Access the full text.
Sign up today, get DeepDyve free for 14 days.
Michael Weber, E. Harada, C. Vess, E. Roepenack-Lahaye, S. Clemens (2004)
Comparative microarray analysis of Arabidopsis thaliana and Arabidopsis halleri roots identifies nicotianamine synthase, a ZIP transporter and other genes as potential metal hyperaccumulation factors.The Plant journal : for cell and molecular biology, 37 2
D. Salt, R. Prince, A. Baker, I. Raskin, I. Pickering (1999)
Zinc Ligands in the Metal Hyperaccumulator Thlaspi caerulescens As Determined Using X-ray Absorption SpectroscopyEnvironmental Science & Technology, 33
Liping Huang, Catherine Kirschke, J. Gitschier (2002)
Functional Characterization of a Novel Mammalian Zinc Transporter, ZnT6*The Journal of Biological Chemistry, 277
E. Delhaize, T. Kataoka, D. Hebb, R. White, P. Ryan (2003)
Genes Encoding Proteins of the Cation Diffusion Facilitator Family That Confer Manganese Tolerance Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.009134.The Plant Cell Online, 15
J. Freeman, M. Persans, Ken Nieman, C. Albrecht, W. Peer, I. Pickering, D. Salt (2004)
Increased Glutathione Biosynthesis Plays a Role in Nickel Tolerance in Thlaspi Nickel HyperaccumulatorsThe Plant Cell Online, 16
V. Vacchina, S. Mari, P. Czernic, L. Marquès, Katia Pianelli, D. Schaumlöffel, M. Lebrun, R. Lobinski (2003)
Speciation of nickel in a hyperaccumulating plant by high-performance liquid chromatography-inductively coupled plasma mass spectrometry and electrospray MS/MS assisted by cloning using yeast complementation.Analytical chemistry, 75 11
R. and, A. Baker (1984)
STUDIES ON METAL UPTAKE BY PLANTS FROM SERPENTINE AND NON-SERPENTINE POPULATIONS OF THLASPI GOESINGENSE HÁLÁCSY (CRYCUFERAE).The New phytologist, 98 1
T. Kambe, H. Narita, Y. Yamaguchi-Iwai, J. Hirose, Tatsuaki Amano, N. Sugiura, R. Sasaki, K. Mori, T. Iwanaga, M. Nagao (2002)
Cloning and Characterization of a Novel Mammalian Zinc Transporter, Zinc Transporter 5, Abundantly Expressed in Pancreatic β Cells*The Journal of Biological Chemistry, 277
A. Assunção, P. Martins, S. Folter, R. Vooijs, H. Schat, M. Aarts (2001)
Elevated expression of metal transporter genes in three accessions of the metal hyperaccumulator Thlaspi caerulescensPlant Cell and Environment, 24
R. Boominathan, P. Doran (2002)
Ni-induced oxidative stress in roots of the Ni hyperaccumulator, Alyssum bertolonii.The New phytologist, 156 2
Richard D. Palmiter, T. Cole, C. Quaife, S. Findley (1996)
ZnT-3, a putative transporter of zinc into synaptic vesicles.Proceedings of the National Academy of Sciences of the United States of America, 93 25
Liping Huang, J. Gitschier (1997)
A novel gene involved in zinc transport is deficient in the lethal milk mouseNature Genetics, 17
Richard D. Palmiter, T. Cole, Seth Findley (1996)
ZnT‐2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration.The EMBO Journal, 15
W. Henke, Kerstin Herdel, K. Jung, D. Schnorr, S. Loening (1997)
Betaine improves the PCR amplification of GC-rich DNA sequences.Nucleic acids research, 25 19
M. Carvalho, C. Andrew, D. Edwards, C. Asher (1980)
Comparative performance of six Stylosanthes species in three acid soils.Crop & Pasture Science, 31
Catherine Kirschke, Liping Huang (2003)
ZnT7, a Novel Mammalian Zinc Transporter, Accumulates Zinc in the Golgi Apparatus*The Journal of Biological Chemistry, 278
M. Ghosh, Jian Shen, Barry Rosen (1999)
Pathways of As(III) detoxification in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America, 96 9
Conklin (1992)
COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiaeMol. Cell. Biol., 12
M. Manolson, Bingruo Wu, D. Proteau, B. Taillon, B. Roberts, M. Hoyt, E. Jones (1994)
STV1 gene encodes functional homologue of 95-kDa yeast vacuolar H(+)-ATPase subunit Vph1p.The Journal of biological chemistry, 269 19
Ute Krämer, I. Pickering, R. Prince, I. Raskin, D. Salt (2000)
Subcellular localization and speciation of nickel in hyperaccumulator and non-accumulator Thlaspi species.Plant physiology, 122 4
A. Daar, H. Thorsteinsdóttir, Douglas Martin, Alyna Smith, Shauna Nast, P. Singer (2002)
Top ten biotechnologies for improving health in developing countriesNature Genetics, 32
D. Blaudez, A. Kohler, F. Martin, D. Sanders, M. Chalot (2003)
Poplar Metal Tolerance Protein 1 Confers Zinc Tolerance and Is an Oligomeric Vacuolar Zinc Transporter with an Essential Leucine Zipper Motif Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.017541.The Plant Cell Online, 15
I. Paulsen, M. Saier (1997)
A Novel Family of Ubiquitous Heavy Metal Ion Transport ProteinsThe Journal of Membrane Biology, 156
Assunção (2001)
Elevated expression of metal transporter genes in three accessions of the metal hyperaccumulator Thlaspi caerulescensPlant Cell Environ., 24
C. MacDiarmid, M. Milanick, D. Eide (2003)
Induction of the ZRC1 Metal Tolerance Gene in Zinc-limited Yeast Confers Resistance to Zinc Shock*The Journal of Biological Chemistry, 278
Dietrich Nies (1992)
CzcR and CzcD, gene products affecting regulation of resistance to cobalt, zinc, and cadmium (czc system) in Alcaligenes eutrophusJournal of Bacteriology, 174
Hendrik Küpper, Enzo Lombi, Fang-Jie Zhao, G. Wieshammer, Steve McGrath (2001)
Cellular compartmentation of nickel in the hyperaccumulators Alyssum lesbiacum, Alyssum bertolonii and Thlaspi goesingense.Journal of experimental botany, 52 365
D. Kim, Y. Eu, C. Yoo, Y. Kim, K. Pih, J. Jin, S. Kim, H. Stenmark, I. Hwang (2001)
Trafficking of Phosphatidylinositol 3-Phosphate from the trans-Golgi Network to the Lumen of the Central Vacuole in Plant CellsPlant Cell, 13
C. MacDiarmid, L. Gaither, D. Eide (2000)
Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiaeThe EMBO Journal, 19
A. Maris, A. Kern, J. Picada, F. Boccardi, M. Brendel, J. Henriques (2000)
Glutathione, but not transcription factor Yap1, is required for carbon source-dependent resistance to oxidative stress in Saccharomyces cerevisiaeCurrent Genetics, 37
B. Zaal, L. Neuteboom, J. Pinas, A. Chardonnens, H. Schat, J. Verkleij, P. Hooykaas (1999)
Overexpression of a novel Arabidopsis gene related to putative zinc-transporter genes from animals can lead to enhanced zinc resistance and accumulation.Plant physiology, 119 3
P. Mäser, S. Thomine, J. Schroeder, J. Ward, K. Hirschi, H. Sze, Ina Talke, A. Amtmann, F. Maathuis, D. Sanders, J. Harper, J. Tchieu, M. Gribskov, M. Persans, D. Salt, Sun Kim, M. Guerinot (2001)
Phylogenetic relationships within cation transporter families of Arabidopsis.Plant physiology, 126 4
H. Weber, Aurore Chételat, P. Reymond, E. Farmer (2004)
Selective and powerful stress gene expression in Arabidopsis in response to malondialdehyde.The Plant journal : for cell and molecular biology, 37 6
S. Kobayashi, Shinji Miyabe, S. Izawa, Y. Inoue, Akira Kimura (1996)
Correlation of the OSR/ZRCI gene product and the intracellular glutathione levels in Saccharomyces cerevisiaeBiotechnology and Applied Biochemistry, 23
R. Palmiter, S. Findley (1995)
Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc.The EMBO Journal, 14
R. Bookstein, Chen-Ching Lai, Hoang To, Wen-Hwa Lee (1990)
PCR-based detection of a polymorphic BamHI site in intron 1 of the human retinoblastoma (RB) gene.Nucleic acids research, 18 6
Hui Zhao, David Eide (1996)
The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation.Proceedings of the National Academy of Sciences of the United States of America, 93 6
Tanja Bloss, S. Clemens, D. Nies (2002)
Characterization of the ZAT1p zinc transporter from Arabidopsis thaliana in microbial model organisms and reconstituted proteoliposomesPlanta, 214
Y. Niwa, T. Hirano, K. Yoshimoto, M. Shimizu, Hirokazu Kobayashi (1999)
Non-invasive quantitative detection and applications of non-toxic, S65T-type green fluorescent protein in living plants.The Plant journal : for cell and molecular biology, 18 4
J. Johnston (1994)
Molecular genetics of yeast :a practical approach
W. Wenzel, F. Jockwer (1999)
Accumulation of heavy metals in plants grown on mineralised soils of the Austrian AlpsEnvironmental Pollution, 104
Ute Krämer, Robert Smith, W. Wenzel, Ilya Raskin, D. Salt, D. Salt (1997)
The Role of Metal Transport and Tolerance in Nickel Hyperaccumulation by Thlaspi goesingense Halacsy, 115
A. Kamizono, M. Nishizawa, Y. Teranishi, K. Murata, A. Kimura (1989)
Identification of a gene conferring resistance to zinc and cadmium ions in the yeast Saccharomyces cerevisiaeMolecular and General Genetics MGG, 219
Hendrik Küpper, Fang-Jie Zhao, Steve McGrath (1999)
Cellular compartmentation of zinc in leaves of the hyperaccumulator thlaspi caerulescensPlant physiology, 119 1
D. Nies, S. Silver (1995)
Ion efflux systems involved in bacterial metal resistancesJournal of Industrial Microbiology, 14
D. Conklin, J. Mcmaster, M. Culbertson, C. Kung (1992)
COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiaeMolecular and Cellular Biology, 12
H. Küpper, E. Lombi, F. Zhao, S. McGrath (2000)
Cellular compartmentation of cadmium and zinc in relation to other elements in the hyperaccumulator Arabidopsis halleriPlanta, 212
W. Peer, Mehrzad Mamoudian, Brett Lahner, R. Reeves, A. Murphy, D. Salt (2003)
Identifying model metal hyperaccumulating plants: germplasm analysis of 20 Brassicaceae accessions from a wide geographical area.The New phytologist, 159 2
J. Jin, Y. Kim, S. Kim, S. Lee, D. Kim, G. Cheong, I. Hwang (2001)
A New Dynamin-Like Protein, ADL6, Is Involved in Trafficking from the trans-Golgi Network to the Central Vacuole in ArabidopsisThe Plant Cell Online, 13
Wendy Peer, Angus Murphy (2003)
Floral scent of Arabidopsis lyrata (Brassicaceae)Biochemical Systematics and Ecology, 31
M. Persans, Ken Nieman, D. Salt (2001)
Functional activity and role of cation-efflux family members in Ni hyperaccumulation in Thlaspi goesingenseProceedings of the National Academy of Sciences of the United States of America, 98
Liangtao Li, J. Kaplan (1998)
Defects in the Yeast High Affinity Iron Transport System Result in Increased Metal Sensitivity because of the Increased Expression of Transporters with a Broad Transition Metal Specificity*The Journal of Biological Chemistry, 273
Liangtao Li, J. Kaplan (2001)
The Yeast Gene MSC2, a Member of the Cation Diffusion Facilitator Family, Affects the Cellular Distribution of Zinc*The Journal of Biological Chemistry, 276
Joohyun Lee, H. Bae, Jeeyon Jeong, Jae-Yun Lee, Young-Yell Yang, I. Hwang, E. Martinoia, Youngsook Lee (2003)
Functional Expression of a Bacterial Heavy Metal Transporter in Arabidopsis Enhances Resistance to and Decreases Uptake of Heavy Metals1[w]Plant Physiology, 133
M. Lasat, Alan Baker, L. Kochian (1998)
Altered Zn compartmentation in the root symplasm and stimulated Zn absorption into the leaf as mechanisms involved in Zn hyperaccumulation in thlaspi caerulescensPlant physiology, 118 3
Martina Becher, Ina Talke, L. Krall, U. Krämer (2004)
Cross-species microarray transcript profiling reveals high constitutive expression of metal homeostasis genes in shoots of the zinc hyperaccumulator Arabidopsis halleri.The Plant journal : for cell and molecular biology, 37 2
C. MacDiarmid, M. Milanick, D. Eide (2002)
Biochemical Properties of Vacuolar Zinc Transport Systems ofSaccharomyces cerevisiae *The Journal of Biological Chemistry, 277
To avoid metal toxicity, organisms have evolved mechanisms including efflux of metal ions from cells and sequestration into internal cellular compartments. Members of the ubiquitous cation diffusion facilitator (CDF) family are known to play an important role in these processes. Overexpression of the plant CDF family member metal tolerance protein 1 (MTP1) from the Ni/Zn hyperaccumulator Thlaspi goesingense (TgMTP1), in the Saccharomyces cerevisiaeΔ zinc resistance conferring (zrc)1Δ cobalt transporter (cot)1 double mutant, suppressed the Zn sensitivity of this strain. T. goesingense was found to contain several allelic variants of TgMTP1, all of which confer similar resistance to Zn in Δzrc1Δcot1. Similarly, MTP1 from various hyperaccumulator and non‐accumulator species also confer similar resistance to Zn. Δzrc1Δcot1 lacks the ability to accumulate Zn in the vacuole and has lower accumulation of Zn after either long‐ or short‐term Zn exposure. Expression of TgMTP1 in Δzrc1Δcot1 leads to further lowering of Zn accumulation and an increase in Zn efflux from the cells. Expression of TgMTP1 in a V‐type ATPase‐deficient S. cerevisiae strain also confers increased Zn resistance. In vivo and in vitro immunological staining of hemagglutinin (HA)‐tagged TgMTP1::HA reveals the protein to be localized in both the S. cerevisiae vacuolar and plasma membranes. Taken together, these data are consistent with MTP1 functioning to enhance plasma membrane Zn efflux, acting to confer Zn resistance independent of the vacuole in S. cerevisiae. Transient expression in Arabidopsis thaliana protoplasts also reveals that TgMTP1::green fluorescent protein (GFP) is localized at the plasma membrane, suggesting that TgMTP1 may also enhance Zn efflux in plants.
The Plant Journal – Wiley
Published: Jul 1, 2004
Keywords: ; ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.