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L. Byberg, A. Siegbahn, L. Berglund, P. McKeigue, R. Reneland, H. Lithell (1998)
Plasminogen activator inhibitor-1 activity is independently related to both insulin sensitivity and serum triglycerides in 70-year-old men.Arteriosclerosis, thrombosis, and vascular biology, 18 2
Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Troglitazone Improves Defects in Insulin Action, Insulin Secretion, Ovarian Steroidogenesis, and Fibrinolysis in Women with Polycystic Ovary Syndr
M. Alessi, I. Juhan-vague (1997)
[Endothelium, thrombosis and fibrinolysis].La Revue du praticien, 47 20
D. Schneider, T. Nordt, B. Sobel (1993)
Attenuated Fibrinolysis and Accelerated Atherogenesis in Type II Diabetic PatientsDiabetes, 42
K. Landin, L. Tengborn, J. Chmielewska, H. Schenck, U. Smith (1991)
The Acute Effect of Insulin on Tissue Plasminogen Activator and Plasminogen Activator Inhibitor in ManThrombosis and Haemostasis, 65
L. Frittitta, J. Youngren, P. Sbraccia, M. D’Adamo, A. Buongiorno, R. Vigneri, I. Goldfine, V. Trischitta (1997)
Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-a gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activityDiabetologia, 40
S. Dawson, A. Hamsten, B. Wiman, A. Henney, S. Humphries (1991)
Genetic variation at the plasminogen activator inhibitor-1 locus is associated with altered levels of plasma plasminogen activator inhibitor-1 activity.Arteriosclerosis and thrombosis : a journal of vascular biology, 11 1
F. Ofei, S. Hurel, J. Newkirk, M. Sopwith, Roy Taylor (1996)
Effects of an Engineered Human Anti–TNF-α Antibody (CDP571) on Insulin Sensitivity and Glycemic Control in Patients With NIDDMDiabetes, 45
W. Thompson, E. Smith (1989)
Atherosclerosis and the coagulation systemThe Journal of Pathology, 159
Massimo Cigolini, M. Tonoli, L. Borgato, L. Frigotto, Franco Manzato, S. Zeminian, C. Cardinale, M. Camin, E. Chiaramonte, G. Sandre, Claudio Lunardi (1999)
Expression of plasminogen activator inhibitor-1 in human adipose tissue: a role for TNF-alpha?Atherosclerosis, 143 1
N. Brown, Mehmet Agirbasli, Douglas Vaughan (1999)
Comparative effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor antagonism on plasma fibrinolytic balance in humans.Hypertension, 34 2
A. Mavri, M. Stegnar, M. Krebs, J. Sentočnik, M. Geiger, B. Binder (1999)
Impact of adipose tissue on plasma plasminogen activator inhibitor-1 in dieting obese women.Arteriosclerosis, thrombosis, and vascular biology, 19 6
F. Samad, K. Uysal, S. Wiesbrock, M. Pandey, G. Hotamisligil, D. Loskutoff (1999)
Tumor necrosis factor α is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1Proceedings of the National Academy of Sciences of the United States of America, 96
G. Reaven (1988)
Banting lecture 1988. Role of insulin resistance in human disease.Diabetes, 37 12
The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 1999 by The Endocrine Society Synthesis and Secretion of Plasminogen Activator
M. Naito, C. Funaki, T. Hayashi, K. Yamada, K. Asai, N. Yoshimine, F. Kuzuya (1992)
Substrate-bound fibrinogen, fibrin and other cell attachment-promoting proteins as a scaffold for cultured vascular smooth muscle cells.Atherosclerosis, 96 2-3
I. Toft, K. Bønaa, O. Ingebretsen, A. Nordøy, K. Birkeland, Trond Jenssen (1997)
Gender differences in the relationships between plasma plasminogen activator inhibitor-1 activity and factors linked to the insulin resistance syndrome in essential hypertension.Arteriosclerosis, thrombosis, and vascular biology, 17 3
(1997)
Plasminogen activator inhibitor-1 antigen levels are related to gamma glutamyl transferase in hyperlipidaemic women
A Asplund‐Carlson, A Hamsten, B Wiman, LA Carlson (1993)
Relationship between plasma plasminogen activator inhibitor‐1 activity and VLDL triglyceride concentration, insulin levels and insulin sensitivity: studies in randomly selected normo‐ and hyper‐triglyceridaemic menDiabetologia, 36
M. Alessi, F. Peiretti, P. Morange, M. Henry, G. Nalbone, I. Juhan-vague (1997)
Production of Plasminogen Activator Inhibitor 1 by Human Adipose Tissue: Possible Link Between Visceral Fat Accumulation and Vascular DiseaseDiabetes, 46
B. Janand-Delenne, C. Chagnaud, D. Raccah, M. Alessi, I. Juhan-vague, P. Vague (1998)
Visceral fat as a main determinant of plasminogen activator inhibitor 1 level in womenInternational Journal of Obesity, 22
T. Vukovich, S. Proidl, P. Knöbl, H. Teufelsbauer, C. Schnack, G. Schernthaner (1992)
The Effect of Insulin Treatment on the Balance between Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Type 2 Diabetic PatientsThrombosis and Haemostasis, 68
F Ofei, S Hurel, J Newkirk, M Sopwith (1996)
Taylor R. Effects of an engineered human anti‐TNF‐alpha antibody (CDP571) on insulin sensitivity and glycaemic control in patients with NIDDMDiabetes, 45
(1991)
The effects of metformin on the ®brinolytic system in diabetic and non-diabetic subjects
P. Vague, I. Juhan-vague, M. Aillaud, C. Badier, R. Viard, M. Alessi, D. Collen (1986)
Correlation between blood fibrinolytic activity, plasminogen activator inhibitor level, plasma insulin level, and relative body weight in normal and obese subjects.Metabolism: clinical and experimental, 35 3
P. Ridker, C. Gaboury, P. Conlin, E. Seely, G. Williams, D. Vaughan (1993)
Stimulation of Plasminogen Activator Inhibitor In Vivo by Infusion of Angiotensin II Evidence of a Potential Interaction Between the Renin‐Angiotensin System and Fibrinolytic FunctionCirculation, 87
M. Alessi, I. Juhan-Vague, Teake Kooistra, P. Declerck, D. Collen (1988)
Insulin Stimulates the Synthesis of Plasminogen Activator Inhibitor 1 by the Human Hepatocellular Cell Line Hep G2Thrombosis and Haemostasis, 60
M. Cigolini, G. Targher, I. Andreis, M. Tonoli, G. Agostino, G. Sandre (1996)
Visceral fat accumulation and its relation to plasma hemostatic factors in healthy men.Arteriosclerosis, thrombosis, and vascular biology, 16 3
J. Meigs, M. Mittleman, D. Nathan, G. Tofler, Daniel Singer, Patricia Murphy-Sheehy, I. Lipińska, R. D’Agostino, P. Wilson (2000)
Hyperinsulinemia, hyperglycemia, and impaired hemostasis: the Framingham Offspring Study.JAMA, 283 2
L Mussoni, P Maderna, M Camera, F Bernini, L Sironi, M Sirtori, E Tremoli (1990)
Atherogenic lipoproteins and PAI‐1 releases by endothelial cellsFibrinolysis, 4
A. Sylvan, J. Rutegård, K. Janunger, B. Sjölund, T. Nilsson (1992)
Normal plasminogen activator inhibitor levels at long-term follow-up after jejuno-ileal bypass surgery in morbidly obese individuals.Metabolism: clinical and experimental, 41 12
TK Nordt, KJ Klassen, DJ Schneider, BE Sobel (1993)
Augmentation of synthesis of plasma plasminogen activator inhibitor 1 in arterial cells by glucose and its implications for local fibrinolysisArterioscler Thromb Vasc Biol, 13
Philippe Vague, I. Juhan-Vague, V. Chabert, M. Alessi, C. Atlan (1989)
Fat distribution and plasminogen activator inhibitor activity in nondiabetic obese women.Metabolism: clinical and experimental, 38 9
P. Schling, H. Mallow, A. Trindl, G. Löffler (1999)
Evidence for a local renin angiotensin system in primary cultured human preadipocytesInternational Journal of Obesity, 23
L. Nilsson, C. Banfi, U. Diczfalusy, E. Tremoli, A. Hamsten, P. Eriksson (1998)
Unsaturated fatty acids increase plasminogen activator inhibitor-1 expression in endothelial cells.Arteriosclerosis, thrombosis, and vascular biology, 18 11
L. Mykkänen, Tapani Rönnemaa, Jukka Marniemi, S. Haffner, Richard Bergman, Markku Laakso (1994)
Insulin sensitivity is not an independent determinant of plasma plasminogen activator inhibitor-1 activity.Arteriosclerosis and thrombosis : a journal of vascular biology, 14 8
L. Almér, H. Öhlin (1987)
Elevated levels of the rapid inhibitor of plasminogen activator (t-PAI) in acute myocardial infarction.Thrombosis research, 47 3
C. Karlsson, K. Lindell, M. Ottosson, L. Sjöström, B. Carlsson, L. Carlsson (1998)
Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II.The Journal of clinical endocrinology and metabolism, 83 11
Ken Kato, H. Satoh, Y. Endo, D. Yamada, S. Midorikawa, W. Sato, Kenji Mizuno, T. Fujita, K. Tsukamoto, Tsuyoshi Watanabe (1999)
Thiazolidinediones down-regulate plasminogen activator inhibitor type 1 expression in human vascular endothelial cells: A possible role for PPARgamma in endothelial function.Biochemical and biophysical research communications, 258 2
S. Ye, F. Green, P. Scarabin, Nicaud, L. Bara, S. Dawson, S. Humphries, Alun Evans, G. Luc, J. Cambou (1995)
The 4G/5G Genetic Polymorphism in the Promoter of the Plasminogen Activator Inhibitor-1 (PAI-1) Gene Is Associated with Differences in Plasma PAI-1 Activity but not with Risk of Myocardial Infarction in the ECTIM StudyThrombosis and Haemostasis, 74
I. Wanless, John Lentz (1990)
Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factorsHepatology, 12
M. Mansfield, M. Stickland, A. Carter, P. Grant (1994)
Polymorphisms of the Plasminogen Activator Inhibitor- 1 Gene in Type 1 and Type 2 Diabetes, and in Patients with Diabetic RetinopathyThrombosis and Haemostasis, 71
D. Schneider, P. Absher, M. Ricci (1997)
Dependence of augmentation of arterial endothelial cell expression of plasminogen activator inhibitor type 1 by insulin on soluble factors released from vascular smooth muscle cells.Circulation, 96 9
Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-�, in Vivo*
R. Mahmoud, D. Raccah, M. Alessi, M. Aillaud, I. Juhan-vague, P. Vague (1992)
Fibrinolysis in insulin dependent diabetic patients with or without nephropathyFibrinolysis and Proteolysis, 6
H. Koistinen, J. Bastard, E. Dusserre, P. Ebeling, N. Zegari, F. Andreelli, C. Jardel, M. Donner, L. Meyer, P. Moulin, B. Hainque, J. Riou, M. Laville, V. Koivisto, H. Vidal (2000)
Subcutaneous adipose tissue expression of tumour necrosis factor‐α is not associated with whole body insulin resistance in obese nondiabetic or in type‐2 diabetic subjectsEuropean Journal of Clinical Investigation, 30
GM Reaven (1995)
Pathogenesis of insulin resistance in human diseasePhysiol Rev, 75
M. Cigolini, G. Targher, G. Agostino, M. Tonoli, M. Muggeo, G. Sandre (1996)
Liver Steatosis and Its Relation to Plasma Haemostatic Factors in Apparently Healthy Men - Role of the Metabolic SyndromeThrombosis and Haemostasis, 76
Jean-Philippe Bastard, Hubert Vidal, Claude Jardel, Eric Bruckert, Danielle Robin, Paulette Vallier, Patricia Blondy, G. Turpin, Claude Forest, Bernard Hainque (2000)
Subcutaneous adipose tissue expression of plasminogen activator inhibitor-1 gene during very low calorie diet in obese subjectsInternational Journal of Obesity, 24
Y. Erdem, C. Usalan, İ. Haznedaroğlu, B. Altun, M. Arıcı, Ü. Yasavul, Ç. Turgan, Şali Çaǧlar (1999)
Effects of angiotensin converting enzyme and angiotensin II receptor inhibition on impaired fibrinolysis in systemic hypertension.American journal of hypertension, 12 11 Pt 1
LO Almer, H Ohlin (1987)
Elevated levels of the rapid inhibitor of plasminogen activator inhibitor (t‐PAI) in acute myocardial infarctionThomb Res, 47
J. Bastard, E. Bruckert, D. Porquet, C. Jardel, A. Ankri, J. Delattre, B. Hainque (1996)
Evidence for a relationship between plasminogen activator inhibitor-1 and gamma glutamyl transferase.Thrombosis research, 81 2
G. Reaven (1988)
Role of Insulin Resistance in Human DiseaseDiabetes, 37
L. Mussoni, L. Mannucci, M. Sirtori, M. Camera, P. Maderna, L. Sironi, E. Tremoli (1992)
Hypertriglyceridemia and regulation of fibrinolytic activity.Arteriosclerosis and thrombosis : a journal of vascular biology, 12 1
B. Howard (1999)
Insulin resistance and lipid metabolism.The American journal of cardiology, 84 1A
Per Eriksson, S. Reynisdottir, F. Lönnqvist, V. Stemme, A. Hamsten, P. Arner (1998)
Adipose tissue secretion of plasminogen activator inhibitor-1 in non-obese and obese individualsDiabetologia, 41
M. Kockx, R. Leenen, J. Seidell, H. Princen, T. Kooistra (1999)
Relationship between Visceral Fat and PAI-1 in Overweight Men and Women before and after Weight LossThrombosis and Haemostasis, 82
K. Alberti, P. Zimmet (1998)
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO ConsultationDiabetic Medicine, 15
B. Loon, C. Kluft, J. Radder, M. Blankenstein, A. Meinders (1993)
The cardiovascular risk factor plasminogen activator inhibitor type 1 is related to insulin resistance.Metabolism: clinical and experimental, 42 8
K. Landin, L. Stigendal, E. Eriksson, M. Krotkiewski, B. Risberg, L. Tengborn, U. Smith (1990)
Abdominal obesity is associated with an impaired fibrinolytic activity and elevated plasminogen activator inhibitor-1.Metabolism: clinical and experimental, 39 10
A. Stiko-Rahm, B. Wiman, A. Hamsten, J. Nilsson (1990)
Secretion of plasminogen activator inhibitor-1 from cultured human umbilical vein endothelial cells is induced by very low density lipoprotein.Arteriosclerosis, 10 6
B. Olofsson, G. Dahlén, T. Nilsson (1989)
Evidence for increased levels of plasminogen activator inhibitor and tissue plasminogen activator in plasma of patients with angiographically verified coronary artery disease.European heart journal, 10 1
O. Etingin, D Hajjar, K. Hajjar, P. Harpel, R Nachman (1991)
Lipoprotein (a) regulates plasminogen activator inhibitor-1 expression in endothelial cells. A potential mechanism in thrombogenesis.The Journal of biological chemistry, 266 4
Teake Kooistra, P Bosma, H. Tons, A. Berg, Peter Meyer, Hans Princen (1989)
Plasminogen Activator Inhibitor 1: Biosynthesis and mRNA Level Are Increased by Insulin in Cultured Human HepatocytesThrombosis and Haemostasis, 62
G. Hotamisligil, N. Shargill, B. Spiegelman (1993)
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.Science, 259 5091
A. Hamsten, G. Walldius, A. Szamosi, M. Blombäck, U. Faire, G. Dahlén, C. Landou, B. Wiman (1987)
PLASMINOGEN ACTIVATOR INHIBITOR IN PLASMA: RISK FACTOR FOR RECURRENT MYOCARDIAL INFARCTIONThe Lancet, 330
E. Velazquez, E. Velazquez, S. Mendoza, S. Mendoza, Ping Wang, Ping Wang, C. Glueck, C. Glueck (1997)
Metformin therapy is associated with a decrease in plasma plasminogen activator inhibitor-1, lipoprotein(a), and immunoreactive insulin levels in patients with the polycystic ovary syndrome.Metabolism: clinical and experimental, 46 4
C. Doggen, R. Bertina, V. Cats, P. Reitsma, F. Rosendaal (1999)
The 4G/5G Polymorphism in the Plasminogen Activator Inhibitor-1 Gene Is not Associated with Myocardial InfarctionThrombosis and Haemostasis, 82
M. Henry, N. Chomiki, P. Scarabin, M. Alessi, F. Peiretti, D. Arveiler, J. Ferrières, A. Evans, P. Amouyel, O. Poirier, F. Cambien, I. Juhan-vague (1997)
Five frequent polymorphisms of the PAI-1 gene: lack of association between genotypes, PAI activity, and triglyceride levels in a healthy population.Arteriosclerosis, thrombosis, and vascular biology, 17 5
BM Spiegelman (1998)
PPAR‐γ: adipogenic regulator and thiazolidindione receptorDiabetes, 47
John Yudkin, S. Coppack, Karen Bulmer, A. Rawesh, V. Mohamed-ali (1999)
Lack of evidence for secretion of plasminogen activator inhibitor-1 by human subcutaneous adipose tissue in vivo.Thrombosis research, 96 1
JW Jeng, HH Sheu, C Jeng, S Huang, S Shieh (1996)
Impaired fibrinolysis and insulin resistance in hypertensionAm J Hypertens, 26
(1991)
Increased plasma plasminogen inhibitor 1 levels. A possible link between insulin resistance and atherothrombosis
D. Nagi, J. Yudkin (1993)
Effects of Metformin on Insulin Resistance, Risk Factors for Cardiovascular Disease, and Plasminogen Activator Inhibitor in NIDDM Subjects: A study of two ethnic groupsDiabetes Care, 16
P. Björntorp (1995)
Liver triglycerides and metabolism.International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 19 12
DA Ehrmann, DJ Schneider, BE Sobel, MK Cavaghan, J Imperial, RL Rosenfield, KS Polonsky (1997)
Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndromeJ Clin Endocrinol Metab, 82
V Mohamed‐Ali, S Goodrick, A Rawesh, DR Katz, JM Miles, JS Yudkin, S Klein, SW Coppack (1997)
Subcutaneous adipose tissue releases interleukin‐6, but not tumor necrosis factor‐α, in vivoJ Clin Endocrinol Metab, 82
H. Brussaard, J. Leuven, H. Krans, P. Meijer, R. Buytenhek, C. Kluft (1994)
Non-Esterified Fatty Acids are Related with Hypofibrinolysis in Type 2 Diabetes MellitusFibrinolysis and Proteolysis, 8
K. Landin, L. Tengborn, Ulf Smith (1990)
Elevated fibrinogen and plasminogen activator inhibitor (PAI‐1) in hypertension are related to metabolic risk factors for cardiovascular diseaseJournal of Internal Medicine, 227
P. Kern, M. Saghizadeh, J. Ong, R. Bosch, R. Deem, R. Simsolo (1995)
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.The Journal of clinical investigation, 95 5
D. Schneider, B. Sobel (1996)
Synergistic augmentation of expression of plasminogen activator inhibitor type‐1 induced by insulin, very‐low-density lipoproteins, and fatty acidsCoronary Artery Disease, 7
G. Hotamisligil, P. Arner, J. Caro, R. Atkinson, B. Spiegelman (1995)
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.The Journal of clinical investigation, 95 5
E. Feener, J. Northrup, L. Aiello, G. King (1995)
Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells.The Journal of clinical investigation, 95 3
I. Juhan-vague, M. Alessi, G. Nalbone (1993)
Fibrinolysis and atherothrombosisCurrent Opinion in Lipidology, 4
P Eriksson, B Kallin, FM Van'tHoof, P Bavenholm, A Hamsten (1995)
Allele‐specific increase in basal transcription of the plasminogen activator inhibitor 1 gene is associated with myocardial infarctionProc Natl Acad Sci U S A, 92
N. Marx, T. Bourcier, G. Sukhova, P. Libby, J. Plutzky (1999)
PPARγ Activation in Human Endothelial Cells Increases Plasminogen Activator Inhibitor Type-1 Expression PPARγ as a Potential Mediator in Vascular DiseaseArteriosclerosis, Thrombosis, and Vascular Biology, 19
D. Loskutoff, F. Samad (1998)
The adipocyte and hemostatic balance in obesity: studies of PAI-1.Arteriosclerosis, thrombosis, and vascular biology, 18 1
I. Juhan-vague, M. Alessi (1997)
PAI-1, Obesity, Insulin Resistance and Risk of Cardiovascular EventsThrombosis and Haemostasis, 78
W. Litchfield, N. Brown, D. Vaughan (1997)
Plasminogen activator inhibitor type 1 in diabetes and hypertensionCurrent Opinion in Endocrinology & Diabetes, 4
Erik Giltay, J. Elbers, Louis Gooren, J. Emeis, T. Kooistra, H. Asscheman, Coen Stehouwer (1998)
Visceral fat accumulation is an important determinant of PAI-1 levels in young, nonobese men and women: modulation by cross-sex hormone administration.Arteriosclerosis, thrombosis, and vascular biology, 18 11
B. Spiegelman (1998)
PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.Diabetes, 47 4
I. Juhan-vague, M. Alessi (1993)
Plasminogen Activator Inhibitor 1 and AtherothrombosisThrombosis and Haemostasis, 70
E Bruckert, A Ankri, P Giral, G Turpin (1994)
Relationship between plasma plasminogen activator inhibitor‐1 and hepatic enzyme concentrations in hyperlipidemic patientsThromb Haemost, 72
J. Jeng, W. Sheu, C. Jeng, S. Huang, S. Shieh (1996)
Impaired fibrinolysis and insulin resistance in patients with hypertension.American journal of hypertension, 9 5
P. Vague, I. Juhan-vague, M. Alessi, C. Badier, J. Valadier (1987)
Metformin Decreases the High Plasminogen Activator Inhibition Capacity, Plasma Insulin and Triglyceride Levels in Non-Diabetic Obese SubjectsThrombosis and Haemostasis, 57
E. Bruckert, A. Ankri, P. Glral, G. Turpin (1994)
Relation between Plasminogen Activator Inhibitor-1 and Hepatic Enzyme Concentrations in Hyperlipidemic PatientsThrombosis and Haemostasis, 72
L. Mussoni, P. Madema, M. Camera, F. Bemini, L. Sironi, M. Sirtori, E. Tremoli (1990)
Atherogenic lipoproteins and release of plasminogen activator inhibitor-1 (PAI-1) by endothelial cellsFibrinolysis and Proteolysis, 4
D. Vaughan, P. Declerck, Elizabeth Houtte, M. Mol, D. Collen (1992)
Reactivated Recombinant Plasminogen Activator Inhibitor-1 (rPAI-1) Effectively Prevents Thrombolysis In VivoThrombosis and Haemostasis, 68
DL Crandall, EM Quinet, GA Morgan, DE Busler, B McHendry‐Rinde, JG Kral (1999)
Synthesis and secretion of plasminogen activator inhibitor‐1 by human preadipocytesJ Clin Endocrinol Metab, 84
Nancy Brown, Mehmet Agirbasli, Gordon Williams, W. Litchfield, Douglas Vaughan (1998)
Effect of activation and inhibition of the renin-angiotensin system on plasma PAI-1.Hypertension, 32 6
H. Lijnen, D. Collen (1995)
Mechanisms of physiological fibrinolysis.Bailliere's clinical haematology, 8 2
A. Bini, B. Kudryk (1992)
Fibrin and Its Derivatives in the Normal and Diseased Vessel WallAnnals of the New York Academy of Sciences, 667
F. Samad, D. Loskutoff (1996)
Tissue Distribution and Regulation of Plasminogen Activator Inhibitor-1 in Obese MiceMolecular Medicine, 2
S. Padayatty, S. Orme, P. Zenobi, M. Stickland, P. Belchetz, P. Grant (1993)
The Effects of Insulin-Like Growth Factor-1 on Plasminogen Activator Inhibitor-1 Synthesis and Secretion: Results from In Vitro and In Vivo StudiesThrombosis and Haemostasis, 70
E. Smith, Susan Cochran (1990)
Factors influencing the accumulation in fibrous plaques of lipid derived from low density lipoprotein. II. Preferential immobilization of lipoprotein (a) (Lp(a)).Atherosclerosis, 84 2-3
T. Nordt, K. Klassen, D. Schneider, B. Sobel (1993)
Augmentation of synthesis of plasminogen activator inhibitor type-1 in arterial endothelial cells by glucose and its implications for local fibrinolysis.Arteriosclerosis and thrombosis : a journal of vascular biology, 13 12
A. Hamsten, B. Wiman, U. Faire, M. Blombäck (1985)
Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction.The New England journal of medicine, 313 25
W. Steenbergen, S. Lanckmans (1995)
Liver disturbances in obesity and diabetes mellitus.International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 19 Suppl 3
P. Grant, E. Kruithof, C. Felley, J. Felber, F. Bachmann (1990)
Short-term infusions of insulin, triacylglycerol and glucose do not cause acute increases in plasminogen activator inhibitor-1 concentrations in man.Clinical science, 79 5
Ole Svendsen, Christian Hassager, Claus Christiansen, Jørn Nielsen, Kaj Winther (1996)
Plasminogen activator inhibitor-1, tissue-type plasminogen activator, and fibrinogen: Effect of dieting with or without exercise in overweight postmenopausal women.Arteriosclerosis, thrombosis, and vascular biology, 16 3
JB Meigs, MA Mittleman, DM Nathan, GH Tofler, DE Singer, PM Murphy‐Sheehy, I Lipinska, RB D'Agostino, PWF Wilson (2000)
Hyperinsulinemia, hyperglycemia and impaired hemostasisJAMA, 283
P. Morange, M. Alessi, M. Verdier, D. Casanova, G. Magalon, I. Juhan-vague (1999)
PAI-1 produced ex vivo by human adipose tissue is relevant to PAI-1 blood level.Arteriosclerosis, thrombosis, and vascular biology, 19 5
I. Juhan-vague, C. Roul, M. Alessi, J. Ardissone, M. Heim, P. Vague (1989)
Increased Plasminogen Activator Inhibitor Activity in Non Insulin Dependent Diabetic Patients – Relationship with Plasma InsulinThrombosis and Haemostasis, 61
A. Folsom, Hekmat Qamhieh, R. Wing, R. Jeffery, V. Stinson, L. Kuller, K. Wu (1993)
Impact of weight loss on plasminogen activator inhibitor (PAI-1), factor VII, and other hemostatic factors in moderately overweight adults.Arteriosclerosis and thrombosis : a journal of vascular biology, 13 2
B. Loon, A. Bart, J. Radder, M. Frölich, C. Kluft, A. Meinders (1990)
Acute exogenous hyperinsulinaemia does not result in elevation of plasma plasminogen activator inhibitor-1 (PAI-1) in humansFibrinolysis and Proteolysis, 4
K. Landin, Lilian Tengborn, Ulf Smith (1991)
Treating insulin resistance in hypertension with metformin reduces both blood pressure and metabolic risk factorsJournal of Internal Medicine, 229
A. Fontbonne, M. Charles, I. Juhan-vague, J. Bard, P. André, F. Isnard, J. Cohen, P. Grandmottet, P. Vague, M. Safar, E. Eschwège (1996)
The Effect of Metformin on the Metabolic Abnormalities Associated With Upper-Body Fat Distribution. BIGPRO Study GroupDiabetes Care, 19
F. Samad, Koji Yamamoto, D. Loskutoff (1996)
Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide.The Journal of clinical investigation, 97 1
M Henry, N Chomiki, PY Scarabin, MC Alessi, F Peiretti, D Arveiler, J Ferrieres, A Evans, P Amouyel, O Poirier, F Cambien, I Juhan‐Vague (1997)
Five frequent polymorphisms of plasminogen activator inhibitor 1 gene: lack of association between genotypes, PAI activity and triglyceride levels in a healthy populationArterioscler Thromb Vasc Biol, 17
M. Cigolini, G. Targher, Jaap Seidell, Marco Tonoli, R. Schiavon, Giovanna Agostino, G. Sandre (1995)
Relationships of blood pressure to fibrinolysis: influence of anthropometry, metabolic profile and behavioural variablesJournal of Hypertension, 13
井海 江利子 (1994)
Serum gamma-glutamyl transpeptidase level and blood pressure in nondrinkers: a possible pathogenetic role of fatty liver in obesity-related hypertension.Journal of human hypertension, 8 2
D. Vaughan, S. Lazos, Kirk Tong (1995)
Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis.The Journal of clinical investigation, 95 3
R. DeFronzo, J. Tobin, R. Andres (1979)
Glucose clamp technique: a method for quantifying insulin secretion and resistance.The American journal of physiology, 237 3
J. Bastard, E. Bruckert, J. Robert, A. Ankri, A. Grímaldi, C. Jardel, B. Hainque (1995)
Are free fatty acids related to plasma plasminogen activator inhibitor 1 in android obesity?International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 19 11
V. Scelles, Denis Raccah, M. Alessi, J. Vialle, I. Juhan-Vague, Philippe Vague (1992)
Plasminogen activator inhibitor 1 and insulin levels in various insulin resistance states.Diabete & metabolisme, 18 1
M. Meijer, H. Pannekoek (1995)
Structure of plasminogen activator inhibitor 1 (PAI-1) and its function in fibrinolysis: an updateFibrinolysis and Proteolysis, 9
A. Panahloo, V. Mohamed-ali, A. Lane, F. Green, S. Humphries, J. Yudkin (1995)
Determinants of Plasminogen Activator Inhibitor 1 Activity in Treated NIDDM and Its Relation to a Polymorphism in the Plasminogen Activator Inhibitor 1 GeneDiabetes, 44
J. Callés-Escandon, D. Ballor, J. Harvey-Berino, P. Ades, R. Tracy, B. Sobel (1996)
Amelioration of the inhibition of fibrinolysis in elderly, obese subjects by moderate energy intake restriction.The American journal of clinical nutrition, 64 1
F. Anfosso, N. Chomiki, M. Alessi, P. Vague, I. Juhan-vague (1993)
Plasminogen activator inhibitor-1 synthesis in the human hepatoma cell line Hep G2. Metformin inhibits the stimulating effect of insulin.The Journal of clinical investigation, 91 5
V. Fonseca, Tammy Reynolds, Donna Hemphill, C. Randolph, Jannaya Wall, Thomas Valiquet, J. Graveline, L. Fink (1998)
Effect of troglitazone on fibrinolysis and activated coagulation in patients with non-insulin-dependent diabetes mellitus.Journal of diabetes and its complications, 12 4
M. Levi, B. Biemond, A. Zonneveld, J. Tencate, H. Pannekoek (1992)
Inhibition of Plasminogen Activator Inhibitor‐1 Activity Results in Promotion of Endogenous Thrombolysis and Inhibition of Thrombus Extension in Models of Experimental ThrombosisCirculation, 85
C. Lundgren, S. Brown, T. Nordt, B. Sobel, Satoshi Fujii (1996)
Elaboration of type-1 plasminogen activator inhibitor from adipocytes. A potential pathogenetic link between obesity and cardiovascular disease.Circulation, 93 1
KN Frayn (1993)
Insulin resistance and lipid metabolismCurr Opin Lipidol, 4
M. Davies, A. Thomas (1984)
Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death.The New England journal of medicine, 310 18
J. McGill, D. Schneider, C. Arfken, C. Lucore, B. Sobel (1994)
Factors Responsible for Impaired Fibrinolysis in Obese Subjects and NIDDM PatientsDiabetes, 43
J. Callés-Escandon, S. Mirza, B. Sobel, D. Schneider (1998)
Induction of Hyperinsulinemia Combined With Hyperglycemia and Hypertriglyceridemia Increases Plasminogen Activator Inhibitor 1 in Blood in Normal Human SubjectsDiabetes, 47
P. Bosma, E. Berg, T. Kooistra, D. Siemieniak, J. Slightom (1988)
Human plasminogen activator inhibitor-1 gene. Promoter and structural gene nucleotide sequences.The Journal of biological chemistry, 263 19
I. Shimomura, Tohru Funahasm, Masahiko Takahashi, K. Maeda, K. Kotani, Tadashi Nakamura, S. Yamashita, M. Miura, Y. Fukuda, K. Takemura, K. Tokunaga, Y. Matsuzawa (1996)
Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeistyNature Medicine, 2
Sally DawsonS, Bjorn Wimans, A. Hamsten, F. Green, S. Humphries, A. Henney (1993)
The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells.The Journal of biological chemistry, 268 15
R. Bergman, D. Finegood, M. Ader (1985)
Assessment of insulin sensitivity in vivo.Endocrine reviews, 6 1
M. Mansfield, M. Stickland, P. Grant (1995)
Environmental and Genetic Factors in Relation to Elevated Circulating Levels of Plasminogen Activator Inhibitor-1 in Caucasian Patients with Non-Insulin-Dependent Diabetes MellitusThrombosis and Haemostasis, 74
K. Klinger, R. Winqvist, A. Riccio, P. Andreasen, R. Sartorio, L. Nielsen, N. Stuart, P. Stanislovitis, P. Watkins, R. Douglas (1987)
Plasminogen activator inhibitor type 1 gene is located at region q21.3-q22 of chromosome 7 and genetically linked with cystic fibrosis.Proceedings of the National Academy of Sciences of the United States of America, 84 23
D. Kerins, Q. Hao, D. Vaughan (1995)
Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV.The Journal of clinical investigation, 96 5
D. Schneider, B. Sobel (1991)
Augmentation of synthesis of plasminogen activator inhibitor type 1 by insulin and insulin-like growth factor type I: Implications for vascular disease in hyperinsulinemic statesProceedings of the National Academy of Sciences of the United States of America, 89
(1995)
Hypo®brinolysis and the insulin resistance syndrome
Michael, S., Sawdey (1991)
Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta.The Journal of clinical investigation, 88 4
G. Reaven (1995)
Pathophysiology of insulin resistance in human disease.Physiological reviews, 75 3
G. Marchesini, M. Brizi, A. Morselli-Labate, G. Bianchi, E. Bugianesi, A. McCullough, G. Forlani, N. Melchionda (1999)
Association of nonalcoholic fatty liver disease with insulin resistance.The American journal of medicine, 107 5
P. Grant (1996)
The Effects of High- and Medium-Dose Metformin Therapy on Cardiovascular Risk Factors in Patients With Type II DiabetesDiabetes Care, 19
H. Vuorinen-Markkola, llpo Puhakainen, H. Yki-Järvinen (1992)
No Evidence for Short-Term Regulation of Plasminogen Activator Inhibitor Activity by Insulin in ManThrombosis and Haemostasis, 67
D. Raccah, M. Alessi, V. Scelles, C. Ménard, I. Juhan-vague, P. Vague (1993)
Plasminogen Activator Inhibitor Activity in Various Types of Endogenous HypertriglyceridemiaFibrinolysis and Proteolysis, 7
E. Kruithof (1988)
Plasminogen activator inhibitor type 1: Biochemical, biological and clinical aspectsFibrinolysis and Proteolysis, 2
High plasminogen activator inhibitor 1 (PAI‐1) levels are associated with an increased cardiovascular risk of atherothrombosis. Furthermore, increased plasma PAI‐1 levels are associated with dyslipidemia, hyperinsulinemia and hypertension. This association between PAI‐1 and metabolic components of the Metabolic Syndrome could explain the predisposition of insulin resistant patients to atherothrombosis. Recent studies have suggested that visceral adipose tissue might be the link between elevated plasma PAI‐1 and insulin resistance in the Metabolic Syndrome. Indeed, visceral adipose tissue was proposed as a potentially important source of PAI‐1 in humans. However, in light of recent studies, visceral adipose tissue appears to be involved in the increase of plasma PAI‐1 via the metabolic disorders usually associated with central obesity, rather than directly. High plasma PAI‐1 levels are undoubtedly related to insulin resistance, and the mechanisms which could explain such an increase in the Metabolic Syndrome appear to be multi‐factorial and remain to be elucidated. These mechanisms may involve several metabolic disorders such as hyperinsulinemia, dyslipidemia, impaired glucose tolerance and hypertension, which would favor PAI‐1 synthesis and release from different cell types. Copyright © 2000 John Wiley & Sons, Ltd.
Diabetes/Metabolism: Research and Reviews – Wiley
Published: May 1, 2000
Keywords: ; ; ; ; ;
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