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P. Niermeijer, C. Gips, J. Huizenga, H. Houthoff, J. Snijder (1980)
Anti-HBc titers and anti-HBc immunoglobulin (M/G) classes in acute, chronic and resolved hepatitis B.Hepato-gastroenterology, 27 4
W. Brzosko, B. Mikulska, J. Cianciara, J. Babiuch (1975)
Immunoglobulin classes of antibody to hepatitis B core antigen.The Journal of infectious diseases, 132 1
W. Gerlich, W. Lüer (1979)
Selective detection of IgM‐antibody against core antigen of the hepatitis B virus by a modified enzyme immune assayJournal of Medical Virology, 4
P. Kryger, L. Mathiesen, A. Møller, J. Aldershvile, B. Hansson, J. Nielsen (1981)
Enzyme-linked immunosorbent assay for detection of immunoglobulin M antibody to hepatitis B core antigenJournal of Clinical Microbiology, 13
Dormeyer (1981)
675Klin Wochenschr, 59
Kaplan Kaplan, Greenman Greenman, Gerin Gerin (1973)
DNA polymerase associated with hepatitis B antigenJ Virol, 12
M. Roggendorf, F. Deinhardt, G. Frösner, R. Scheid, B. Bayerl, R. Zachoval (1981)
Immunoglobulin M antibodies to hepatitis B core antigen: evaluation of enzyme immunoassay for diagnosis of hepatitis B virus infectionJournal of Clinical Microbiology, 13
R. Decker, S. Kosakowski, A. Vanderbilt, C. Ling, R. Chairez, L. Overby (1981)
Diagnosis of acute hepatitis A by HAVAB-M, a direct radioimmunoassay for IgM anti-HAV.American journal of clinical pathology, 76 2
P. Kryger, L. Mathiesen, J. Aldershvile, J. Nielsen (1981)
Presence and meaning of anti‐HBc IgM as determined by ELISA in patients with acute type B hepatitis and healthy HBsAg carriersHepatology, 1
(1976)
Radioimmunoassay for anticore as evidence for exposure to hepatitis B virus
S. Lemon, N. Gates, Thomas Simms, W. Bancroft (1981)
IgM antibody to hepatitis B core antigen as a diagnostic parameter of acute infection with hepatitis B virus.The Journal of infectious diseases, 143 6
R. Hawkes, C. Boughton, V. Ferguson, N. Lehmann (1980)
Use of immunoglobulin M antibody to hepatitis B core antigen in diagnosis of viral hepatitisJournal of Clinical Microbiology, 11
Niermeijer (1980)
271Hepato-Gastroenterology, 27
I. Mushahwar, J. Dienstag, H. Polesky, L. McGrath, R. Decker, L. Overby (1981)
Interpretation of various serological profiles of hepatitis B virus infection.American journal of clinical pathology, 76 6
W. Robinson, R. Greenman (1974)
DNA Polymerase in the Core of the Human Hepatitis B Virus CandidateJournal of Virology, 13
Dormeyer Dormeyer, Arnold Arnold, Kryger Kryger (1981)
IgM antibody to hepatitis B core antigen (anti‐HBc IgM) in healthy HBsAg carriers: a longitudinal study of 75 casesKlin Wochenschr, 59
P. Kaplan, R. Greenman, J. Gerin, R. Purcell, W. Robinson (1973)
DNA Polymerase Associated with Human Hepatitis B AntigenJournal of Virology, 12
W. Gerlich, W. Lüer, R. Thomssen (1980)
Diagnosis of acute and inapparent hepatitis B virus infections by measurement of IgM antibody to hepatitis B core antigen.The Journal of infectious diseases, 142 1
P. Kryger, J. Aldershvile, L. Mathiesen, J. Nielsen (2007)
Acute Type B Hepatitis among HBsAg Negative Patients Detected by Anti‐HBc IgMHepatology, 2
R. Tedder, R. Wilson‐Croome (1981)
IgM-antibody response to the hepatitis B core antigen in acute and chronic hepatitis BJournal of Hygiene, 86
R. Tedder, R. Wilson‐Croome (1980)
Detection by radioimmunoassay of igm class antibody to hepatitis b core antigen: a comparison of two methodsJournal of Medical Virology, 6
B. Cohen, NT I (1978)
The IgM antibody responses to the core antigen of hepatitis B virusJournal of Medical Virology, 3
P. Mortimer, E. Vandervelde, J. Parry, B. Cohen, R. Tedder (1981)
The anti-HBc IgM response in the acute and convalescent phases of acute hepatitis.The Journal of infection, 3 4
Overby (1976)
83Rush-Presbyt St Luke Med Bull, 15
time sequence, relative reactivity, and persistence of anti‐HBc IgM were assessed in patients with HBsAg‐positive viral hepatitis. A solid‐phase immunoassay was developed using the IgM capture procedure with anti‐m̈ated polystyrene beads. HBcAg was purified from serum Dane particles and used as a probe with 125I‐labeled anti‐HBc IgG. This immunoassay exhibited a pronounced prozoning phenomenon, and relative titers of sera differed widely depending upon the dilution of serum tested. When all sera were tested at 1:5,000 dilution, results were comparable in different patient groups. HBc IgM persisted at detectable levels for up to 2 years, and it was necessary to establish relative titers to discriminate current from remote infections. A cut‐off assay value was established, and in 12 cases of acute hepatitis B virus (HBV) infection, antibody exceeded this value for about 6 months after onset of HBs antigenemia. A similar profile of anti‐HBc IgM persistence was observed in seven patients who developed an HBsAg chronic carrier state. Long‐term viral replication did not sustain elevated IgM class‐specific antibody levels. studies suggest that anti‐HBc IgM analyses may be useful for differentiating recent and current HBV infections from remote infections, eliminating HBV as the agent for non‐A, non‐B hepatitis in asymptomatic HBsAg carriers, and detecting HBV as the etiologic agent during silent (HBsAg negative) infections.
Hepatology – Wiley
Published: Jan 1, 1983
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