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Expression of NMDA channels on cerebellar Purkinje cells acutely dissociated from newborn rats

Expression of NMDA channels on cerebellar Purkinje cells acutely dissociated from newborn rats Abstract 1. Conflicting evidence exists concerning the expression and properties of N-methyl-D-aspartate (NMDA) receptors on cerebellar Purkinje cells during development. We used whole-cell and single-channel recording to examine NMDA receptors on acutely dissociated Purkinje cells from newborn rats (postnatal day 0-4). 2. NMDA channels were present on > 80% of identified Purkinje cells and had pharmacological and single-channel properties that were indistinguishable from NMDA receptors on other neurons. In particular, responses were glycine-dependent and Mg2+ produced flickery open-channel block. 3. Our results demonstrate the transient expression of NMDA receptor/channels on Purkinje cells early in development. As NMDA receptors have been implicated in developmental plasticity in other regions of the CNS, a similar role is feasible during climbing fiber innervation of Purkinje cells. Copyright © 1992 the American Physiological Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurophysiology The American Physiological Society

Expression of NMDA channels on cerebellar Purkinje cells acutely dissociated from newborn rats

Journal of Neurophysiology , Volume 68 (5): 1901 – Nov 1, 1992

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Publisher
The American Physiological Society
Copyright
Copyright © 1992 the American Physiological Society
ISSN
0022-3077
eISSN
1522-1598
Publisher site
See Article on Publisher Site

Abstract

Abstract 1. Conflicting evidence exists concerning the expression and properties of N-methyl-D-aspartate (NMDA) receptors on cerebellar Purkinje cells during development. We used whole-cell and single-channel recording to examine NMDA receptors on acutely dissociated Purkinje cells from newborn rats (postnatal day 0-4). 2. NMDA channels were present on > 80% of identified Purkinje cells and had pharmacological and single-channel properties that were indistinguishable from NMDA receptors on other neurons. In particular, responses were glycine-dependent and Mg2+ produced flickery open-channel block. 3. Our results demonstrate the transient expression of NMDA receptor/channels on Purkinje cells early in development. As NMDA receptors have been implicated in developmental plasticity in other regions of the CNS, a similar role is feasible during climbing fiber innervation of Purkinje cells. Copyright © 1992 the American Physiological Society

Journal

Journal of NeurophysiologyThe American Physiological Society

Published: Nov 1, 1992

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