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NEUROGLIAL LOCALIZATION OF POTASSIUM AND SODIUM EFFECTS ON RESPIRATION IN BRAIN

NEUROGLIAL LOCALIZATION OF POTASSIUM AND SODIUM EFFECTS ON RESPIRATION IN BRAIN Department of Biochemistry A, University of Copenhagen, 30 Juliane Maries Vej and Biological Institute of the Carlsberg Foundation, Copenhagen a, Denmark (Reeeited 7 May 1966) BRAIN slices react to an increased concentration of potassium or a decreased concentration of sodium in a manner, which is unique to this tissue (ASHFORD DIXON, and 1935; DICKENS GREVILLE, and 1935; ELLIOTT LIBET, and 1942; HERTZ CLAUSEN, and 1963). During incubation in media with a ‘balanced’ ion composition (e.g. 120 mM-sodium and 5 mM-potassium), their rate of oxygen consumption is quite well maintained at about 90 pmoles/g fresh wt./hr. Exposure to sodium-free media, however, causes a very rapid decrease of the respiration, until the rate of oxygen uptake reaches a level at about 10 per cent of its original value; thereafter the decline stops and the residual respiration-which seems to be unaffected by lack of sodiumcontinues for hours. This peculiar course of the respiration may indicate that the slice contains two different fractions, e.g. two cell types, which do not react identically to lack of sodium. The originally larger fraction shows a rapidly declining rate of oxygen uptake, whereas the respiration in the originally smaller fraction remains stable and accordingly is unmasked http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

NEUROGLIAL LOCALIZATION OF POTASSIUM AND SODIUM EFFECTS ON RESPIRATION IN BRAIN

Hertz, Leif
Journal of Neurochemistry , Volume 13 (12) – Dec 1, 1966
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References (9)

Publisher
Wiley
Copyright
Copyright © 1966 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
DOI
10.1111/j.1471-4159.1966.tb04300.x
Publisher site
See Article on Publisher Site

Abstract

Department of Biochemistry A, University of Copenhagen, 30 Juliane Maries Vej and Biological Institute of the Carlsberg Foundation, Copenhagen a, Denmark (Reeeited 7 May 1966) BRAIN slices react to an increased concentration of potassium or a decreased concentration of sodium in a manner, which is unique to this tissue (ASHFORD DIXON, and 1935; DICKENS GREVILLE, and 1935; ELLIOTT LIBET, and 1942; HERTZ CLAUSEN, and 1963). During incubation in media with a ‘balanced’ ion composition (e.g. 120 mM-sodium and 5 mM-potassium), their rate of oxygen consumption is quite well maintained at about 90 pmoles/g fresh wt./hr. Exposure to sodium-free media, however, causes a very rapid decrease of the respiration, until the rate of oxygen uptake reaches a level at about 10 per cent of its original value; thereafter the decline stops and the residual respiration-which seems to be unaffected by lack of sodiumcontinues for hours. This peculiar course of the respiration may indicate that the slice contains two different fractions, e.g. two cell types, which do not react identically to lack of sodium. The originally larger fraction shows a rapidly declining rate of oxygen uptake, whereas the respiration in the originally smaller fraction remains stable and accordingly is unmasked

Journal

Journal of Neurochemistry – Wiley

Published: Dec 1, 1966

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