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Novel Glutamate Receptor Antagonists Selectively Protect Against Kainic Acid Neurotoxicity in Cultured Cerebral Cortex Neurons

Novel Glutamate Receptor Antagonists Selectively Protect Against Kainic Acid Neurotoxicity in... Abstract: The effect on excitatory amino acid (EAA)‐induced toxicity of two novel non‐N‐methyl‐d‐aspartate (non‐NMDA) antagonists 2‐amino‐3‐(3‐(carboxymethoxy)‐5‐methylisoxazol‐4‐yl)propionic acid (AMOA) and 2‐amino‐3‐(2‐(3‐hydroxy‐5‐methyl‐isoxazol‐4‐yl)methyl‐5‐methyl‐3‐oxoisoxazolin‐4‐yl)propionic acid (AMNH) was tested in primary cultures of cerebral cortex neurons. Such cultures provide a useful model for the investigation of the toxicity of EAAs and a convenient screening system for potential neuroprotective activity of pharmacological agents. It was demonstrated that AMNH and AMOA abolished neurotoxicity induced by kainic acid with IC50 values of 62 ± 10 and 120 ± 19 μM, respectively. No effect on neuronal damage induced by NMDA or AMPA could be detected. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

Novel Glutamate Receptor Antagonists Selectively Protect Against Kainic Acid Neurotoxicity in Cultured Cerebral Cortex Neurons

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References (30)

Publisher
Wiley
Copyright
Copyright © 1990 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
DOI
10.1111/j.1471-4159.1990.tb04976.x
Publisher site
See Article on Publisher Site

Abstract

Abstract: The effect on excitatory amino acid (EAA)‐induced toxicity of two novel non‐N‐methyl‐d‐aspartate (non‐NMDA) antagonists 2‐amino‐3‐(3‐(carboxymethoxy)‐5‐methylisoxazol‐4‐yl)propionic acid (AMOA) and 2‐amino‐3‐(2‐(3‐hydroxy‐5‐methyl‐isoxazol‐4‐yl)methyl‐5‐methyl‐3‐oxoisoxazolin‐4‐yl)propionic acid (AMNH) was tested in primary cultures of cerebral cortex neurons. Such cultures provide a useful model for the investigation of the toxicity of EAAs and a convenient screening system for potential neuroprotective activity of pharmacological agents. It was demonstrated that AMNH and AMOA abolished neurotoxicity induced by kainic acid with IC50 values of 62 ± 10 and 120 ± 19 μM, respectively. No effect on neuronal damage induced by NMDA or AMPA could be detected.

Journal

Journal of NeurochemistryWiley

Published: Nov 1, 1990

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