Access the full text.
Sign up today, get DeepDyve free for 14 days.
X. Gu, Desh Vermal (1996)
Phragmoplastin, a dynamin‐like protein associated with cell plate formation in plants.The EMBO Journal, 15
T. Baba, H. Damke, J. Hinshaw, K. Ikeda, S. Schmid, D. Warnock (1995)
Role of dynamin in clathrin-coated vesicle formation.Cold Spring Harbor symposia on quantitative biology, 60
H. Damke, Takeshi Baba, Alexander Bliek, Sandra Schmid (1995)
Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynaminThe Journal of Cell Biology, 131
Pamela Tuma, Mary Stachniak, Christine Collins (1993)
Activation of dynamin GTPase by acidic phospholipids and endogenous rat brain vesicles.The Journal of biological chemistry, 268 23
P. Robinson, Jun-Ping Liu, K. Powell, E. Fykse, T. Südhof (1994)
Phosphorylation of dynamin I and synaptic-vesicle recyclingTrends in Neurosciences, 17
Yun-Taik Kim, Chun-Fang Wu (1990)
Allelic interactions at the shibire locus of Drosophila: effects on behavior.Journal of neurogenetics, 7 1
Grigliatt (1973)
107Mol. Gen. Genet., 120
B. Mayer, M. Eck (1995)
SH3 Domains: Minding your p's and q'sCurrent Biology, 5
J. Hinshaw, S. Schmid (1995)
Dynamin self-assembles into rings suggesting a mechanism for coated vesicle buddingNature, 374
Sontag (1994)
4547J. Biol. Chem., 269
Ross Anderson, S. Vaudenay (1996)
Minding your p's and q's
R. Obar, C. Collins, J. Hammarback, H. Shpetner, R. Vallee (1990)
Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteinsNature, 347
Mani Ramaswami, Sujata Rao, A. Bliek, R. Kelly, K. Krishnan (1993)
Genetic studies on dynamin function in Drosophila.Journal of neurogenetics, 9 2
G. Shaw (1996)
The pleckstrin homology domain: An intriguing multifunctional protein moduleBioEssays, 18
K. Ferguson, M. Lemmon, J. Schlessinger, P. Sigler (1994)
Crystal structure at 2.2 Å resolution of the pleckstrin homology domain from human dynaminCell, 79
van derBliek van derBliek, Redelmeier Redelmeier, Damke Damke, Tisdale Tisdale, Meyerowitz Meyerowitz, Schmid Schmid (1993)
Mutations in human dynamin block an early stage in coated vesicle formationJ. Cell Biol., 122
H. Bourne, D. Sanders, F. McCormick (1991)
The GTPase superfamily: conserved structure and molecular mechanismNature, 349
Li‐Hsien Wang, T. Südhof, R. Anderson (1995)
The Appendage Domain of α-Adaptin Is a High Affinity Binding Site for Dynamin (*)The Journal of Biological Chemistry, 270
Liu (1995)
590Endocrine Rev., 16
M. Schwemmle, M. Richter, C. Herrmann, N. Nassar, P. Staeheli (1995)
Unexpected Structural Requirements for GTPase Activity of the Interferon-induced MxA Protein(*)The Journal of Biological Chemistry, 270
Tsuruhara Tsuruhara, Koenig Koenig, Ikeda Ikeda (1990)
Synchronized endocytosis studied in the oocyte of a temperature‐sensitive mutant of Drosophila melanogasterCell Tissue Res., 259
Jie Zheng, S. Cahill, M. Lemmon, D. Fushman, J. Schlessinger, D. Cowburn (1996)
Identification of the binding site for acidic phospholipids on the pH domain of dynamin: implications for stimulation of GTPase activity.Journal of molecular biology, 255 1
Toshio Kosaka, Kazuo Ikeda (1983)
Possible temperature-dependent blockage of synaptic vesicle recycling induced by a single gene mutation in Drosophila.Journal of neurobiology, 14 3
J. Koenig, Kazuo Ikeda (1989)
Disappearance and reformation of synaptic vesicle membrane upon transmitter release observed under reversible blockage of membrane retrieval, 9
H. Shpetner, R. Vallee (1989)
Identification of dynamin, a novel mechanochemical enzyme that mediates interactions between microtubulesCell, 59
D. Warnock, J. Hinshaw, S. Schmid (1996)
Dynamin Self-assembly Stimulates Its GTPase Activity*The Journal of Biological Chemistry, 271
H. Damke, T. Baba, D. Warnock, S. Schmid (1994)
Induction of mutant dynamin specifically blocks endocytic coated vesicle formationThe Journal of Cell Biology, 127
C. Vater, C. Raymond, K. Ekena, Isabelle Howald-Stevenson, T. Stevens (1992)
The VPS1 protein, a homolog of dynamin required for vacuolar protein sorting in Saccharomyces cerevisiae, is a GTPase with two functionally separable domainsThe Journal of Cell Biology, 119
Tuma (1993)
17240J. Biol. Chem., 268
R. Vallee, P. Okamoto (1995)
The regulation of endocytosis: identifying dynamin's binding partners.Trends in cell biology, 5 2
J. Herskovits, H. Shpetner, C. Burgess, R. Vallee (1993)
Microtubules and Src homology 3 domains stimulate the dynamin GTPase via its C-terminal domain.Proceedings of the National Academy of Sciences of the United States of America, 90 24
H. Damke (1996)
Dynamin and receptor‐mediated endocytosisFEBS Letters, 389
J. Sontag, E. Fykse, Yuri Ushkaryov, Jun-Ping Liu, Phillip Robinson, Thomas Südhof (1994)
Differential expression and regulation of multiple dynamins.The Journal of biological chemistry, 269 6
K. Maéda, T. Nakata, Y. Noda, R. Sato-Yoshitake, N. Hirokawa (1992)
Interaction of dynamin with microtubules: its structure and GTPase activity investigated by using highly purified dynamin.Molecular biology of the cell, 3 10
Koenig (1990)
233Cell Tissue Res., 262
T. Nakata, R. Takemura, N. Hirokawa (1993)
A novel member of the dynamin family of GTP-binding proteins is expressed specifically in the testis.Journal of cell science, 105 ( Pt 1)
Robin Scaife, R. Margolis (1990)
Biochemical and immunochemical analysis of rat brain dynamin interaction with microtubules and organelles in vivo and in vitroThe Journal of Cell Biology, 111
D. Warnock, L. Terlecky, S. Schmid (1995)
Dynamin GTPase is stimulated by crosslinking through the C‐terminal proline‐rich domain.The EMBO Journal, 14
The Scripps Research Institute, 10550 N. Torrey Pines Rd
Takei Takei, McPherson McPherson, Schmid Schmid, De Camilli De Camilli (1995)
Dynamin coated tubular membrane invaginations induced by GTPγS in nverve terminalsNature, 374
Koenig Koenig, Ikeda Ikeda (1990)
Transformational process of the endosomal compartment in nephrocytes of Drosophila melanogasterCell Tissue Res., 262
S. Schmid (1993)
Coated-vesicle formation in vitro: conflicting results using different assays.Trends in cell biology, 3 5
T. Grigliatti, L. Hall, R. Rosenbluth, D. Suzuki (1973)
Temperature-sensitive mutations in Drosophila melanogaster. XIV. A selection of immobile adults.Molecular & general genetics : MGG, 120 2
P. Tuma, C. Collins (1994)
Activation of dynamin GTPase is a result of positive cooperativity.The Journal of biological chemistry, 269 49
H. Shpetner, R. Vallee (1992)
Dynamin is a GTPase stimulated to high levels of activity by microtubulesNature, 355
A. Gammie, Laurie Kurihara, Richard Vallee, M. Rose (1995)
DNM1, a dynamin-related gene, participates in endosomal trafficking in yeastThe Journal of Cell Biology, 130
T. Cook, R. Urrutia, M. McNiven (1994)
Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues.Proceedings of the National Academy of Sciences of the United States of America, 91
Jun-Ping Liu, Qun‐Xing Zhang, G. Baldwin, P. Robinson (1996)
Calcium Binds Dynamin I and Inhibits Its GTPase ActivityJournal of Neurochemistry, 66
Liu Liu, Robinson Robinson (1995)
Dynamin and endocytosisEndocrine Rev., 16
Ilona Kessell, B. Holst, T. Roth (1989)
Membranous intermediates in endocytosis are labile, as shown in a temperature-sensitive mutant.Proceedings of the National Academy of Sciences of the United States of America, 86 13
A. Downing, P. Driscoll, I. Gout, K. Salim, M. Zvelebil, M. Waterfield (1994)
Three-dimensional solution structure of the pleckstrin homology domain from dynaminCurrent Biology, 4
Bonnie Berger, David Wilson, Ethan Wolf, Theodore Tonchev, Maria Milla, Peter Kim (1995)
Predicting coiled coils by use of pairwise residue correlations.Proceedings of the National Academy of Sciences of the United States of America, 92 18
Carol David, Peter McPherson, O. Mundigl, P. Camilli (1996)
A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals.Proceedings of the National Academy of Sciences of the United States of America, 93 1
Tsuruhara (1990)
199Cell Tissue Res., 259
John Henley, M. McNiven (1996)
Association of a dynamin-like protein with the Golgi apparatus in mammalian cellsThe Journal of Cell Biology, 133
A. Bliek, T. Redelmeier, H. Damke, E. Tisdale, E. Meyerowitz, S. Schmid, S. Schmid (1993)
Mutations in human dynamin block an intermediate stage in coated vesicle formationThe Journal of Cell Biology, 122
Tuma (1994)
30842J. Biol. Chem., 269
H. Shpetner, J. Herskovits, R. Vallee (1996)
A Binding Site for SH3 Domains Targets Dynamin to Coated Pits (*)The Journal of Biological Chemistry, 271
J. Herskovits, C. Burgess, R. Obar, R. Vallee (1993)
Effects of mutant rat dynamin on endocytosisThe Journal of Cell Biology, 122
A. Bliek, Elliot Meyerowrtz (1991)
Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular trafficNature, 351
K. Takei, P. McPherson, S. Schmid, P. Camilli (1995)
Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminalsNature, 374
G. Gass, J. Lin, R. Scaife, C. Wu (1995)
Two isoforms of Drosophila dynamin in wild-type and shibire(ts) neural tissue: different subcellular localization and association mechanisms.Journal of neurogenetics, 10 3
D. Suzuki (1970)
Temperature-sensitive mutations in Drosophila melanogaster.Science, 170
P. Camilli, K. Takei, P. McPherson (1995)
The function of dynamin in endocytosisCurrent Opinion in Neurobiology, 5
Laura Carter, Thomas Redelmeier, Leslie Woollenweber, Sandra Schmid (1993)
Multiple GTP-binding proteins participate in clathrin-coated vesicle- mediated endocytosisThe Journal of Cell Biology, 120
C. Poodry, L. Edgar (1979)
Reversible alteration in the neuromuscular junctions of Drosophila melanogaster bearing a temperature-sensitive mutation, shibireThe Journal of Cell Biology, 81
M. Chen, R. Obar, C. Schroeder, T. Austin, C. Poodry, S. Wadsworth, R. Vallee (1991)
Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosisNature, 351
Nakata (1993)
1J. Cell Sci., 105
Dynamin is a GTPase that regulates late events in clathrin‐coated vesicle formation. Our current working model suggests that dynamin is targeted to coated pits in its unoccupied or GDP‐bound form, where it is initially distributed uniformly throughout the clathrin lattice. GTP/GDP exchange triggers its release from these sites and its assembly into short helices that encircle the necks of invaginated coated pits like a collar. GTP hydrolysis, which is required for vesicle detachment, presumably induces a concerted conformation change, tightening the collar. Unlike most of its GTPase cousins that serve as molecular switches, dynamin has a low affinity for GTP, a very high intrinsic rate of GTP hydrolysis and functions as a homo‐oligomer. A concerted conformational change resulting from coordinated GTP hydrolysis by the dynamin oligomer might be sufficient to generate force. In this case, dynamin would be the first GTPase identified that acts as a structural protein with mechano‐chemical function.
BioEssays – Wiley
Published: Nov 1, 1996
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.