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V. Diehl, G. Henle, W. Henle, G. Kohn (1968)
Demonstration of a Herpes Group Virus in Cultures of Peripheral Leukocytes from Patients with Infectious MononucleosisJournal of Virology, 2
George Klein, Gary Pearson, J. Nadkarni, J. Nadkarni, Eva Klein, G. Henle, Werner Henle, Peter Clifford (1968)
RELATION BETWEEN EPSTEIN-BARR VIRAL AND CELL MEMBRANE IMMUNOFLUORESCENCE OF BURKITT TUMOR CELLSThe Journal of Experimental Medicine, 128
M. Epstein, B. Achong, Y. Barr, B. Zajac, G. Henle, W. Henle (1966)
Morphological and virological investigations on cultured Burkitt tumor lymphoblasts (strain Raji).Journal of the National Cancer Institute, 37 4
M. Epstein, Y. Barr, B. Achong (1965)
Studies with Burkitt's lymphoma.The Wistar Institute symposium monograph, 4
G. Klein, G. Pearson, G. Henle, W. Henle, Volker Diehl, J. Niederman (1968)
RELATION BETWEEN EPSTEIN-BARR VIRAL AND CELL MEMBRANE IMMUNOFLUORESCENCE IN BURKITT TUMOR CELLSThe Journal of Experimental Medicine, 128
G. Henle, W. Henle (1966)
Immunofluorescence in Cells Derived from Burkitt's LymphomaJournal of Bacteriology, 91
J. Nadkarni, J. Nadkarni, P. Clifford, G. Manolov, E. Fenyö, E. Klein (1969)
Characteristics of new cell lines derived from Burkitt lymphomasCancer, 23
Epstein Epstein, Barr Barr, Achong Achong (1965)
Studies with Burkitt&s lymphomaWistar Institute Symposium Monograph, 4
G. Klein, P. Clifford, E. Klein, J. Stjernsward (1966)
Search for tumor-specific immune reactions in Burkitt lymphoma patients by the membrane immunofluorescence reaction.Proceedings of the National Academy of Sciences of the United States of America, 55 6
Klein Klein, Pearson Pearson, Nadkarni Nadkarni, Nadkarni Nadkarni, Klein Klein, Henle Henle, Henle Henle, Clifford Clifford (1968b)
Relation between Epstein‐Barr viral and cell membrane immunofluorescence of Burkitt tumor cells. I. Dependence of cell membrane immunofluorescence on presence of EB virusJ. exp. Med., 128
W. Henle, G. Henle (1968)
Effect of Arginine-deficient Media on the Herpes-Type Virus Associated with Cultured Burkitt Tumor CellsJournal of Virology, 2
G. Henle, Werner Henle, Peter Clifford, Volker Diehl, George Kafuko, Barnabas Kirya, George Klein, Richard Morrow, Germano Munube, Patricia Pike, Peter Tukel, John Ziegler (1969)
Antibodies to Epstein-Barr virus in Burkitt's lymphoma and control groups.Journal of the National Cancer Institute, 43 5
(1968)
Present status of the herpes group virus associated with cultures of the hematopoietic system
Klein Klein, Pearson Pearson, Henle Henle, Henle Henle, Diehl Diehl, Niederman Niederman (1968a)
Relation between Epstein‐Barr viral and cell membrane immunofluorescence in Burkitt tumor cells. II. Comparison of cells and sera from patients with Burkitt&s lymphoma and infectious mononucleosisJ. exp. Med., 128
E. Griffin, D. Wright, T. Bell, M. Ross (1966)
Demonstration of virus particles in biopsy material from cases of Burkitt's tumour.European journal of cancer, 2 4
A. Rabson, G. O'conor, S. Baron, J. Whang, F. Legallais (1966)
Morphologic, cytogenetic and virologic studies in vitro of a malignant lymphoma from an African childInternational Journal of Cancer, 1
Pearson Pearson, Klein Klein, Henle Henle, Henle Henle, Clifford Clifford (1969)
Relation between Epstein‐Barr viral and membrane immunofluorescence in Burkitt tumor cells. IV. Differentiation between antibodies responsible for membrane and viral immunofluorescenceJ. exp. Med., 129
G. Klein, P. Clifford, E. Klein, R. Smith, J. Minowada, F. Kourilsky, J. Burchenal (1967)
Membrane immunofluorescence reactions of Burkitt lymphoma cells from biopsy specimens and tissue cultures.Journal of the National Cancer Institute, 39 5
Klein Klein, Pearson Pearson, Henle Henle, Henle Henle, Goldstein Goldstein, Clifford Clifford (1969)
Relation between Epstein‐Barr viral and membrane immunofluorescence in Burkitt&s tumor cells. III. Comparison of blocking of direct membrane immunofluorescence and anti‐EBV reactivities of different seraJ. exp. Med., 129
The emergence of cells producing EB viral antigens in cultures of Burkitt tumor biopsies was studied by means of immunofluorescence techniques. Definitely or questionably positive cells were seen in acetone‐fixed smears of 6% and 29% of the biopsies, respectively, which amounted to no more than a few cells among several hundred thousands. Yet in culture, specifically stainable cells often appeared within 3 to 10 days, occasionally in substantial numbers (up to 5%). Repeated biopsies from the same donors gave remarkably similar results. In time all cultures which developed into lines showed the presence of EBV. Arginine‐free medium failed to facilitate emergence of EBV antigen‐producing cells in young cultures or to increase their number, unless about 0.5% or more of the cells in the control cultures were productively infected. The implications of these findings are discussed.
International Journal of Cancer – Wiley
Published: Jul 15, 1970
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