Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

BCL-2 GENE FAMILY IN THE NERVOUS SYSTEM

BCL-2 GENE FAMILY IN THE NERVOUS SYSTEM ▪ Abstract A growing family of genes that share homology with the bcl-2 proto-oncogene is involved in the regulation of cell death. Many of these proteins show widespread expression and are expressed in the nervous system in developing and adult organisms. A physiologic role for Bcl-2 and Bcl-x in neuron survival has been shown. In addition, these proteins have been shown to protect neurons from a wide array of toxic insults. In this review, we discuss the Bcl-2 family of proteins with regard to their structure and interactions. We then discuss the role of apoptotic cell death in the development of the nervous system and as a response to neuronal injury. Lastly, we discuss the evidence for a role for these cell death regulators in neuronal death decisions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Neuroscience Annual Reviews

BCL-2 GENE FAMILY IN THE NERVOUS SYSTEM

Merry, D. E.
Annual Review of Neuroscience , Volume 20 (1) – Mar 1, 1997
Download PDF
23 pages

Loading next page...
 
/lp/annual-reviews/bcl-2-gene-family-in-the-nervous-system-pB9p0iq0Bv

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Annual Reviews
Copyright
Copyright © 1997 by Annual Reviews Inc. All rights reserved
Subject
Review Articles
ISSN
0147-006X
eISSN
1545-4126
DOI
10.1146/annurev.neuro.20.1.245
pmid
9056714
Publisher site
See Article on Publisher Site

Abstract

▪ Abstract A growing family of genes that share homology with the bcl-2 proto-oncogene is involved in the regulation of cell death. Many of these proteins show widespread expression and are expressed in the nervous system in developing and adult organisms. A physiologic role for Bcl-2 and Bcl-x in neuron survival has been shown. In addition, these proteins have been shown to protect neurons from a wide array of toxic insults. In this review, we discuss the Bcl-2 family of proteins with regard to their structure and interactions. We then discuss the role of apoptotic cell death in the development of the nervous system and as a response to neuronal injury. Lastly, we discuss the evidence for a role for these cell death regulators in neuronal death decisions.

Journal

Annual Review of Neuroscience – Annual Reviews

Published: Mar 1, 1997

There are no references for this article.