Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Macdonald, I. Módy, M. Salter (1989)
Regulation of N‐methyl‐D‐aspartate receptors revealed by intracellular dialysis of murine neurones in culture.The Journal of Physiology, 414
A. Alonso, R. Llinás (1989)
Subthreshold Na+-dependent theta-like rhythmicity in stellate cells of entorhinal cortex layer IINature, 342
S. Fedulova, P. Kostyuk, N. Veselovsky (1985)
Two types of calcium channels in the somatic membrane of new‐born rat dorsal root ganglion neurones.The Journal of Physiology, 359
A. Kay, R. Wong (1986)
Isolation of neurons suitable for patch-clamping from adult mammalian central nervous systemsJournal of Neuroscience Methods, 16
Hamill Hamill, Marty Marty, Neher Neher, Sakmann Sakmann, Sigworth Sigworth (1981)
Improved patch‐clamp techniques for high‐resolution current recording from cells and cell‐free membrane patchesPflügers Arch., 391
Levitan Levitan (1985)
Phosphorylation of ion channelsJ. Membr. Biol., 87
E. Ficker, Uwe Heinemann (1992)
Slow and fast transient potassium currents in cultured rat hippocampal cells.The Journal of Physiology, 445
Perozo Perozo, Bezanilla Bezanilla, DiPolo DiPolo (1989)
Modulation of K channels in dialyzed squid axonsJ. Gen. Physiol., 93
M. Stewart, S. Fox (1990)
Do septal neurons pace the hippocampal theta rhythm?Trends in Neurosciences, 13
J. Dreier, U. Heinemann (1990)
Late low magnesium-induced epileptiform activity in rat entorhinal cortex slices becomes insensitive to the anticonvulsant valproic acidNeuroscience Letters, 119
A. Marty, E. Neher (1985)
Potassium channels in cultured bovine adrenal chromaffin cells.The Journal of Physiology, 367
B. Gustafsson, M. Galvan, Peter Grafe, H. Wigström (1982)
A transient outward current in a mammalian central neurone blocked by 4-aminopyridineNature, 299
M. Segal, J. Barker (1984)
Rat hippocampal neurons in culture: potassium conductances.Journal of neurophysiology, 51 6
O. Belluzzi, O. Sacchi (1990)
The calcium‐dependent potassium conductance in rat sympathetic neurones.The Journal of Physiology, 422
Connor Connor, Stevens Stevens (1971)
Voltage clamp studies of a transient outward current in gastropod neural somataJ. Physiol. (Lond.), 213
R. Tsien, W. Giles, P. Greengard (1972)
Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres.Nature: New biology, 240 101
S. Cull-Candy, Cameron Marshall, David Ogden (1989)
Voltage‐activated membrane currents in rat cerebellar granule neurones.The Journal of Physiology, 414
Elizabeth Fenwick, Alain Marty, Erwin Neher (1982)
Sodium and calcium channels in bovine chromaffin cellsThe Journal of Physiology, 331
J. Halliwell, I. Othman, A. Pelchen-Matthews, J. Dolly (1986)
Central action of dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors.Proceedings of the National Academy of Sciences of the United States of America, 83 2
W. Spain, P. Schwindt, W. Crill (1991)
Two transient potassium currents in layer V pyramidal neurones from cat sensorimotor cortex.The Journal of Physiology, 434
Eduardo Perozo, Francisco Bezanilla, R. Dipolo (1989)
Modulation of K channels in dialyzed squid axons. ATP-mediated phosphorylationThe Journal of General Physiology, 93
R. Horn, A. Marty (1988)
Muscarinic activation of ionic currents measured by a new whole-cell recording methodThe Journal of General Physiology, 92
C. Zona, G. Pirrone, M. Avoli, M. Dichter (1988)
Delayed and fast transient potassium currents in rat neocortical neurons in cell cultureNeuroscience Letters, 94
R. Numann, W. Wadman, R. Wong (1987)
Outward currents of single hippocampal cells obtained from the adult guinea‐pig.The Journal of Physiology, 393
R. Jones, U. Heinemann (1988)
Synaptic and intrinsic responses of medical entorhinal cortical cells in normal and magnesium-free medium in vitro.Journal of neurophysiology, 59 5
Qx Chen, R. Wong (1991)
Intracellular Ca2+ suppressed a transient potassium current in hippocampal neurons, 11
Stephen Korn, Richard Horn (1989)
Influence of sodium-calcium exchange on calcium current rundown and the duration of calcium-dependent chloride currents in pituitary cells, studied with whole cell and perforated patch recordingThe Journal of General Physiology, 94
Pusch Pusch, Neher Neher (1988)
Rates of diffusional exchange between small cells and a measuring patch pipettePflügers Arch., 411
Marty Marty, Neher Neher (1985)
Potassium channels in cultured adrenal chromaffin cellsJ. Physiol. (Lond.), 367
H. Walther, J. Lambert, R. Jones, U. Heinemann, B. Hamon (1986)
Epileptiform activity in combined slices of the hippocampus, subiculum and entorhinal cortex during perfusion with low magnesium mediumNeuroscience Letters, 69
D. Brown, W. Griffith (1983)
Calcium‐activated outward current in voltage‐clamped hippocampal neurones of the guinea‐pig.The Journal of Physiology, 337
D. Doerner, T. Pitler, B. Alger (1988)
Protein kinase C activators block specific calcium and potassium current components in isolated hippocampal neurons, 8
M. Segal, M. Rogawski, J. Barker (1984)
A transient potassium conductance regulates the excitability of cultured hippocampal and spinal neurons, 4
P. Germroth, W. Schwerdtfeger, E. Buhl (1989)
Morphology of identified entorhinal neurons projecting to the hippocampus. A light microscopical study combining retrograde tracing and intracellular injectionNeuroscience, 30
E. Neher (1971)
Two Fast Transient Current Components during Voltage Clamp on Snail NeuronsThe Journal of General Physiology, 58
S. Thompson (1982)
Aminopyridine block of transient potassium currentThe Journal of General Physiology, 80
J. Connor, C. Stevens (1971)
Voltage clamp studies of a transient outward membrane current in gastropod neural somataThe Journal of Physiology, 213
Tsien Tsien, Giles Giles, Greengard Greengard (1972)
Cyclic AMP mediates the action of norepinephrine on the action potential plateau of cardiac Purkinje fibresNature, 240
A. Alonso, M. Curtis, R. Llinás (1990)
Postsynaptic Hebbian and non-Hebbian long-term potentiation of synaptic efficacy in the entorhinal cortex in slices and in the isolated adult guinea pig brain.Proceedings of the National Academy of Sciences of the United States of America, 87
Christina Augustine, Francisco Bezanilla (1990)
Phosphorylation modulates potassium conductance and gating current of perfused giant axons of squidThe Journal of General Physiology, 95
N. Silva, C. Pechura, J. Barker (1990)
Postnatal rat nigrostriatal dopaminergic neurons exhibit five types of potassium conductances.Journal of neurophysiology, 64 1
N. Tohse, M. Kameyama, K. Sekiguchi, M. Shearman, M. Kanno (1990)
Protein kinase C activation enhances the delayed rectifier potassium current in guinea-pig heart cells.Journal of molecular and cellular cardiology, 22 6
We have studied outward currents of neurons acutely isolated from superficial layers of the entorhinal cortex with whole‐cell patch‐clamp recordings. If cells were held more negative than ‐50 mV, depolarizing voltage commands activated a transient A‐type current together with a sustained outward current. Both currents were sensitive to 4‐aminopyridine, while only the sustained current was blocked by tetraethylammonium. The sustained outward current showed a considerable rundown in amplitude over prolonged recording periods. At the same time its half‐maximal inactivation shifted from ‐74 to ‐ 114 mV. Nystatin perforated patch recordings were used to minimize these perfusion effects. Under such conditions the amplitude and the steady‐state inactivation properties of the sustained outward current remained stable for more than 1 h. Pharmacological investigations revealed that only a small part of the sustained outward current could be attributed to a calcium‐activated potassium current. Therefore most of the rundown has to be due to changes in the delayed rectifier outward current. These results may suggest that the delayed rectifier current is under considerable metabolic control.
European Journal of Neuroscience – Wiley
Published: Dec 1, 1991
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.