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A randomised controlled trial of perineural vs intravenous dexamethasone for foot surgery

A randomised controlled trial of perineural vs intravenous dexamethasone for foot surgery Summary We used 20 ml ropivacaine 0.75% for ankle blocks before foot surgery in 90 participants who we allocated in equal numbers to: perineural dexamethasone 8 mg and intravenous saline 0.9%; perineural saline 0.9% and intravenous dexamethasone 8 mg; or perineural and intravenous saline 0.9%. Dexamethasone increased the median (IQR (range)) time for the return of some sensation or movement, from 14.6 (10.8–18.8 (5.5–38.0)) h with saline to 24.1 (19.3–29.3 (5.0–44.0)) h when given perineurally, p = 0.00098, and to 20.9 (18.3–27.8 (8.8–31.3)) h when given intravenously, p = 0.0067. Dexamethasone increased the median (IQR (range)) time for the return of normal neurology, from 17.6 (14.0–21.0 (9.5–40.5)) h with saline to 27.5 (22.0–36.3 (7.0–53.0)) h when given perineurally, p = 0.00016, and to 24.0 (20.5–32.3 (13.0–42.5)) h when given intravenously, p = 0.0022. Dexamethasone did not affect the rates of block success, postoperative pain scores, analgesic use, or nausea and vomiting. The route of dexamethasone administration did not alter its effects. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Anaesthesia Wiley

A randomised controlled trial of perineural vs intravenous dexamethasone for foot surgery

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References (36)

Publisher
Wiley
Copyright
Copyright © 2016 © The Association of Anaesthetists of Great Britain and Ireland
ISSN
0003-2409
eISSN
1365-2044
DOI
10.1111/anae.13346
pmid
26682721
Publisher site
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Abstract

Summary We used 20 ml ropivacaine 0.75% for ankle blocks before foot surgery in 90 participants who we allocated in equal numbers to: perineural dexamethasone 8 mg and intravenous saline 0.9%; perineural saline 0.9% and intravenous dexamethasone 8 mg; or perineural and intravenous saline 0.9%. Dexamethasone increased the median (IQR (range)) time for the return of some sensation or movement, from 14.6 (10.8–18.8 (5.5–38.0)) h with saline to 24.1 (19.3–29.3 (5.0–44.0)) h when given perineurally, p = 0.00098, and to 20.9 (18.3–27.8 (8.8–31.3)) h when given intravenously, p = 0.0067. Dexamethasone increased the median (IQR (range)) time for the return of normal neurology, from 17.6 (14.0–21.0 (9.5–40.5)) h with saline to 27.5 (22.0–36.3 (7.0–53.0)) h when given perineurally, p = 0.00016, and to 24.0 (20.5–32.3 (13.0–42.5)) h when given intravenously, p = 0.0022. Dexamethasone did not affect the rates of block success, postoperative pain scores, analgesic use, or nausea and vomiting. The route of dexamethasone administration did not alter its effects.

Journal

Anaesthesia – Wiley

Published: Mar 1, 2016

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