived neurotrophic factor/neurotrophin‐4 receptor TrkB is localized on ganglion cells and dopaminergic amacrine cells in the vertebrate retinaJournal of Comparative Neurology, 386
T. Boulton, N. Stahl, G. Yancopoulos (1994)
Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors.The Journal of biological chemistry, 269 15
MATTHEW d, ELLA Faktorovich, JEANNE Hepler, KATHRYN Pearson, D. Yasumura, M. Matthes, ROY Steinberg (1991)
Basic Fibroblast Growth Factor Protects Photoreceptors from Light‐Induced Degeneration in Albino Rats aAnnals of the New York Academy of Sciences, 638
S. Gupta, C. Jollimore, M. McLaren, G. Inana, M. Kelly (1997)
Mammalian retinal pigment epithelial cells in vitro respond to the neurokines ciliary neurotrophic factor and leukemia inhibitory factor.Biochemistry and cell biology = Biochimie et biologie cellulaire, 75 2
G. Putcha, Charles Harris, K. Moulder, R. Easton, C. Thompson, Eugene Johnson (2002)
Intrinsic and extrinsic pathway signaling during neuronal apoptosisThe Journal of Cell Biology, 157
J. Phelan, Dean Bok (2000)
A brief review of retinitis pigmentosa and the identified retinitis pigmentosa genes.Molecular vision, 6
A. Maroney, James Finn, D. Bozyczko‐Coyne, T. O’Kane, Nicola Neff, A. Tolkovsky, David Park, Chao Yan, C. Troy, Lloyd Greene (1999)
CEP‐1347 (KT7515), an Inhibitor of JNK Activation, Rescues Sympathetic Neurons and Neuronally Differentiated PC12 Cells from Death Evoked by three Distinct InsultsJournal of Neurochemistry, 73
Hua Gao, J. Hollyfield (1996)
Basic fibroblast growth factor: increased gene expression in inherited and light-induced photoreceptor degeneration.Experimental eye research, 62 2
M. Tcheng, G. Fuhrmann, M. Hartmann, Y. Courtois, J. Jeanny (1994)
Spatial and temporal expression patterns of FGF receptor genes type 1 and type 2 in the developing chick retina.Experimental eye research, 58 3
P. Maisonpierre, L. Belluscio, B. Friedman, R. Alderson, S. Wiegand, M. Furth, R. Lindsay, G. Yancopoulos (1990)
NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expressionNeuron, 5
M. Yamada, H. Ohnishi, S. Sano, A. Nakatani, T. Ikeuchi, H. Hatanaka (1997)
Insulin Receptor Substrate (IRS)-1 and IRS-2 Are Tyrosine-phosphorylated and Associated with Phosphatidylinositol 3-Kinase in Response to Brain-derived Neurotrophic Factor in Cultured Cerebral Cortical Neurons*The Journal of Biological Chemistry, 272
M. Tso, Chang Zhang, A. Abler, Cheng‐Jong Chang, F. Wong, G. Chang, T. Lam (1994)
Apoptosis leads to photoreceptor degeneration in inherited retinal dystrophy of RCS rats.Investigative ophthalmology & visual science, 35 6
Changdong Liu, Min Peng, A. Laties, Rong Wen (1998)
Preconditioning with Bright Light Evokes a Protective Response against Light Damage in the Rat RetinaThe Journal of Neuroscience, 18
N. Colley, J. CASSILLt, Elizabeth Baker, Charles ZUKERt (1995)
Defective intracellular transport is the molecular basis of rhodopsin-dependent dominant retinal degeneration.Proceedings of the National Academy of Sciences of the United States of America, 92
S. Ying, H. Jansen, M. Lehman, S. Fong, W. Kao (2000)
Retinal degeneration in cone photoreceptor cell-ablated transgenic mice.Molecular vision, 6
N. Stahl, T. Boulton, T. Farruggella, N. Ip, S. Davis, B. Witthuhn, F. Quelle, O. Silvennoinen, G. Barbieri, S. Pellegrini, J. Ihle, G. Yancopoulos (1994)
Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.Science, 263 5143
N. Katai, N. Yoshimura (1999)
Apoptotic retinal neuronal death by ischemia-reperfusion is executed by two distinct caspase family proteases.Investigative ophthalmology & visual science, 40 11
C. Nobes, A. Tolkovsky (1995)
Neutralizing Anti‐p21ras Fabs Suppress Rat Sympathetic Neuron Survival Induced by NGF, LIF, CNTF and cAMPEuropean Journal of Neuroscience, 7
G. Tezel, L. Li, R. Patil, R. Patil, M. Wax (2001)
TNF-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes.Investigative ophthalmology & visual science, 42 8
Jeannie Chen, John FLANNERYt, MATrHEW Lavail, Roy Steinberg, Jun Xus, Melvin Simon (1996)
bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations.Proceedings of the National Academy of Sciences of the United States of America, 93 14
A. Polo, L. Aigner, R. Dunn, G. Bray, A. Aguayo (1998)
Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells.Proceedings of the National Academy of Sciences of the United States of America, 95 7
Z. Xia, M. Dickens, J. Raingeaud, R. Davis, M. Greenberg (1995)
Opposing Effects of ERK and JNK-p38 MAP Kinases on ApoptosisScience, 270
P. Coffer, Jing-Yun Jin, J. Woodgett (1998)
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.The Biochemical journal, 335 ( Pt 1)
S. Davies, Helen Reddy, M. Caivano, P. Cohen (2000)
Specificity and mechanism of action of some commonly used protein kinase inhibitors.The Biochemical journal, 351 Pt 1
E. Pierce (2001)
Pathways to photoreceptor cell death in inherited retinal degenerationsBioEssays, 23
C. Thompson (1995)
Apoptosis in the pathogenesis and treatment of diseaseScience, 267
W. Kolch (2000)
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions.The Biochemical journal, 351 Pt 2
N. Klöcker, P. Kermer, Jochen Weishaupt, M. Labes, R. Ankerhold, M. Bähr (2000)
Brain-Derived Neurotrophic Factor-Mediated Neuroprotection of Adult Rat Retinal Ganglion Cells In Vivo Does Not Exclusively Depend on Phosphatidyl-Inositol-3′-Kinase/Protein Kinase B SignalingThe Journal of Neuroscience, 20
G. Carmignoto, L. Maffei, P. Candeo, R. Canella, C. Comelli (1989)
Effect of NGF on the survival of rat retinal ganglion cells following optic nerve section, 9
K. Virdee, A. Tolkovsky (1996)
Inhibition of p42 and p44 Mitogen‐Activated Protein Kinase Activity by PD98059 Does Not Suppress Nerve Growth Factor‐Induced Survival of Sympathetic NeuronesJournal of Neurochemistry, 67
Kazuhiko Unoki, M. Lavail (1994)
Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor.Investigative ophthalmology & visual science, 35 3
C. Jolly, R. Morimoto (2000)
Role of the heat shock response and molecular chaperones in oncogenesis and cell death.Journal of the National Cancer Institute, 92 19
Gabriel Travis (1998)
Mechanisms of cell death in the inherited retinal degenerations.American journal of human genetics, 62 3
G. Cohen (1997)
Caspases: the executioners of apoptosis.The Biochemical journal, 326 ( Pt 1)
R. Takano, S. Hisahara, K. Namikawa, H. Kiyama, H. Okano, Masayuki Miura (2000)
Nerve Growth Factor Protects Oligodendrocytes from Tumor Necrosis Factor-α-induced Injury through Akt-mediated Signaling Mechanisms*The Journal of Biological Chemistry, 275
W. Cao, R. Wen, F. Li, T. Cheng, R. Steinberg (1997)
Induction of basic fibroblast growth factor mRNA by basic fibroblast growth factor in Müller cells.Investigative ophthalmology & visual science, 38 7
Stephen Tsang, Jeannie Chen, H. Kjeldbye, Wen-song Li, Melvin Simon, Peter Gouras, S. Goff (1997)
Retarding photoreceptor degeneration in Pdegtm1/Pdegtml mice by an apoptosis suppressor gene.Investigative ophthalmology & visual science, 38 5
S. Hackett, C. Schoenfeld, John Freund, J. Gottsch, Sudeepta Bhargave, P. Campochiaro (1997)
Neurotrophic factors, cytokines and stress increase expression of basic fibroblast growth factor in retinal pigmented epithelial cells.Experimental eye research, 64 6
Vittorio Porciatti, Tommaso Pizzorusso, Tommaso Pizzorusso, M. Cenni, L. Maffei, L. Maffei (1996)
The visual response of retinal ganglion cells is not altered by optic nerve transection in transgenic mice overexpressing Bcl-2.Proceedings of the National Academy of Sciences of the United States of America, 93 25
H. Takagi, N. Yoshimura, H. Tanihara, Y. Honda (1994)
Insulin-like growth factor-related genes, receptors, and binding proteins in cultured human retinal pigment epithelial cells.Investigative ophthalmology & visual science, 35 3
M. Lavail, K. Unoki, D. Yasumura, M. Matthes, G. Yancopoulos, R. Steinberg (1992)
Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light.Proceedings of the National Academy of Sciences of the United States of America, 89 23
Liya Yuan, A. Neufeld (2000)
Tumor necrosis factor‐α: A potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve headGlia, 32
Fong-Qi Liang, T. Aleman, N. Dejneka, L. Dudus, Krishna Fisher, A. Maguire, S. Jacobson, Jean Bennett (2001)
Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa.Molecular therapy : the journal of the American Society of Gene Therapy, 4 5
E. Garcia-Valenzuela, Sharma Sc (1998)
Rescue of retinal ganglion cells from axotomy-induced apoptosis through TRK oncogene transfer.Neuroreport, 9
Jeannie Chen, Melvin Simon, M. Matthes, D. Yasumura, M. Lavail (1999)
Increased susceptibility to light damage in an arrestin knockout mouse model of Oguchi disease (stationary night blindness)Investigative ophthalmology & visual science, 40 12
E. Faktorovich, R. Steinberg, D. Yasumura, M. Matthes, M. Lavail (1990)
Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factorNature, 347
Gordon Fain, John Lisman (1999)
Light, Ca2+, and photoreceptor death: new evidence for the equivalent-light hypothesis from arrestin knockout mice.Investigative ophthalmology & visual science, 40 12
Wenhua Zheng, S. Kar, R. Quirion (2002)
Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons.Molecular pharmacology, 62 2
P. Kermer, N. Klöcker, M. Labes, M. Bähr (1998)
Inhibition of CPP32-Like Proteases Rescues Axotomized Retinal Ganglion Cells from Secondary Cell Death In VivoThe Journal of Neuroscience, 18
S. Skaper, M. Floreani, A. Negro, L. Facci, P. Giusti (1998)
Neurotrophins Rescue Cerebellar Granule Neurons from Oxidative Stress‐Mediated Apoptotic Death: Selective Involvement of Phosphatidylinositol 3‐Kinase and the Mitogen‐Activated Protein Kinase PathwayJournal of Neurochemistry, 70
D. Martin, D. Yee, E. Feldman (1992)
Gene expression of the insulin-like growth factors and their receptors in cultured human retinal pigment epithelial cells.Brain research. Molecular brain research, 12 1-3
A. Caffé, A. Caffé, A. Söderpalm, I. Holmqvist, T. Veen (2001)
A combination of CNTF and BDNF rescues rd photoreceptors but changes rod differentiation in the presence of RPE in retinal explants.Investigative ophthalmology & visual science, 42 1
R. Krishnamoorthy, P. Agarwal, G. Prasanna, K. Vopat, W. Lambert, H. Sheedlo, I. Pang, D. Shade, R. Wordinger, T. Yorio, A. Clark, N. Agarwal (2001)
Characterization of a transformed rat retinal ganglion cell line.Brain research. Molecular brain research, 86 1-2
J. Perry, J. Du, H. Kjeldbye, P. Gouras (1995)
The effects of bFGF on RCS rat eyes.Current eye research, 14 7
W. Hare, E. Woldemussie, Ron Lai, H. Ton, G. Ruiz, B. Feldmann, M. Wijono, T. Chun, Larry Wheeler (2001)
Efficacy and safety of memantine, an NMDA-type open-channel blocker, for reduction of retinal injury associated with experimental glaucoma in rat and monkey.Survey of ophthalmology, 45 Suppl 3
M. Cayouette, D. Behn, M. Sendtner, P. Lachapelle, C. Gravel (1998)
Intraocular Gene Transfer of Ciliary Neurotrophic Factor Prevents Death and Increases Responsiveness of Rod Photoreceptors in theretinal degeneration slow mouseThe Journal of Neuroscience, 18
M. Deshmukh, J. Vasilakos, T. Deckwerth, P. Lampe, B. Shivers, Eugene Johnson (1996)
Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteasesThe Journal of Cell Biology, 135
T. Kurokawa, N. Katai, H. Shibuki, S. Kuroiwa, Yasuo Kurimoto, C. Nakayama, Nagahisa Yoshimura (1999)
BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia.Investigative ophthalmology & visual science, 40 12
R. Clem, M. Fechheimer, L. Miller (1991)
Prevention of apoptosis by a baculovirus gene during infection of insect cells.Science, 254 5036
S. Mah, Li-Tao Zhong, Yanjun Liu, A. Roghani, R.H. Edwards, D. Bredesen (1993)
The Protooncogene bcl‐2 Inhibits Apoptosis in PC12 CellsJournal of Neurochemistry, 60
Jean Bennett, Yong Zeng, R. Bajwa, L. Klatt, Y. Li, A. Maguire (1998)
Adenovirus-mediated delivery of rhodopsin-promoted bcl-2 results in a delay in photoreceptor cell death in the rd/rd mouseGene Therapy, 5
R. Lolley, D. Farber, M. Rayborn, J. Hollyfield (1977)
Cyclic GMP accumulation causes degeneration of photoreceptor cells: simulation of an inherited disease.Science, 196 4290
R. Waldbillig, B. Pfeffer, T. Schoen, Alice Adler, Z. Shen‐Orr, L. Scavo, Derek ERoith, G. Chader (1991)
Evidence for an Insulin‐Like Growth Factor Autocrine‐Paracrine System in the Retinal Photoreceptor‐Pigment Epithelial Cell ComplexJournal of Neurochemistry, 57
G. Chang, Y. Hao, F. Wong (1993)
Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice.Neuron, 11 4
J. Pastorino, G. Simbula, K. Yamamoto, P. Glascott, R. Rothman, J. Farber (1996)
The Cytotoxicity of Tumor Necrosis Factor Depends on Induction of the Mitochondrial Permeability Transition*The Journal of Biological Chemistry, 271
N. Fayein, Y. Courtois, J. Jeanny (1990)
Ontogeny of basic fibroblast growth factor binding sites in mouse ocular tissues.Experimental cell research, 188 1
B. Pulverer, J. Kyriakis, J. Avruch, E. Nikolakaki, J. Woodgett (1991)
Phosphorylation of c-jun mediated by MAP kinasesNature, 353
L. Minichiello, F. Casagranda, Rosa Tatche, C. Stucky, A. Postigo, G. Lewin, A. Davies, R. Klein (1998)
Point Mutation in trkB Causes Loss of NT4-Dependent Neurons without Major Effects on Diverse BDNF ResponsesNeuron, 21
H. Dudek, S. Datta, T. Franke, M. Birnbaum, R. Yao, G. Cooper, R. Segal, D. Kaplan, M. Greenberg (1997)
Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase AktScience, 275
L. Yuan, A. Neufeld (2000)
Tumor necrosis factor-alpha: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head.Glia, 32 1
F. Hafezi, J. Steinbach, A. Marti, K. Munz, Zhao-Qi Wang, E. Wagner, A. Aguzzi, C. Remé (1997)
The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivoNature Medicine, 3
Michel Cayouette, Claude Gravel (1997)
Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse.Human gene therapy, 8 4
E. Yang, J. Zha, J. Jockel, L. Boise, C. Thompson, S. Korsmeyer (1995)
Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell deathCell, 80
I. Nir, W. Kedzierski, Jeannie Chen, G. Travis (2000)
Expression of Bcl-2 Protects against Photoreceptor Degeneration in retinal degeneration slow (rds) MiceThe Journal of Neuroscience, 20
G. Tezel, M. Wax (2000)
Increased Production of Tumor Necrosis Factor-α by Glial Cells Exposed to Simulated Ischemia or Elevated Hydrostatic Pressure Induces Apoptosis in Cocultured Retinal Ganglion CellsThe Journal of Neuroscience, 20
S. Pugazhenthi, A. Nesterova, C. Sable, K. Heidenreich, L. Boxer, L. Heasley, J. Reusch (2000)
Akt/Protein Kinase B Up-regulates Bcl-2 Expression through cAMP-response Element-binding Protein*The Journal of Biological Chemistry, 275
R. Armstrong, Teresa Aja, K. Hoang, S. Gaur, X. Bai, E. Alnemri, G. Litwack, D. Karanewsky, L. Fritz, K. Tomaselli (1997)
Activation of the CED3/ICE-Related Protease CPP32 in Cerebellar Granule Neurons Undergoing Apoptosis But Not NecrosisThe Journal of Neuroscience, 17
Frank Gunn‐Moore, Alan Williams, Nick Toms, J. Tavaré (1997)
Activation of mitogen-activated protein kinase and p70S6 kinase is not correlated with cerebellar granule cell survival.The Biochemical journal, 324 ( Pt 2)
S. Estus, W. Zaks, R. Freeman, M. Gruda, R. Bravo, Eugene Johnson (1994)
Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosisThe Journal of Cell Biology, 127
G. Putcha, M. Deshmukh, Eugene Johnson (1999)
BAX Translocation Is a Critical Event in Neuronal Apoptosis: Regulation by Neuroprotectants, BCL-2, and CaspasesThe Journal of Neuroscience, 19
For more than a decade it has been known that certain growth factors inhibit apoptosis in genetically determined and experimental models of inner and outer retinal degeneration. The molecular mechanisms underlying these protective effects and the signaling that supports the survival of photoreceptors and retinal ganglion cells in these models have recently come under more in depth investigation. This paper reviews our current understanding of the balance of pro‐ and antiapoptotic signals that determine cell fate in the retina and how the activation of key signal transduction pathways by specific classes of neurotrophins protects retinal neurons. © 2002 Wiley‐Liss, Inc.
Journal of Cellular Biochemistry – Wiley
Published: Jan 1, 2003
Keywords: ; ; ; ; ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.