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Proliferative activity detected by Ki67 correlates with poor outcome in Merkel cell carcinoma

Proliferative activity detected by Ki67 correlates with poor outcome in Merkel cell carcinoma Sir : Merkel cell carcinoma (MCC) is a rare primary neuroendocrine carcinoma of the skin affecting mainly the elderly White people. Local recurrences are common, as is early and frequent metastasis to local lymph nodes before progression to systemic disease. In the current study, we examined proliferative activity in primary MCC samples, comparing immunohistochemical data with clinical outcome in order to establish whether proliferative activity could serve as a prognostic marker for survival. Immunohistochemistry was performed on 24 primary MCC tumour samples obtained from 24 patients operated on at the Department of Plastic Surgery, Helsinki University Hospital between 1987 and 2003. None of the patients received chemotherapy or radiation therapy preoperatively. Diagnoses were confirmed by immunohistochemical analysis using CK20 and TTF‐1 antibodies; the latter was negative in all samples. Distribution of Ki67 immunoreactivity was expressed as the labelling index (LI). For statistical analysis, 35% was chosen as the cut‐off point. The correlation between quantitative expression of Ki67 and size and tumour location, local recurrence and metastatic dissemination was calculated by Student's t ‐test. The level of significance was chosen as P < 0.05. All 24 samples stained positively for Ki67 ( Figure 1 ). The mean LI was http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Histopathology Wiley

Proliferative activity detected by Ki67 correlates with poor outcome in Merkel cell carcinoma

Histopathology , Volume 49 (5) – Nov 1, 2006

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References (15)

Publisher
Wiley
Copyright
Copyright © 2006 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0309-0167
eISSN
1365-2559
DOI
10.1111/j.1365-2559.2006.02511.x
pmid
17064309
Publisher site
See Article on Publisher Site

Abstract

Sir : Merkel cell carcinoma (MCC) is a rare primary neuroendocrine carcinoma of the skin affecting mainly the elderly White people. Local recurrences are common, as is early and frequent metastasis to local lymph nodes before progression to systemic disease. In the current study, we examined proliferative activity in primary MCC samples, comparing immunohistochemical data with clinical outcome in order to establish whether proliferative activity could serve as a prognostic marker for survival. Immunohistochemistry was performed on 24 primary MCC tumour samples obtained from 24 patients operated on at the Department of Plastic Surgery, Helsinki University Hospital between 1987 and 2003. None of the patients received chemotherapy or radiation therapy preoperatively. Diagnoses were confirmed by immunohistochemical analysis using CK20 and TTF‐1 antibodies; the latter was negative in all samples. Distribution of Ki67 immunoreactivity was expressed as the labelling index (LI). For statistical analysis, 35% was chosen as the cut‐off point. The correlation between quantitative expression of Ki67 and size and tumour location, local recurrence and metastatic dissemination was calculated by Student's t ‐test. The level of significance was chosen as P < 0.05. All 24 samples stained positively for Ki67 ( Figure 1 ). The mean LI was

Journal

HistopathologyWiley

Published: Nov 1, 2006

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