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I. troduction ......................................................... II. Manganese .......................................................... A. troduction ...................................................... B. Congenital abnormalities resultg from manganese deficiency ......... C. Manganese mutants.. ............................................. D. Mucopolysaccharide synthesis calcification ....................... E. fluence genetic stra on response to manganese deficiency ........ III. Zc ................................................................ A. troduction ...................................................... B. Congenital abnormalities zc deficiency ........................... C. Rapid effect zc deficiency ...................................... D. Other changes zc-deficient pregnant rats ........................ E. Mobilization zc from maternal tissues ........................... F. Mechanisms teratogenesis zc deficiency ....................... G. fluence level dietary zc .................................... H. Postnatal effects prenatal zc deficiency .......................... ............................... I. teractions zc other factors J. Teratogenic zc deficiency humans ............................... IV. Copper .............................................................. A. troduction ...................................................... ............................. B. Teratogenic effects copper deficiency ............................................... C. Genetic teractions V. Conclusion .......................................................... I. TRODUCTION Congenital malformation is the most dramatic unequivocal manifestation abnormal prenatal development. However, other more subtle abnormalities, cludg microscopic morphological anomalies or biochemical lesions, may be equally important affectg the well-beg the dividual. 0031-9333/81/000000-00$01.25 Copyright 0 1981 the American Physiological Society 249 L. S. HURLEY Volume Although congenital have been recognized sce prehistoric times (275), the fluence nutritional factors their production has been considered only recently. The maternal dietary take many nutrients affects the prenatal development the embryo fetus,
Physiological Reviews – The American Physiological Society
Published: Apr 1, 1981
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