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S. Giannattasio, Nicoletta Guaragnella, M. Côrte-Real, S. Passarella, E. Marra (2005)
Acid stress adaptation protects Saccharomyces cerevisiae from acetic acid-induced programmed cell death.Gene, 354
I. Wadskog, Corinna Maldener, Astrid Proksch, F. Madeo, L. Adler (2003)
Yeast lacking the SRO7/SOP1-encoded tumor suppressor homologue show increased susceptibility to apoptosis-like cell death on exposure to NaCl stress.Molecular biology of the cell, 15 3
J. Maier (1991)
Guide to yeast genetics and molecular biology.Methods in enzymology, 194
D. Wu, P. Chen, S. Chen, Y. Hu, G. Núñez, R. Ellis (1999)
C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death.Development, 126 9
S. Manon, B. Chaudhuri, M. Guérin (1997)
Release of cytochrome c and decrease of cytochrome c oxidase in Bax‐expressing yeast cells, and prevention of these effects by coexpression of Bcl‐xLFEBS Letters, 415
Cole Haynes, Eric Titus, A. Cooper (2004)
Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death.Molecular cell, 15 5
F. Madeo, E. Fröhlich, M. Ligr, M. Grey, S. Sigrist, D. Wolf, K. Fröhlich (1999)
Oxygen Stress: A Regulator of Apoptosis in YeastThe Journal of Cell Biology, 145
P. Boya, I. Cohen, N. Zamzami, H. Vieira, G. Kroemer (2002)
Endoplasmic reticulum stress-induced cell death requires mitochondrial membrane permeabilizationCell Death and Differentiation, 9
M. Priault, J. Bessoule, Angela Grelaud-Coq, N. Camougrand, S. Manon (2002)
Bax-induced cell death in yeast depends on mitochondrial lipid oxidation.European journal of biochemistry, 269 22
N. Morishima, K. Nakanishi, Hiromi Takenouchi, T. Shibata, Y. Yasuhiko (2002)
An Endoplasmic Reticulum Stress-specific Caspase Cascade in ApoptosisThe Journal of Biological Chemistry, 277
M. Bettiga, L. Calzari, I. Orlandi, L. Alberghina, M. Vai (2004)
Involvement of the yeast metacaspase Yca1 in ubp10Δ‐programmed cell deathFems Yeast Research, 5
C. Candé, F. Cecconi, P. Dessen, G. Kroemer (2002)
Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?Journal of Cell Science, 115
W. Burhans, M. Weinberger, Maria Marchetti, Lakshmi Ramachandran, G. D’urso, J. Huberman (2003)
Apoptosis-like yeast cell death in response to DNA damage and replication defects.Mutation research, 532 1-2
N. Hong, M. Flannery, S. Hsieh, D. Cado, R. Pedersen, A. Winoto (2000)
Mice lacking Dad1, the defender against apoptotic death-1, express abnormal N-linked glycoproteins and undergo increased embryonic apoptosis.Developmental biology, 220 1
P. Laun, A. Pichová, F. Madeo, J. Fuchs, A. Ellinger, S. Kohlwein, I. Dawes, K. Fröhlich, M. Breitenbach (2001)
Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosisMolecular Microbiology, 39
A. Uren, K. O'Rourke, L. Aravind, M. Pisabarro, S. Seshagiri, E. Koonin, V. Dixit (2000)
Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.Molecular cell, 6 4
L. Lehle, W. Tanner (1976)
The specific site of tunicamycin inhibition in the formation of dolichol‐bound N‐acetylglucosamine derivativesFEBS Letters, 71
Rao Rao, Castro‐Obregon Castro‐Obregon, Frankowski Frankowski, Schuler Schuler, Stoka Stoka, Del Rio Del Rio (2002)
Coupling endoplasmic reticulum stress to the cell death program. An Apaf‐1‐independent intrinsic pathwayJ Biol Chem, 277
J. Hardwick, Wen-Chih Cheng (2004)
Mitochondrial programmed cell death pathways in yeast.Developmental cell, 7 5
A. Verhagen, J. Silke, P. Ekert, M. Pakusch, H. Kaufmann, L. Connolly, C. Day, A. Tikoo, R. Burke, Carolyn Wrobel, R. Moritz, R. Simpson, D. Vaux (2002)
HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins*The Journal of Biological Chemistry, 277
L. Pleyer, Inge Tinhofer, R. Greil, G. Damia, S. Marsoni (2007)
Regulation of apoptosis
N. Hatsugai, M. Kuroyanagi, Kenji Yamada, T. Meshi, S. Tsuda, M. Kondo, M. Nishimura, I. Hara-Nishimura (2004)
A Plant Vacuolar Protease, VPE, Mediates Virus-Induced Hypersensitive Cell DeathScience, 305
I. Ivanovska, J. Hardwick, J. Hardwick (2005)
Viruses activate a genetically conserved cell death pathway in a unicellular organismThe Journal of Cell Biology, 170
M. Aridor, W. Balch (1999)
Integration of endoplasmic reticulum signaling in health and diseaseNature Medicine, 5
R. Wysocki, S. Kron (2004)
Yeast cell death during DNA damage arrest is independent of caspase or reactive oxygen speciesThe Journal of Cell Biology, 166
S. Matsuyama, Qunli Xu, J. Velours, John Reed (1998)
The Mitochondrial F 0 F 1-ATPase Proton Pump Is Required for Function of the Proapoptotic Protein Bax in Yeast and Mammalian Cells
Yihru Fannjiang, Wen-Chih Cheng, Sarah Lee, Bing Qi, J. Pevsner, J. McCaffery, R. Hill, G. Basañez, J. Hardwick (2004)
Mitochondrial fission proteins regulate programmed cell death in yeast.Genes & development, 18 22
T. Shirogane, Toshiyuki Fukada, Joyce Müller, David Shima, Masahiko Hibi, Toshio Hirano (1999)
Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.Immunity, 11 6
F. Madeo, E. Herker, Corinna Maldener, S. Wissing, Stephan Lächelt, Mark Herlan, Markus Fehr, K. Lauber, S. Sigrist, S. Wesselborg, K. Fröhlich (2002)
A caspase-related protease regulates apoptosis in yeast.Molecular cell, 9 4
Jürg Häcki, L. Egger, L. Monney, S. Conus, Thierry Rossé, I. Fellay, C. Borner (2000)
Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2Oncogene, 19
B. Turk, V. Stoka, J. Rozman-Pungercar, T. Cirman, Gabriela Droga-Mazovec, Kristina Oresić, V. Turk (2002)
Apoptotic Pathways: Involvement of Lysosomal Proteases, 383
J. Kerr (2002)
History of the events leading to the formulation of the apoptosis concept.Toxicology, 181-182
Rao Rao, Ellerby Ellerby, Bredesen Bredesen (2004)
Coupling endoplasmic reticulum stress to the cell death programCell Death Differ, 11
R. Rao, S. Castro-Obregón, H. Frankowski, Martin Schuler, V. Stoka, G. Rio, D. Bredesen, H. Ellerby (2001)
Coupling Endoplasmic Reticulum Stress to the Cell Death ProgramThe Journal of Biological Chemistry, 276
T. Makishima, T. Nakashima, K. Nagata-kuno, K. Fukushima, H. Iida, M. Sakaguchi, Y. Ikehara, S. Komiyama, T. Nishimoto (1997)
The highly conserved DAD1 protein involved in apoptosis is required for N‐linked glycosylationGenes to Cells, 2
T. Nakashima, Takeshi Sekiguchi, A. Kuraoka, K. Fukushima, Y. Shibata, Sohtaro Komiyama, Takeharu Nishimoto (1993)
Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cellsMolecular and Cellular Biology, 13
Katherine Niederer, Daniel Morrow, Justin Gettings, Molly Irick, Alexander Krawiecki, J. Brewster (2005)
Cypermethrin blocks a mitochondria-dependent apoptotic signal initiated by deficient N-linked glycosylation within the endoplasmic reticulum.Cellular signalling, 17 2
V. Skulachev (2002)
Programmed death in yeast as adaptation?FEBS Letters, 528
Chris Patil, Peter Walter (2001)
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals.Current opinion in cell biology, 13 3
Stephan, te Heesen, Bernd Janetzkyl, Ludwig Lehiel, Markus Aebi (1992)
The yeast WBP1 is essential for oligosaccharyl transferase activity in vivo and in vitro.The EMBO Journal, 11
Tanner Tanner, Lehle Lehle (1987)
Protein glycosylation in yeastBiochim Biophys Acta, 906
S. Matsuyama, Q. Xu, J. Velours, John Reed (1998)
The Mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells.Molecular cell, 1 3
B. Tu, J. Weissman (2002)
The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum.Molecular cell, 10 5
S. Susin, H. Lorenzo, N. Zamzami, I. Marzo, B. Snow, G. Brothers, J. Mangion, E. Jacotot, P. Costantini, M. Loeffler, N. Larochette, D. Goodlett, R. Aebersold, D. Siderovski, J. Penninger, G. Kroemer (1999)
Molecular characterization of mitochondrial apoptosis-inducing factorNature, 397
F. Madeo, E. Herker, S. Wissing, H. Jungwirth, T. Eisenberg, K. Fröhlich (2004)
Apoptosis in yeast.Current opinion in microbiology, 7 6
H. Harding, Yuhong Zhang, H. Zeng, I. Novoa, Phoebe Lu, M. Calfon, Navid Sadri, Chi Yun, B. Popko, R. Paules, D. Stojdl, J. Bell, T. Hettmann, J. Leiden, D. Ron (2003)
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.Molecular cell, 11 3
W. Greenhalf, C. Stephan, B. Chaudhuri (1996)
Role of mitochondria and C‐terminal membrane anchor of Bcl‐2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiaeFEBS Letters, 380
Tomoko Makishima, M. Yoshimi, Sohtaro Komiyama, Nobuyuki Hara, Takeharu Nishimoto (2000)
A subunit of the mammalian oligosaccharyltransferase, DAD1, interacts with Mcl-1, one of the bcl-2 protein family.Journal of biochemistry, 128 3
V. Hedge, G. Williams (2002)
Commitment to apoptosis induced by tumour necrosis factor-α is dependent on caspase activityApoptosis, 7
E. Ioffe, P. Stanley (1994)
Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates.Proceedings of the National Academy of Sciences of the United States of America, 91
J. Jaeken, H. Carchon (2004)
Congenital disorders of glycosylation: a booming chapter of pediatrics.Current opinion in pediatrics, 16 4
A. Helenius, and Aebi (2001)
Intracellular functions of N-linked glycans.Science, 291 5512
R. Knauer, L. Lehle (1999)
The oligosaccharyltransferase complex from yeast.Biochimica et biophysica acta, 1426 2
M. Kukuruzinska, M. Bergh, B. Jackson (1987)
Protein glycosylation in yeast.Annual review of biochemistry, 56
Yasuyuki Suzuki, Y. Imai, H. Nakayama, Kazuko Takahashi, K. Takio, R. Takahashi (2001)
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.Molecular cell, 8 3
M. Bettiga, L. Calzari, I. Orlandi, L. Alberghina, M. Vai (2004)
Involvement of the yeast metacaspase Yca1 in ubp10Delta-programmed cell death.FEMS yeast research, 5 2
E. Herker, H. Jungwirth, Katharina Lehmann, Corinna Maldener, K. Fröhlich, S. Wissing, S. Büttner, Markus Fehr, S. Sigrist, F. Madeo (2004)
Chronological aging leads to apoptosis in yeastThe Journal of Cell Biology, 164
G. Huh, B. Damsz, T. Matsumoto, M. Reddy, A. Rus, J. Ibeas, M. Narasimhan, R. Bressan, P. Hasegawa (2002)
Salt causes ion disequilibrium-induced programmed cell death in yeast and plants.The Plant journal : for cell and molecular biology, 29 5
Anna Schinzel, T. Kaufmann, C. Borner (2004)
Bcl-2 family members: integrators of survival and death signals in physiology and pathology [corrected].Biochimica et biophysica acta, 1644 2-3
Morishima Morishima, Nakanishi Nakanishi, Takenouchi Takenouchi, Shibata Shibata, Yasuhiko Yasuhiko (2002)
An endoplasmic reticulum stress‐specific caspase cascade in apoptosis. Cytochrome c ‐independent activation of caspase‐9 by caspase‐12J Biol Chem, 277
J. Rozman-Pungercar, N. Kopitar-Jerala, M. Bogyo, D. Turk, O. Vasiljeva, I. Štefe, P. Vandenabeele, D. Brömme, V. Puizdar, M. Fonović, M. Trstenjak-Prebanda, I. Dolenc, V. Turk, B. Turk (2003)
Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificityCell Death and Differentiation, 10
Susana Silberstein, Pallia Collins, D. Kelleher, Reid Gilmore (1995)
The essential OST2 gene encodes the 16-kD subunit of the yeast oligosaccharyltransferase, a highly conserved protein expressed in diverse eukaryotic organismsThe Journal of Cell Biology, 131
Y. Kouroku, E. Fujita, A. Jimbo, T. Kikuchi, T. Yamagata, M. Momoi, E. Kominami, K. Kuida, K. Sakamaki, S. Yonehara, T. Momoi (2002)
Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation.Human molecular genetics, 11 13
M. Ligr, F. Madeo, E. Fröhlich, W. Hilt, K. Fröhlich, D. Wolf (1998)
Mammalian Bax triggers apoptotic changes in yeastFEBS Letters, 438
D. Pérez-Sala, F. Mollinedo (1995)
Inhibition of N‐linked glycosylation induces early apoptosis in human promyelocytic HL‐60 cellsJournal of Cellular Physiology, 163
L. Egger, L. Egger, J. Schneider, C. Rhême, M. Tapernoux, Jürg Häcki, C. Borner (2003)
Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditionsCell Death and Differentiation, 10
S. Wissing, P. Ludovico, E. Herker, S. Büttner, S. Engelhardt, Thorsten Decker, A. Link, Astrid Proksch, F. Rodrigues, M. Côrte-Real, K. Fröhlich, J. Manns, C. Candé, S. Sigrist, G. Kroemer, F. Madeo (2004)
An AIF orthologue regulates apoptosis in yeastThe Journal of Cell Biology, 166
Yasumasa Itô, P. Pandey, N. Mishra, Shailendra Kumar, N. Narula, S. Kharbanda, S. Saxena, D. Kufe (2001)
Targeting of the c-Abl Tyrosine Kinase to Mitochondria in Endoplasmic Reticulum Stress-Induced ApoptosisMolecular and Cellular Biology, 21
W. Paschen, A. Frandsen (2001)
Endoplasmic reticulum dysfunction – a common denominator for cell injury in acute and degenerative diseases of the brain?Journal of Neurochemistry, 79
D. Rutkowski, R. Kaufman (2004)
A trip to the ER: coping with stress.Trends in cell biology, 14 1
Anna Schinzel, T. Kaufmann, C. Borner (2004)
Bcl-2 family members: intracellular targeting, membrane-insertion, and changes in subcellular localizationBiochimica et Biophysica Acta, 1644
T. Nakagawa, Hong Zhu, N. Morishima, En Li, Jin Xu, B. Yankner, Junying Yuan (2000)
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-βNature, 403
C. Reimertz, D. Kögel, A. Rami, T. Chittenden, J. Prehn (2003)
Gene expression during ER stress–induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway
P. Fabrizio, L. Battistella, Raffaello Vardavas, Cristina Gattazzo, Lee-Loung Liou, A. Diaspro, Janis Dossen, E. Gralla, V. Longo (2004)
Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiaeThe Journal of Cell Biology, 166
P. Ludovico, P. Ludovico, M. Sousa, Manuel Silva, C. Leão, M. Côrte-Real (2001)
Saccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid.Microbiology, 147 Pt 9
J. Heinisch, A. Lorberg, H. Schmitz, J. Jacoby (1999)
The protein kinase C‐mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiaeMolecular Microbiology, 32
M. Latterich, K. Fröhlich, R. Schekman (1995)
Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranesCell, 82
R. Kornfeld, S. Kornfeld (1985)
Assembly of asparagine-linked oligosaccharides.Annual review of biochemistry, 54
C. Hetz, M. Russelakis‐Carneiro, K. Maundrell, J. Castilla, C. Soto (2003)
Caspase‐12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion proteinThe EMBO Journal, 22
B. Fahrenkrog, U. Sauder, U. Aebi (2004)
The S. cerevisiae HtrA-like protein Nma111p is a nuclear serine protease that mediates yeast apoptosisJournal of Cell Science, 117
T. Huffaker, P. Robbins (1983)
Yeast mutants deficient in protein glycosylation.Proceedings of the National Academy of Sciences of the United States of America, 80 24
W. Zong, Chi Li, G. Hatzivassiliou, T. Lindsten, Qian-chun Yu, Junying Yuan, C. Thompson (2003)
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosisThe Journal of Cell Biology, 162
(1995)
brane fusion and the
S. Silberstein, R. Gilmore (1996)
Biochemistry, molecular biology, and genetics of the oligosaccharyltransferaseThe FASEB Journal, 10
M. Annis, J. Yethon, B. Leber, D. Andrews (2004)
There is more to life and death than mitochondria: Bcl-2 proteins at the endoplasmic reticulum.Biochimica et biophysica acta, 1644 2-3
L. Filippin, P. Magalhães, Giulietta Benedetto, M. Colella, T. Pozzan (2003)
Stable Interactions between Mitochondria and Endoplasmic Reticulum Allow Rapid Accumulation of Calcium in a Subpopulation of Mitochondria*Journal of Biological Chemistry, 278
Margot Mayer, Mark Noble (1994)
N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro.Proceedings of the National Academy of Sciences of the United States of America, 91 16
John Kerr, A. Wyllie, R. Alastair, Currie (1972)
Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue KineticsBritish Journal of Cancer, 26
J. Reiter, E. Herker, F. Madeo, M. Schmitt (2005)
Viral killer toxins induce caspase-mediated apoptosis in yeastThe Journal of Cell Biology, 168
J. Rudner, Verena Jendrossek, Claus Belka (2002)
New insights in the role of Bcl-2 Bcl-2 and the endoplasmic reticulumApoptosis, 7
F. Madeo, E. Fröhlich, K. Fröhlich (1997)
A Yeast Mutant Showing Diagnostic Markers of Early and Late ApoptosisThe Journal of Cell Biology, 139
D. Breckenridge, M. Germain, Jaigi Mathai, M. Nguyen, G. Shore (2003)
Regulation of apoptosis by endoplasmic reticulum pathwaysOncogene, 22
Weikang Tao, C. Kurschner, J. Morgan (1997)
Modulation of Cell Death in Yeast by the Bcl-2 Family of Proteins*The Journal of Biological Chemistry, 272
U. Güldener, S. Heck, T. Fiedler, J. Beinhauer, J. Hegemann (1996)
A new efficient gene disruption cassette for repeated use in budding yeastNucleic acids research, 24 13
J. Brewster, Stacey Martin, Jennifer Toms, D. Goss, Kia Wang, Keith Zachrone, A. Davis, G. Carlson, Leroy Hood, J. Coffin (2000)
Deletion of Dad1 in mice induces an apoptosis‐associated embryonic deathgenesis, 26
V. Longo, L. Ellerby, D. Bredesen, J. Valentine, E. Gralla (1997)
Human Bcl-2 Reverses Survival Defects in Yeast Lacking Superoxide Dismutase and Delays Death of Wild-Type YeastThe Journal of Cell Biology, 137
V. Hedge, G. Williams (2002)
Commitment to apoptosis induced by tumour necrosis factor-alpha is dependent on caspase activity.Apoptosis : an international journal on programmed cell death, 7 2
Summary N‐glycosylation in the endoplasmic reticulum is an essential protein modification and highly conserved in evolution from yeast to man. Defects of N‐glycosylation in humans lead to congenital disorders. The pivotal step of this pathway is the transfer of the evolutionarily conserved lipid‐linked core‐oligosaccharide to the nascent polypeptide chain, catalysed by the oligosaccharyltransferase. One of its nine subunits, Ost2, has homology to DAD1, originally characterized in hamster cells as a defender against apoptotic death. Here we show that ost mutants, such as ost2 and wbp1‐1, display morphological and biochemical features of apoptosis upon induction of the glycosylation defect. We observe nuclear condensation, DNA fragmentation as well as externalization of phosphatidylserine. We also demonstrate induction of caspase‐like activity, both determined by flow cytometric analysis and in cell‐free extracts. Similarly, the N‐glycosylation inhibitor tunicamycin in combination with elevated temperature is able to challenge the apoptotic cascade. Heterologous expression of anti‐apoptotic human Bcl‐2 diminishes caspase activation, improves survival of cells and suppresses the temperature‐sensitive growth defect of wbp1‐1. Furthermore, accumulation of reactive oxygen species occurs in response to defective glycosylation. As deletion of the metacaspase YCA1 does not seem to abrogate glycosylation‐induced apoptosis, we postulate a different proteolytic process to be involved in this death pathway.
Molecular Microbiology – Wiley
Published: Feb 1, 2006
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