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Hua Zou, W. Henzel, X. Liu, Alexis Lutschg, Xiaodong Wang (1997)
Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3Cell, 90
B. An, Q. Dou (1996)
Cleavage of retinoblastoma protein during apoptosis: an interleukin 1 beta-converting enzyme-like protease as candidate.Cancer research, 56 3
H. Sakahira, M. Enari, S. Nagata (1998)
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosisNature, 391
Dayang Wu, H. Wallen, N. Inohara, G. Núñez (1997)
Interaction and Regulation of the Caenorhabditis elegans Death Protease CED-3 by CED-4 and CED-9*The Journal of Biological Chemistry, 272
M. Spector, S. Desnoyers, D. Hoeppner, M. Hengartner (1997)
Interaction between the C. elegans cell-death regulators CED-9 and CED-4Nature, 385
F. Numa, K. Hirabayashi, N. Tsunaga, H. Kato, K. O’Rourke, H. Shao, Connie Stechmann-Lebakken, J. Varani, A. Rapraeger, V. Dixit (1995)
Elevated levels of syndecan-1 expression confer potent serum-dependent growth in human 293T cells.Cancer research, 55 20
L. Casciola-Rosen, Douglas Miller, G. Anhalt, A. Rosen (1994)
Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.The Journal of biological chemistry, 269 49
M. Enari, H. Sakahira, H. Yokoyama, K. Okawa, A. Iwamatsu, S. Nagata (1998)
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICADNature, 391
M. Jacobson, M. Weil, M. Raff (1997)
Programmed Cell Death in Animal DevelopmentCell, 88
U. Danesch, W. Hoeck, G. Ringold (1992)
Cloning and transcriptional regulation of a novel adipocyte-specific gene, FSP27. CAAT-enhancer-binding protein (C/EBP) and C/EBP-like proteins interact with sequences required for differentiation-dependent expression.The Journal of biological chemistry, 267 10
Dayang Wu, H. Wallen, G. Núñez (1997)
Interaction and Regulation of Subcellular Localization of CED-4 by CED-9Science, 275
X. Wang, J. Pai, E. Wiedenfeld, J. Medina, C. Slaughter, J. Goldstein, M. Brown (1995)
Purification of an Interleukin-1 Converting Enzyme-related Cysteine Protease That Cleaves Sterol Regulatory Element-binding Proteins between the Leucine Zipper and Transmembrane Domains (*)The Journal of Biological Chemistry, 270
C. Thompson (1995)
Apoptosis in the pathogenesis and treatment of diseaseScience, 267
Y. Lazebnik, S. Kaufmann, S. Desnoyers, G. Poirier, W. Earnshaw (1994)
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICENature, 371
R. Lockshin, J. Beaulaton (1974)
Programmed cell death.Life sciences, 15 9
Qizhong Song, S. Lees-Miller, Sharad Kumar, Ning Zhang, Doug Chan, G. Smith, Stephen Jackson, Emad Alnemri, Gerald Litwack, K. Khanna, Martin, F. Lavin (1996)
DNA‐dependent protein kinase catalytic subunit: a target for an ICE‐like protease in apoptosis.The EMBO Journal, 15
J. Xiang, D. Chao, S. Korsmeyer (1996)
BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases.Proceedings of the National Academy of Sciences of the United States of America, 93 25
N. Inohara, T. Koseki, Yuanming Hu, Shu Chen, G. Núñez (1997)
CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis.Proceedings of the National Academy of Sciences of the United States of America, 94 20
N. Inohara, Liyun Ding, Shu Chen, G. Núñez (1997)
harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival‐promoting proteins Bcl‐2 and Bcl‐XLThe EMBO Journal, 16
N. McCarthy, M. Whyte, C. Gilbert, G. Evan (1997)
Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue BakThe Journal of Cell Biology, 136
E. Alnemri, D. Livingston, D. Nicholson, G. Salvesen, N. Thornberry, W. Wong, Junying Yuan (1996)
Human ICE/CED-3 Protease NomenclatureCell, 87
S. Nagata (1997)
Apoptosis by Death FactorCell, 88
A. Chinnaiyan, K. O’Rourke, Brian Lane, V. Dixit (1997)
Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell DeathScience, 275
G. Cohen (1997)
Caspases: the executioners of apoptosis.The Biochemical journal, 326 ( Pt 1)
Paul Williams, D. Chang, Ulrich Danesch, Gordon Ringold, Renu Heller (1992)
CCAAT/enhancer binding protein expression is rapidly extinguished in TA1 adipocyte cells treated with tumor necrosis factor.Molecular endocrinology, 6 7
E. White (1996)
Life, death, and the pursuit of apoptosis.Genes & development, 10 1
D. Nicholson, Ambereen Ali, N. Thornberry, J. Vaillancourt, Connie Ding, M. Gallant, Y. Gareau, P. Griffin, M. Labelle, Y. Lazebnik, N. Munday, S. Raju, M. Smulson, T. Yamin, Violeta Yu, Douglas Miller (1995)
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisNature, 376
DFF45 is a subunit of the DNA fragmentation factor (DFF) that is cleaved by caspase‐3 during apoptosis. However, the mechanism by which DFF45 regulates apoptotic cell death remains poorly understood. Here we report the identification and characterization of two mammalian genes, CIDE‐A and CIDE‐B, encoding highly related proteins with homology to the N‐terminal region of DFF45. CIDE‐A and CIDE‐B were found to activate apoptosis in mammalian cells, which was inhibited by DFF45 but not by caspase inhibitors. Expression of CIDE‐A induced DNA fragmentation in 293T cells, which was inhibited by DFF45, further suggesting that DFF45 inhibits the apoptotic activities of CIDEs. In addition to mammalian CIDE‐A and CIDE‐B, we identified DREP‐1, a Drosophila melanogaster homolog of DFF45 that could inhibit CIDE‐A‐mediated apoptosis. Mutant analysis revealed that the C‐terminal region of CIDE‐A was necessary and sufficient for killing whereas the region with homology to DFF45 located in the N‐terminus was required for DFF45 to inhibit CIDE‐A‐induced apoptosis. CD95/Fas‐mediated apoptosis was enhanced by CIDEs but inhibited by DFF45. These studies suggest that DFF45 is evolutionarily conserved and implicate CIDEs as DFF45‐inhibitable effectors that promote cell death and DNA fragmentation.
The EMBO Journal – Wiley
Published: Jan 1, 1998
Keywords: ; ; ; ;
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