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Abstract: The effect on excitatory amino acid (EAA)‐induced toxicity of two novel non‐N‐methyl‐d‐aspartate (non‐NMDA) antagonists 2‐amino‐3‐(3‐(carboxymethoxy)‐5‐methylisoxazol‐4‐yl)propionic acid (AMOA) and 2‐amino‐3‐(2‐(3‐hydroxy‐5‐methyl‐isoxazol‐4‐yl)methyl‐5‐methyl‐3‐oxoisoxazolin‐4‐yl)propionic acid (AMNH) was tested in primary cultures of cerebral cortex neurons. Such cultures provide a useful model for the investigation of the toxicity of EAAs and a convenient screening system for potential neuroprotective activity of pharmacological agents. It was demonstrated that AMNH and AMOA abolished neurotoxicity induced by kainic acid with IC50 values of 62 ± 10 and 120 ± 19 μM, respectively. No effect on neuronal damage induced by NMDA or AMPA could be detected.
Journal of Neurochemistry – Wiley
Published: Nov 1, 1990
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