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Carl Hanson, L Crawford-Miksza, Haynes Sheppard (1990)
Application of a rapid microplaque assay for determination of human immunodeficiency virus neutralizing antibody titersJournal of Clinical Microbiology, 28
G. DiMinno, M. Silver, S. Murphy (1982)
Stored human platelets retain full aggregation potential in response to pairs of aggregating agents.Blood, 59 3
E. Chiu, K. Yuen, A. Lie, R. Liang, Yun-Fai Lau, A. Lee, Y. Kwong, S. Wong, M. Ng, T. Chan (1994)
A prospective study of symptomatic bacteremia following platelet transfusion and of its managementTransfusion, 34
E. Ben-hur, B. Horowitz (1995)
ADVANCES IN PHOTOCHEMICAL APPROACHES FOR BLOOD STERILIZATIONPhotochemistry and Photobiology, 62
Murphy Murphy, Francis Francis (1971)
The estimation of blood platelet survival. II. The multiple hit modelThromb Diath Haemorrh, 25
Raymond Goodrich, Nagender Yerram, H. Boon, TAY-GOODRICH, Patricia Forster, Matthew PLATZt, Chandrika KASTURIt, Sang Parks, Jean Nicholas, AEBISCHERf, Saroj RAIt, Loretta KULAGAt (1994)
Selective inactivation of viruses in the presence of human platelets: UV sensitization with psoralen derivatives.Proceedings of the National Academy of Sciences of the United States of America, 91 12
S. Murphy, Paulo Rebulla, F. Bertolini, S. Holme, G. Moroff, E. Snyder, Robert Stromberg (1994)
In vitro assessment of the quality of stored platelet concentrates. The BEST (Biomedical Excellence for Safer Transfusion) Task Force of the International Society of Blood Transfusion.Transfusion medicine reviews, 8 1
Londe Londe, Alfonso Alfonso, Janda Janda (1994)
Photochemical inactivation of bacteria in platelet concentrates (abstract)Vox Sang, 67
M. Popovič, P. Sarin, M. Robert-Gurroff, V. Kalyanaraman, D. Mann, J. Minowada, R. Gallo (1983)
Isolation and transmission of human retrovirus (human t-cell leukemia virus).Science, 219 4586
(1995)
In vivo survival of platelets subjected to virus inactivation protocols using psoralen and coumarin photosensitizers ( abstract )
Lin Lin, Dikeman Dikeman, Corten Corten (1994)
Photochemical inactivation of pathogenic bacteria in platelet concentrates using a novel psoralen (abstract)Transfusion, 34
E. Murphy, M. Francis (1971)
The Estimation of Blood Platelet Survival II. The Multiple Hit ModelThrombosis and Haemostasis, 25
P. Stenberg, R. McEver, M. Shuman, Y. Jacques, D. Bainton (1985)
A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activationThe Journal of Cell Biology, 101
Goldman Goldman, Blajchman Blajchman (1991)
Blood product‐associated bacterial sepsisTransfus Med Rev, 5
R. McEver, Mary, Martin (1984)
A monoclonal antibody to a membrane glycoprotein binds only to activated platelets.The Journal of biological chemistry, 259 15
D. Ganem, H. Varmus (1987)
The molecular biology of the hepatitis B viruses.Annual review of biochemistry, 56
H. Gulliksson, L. Eriksson, C. Högman, J. Payrat (1995)
Buffy-Coat-Derived Platelet Concentrates Prepared from Half-Strength Citrate CPD and CPD Whole-Blood UnitsVox Sanguinis, 68
J. Morrow, H. Braine, T. Kickler, P. Ness, J. Dick, A. Fuller (1991)
Septic reactions to platelet transfusions. A persistent problem.JAMA, 266 4
PhD, Director of Red Cell Development, Cerus
T. Kunicki, M. Tuccelli, G. Becker, R. Aster (2003)
A Study of Variables Affecting the Quality of Platelets Stored at “Room Temperature”Transfusion, 15
(1938)
Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989. Reed LJ, Muench H. Asimple method of estimating fiftypercent endpoints
(1994)
Adverse consequences of blood transfusion : quantitative risk estimates
E. Wallace, W. Churchill, D. Surgenor, J. An, G. Cho, S. McGurk, L. Murphy (1995)
Collection and transfusion of blood and blood components in the United States, 1992Transfusion, 35
T. Lee, R. Stromberg, D. Henrard, M. Busch (1993)
Effect of platelet-associated virus on assays of HIV-1 in plasma.Science, 262 5139
Danny Miller, J. Hardwick (1973)
AND ITS MANAGEMENT
S. Wagner, D. Robinette, J. Storry, X.Y. Chen, J. Shumaker, L. Benade (1994)
Differential sensitivities of viruses in red cell suspensions to methylene blue photosensitizationTransfusion, 34
H. Gulliksson, L. Eriksson, C. Högman, J. Payrat (1995)
Buffy‐Coat‐Derived Platelet Concentrates Prepared from Half‐Strength Citrate CPD and CPD Whole‐Blood Units: Comparison between Three Additive Solutions: In vitro StudiesVox Sanguinis, 68
G. Cimino, H. Gamper, S. Isaacs, J. Hearst (1985)
Psoralens as photoactive probes of nucleic acid structure and function: organic chemistry, photochemistry, and biochemistry.Annual review of biochemistry, 54
Cerus Corporation. Roberta Dikeman, BS, Research Associate, Cerus Corporation
H. Nikaido, M. Vaara (1985)
Molecular basis of bacterial outer membrane permeability.Microbiological reviews, 49 1
L. Corash, Lily Lin, G. Wiesehahn, G. Cimino (1989)
Use of 8-methoxypsoralen and long-wavelength ultraviolet radiation for decontamination of platelet concentrates, 1650
Robert Handin, N. Fortier, C. Valeri (1970)
Platelet Response to Hypotonic Stress after Storage at 4 C or 22 CTransfusion, 10
H. Rinder, M. Murphy, J. Mitchell, J. Stocks, K. Ault, R. Hillman (1991)
Progressive platelet activation with storage: evidence for shortened survival of activated platelets after transfusionTransfusion, 31
(1993)
Use of variable length amplicons to determine the efficiency of viral inactivation by psoralen mediated photochemistry (abstract)
The p - selectin epitope recognized by anti - CD 62 on activated platelets does not correlate with platelet recovery ( abstract )
E. Lackritz, G. Satten, J. Aberle‐grasse, R. Dodd, V. Raimondi, R. Janssen, W. Lewis, E. Notari, L. Petersen (1995)
Estimated risk of transmission of the human immunodeficiency virus by screened blood in the United States.The New England journal of medicine, 333 26
(1938)
Asimple method of estimating fiftyper - cent endpoints
Chief Executive Officer, Cerus Corpora-Susan Wollowitz, PhD, Director of Organic Chemistry
Cerus Corporation, assignee. Compounds for the photodecontamination of pathogens in blood. US patent 5
S. Butera, V. Perez, Bei‐Yu Wu, G. Nabel, T. Folks (1991)
Oscillation of the human immunodeficiency virus surface receptor is regulated by the state of viral activation in a CD4+ cell model of chronic infectionJournal of Virology, 65
C. Ingerman-Wojenski, M. Silver (1984)
A Quick Method for Screening Platelet Dysfunctions Using the Whole Blood Lumi-AggregometerThrombosis and Haemostasis, 51
Lily Lin, H. Londe, JM Janda, C. Hanson, L. Corash (1994)
Photochemical inactivation of pathogenic bacteria in human platelet concentrates.Blood, 83 9
Q. Choo, G. Kuo, A. Weiner, L. Overby, D. Bradley, M. Houghton (1989)
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome.Science, 244 4902
Holme Holme, Vaidja Vaidja, Murphy Murphy (1978)
Platelet storage at 22°C: effect of type of agitation on morphology, viability, and function in vitroBlood, 52
Kenneth Anderson, Michael Lew, B. Gorgone, Joan Martel, Christy Leamy, Bernadette Sullivan (1986)
Transfusion-related sepsis after prolonged platelet storage.The American journal of medicine, 81 3
BACKGROUND: A photochemical treatment process has been developed for the inactivation of viruses and bacteria in platelet concentrates. This process is based on the photochemical reaction of a novel psoralen, S‐ 59, with nucleic acids upon illumination with long‐wavelength ultraviolet light (UVA, 320–400 nm). STUDY DESIGN AND METHODS: High levels of pathogens were added to single‐donor platelet concentrates containing 3 to 5 × 10(11) platelets in 300 mL of 35‐percent autologous plasma and 65‐percent platelet additive solution. After treatment with S‐59 (150 microM) and UVA (0–3 J/cm2), the infectivity of each pathogen was measured with established biologic assays. In vitro platelet function after photochemical treatment was evaluated during 7 days of storage by using a panel of 14 assays. The in vivo recovery and life span of photochemically treated platelets were evaluated after 24 hours of storage in a primate transfusion model. RESULTS: The following levels of pathogen inactivation were achieved:>10(6.7) plaque‐forming units (PFU) per mL of cell‐free human immunodeficiency virus (HIV),>10(6.6) PFU per mL of cell‐associated HIV,>10(6.8) infectious dose (ID50) per mL of duck hepatitis B virus (a model for hepatitis B virus),>10(6.5) PFU per mL of bovine viral diarrhea virus (a model for hepatitis C virus),>10(6.6) colony‐forming units of Staphylococcus epidermidis, and>10(5.6) colony‐forming units of Klebsiella pneumoniae. Expression of integrated HIV was inhibited by 0.1 microM S‐ 59 and 1 J per cm2 of UVA. In vitro and in vivo platelet function were adequately maintained after antiviral and antibacterial treatment. CONCLUSION: Photochemical treatment of platelet concentrates offers the potential for reducing transfusion‐related viral and bacterial diseases.
Transfusion – Wiley
Published: Apr 1, 1997
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