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Myocardial protection is lost before contractile function recovers from ischemic preconditioning

Myocardial protection is lost before contractile function recovers from ischemic preconditioning MURRY, CHARLES E., VINCENT J. RICHARD, ROBERT B. JENNINGS, KEITH A. REIMER. protection is Lost before contractile function recovers from ischemic . Am. J. Physiol. 260 (Heart Circ. Physiol. 29): H796-H804, 1991.- myocardium with brief episodes of ischemia reduces energy dem delays cell death during a subsequent ischemic episode. We hypothesized that postischemic contractile dysfunction after the brief ischemic episodes (“”) causes this reduced energy dem. If this hypothesis is correct, then cardioprotection should persist as long as mechanical function still is depressed at the onset of sustained ischemia. To analyze the temporal relationship between , infarct size was compared in two s of open-chest anesthetized dogs that were preconditioned with a 15-min coronary occlusion followed by a sustained 4O-min occlusion. One received 5 min of reperfusion the second received 120 min of reperfusion between occlusions. Nonpreconditioned controls received a single 40min occlusion. A 15-min occlusion caused severe , which did not improve during 2 h of reperfusion. In the 5min reflow , resulted in dramatically smaller infarcts, averaging 2.2 t 0.9% of the area at risk vs. 26.5 t 4.2% in controls (P < O.Ol), confirmed by a marked shift in the inverse relationship between collateral blood http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Myocardial protection is lost before contractile function recovers from ischemic preconditioning

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Publisher
The American Physiological Society
Copyright
Copyright © 1991 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
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Abstract

MURRY, CHARLES E., VINCENT J. RICHARD, ROBERT B. JENNINGS, KEITH A. REIMER. protection is Lost before contractile function recovers from ischemic . Am. J. Physiol. 260 (Heart Circ. Physiol. 29): H796-H804, 1991.- myocardium with brief episodes of ischemia reduces energy dem delays cell death during a subsequent ischemic episode. We hypothesized that postischemic contractile dysfunction after the brief ischemic episodes (“”) causes this reduced energy dem. If this hypothesis is correct, then cardioprotection should persist as long as mechanical function still is depressed at the onset of sustained ischemia. To analyze the temporal relationship between , infarct size was compared in two s of open-chest anesthetized dogs that were preconditioned with a 15-min coronary occlusion followed by a sustained 4O-min occlusion. One received 5 min of reperfusion the second received 120 min of reperfusion between occlusions. Nonpreconditioned controls received a single 40min occlusion. A 15-min occlusion caused severe , which did not improve during 2 h of reperfusion. In the 5min reflow , resulted in dramatically smaller infarcts, averaging 2.2 t 0.9% of the area at risk vs. 26.5 t 4.2% in controls (P < O.Ol), confirmed by a marked shift in the inverse relationship between collateral blood

Journal

AJP - Heart and Circulatory Physiology – The American Physiological Society

Published: Mar 1, 1991

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