Access the full text.
Sign up today, get DeepDyve free for 14 days.
F. Petitet, B. Jeantaud, M. Reibaud, A. Imperato, M. Dubroeucq (1998)
Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors.Life sciences, 63 1
(1999)
A common neurobiological mechanism regulates cannabinoid and opioid rewarding effects in mice
U. Shalev, Jeffrey Grimm, Y. Shaham (2002)
Neurobiology of Relapse to Heroin and Cocaine Seeking: A ReviewPharmacological Reviews, 54
T. Burkey, R. Quock, P. Consroe, W. Roeske, H. Yamamura (1997)
delta 9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain.European journal of pharmacology, 323 2-3
L. Fattore, G. Cossu, Cristina Martellotta, W. Fratta (2001)
Intravenous self-administration of the cannabinoid CB1 receptor agonist WIN 55,212-2 in ratsPsychopharmacology, 156
G. Cossu, C. Ledent, L. Fattore, A. Imperato, G. Böhme, M. Parmentier, W. Fratta (2001)
Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuseBehavioural Brain Research, 118
F. Weiss, R. Ciccocioppo, L. Parsons, S. Katner, Xiu Liu, E. Zorrilla, G. Valdez, O. Ben-shahar, S. Angeletti, R. Richter (2001)
Compulsive Drug‐Seeking Behavior and RelapseAnnals of the New York Academy of Sciences, 937
Y. Shaham, U. Shalev, Lin Lu, H. Wit, J. Stewart (2003)
The reinstatement model of drug relapse: history, methodology and major findingsPsychopharmacology, 168
French French (1997)
delta9‐Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptorsNeurosci. Lett., 226
Jane Stewart (2000)
Pathways to relapse: the neurobiology of drug- and stress-induced relapse to drug-taking.Journal of psychiatry & neuroscience : JPN, 25 2
R. Tsien, R. Yuste (2001)
The role of withdrawal in heroin addiction : enhances reward or promotes avoidance ?
J. Stewart, P. Vezina (1988)
A comparison of the effects of intra-accumbens injections of amphetamine and morphine on reinstatement of heroin intravenous self-administration behaviorBrain Research, 457
R. Wise, A. Murray, M. Bozarth (2005)
Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever pressing in ratsPsychopharmacology, 100
M. Navarro, M. Carrera, W. Fratta, O. Valverde, G. Cossu, L. Fattore, J. Chowen, R. Gómez, I. Arco, M. Villanúa, R. Maldonado, G. Koob, F. Fonseca (2001)
Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-AdministrationThe Journal of Neuroscience, 21
G. Tanda, P. Munzar, S. Goldberg (2000)
Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeysNature Neuroscience, 3
C. Ledent, O. Valverde, G. Cossu, F. Petitet, J. Aubert, F. Beslot, G. Böhme, A. Imperato, T. Pedrazzini, B. Roques, G. Vassart, W. Fratta, M. Parmentier (1999)
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.Science, 283 5400
S. Schenk, B. Partridge (1999)
Cocaine-seeking produced by experimenter-administered drug injections: dose-effect relationships in ratsPsychopharmacology, 147
F. Weiss, R. Ciccocioppo, L. Parsons, S. Katner, X. Liu, E. Zorrilla, G. Valdez, O. Ben-shahar, S. Angeletti, R. Richter (2001)
Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors.Annals of the New York Academy of Sciences, 937
M. Martellotta, G. Cossu, L. Fattore, G. Gessa, Walter Fratta (1998)
Self-administration of the cannabinoid receptor agonist WIN 55,212-2 in drug-naive miceNeuroscience, 85
T. Vries, Y. Shaham, J. Homberg, H. Crombag, K. Schuurman, Jeanine Dieben, L. Vanderschuren, A. Schoffelmeer (2001)
A cannabinoid mechanism in relapse to cocaine seekingNature Medicine, 7
B. Everitt, A. Dickinson, T. Robbins (2001)
The neuropsychological basis of addictive behaviourBrain Research Reviews, 36
Because opioid and cannabinoid systems have been reported to interact in the modulation of addictive behaviour, this study was aimed at investigating the ability of cannabinoid agents to reinstate or prevent heroin‐seeking behaviour after a prolonged period of extinction. In rats previously trained to self‐administer heroin intravenously, non‐contingent non‐reinforced priming administrations of heroin and cannabinoids were presented after long‐term extinction, and lever pressing following injections was observed. Results showed that: (i) intravenous priming infusions of heroin (0.1 and 0.2 mg/kg) lead to reinstatement of drug‐seeking behaviour; (ii) intraperitoneal priming injections of the central cannabinoid receptor agonists R‐(+)‐(2,3‐dihydro‐5‐methyl‐3‐((4‐morpholinyl)methyl)pyrol(1,2,3‐de)‐1,4‐benzoxazinyl) (1‐naphthalenyl)methanonemesylate (WIN 55,212‐2, 0.15 and 0.3 mg/kg) and (–)‐cis‐3‐(2‐hydroxy‐4(1,1‐dimethyl‐heptyl)phenyl)‐trans‐4‐(3‐hydroxypropyl) cyclohexanol (CP 55,940, 0.05 and 0.1 mg/kg), but not Δ9‐tetrahydrocannabinol (Δ9‐THC, 0.1–1.0 mg/kg), effectively restored heroin‐seeking behaviour; (iii) intraperitoneal priming injection of the central cannabinoid receptor antagonist N‐(piperidin‐1‐yl)‐5‐(4‐chlorophenyl)‐1‐(2,4‐dichloro‐phenyl)4‐methyl‐1H‐pyrazole‐3‐carboxamide (SR 141716A, 0.3 mg/kg) did not reinstate responding, but (iv) completely prevented heroin‐induced reinstatement of drug‐seeking behaviour. Moreover, heroin‐seeking behaviour was still present for a few days following cannabinoid primings, indicating a long‐lasting effect of cannabinoids on responding for heroin. These findings indicate that relapse to heroin after an extended drug‐free period is triggered by cannabinoid agonists and that SR 141716A prevents drug‐seeking behaviour, suggesting that the use of the cannabinoid antagonist could have some therapeutic benefits in heroin‐induced relapse.
European Journal of Neuroscience – Wiley
Published: Apr 1, 2003
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.