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(1995)
Proc Natl Acad Sci
(1997)
TANG Y, GATLEY SJ, VOLKOW ND, LAN R, AND MAKRIYANNIS A
M. Caterina, M. Schumacher, M. Tominaga, Tobias Rosen, J. Levine, D. Julius (1997)
The capsaicin receptor: a heat-activated ion channel in the pain pathwayNature, 389
G. Böhme, M. Laville, C. Ledent, Marc Parmentier, Assunta Imperato (1999)
Enhanced long-term potentiation in mice lacking cannabinoid CB1 receptorsNeuroscience, 95
(1999)
UEDA N, TANIGUCHI K, AND YAMAMOTO S
M. Sickle, L. Oland, W. Ho, C. Hillard, K. Mackie, J. Davison, K. Sharkey (2001)
Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret.Gastroenterology, 121 4
R. Vardaris, D. Weisz, T. Teyler (1977)
Δ9-Tetrahydrocannabinol and the hippocampus: Effects on CA1 field potentials in ratsBrain Research Bulletin, 2
R. Hampson, S. Deadwyler (1998)
Role of Cannabinoid Receptors in Memory StorageNeurobiology of Disease, 5
R. Fitzsimonds, M. Poo (1998)
Retrograde signaling in the development and modification of synapses.Physiological reviews, 78 1
K. Harris, H. Hirase, X. Leinekugel, D. Henze, G. Buzsáki (2001)
Temporal Interaction between Single Spikes and Complex Spike Bursts in Hippocampal Pyramidal CellsNeuron, 32
T. Maejima, K. Hashimoto, Takayuki Yoshida, A. Aiba, M. Kano (2001)
Presynaptic Inhibition Caused by Retrograde Signal from Metabotropic Glutamate to Cannabinoid ReceptorsNeuron, 31
I. Katona, B. Sperlágh, A. Sik, Attila Käfalvi, E. Vizi, K. Mackie, T. Freund (1999)
Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal InterneuronsThe Journal of Neuroscience, 19
T. Pitier, B. Alger (1994)
Depolarization-induced suppression of GABAergic inhibition in rat hippocampal pyramidal cells: G protein involvement in a presynaptic mechanismNeuron, 13
P. Mailleux, J. Vanderhaeghen (1992)
Distribution of neuronal cannabinoid receptor in the adult rat brain: A comparative receptor binding radioautography and in situ hybridization histochemistryNeuroscience, 48
M. Buonamici, G. Young, N. Khazan (1982)
Effects of acute δ9-THC administration on EEG and EEG power spectra in the ratNeuropharmacology, 21
T. Sugiura, S. Kondo, A. Sukagawa, S. Nakane, A. Shinoda, K. Itoh, A. Yamashita, K. Waku (1995)
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain.Biochemical and biophysical research communications, 215 1
B. Alger, T. Pitler (1995)
Retrograde signaling at GABAA-receptor synapses in the mammalian CNSTrends in Neurosciences, 18
Andrea Giuffrida, D. Piomelli (2000)
The endocannabinoid system: a physiological perspective on its role in psychomotor control.Chemistry and physics of lipids, 108 1-2
(2002)
GRIFFIN G, AND CRAVATT BF
M. Bouaboula, C. Poinot-Chazel, B. Bourrie, X. Canat, B. Calandra, M. Rinaldi-Carmona, G. Fur, P. Casellas (1995)
Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1.The Biochemical journal, 312 ( Pt 2)
K. Mackie, B. Hille (1992)
Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells.Proceedings of the National Academy of Sciences of the United States of America, 89
J. Williams, M. Er̀rington, M. Lynch, T. Bliss (1989)
Arachidonic acid induces a long-term activity-dependent enhancement of synaptic transmission in the hippocampusNature, 341
(2000)
Behavioral effects of anandamide and the amidase inhibitor AM374
(2001)
MACKIE K, AND PICKEL VM
M. Patricelli, B. Cravatt (1999)
Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism.Biochemistry, 38 43
Wilson for helpful comments on the manuscript and to Dr. H. Monyer for support. We are also indebted to Drs
M. Rinaldi-Carmona, Françoise Pialot, C. Congy, Elsa Redon, Francis Barth, A. Bachy, J. Breliere, Philippe Soubrié, G. Fur (1996)
Characterization and distribution of binding sites for [3H]-SR 141716A, a selective brain (CB1) cannabinoid receptor antagonist, in rodent brain.Life sciences, 58 15
R. Luján, Z. Nusser, J. Roberts, R. Shigemoto, P. Somogyi (1996)
Perisynaptic Location of Metabotropic Glutamate Receptors mGluR1 and mGluR5 on Dendrites and Dendritic Spines in the Rat HippocampusEuropean Journal of Neuroscience, 8
K. Albert, W. Elliott, R. Abbott, T. Gilbertson, J. Data (1981)
Influence of Kaolin—Pectin Suspension on Steady‐State Plasma Digoxin LevelsThe Journal of Clinical Pharmacology, 21
A. Calignano, G. Rana, A. Giuffrida, D. Piomelli (1998)
Control of pain initiation by endogenous cannabinoidsNature, 394
E. Acquas, A. Pisanu, P. Marrocu, S. Goldberg, G. Chiara (2001)
Δ9-tetrahydrocannabinol enhances cortical and hippocampal acetylcholine release in vivo: a microdialysis studyEuropean Journal of Pharmacology, 419
(1998)
VOL 83 @BULLET JULY 2003 @BULLET www.prv.org in morphine-dependent mice
Timothy Tersigni, H. Rosenberg (1996)
Local pressure application of cannabinoid agonists increases spontaneous activity of rat substantia nigra pars reticulata neurons without affecting response to iontophoretically-applied GABABrain Research, 733
M. Beltramo, D. Piomelli (2000)
Carrier‐mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2‐arachidonylglycerolNeuroReport, 11
K. Campbell, T. Foster, R. Hampson, S. Deadwyler (1986)
delta 9-Tetrahydrocannabinol differentially affects sensory-evoked potentials in the rat dentate gyrus.The Journal of pharmacology and experimental therapeutics, 239 3
Gregory Gerdeman, D. Lovinger (2001)
CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum.Journal of neurophysiology, 85 1
A. Howlett, F. Barth, T. Bonner, G. Cabral, P. Casellas, W. Devane, C. Felder, M. Herkenham, K. Mackie, B. Martin, R. Mechoulam, R. Pertwee (2002)
International Union of Pharmacology. XXVII. Classification of Cannabinoid ReceptorsPharmacological Reviews, 54
E. Ishac, Liu Jiang, K. Lake, K. Varga, M. Abood, G. Kunos (1996)
Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB 1 receptors on peripheral sympathetic nervesBritish Journal of Pharmacology, 118
B. Cravatt, K. Demarest, M. Patricelli, M. Bracey, Dan Giang, B. Martin, A. Lichtman (2001)
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolaseProceedings of the National Academy of Sciences of the United States of America, 98
David Robbe, M. Kopf, A. Rémaury, J. Bockaert, O. Manzoni (2002)
Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbensProceedings of the National Academy of Sciences of the United States of America, 99
I. Katona, E. Rancz, L. Acsády, C. Ledent, K. Mackie, N. Hájos, T. Freund (2001)
Distribution of CB1 Cannabinoid Receptors in the Amygdala and their Role in the Control of GABAergic TransmissionThe Journal of Neuroscience, 21
D. Weisz, D. Gunnell, T. Teyler, R. Vardaris (1982)
Changes in hippocampal CA1 population spikes following administration of delta-9-THCBrain Research Bulletin, 8
J. Gray, N. McNaughton, D. James, P. Kelly (1975)
Effect of minor tranquillisers on hippocampal θ rhythm mimicked by depletion of forebrain noradrenalineNature, 258
J. Ahluwalia, J. Ahluwalia, Laszlo Urban, Stuart Bevan, Marco Capogna, Istvan Nagy (2002)
Cannabinoid 1 receptors are expressed by nerve growth factor- and glial cell-derived neurotrophic factor-responsive primary sensory neuronesNeuroscience, 110
(2002)
BARTH F, BONNER TI, CABRAL G, CASELLAS P, DEVANE WA, FELDER CC, HERKENHAM M, MACKIE K, MARTIN BR, MECHOULAM R, AND PERTWEE RG
Namita Varma, G. Carlson, C. Ledent, B. Alger (2001)
Metabotropic Glutamate Receptors Drive the Endocannabinoid System in HippocampusThe Journal of Neuroscience, 21
P. Vincent, A. Marty (1996)
Fluctuations of inhibitory postsynaptic currents in Purkinje cells from rat cerebellar slices.The Journal of Physiology, 494
(2000)
LAVILLE M, LEDENT C, PARMENTIER M, AND IMPERATO A
T. Ohno-Shosaku, H. Tsubokawa, I. Mizushima, Norihide Yoneda, A. Zimmer, M. Kano (2002)
Presynaptic Cannabinoid Sensitivity Is a Major Determinant of Depolarization-Induced Retrograde Suppression at Hippocampal SynapsesThe Journal of Neuroscience, 22
T. Ohno-Shosaku, Jumpei Shosaku, H. Tsubokawa, M. Kano (2002)
Cooperative endocannabinoid production by neuronal depolarization and group I metabotropic glutamate receptor activationEuropean Journal of Neuroscience, 15
(1995)
HALASY K, PAULSEN O, AND SOMOGYI P
(1995)
G, AND SOUBRIE P
R. Pertwee (2001)
Cannabinoid receptors and painProgress in Neurobiology, 63
(2000)
SATO H, LERNER AE, HEDRICK MP, FECIK RA, MIYAUCHI H, WILKIE GD, AUSTIN BJ, PATRICELLI MP, AND CRAVATT BF
W. Devane, L. Hanuš, A. Breuer, R. Pertwee, L. Stevenson, G. Griffin, D. Gibson, A. Mandelbaum, A. Etinger, R. Mechoulam (1992)
Isolation and structure of a brain constituent that binds to the cannabinoid receptor.Science, 258 5090
J. Magee, D. Johnston (1997)
A Synaptically Controlled, Associative Signal for Hebbian Plasticity in Hippocampal NeuronsScience, 275
K. Tsou, S. Brown, Sañudo-Peña Mc, K. Mackie, J. Walker (1998)
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous systemNeuroscience, 83
D. Misner, J. Sullivan (1999)
Mechanism of Cannabinoid Effects on Long-Term Potentiation and Depression in Hippocampal CA1 NeuronsThe Journal of Neuroscience, 19
D. Compton, B. Martin (1997)
The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity.The Journal of pharmacology and experimental therapeutics, 283 3
Jennelle Richardson, S. Kilo, K. Hargreaves (1998)
Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptorsPain, 75
F. Nava, G. Carta, G. Colombo, G. Gessa (2001)
Effects of chronic Δ9-tetrahydrocannabinol treatment on hippocampal extracellular acetylcholine concentration and alternation performance in the T-mazeNeuropharmacology, 41
A. Calignano, G. Rana, D. Piomelli (2001)
Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide.European journal of pharmacology, 419 2-3
S. Rouse, Michael Marino, Lincoln Potter, P. Conn, Allan Levey (1999)
Muscarinic receptor subtypes involved in hippocampal circuits.Life sciences, 64 6-7
M. Kirby, R. Hampson, S. Deadwyler (1995)
Cannabinoids selectively decrease paired-pulse facilitation of perforant path synaptic potentials in the dentate gyrus in vitroBrain Research, 688
S. Kathuria, S. Gaetani, D. Fegley, F. Valiño, A. Duranti, A. Tontini, M. Mor, G. Tarzia, G. Rana, A. Calignano, A. Giustino, M. Tattoli, M. Palmery, V. Cuomo, D. Piomelli (2003)
Modulation of anxiety through blockade of anandamide hydrolysisNature Medicine, 9
A. Miller, J. Walker (1996)
Electrophysiological effects of a cannabinoid on neural activity in the globus pallidus.European journal of pharmacology, 304 1-3
C. Salio, J. Fischer, M. Franzoni, K. Mackie, T. Kaneko, M. Conrath (2001)
CB1-cannabinoid and μ-opioid receptor co-localization on postsynaptic target in the rat dorsal hornNeuroreport, 12
V. Marzo, D. Melck, T. Bisogno, L. Petrocellis (1998)
Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory actionTrends in Neurosciences, 21
(2000)
SCHELB V, KLEBROFF W, KHAIRALLAH L, AND STARKE K
A. Irving, A. Coutts, J. Harvey, M. Rae, K. Mackie, G. Bewick, R. Pertwee (2000)
Functional expression of cell surface cannabinoid CB1 receptors on presynaptic inhibitory terminals in cultured rat hippocampal neuronsNeuroscience, 98
(1995)
MU J, WHYTE A, AND CHILDERS S
I. Göbel, A. Trendelenburg, S. Cox, A. Meyer, K. Starke (2000)
Electrically Evoked Release of [3H]Noradrenaline from Mouse Cultured Sympathetic NeuronsJournal of Neurochemistry, 75
A. Nowicky, T. Teyler, R. Vardaris (1987)
The modulation of long-term potentiation by delta-9-tetrahydrocannabinol in the rat hippocampus, in vitroBrain Research Bulletin, 19
G. Petersen, K. Chapman, H. Hansen (2000)
A rapid phospholipase D assay using zirconium precipitation of anionic substrate phospholipids: application to n-acylethanolamine formation in vitro.Journal of lipid research, 41 9
J. Ranck (1973)
Studies on single neurons in dorsal hippocampal formation and septum in unrestrained rats. I. Behavioral correlates and firing repertoires.Experimental neurology, 41 2
A. Giuffrida, F. Fonseca, F. Nava, Patrick Loubet-Lescoulié, D. Piomelli (2000)
Elevated circulating levels of anandamide after administration of the transport inhibitor, AM404.European journal of pharmacology, 408 2
T. Bisogno, D. Melck, Bobrov MYu, N. Gretskaya, V. Bezuglov, L. Petrocellis, V. Marzo (2000)
N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo.The Biochemical journal, 351 Pt 3
T. Sasaki, M. Chang (1997)
N-arachidonylethanolamine (anandamide) formation from N-arachidonylphosphatidylethanolamine in rat brain membranes.Life sciences, 61 18
M. Morales, F. Bloom (1997)
The 5-HT3 Receptor Is Present in Different Subpopulations of GABAergic Neurons in the Rat TelencephalonThe Journal of Neuroscience, 17
M. Egertová, M. Elphick (2000)
Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C‐terminal tail of CB1Journal of Comparative Neurology, 422
S. Mazzari, R. Canella, L. Petrelli, G. Marcolongo, A. Leon (1996)
N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation.European journal of pharmacology, 300 3
J. Feigenbaum, F. Bergmann, S. Richmond, R. Mechoulam, V. Nadler, Y. Kloog, M. Sokolovsky (1989)
Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker.Proceedings of the National Academy of Sciences of the United States of America, 86 23
Occlusion of the presynaptic action of 1058 FREUND
G. Carta, F. Nava, G. Gessa (1998)
Inhibition of hippocampal acetylcholine release after acute and repeated Δ9-tetrahydrocannabinol in ratsBrain Research, 809
S. Munro, K. Thomas, Muna Abu-Shaar (1993)
Molecular characterization of a peripheral receptor for cannabinoidsNature, 365
(2000)
CONNOR M, BAGLEY EE, AND CHRISTIE MJ
Graeme Davis, Rodney Murphey (1994)
Retrograde signaling and the development of transmitter release properties in the invertebrate nervous system.Journal of neurobiology, 25 6
S. Goparaju, N. Ueda, H. Yamaguchi, S. Yamamoto (1998)
Anandamide amidohydrolase reacting with 2‐arachidonoylglycerol, another cannabinoid receptor ligandFEBS Letters, 422
J. Sipe, K. Chiang, A. Gerber, E. Beutler, B. Cravatt (2002)
A missense mutation in human fatty acid amide hydrolase associated with problem drug useProceedings of the National Academy of Sciences of the United States of America, 99
V. Marzo, S. Goparaju, Lei Wang, Jie Liu, S. Batkai, Z. Járai, F. Fezza, G. Miura, R. Palmiter, T. Sugiura, G. Kunos (2001)
Leptin-regulated endocannabinoids are involved in maintaining food intakeNature, 410
P. Reggio, Hassimi Traore (2000)
Conformational requirements for endocannabinoid interaction with the cannabinoid receptors, the anandamide transporter and fatty acid amidohydrolase.Chemistry and physics of lipids, 108 1-2
L. Martin, B. Alger (1999)
Muscarinic facilitation of the occurrence of depolarization-induced suppression of inhibition in rat hippocampusNeuroscience, 92
David Robbe, G. Alonso, Florence Duchamp, J. Bockaert, O. Manzoni (2001)
Localization and Mechanisms of Action of Cannabinoid Receptors at the Glutamatergic Synapses of the Mouse Nucleus AccumbensThe Journal of Neuroscience, 21
P. Stanton, J. Sarvey (1985)
Depletion of norepinephrine, but not serotonin, reduces long-term potentiation in the dentate gyrus of rat hippocampal slices, 5
(2000)
V, BREIVOGEL CS, TAO Q, BRIDGEN DT, RAZDAN RK, ZIMMER AM, ZIMMER A, AND MARTIN BR
(2001)
V, GOPARAJU SK, WANG L, LIU J, BATKAI S, JARAI Z, FEZZA F, MIURA GI, PALMITER RD, SUGIURA T, AND KUNOS G
Frank Christ, J. Gamble, H. Baschnegger, I. Gartside (1997)
Relationship Between Venous Pressure and tissue Volume During Venous Congestion Plethysmography in ManThe Journal of Physiology, 503
A. Porter, J. Sauer, M. Knierman, G. Becker, M. Berna, J. Bao, G. Nomikos, Petra Carter, F. Bymaster, Andrea Leese, C. Felder (2002)
Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor.The Journal of pharmacology and experimental therapeutics, 301 3
A. Straiker, Catherine Borden, J. Sullivan (2002)
G-Protein α Subunit Isoforms Couple Differentially to Receptors that Mediate Presynaptic Inhibition at Rat Hippocampal SynapsesThe Journal of Neuroscience, 22
S. Turkanis, R. Karler (1981)
Electrophysiologic Properties of the CannabinoidsThe Journal of Clinical Pharmacology, 21
N. Hájos, C. Ledent, T. Freund (2001)
Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampusNeuroscience, 106
Ernest Jennings, Christopher Vaughan, M. Christie (2001)
Cannabinoid actions on rat superficial medullary dorsal horn neurons in vitroThe Journal of Physiology, 534
T. Klein, C. Newton, H. Friedman (2001)
Cannabinoids and the immune system.Pain research & management, 6 2
G. Thompson (1980)
The regulation of membrane lipid metabolism
L. Petrocellis, T. Bisogno, John Davis, R. Pertwee, V. Marzo (2000)
Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin‐like activityFEBS Letters, 483
Takeshi Nakamura, J. Barbara, Kyoko Nakamura, W. Ross (1999)
Synergistic Release of Ca2+ from IP3-Sensitive Stores Evoked by Synaptic Activation of mGluRs Paired with Backpropagating Action PotentialsNeuron, 24
Y. Kawaguchi, Y. Kubota (1997)
GABAergic cell subtypes and their synaptic connections in rat frontal cortex.Cerebral cortex, 7 6
Dale Boger, R. Fecik, Jean Patterson, Hiroshi Miyauchi, M. Patricelli, B. Cravatt (2000)
Fatty acid amide hydrolase substrate specificity.Bioorganic & medicinal chemistry letters, 10 23
E. Acquas, A. Pisanu, P. Marrocu, G. Chiara (2000)
Cannabinoid CB(1) receptor agonists increase rat cortical and hippocampal acetylcholine release in vivo.European journal of pharmacology, 401 2
Loren Miller, R. Branconnier (1983)
Cannabis: effects on memory and the cholinergic limbic system.Psychological bulletin, 93 3
S. Jaggar, F. Hasnie, S. Sellaturay, A. Rice (1998)
The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory painPain, 76
A. Al-Hayani, K. Wease, R. Ross, R. Pertwee, Stephen Davies (2001)
The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal sliceNeuropharmacology, 41
O. Manzoni, J. Bockaert (2001)
Cannabinoids inhibit GABAergic synaptic transmission in mice nucleus accumbens.European journal of pharmacology, 412 2
K. Tsou, M. Noguerón, S. Muthian, M. Sañudo‐Peña, C. Hillard, D. Deutsch, J. Walker (1998)
Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistryNeuroscience Letters, 254
(1999)
MANNA S, GREENBERG MJ, DICAMELLI R, ROSS RA, STEVENSON LA, MURPHY V, PERTWEE RG, AND CAMPBELL WB
X. Lu, Wei-Yi Ong, Ken Mackie (1999)
A light and electron microscopic study of the CB1 cannabinoid receptor in monkey basal forebrainJournal of Neurocytology, 28
S. Kombian, D. Mouginot, Q. Pittman (1997)
Dendritically Released Peptides Act as Retrograde Modulators of Afferent Excitation in the Supraoptic Nucleus In VitroNeuron, 19
Jennelle Richardson, L. Aanonsen, Kenneth Hargreaves (1998)
Antihyperalgesic effects of spinal cannabinoids.European journal of pharmacology, 345 2
E. Thomas, B. Cravatt, P. Danielson, N. Gilula, J. Sutcliffe (1997)
Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous systemJournal of Neuroscience Research, 50
M. Shen, T. Piser, V. Seybold, S. Thayer (1996)
Cannabinoid Receptor Agonists Inhibit Glutamatergic Synaptic Transmission in Rat Hippocampal CulturesThe Journal of Neuroscience, 16
M. Nakazi, U. Bauer, T. Nickel, M. Kathmann, E. Schlicker (1999)
Inhibition of serotonin release in the mouse brain via presynaptic cannabinoid CB1 receptorsNaunyn-Schmiedeberg's Archives of Pharmacology, 361
Theresa Day, F. Rakhshan, D. Deutsch, E. Barker (2001)
Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide.Molecular pharmacology, 59 6
FREUND, KATONA, AND PIOMELLI Physiol Rev
J. Brooks, Paul Frca (2003)
Cannabinoids and painBJA CEPD Reviews, 3
Miles Herkenham, B. Groen, A. Lynn, B. Costa, E. Richfield (1991)
Neuronal localization of cannabinoid receptors and second messengers in mutant mouse cerebellumBrain Research, 552
M. Nino-Rosales, B. Gouyon, Wei-Chi She, James Luchak, Enrique Turiegano, Jonathan Benito, Maria Capovilla, A. McCall, H. Zoghbi (2000)
Bidirectional control of airway responsiveness by endogenous cannabinoidsNature, 408
(2002)
CHIANG K, GERBER AL, BEUTLER E, AND CRAVATT BF
P. Chan, Savio Chan, W. Yung (1998)
Presynaptic inhibition of GABAergic inputs to rat substantia nigra pars reticulata neurones by a cannabinoid agonistNeuroReport, 9
M. Bouaboula, B. Bourrié, M. Rinaldi-Carmona, D. Shire, G. Fur, P. Casellas (1995)
Stimulation of Cannabinoid Receptor CB1 Induces krox-24 Expression in Human Astrocytoma Cells (*)The Journal of Biological Chemistry, 270
(2000)
HARVEY J, RAE MG, MACKIE K, BEWICK GS, AND PERTWEE RG
G. Gessa, Maria Casu, G. Carta, M. Mascia (1998)
Cannabinoids decrease acetylcholine release in the medial-prefrontal cortex and hippocampus, reversal by SR 141716A.European journal of pharmacology, 355 2-3
M. Herkenham, Abigail Lynn, M.Ross Johnson, L. Melvin, B. Costa, K. Rice (1991)
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study, 11
(2001)
DEMAREST K, PATRICELLI MP, BRACEY MH, GIANG DK, MARTIN BR, AND LICHTMAN AH
G. Zernig, Ian O'Laughlin, H. Fibiger (1997)
Nicotine and heroin augment cocaine-induced dopamine overflow in nucleus accumbens.European journal of pharmacology, 337 1
A. Giuffrida, M. Beltramo, D. Piomelli (2001)
Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology.The Journal of pharmacology and experimental therapeutics, 298 1
A. Hoffman, C. Lupica (2000)
Mechanisms of Cannabinoid Inhibition of GABAASynaptic Transmission in the HippocampusThe Journal of Neuroscience, 20
Anatol Kreitzer, W. Regehr (2001)
Cerebellar Depolarization-Induced Suppression of Inhibition Is Mediated by Endogenous CannabinoidsThe Journal of Neuroscience, 21
M. Kobayashi, M. Ohno, S. Shibata, T. Yamamoto, S. Watanabe (1997)
Concurrent blockade of beta-adrenergic and muscarinic receptors suppresses synergistically long-term potentiation of population spikes in the rat hippocampal CA1 region.Brain research, 777 1-2
G. Moldrich, T. Wenger (2000)
Localization of the CB1 cannabinoid receptor in the rat brain. An immunohistochemical study☆Peptides, 21
F. Rakhshan, Theresa Day, Randy Blakely, Eric Barker (2000)
Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells.The Journal of pharmacology and experimental therapeutics, 292 3
L. Facci, R. Toso, S. Romanello, A. Buriani, S. Skaper, A. Leon (1995)
Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide.Proceedings of the National Academy of Sciences of the United States of America, 92
T. Sugiura, S. Kondo, A. Sukagawa, Takashi Tonegawa, S. Nakane, A. Yamashita, Y. Ishima, K. Waku (1996)
Transacylase-mediated and phosphodiesterase-mediated synthesis of N-arachidonoylethanolamine, an endogenous cannabinoid-receptor ligand, in rat brain microsomes. Comparison with synthesis from free arachidonic acid and ethanolamine.European journal of biochemistry, 240 1
J. Contos, Isao Ishii, Jerold Chun (2000)
Lysophosphatidic acid receptors.Molecular pharmacology, 58 6
(2000)
BRUNEUS M, GATLEY SJ, AND VOLKOW ND
M. Capogna, B. Gahwiler, S. Thompson (1995)
Presynaptic enhancement of inhibitory synaptic transmission by protein kinases A and C in the rat hippocampus in vitro, 15
L. Matsuda, T. Bonner, S. Lolait (1993)
Localization of cannabinoid receptor mRNA in rat brainJournal of Comparative Neurology, 327
G. Carlson, Yue Wang, B. Alger (2002)
Endocannabinoids facilitate the induction of LTP in the hippocampusNature Neuroscience, 5
T. D'ambra, K. Estep, M. Bell, M. Eissenstat, K. Josef, S. Ward, Haycock Da, E. Baizman, F. Casiano, Beglin Nc (1992)
Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor.Journal of medicinal chemistry, 35 1
E. Vizi, I. Katona, T. Freund (2001)
Evidence for presynaptic cannabinoid CB(1) receptor-mediated inhibition of noradrenaline release in the guinea pig lung.European journal of pharmacology, 431 2
(2001)
RABUFFETTI M, AND BELTRAMO M
F. Fonseca, M. Navarro, R. Gómez, L. Escuredo, F. Nava, Jin Fu, E. Murillo-Rodríguez, A. Giuffrida, J. Loverme, S. Gaetani, S. Kathuria, C. Gall, D. Piomelli (2001)
An anorexic lipid mediator regulated by feedingNature, 414
(1989)
BERGMANN F, RICHMOND SA, MECHOULAM R, NADLER V, KLOOG Y, AND SOKOLOVSKY M
Physiol Rev @BULLET
G. Carta, F. Nava, G. Gessa (1998)
Inhibition of hippocampal acetylcholine release after acute and repeated Delta9-tetrahydrocannabinol in rats.Brain research, 809 1
O. Paulsen, T. Sejnowski (2000)
Natural patterns of activity and long-term synaptic plasticityCurrent Opinion in Neurobiology, 10
(1999)
JANSON U, JOHNSON RM, WAHLSTROM G, STENSTROM A, NORSTROM K, AND TIGER G
Kang Tsou, Ken Mackie, Sañudo-Peña Mc, J. Walker (1999)
Cannabinoid CB1 receptors are localized primarily on cholecystokinin-containing GABAergic interneurons in the rat hippocampal formationNeuroscience, 93
H. Cadas, E. Tomaso, D. Piomelli (1997)
Occurrence and Biosynthesis of Endogenous Cannabinoid Precursor,N-Arachidonoyl Phosphatidylethanolamine, in Rat BrainThe Journal of Neuroscience, 17
N. Allbritton, T. Meyer, L. Stryer (1992)
Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate.Science, 258 5089
(1997)
TOMINAGA M, ROSEN TA, LEVINE JD, AND JULIUS D
T. Bisogno, M. Maccarrone, L. Petrocellis, A. Jarrahian, A. Finazzi-Agrò, C. Hillard, V. Marzo (2001)
The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors.European journal of biochemistry, 268 7
P. Schmid, B. Paria, R. Krebsbach, H. Schmid, S. Dey (1997)
Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation.Proceedings of the National Academy of Sciences of the United States of America, 94 8
P. Little, D. Compton, M. Johnson, L. Melvin, B. Martin (1988)
Pharmacology and stereoselectivity of structurally novel cannabinoids in mice.The Journal of pharmacology and experimental therapeutics, 247 3
Thomas Jessell, Eric Kandel (1993)
Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communicationCell, 72
Eva Lago, J. Fernández-Ruiz, S. Ortega‐Gutiérrez, A. Viso, M. López-Rodríguez, J. Ramos (2002)
UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide.European journal of pharmacology, 449 1-2
D. Wilkison, N. Pontzer (1987)
the actions of THC on the intact hippocampus: A comparison of dentate and CA1 responsesBrain Research Bulletin, 19
V. Morisset, J. Ahluwalia, I. Nagy, L. Urbán (2001)
Possible mechanisms of cannabinoid-induced antinociception in the spinal cord.European journal of pharmacology, 429 1-3
L. Acsády, I. Katona, A. Gulyás, R. Shigemoto, T. Freund (1997)
Immunostaining for substance P receptor labels GABAergic cells with distinct termination patterns in the hippocampusJournal of Comparative Neurology, 378
N. Ueda, Kei Yamamoto, Shozo Yamamoto, T. Tokunaga, E. Shirakawa, H. Shinkai, M. Ogawa, Takuji Sato, I. Kudo, Keizō Inoue, H. Takizawa, T. Nagano, M. Hirobe, N. Matsuki, H. Saito (1995)
Lipoxygenase-catalyzed oxygenation of arachidonylethanolamide, a cannabinoid receptor agonist.Biochimica et biophysica acta, 1254 2
REFERENCES
G. Marsicano, B. Lutz (1999)
Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrainEuropean Journal of Neuroscience, 11
D. Collins, R. Pertwee, S. Davies (1995)
Prevention by the cannabinoid antagonist, SR141716A, of cannabinoid‐mediated blockade of long‐term potentiation in the rat hippocampal sliceBritish Journal of Pharmacology, 115
C. Luo, E. Kumamoto, H. Furue, Jun Chen, M. Yoshimura (2002)
Anandamide inhibits excitatory transmission to rat substantia gelatinosa neurones in a manner different from that of capsaicinNeuroscience Letters, 321
V. Marzo, I. Lastres-Becker, T. Bisogno, L. Petrocellis, A. Milone, John Davis, J. Fernández-Ruiz (2001)
Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues.European journal of pharmacology, 420 2-3
(1992)
MEYER T, AND STRYER L
(1998)
HANSSON S, HARTA G, AND MEZEY E
(2001)
KUNOS G, AND NICOLL RA
(2001)
F, NAVARRO M, GOMEZ R, ESCUREDO L, NAVA F, FU J, MURILLO-RODRIGUEZ E, GIUFFRIDA A, LOVERME J, GAETANI S, KATHURIA S, GALL C, AND PIOMELLI D
P. Schweitzer (2000)
Cannabinoids Decrease the K+ M-Current in Hippocampal CA1 NeuronsThe Journal of Neuroscience, 20
(1997)
SAMIIAN L, GATLEY SJ, AND ASHBY CR JR
D. Henry, C. Chavkin (1995)
Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain cannabinoid receptors in Xenopus oocytesNeuroscience Letters, 186
A. Ylinen, I. Soltesz, Anatol Bragin, M. Penttonen, A. Sik, G. Buzsáki (1995)
Intracellular correlates of hippocampal theta rhythm in identified pyramidal cells, granule cells, and basket cellsHippocampus, 5
M. Herkenham, A. Lynn, B. Costa, E. Richfield (1991)
Neuronal localization of cannabinoid receptors in the basal ganglia of the ratBrain Research, 547
A. Miller, J. Walker (1995)
Effects of a cannabinoid on spontaneous and evoked neuronal activity in the substantia nigra pars reticulata.European journal of pharmacology, 279 2-3
D. Compton, Rice Kc, B. Costa, R. Razdan, Lawrence Melvin, M. Johnson, Billy Martin (1993)
Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities.The Journal of pharmacology and experimental therapeutics, 265 1
H. Katsuki, Y. Izumi, C. Zorumski (1997)
Noradrenergic regulation of synaptic plasticity in the hippocampal CA1 region.Journal of neurophysiology, 77 6
(2001)
VISO A, ORTEGA-GUTIERREZ S, LASTRES-BECKER I, GONZALEZ S, FERNANDEZ-RUIZ J, AND RAMOS JA
Wensheng Lang, C. Qin, Sonyuan Lin, A. Khanolkar, A. Goutopoulos, P. Fan, K. Abouzid, Zhaoxing Meng, Diane Biegel, Alexandros Makriyannis (1999)
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.Journal of medicinal chemistry, 42 5
(1999)
TSOU K, AND SANUDO-PENA MC
Jane Sullivan (1999)
Mechanisms of cannabinoid-receptor-mediated inhibition of synaptic transmission in cultured hippocampal pyramidal neurons.Journal of neurophysiology, 82 3
M. Beltramo, N. Stella, A. Calignano, S. Lin, A. Makriyannis, D. Piomelli (1997)
Functional role of high-affinity anandamide transport, as revealed by selective inhibition.Science, 277 5329
J. Chemin, A. Monteil, E. Perez-Reyes, J. Nargeot, P. Lory (2001)
Direct inhibition of T‐type calcium channels by the endogenous cannabinoid anandamideThe EMBO Journal, 20
Bo Åkerström, Darren Flower, J. Salier (2000)
Lipocalins: unity in diversity.Biochimica et biophysica acta, 1482 1-2
SravanKumar Goparaju, N. Ueda, Kyoko Taniguchi, Shozo Yamamoto (1999)
Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors.Biochemical pharmacology, 57 4
B. Alger, T. Pitler, J. Wagner, L. Martin, W. Morishita, S. Kirov, R. Lenz (1996)
Retrograde signalling in depolarization‐induced suppression of inhibition in rat hippocampal CA1 cells.The Journal of Physiology, 496
(1941)
Harvey Lect
S. McAllister, G. Griffin, L. Satin, M. Abood (1999)
Cannabinoid receptors can activate and inhibit G protein-coupled inwardly rectifying potassium channels in a xenopus oocyte expression system.The Journal of pharmacology and experimental therapeutics, 291 2
(2000)
L, BISOGNO T, DAVIS JB, PERTWEE RG, AND DI MARZO V
M. Glass, R. Faull, M. Dragunow (1997)
Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brainNeuroscience, 77
(1997)
LIN S, HILL WA, MORSE KL, SALEHANI D, ARREAZA G, OMEIR RL, AND MAKRIYANNIS A
(1996)
MORISHITA W, KIROV SA, AND LENZ RA
R. Lenz, B. Alger (1999)
Calcium dependence of depolarization‐induced suppression of inhibition in rat hippocampal CA1 pyramidal neuronsThe Journal of Physiology, 521
A. Ameri, Alwina Wilhelm, T. Simmet (1999)
Effects of the endogeneous cannabinoid, anandamide, on neuronal activity in rat hippocampal slicesBritish Journal of Pharmacology, 126
P. Chan, W. Yung (1998)
Occlusion of the presynaptic action of cannabinoids in rat substantia nigra pars reticulata by cadmiumNeuroscience Letters, 249
V. Abadji, Sonyuan Lin, G. Taha, G. Griffin, L. Stevenson, R. Pertwee, A. Makriyannis (1994)
(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability.Journal of medicinal chemistry, 37 12
T. Koos, J. Tepper (1999)
Inhibitory control of neostriatal projection neurons by GABAergic interneuronsNature Neuroscience, 2
D. Pettit, Matthew Harrison, J. Olson, R. Spencer, G. Cabral (1998)
Immunohistochemical localization of the neural cannabinoid receptor in rat brainJournal of Neuroscience Research, 51
(1997)
JARRAHIAN A, AND CAMPBELL WB
M. Morales, C. Bäckman (2002)
Coexistence of serotonin 3 (5‐HT3) and CB1 cannabinoid receptors in interneurons of hippocampus and dentate gyrusHippocampus, 12
Gregory Gerdeman, J. Ronesi, D. Lovinger (2002)
Postsynaptic endocannabinoid release is critical to long-term depression in the striatumNature Neuroscience, 5
Kanji Takahashi, D. Linden (2000)
Cannabinoid receptor modulation of synapses received by cerebellar Purkinje cells.Journal of neurophysiology, 83 3
A. Gifford, L. Samiian, S. Gatley, C. Ashby (1997)
Examination of the effect of the cannabinoid receptor agonist, CP 55,940, on electrically evoked transmitter release from rat brain slices.European journal of pharmacology, 324 2-3
W. Catterall, K. Chandy, D. Clapham, G. Gutman, Franz Hofmann, A. Harmar, D. Abernethy, M. Spedding (2003)
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion ChannelsPharmacological Reviews, 55
N. Emptage, T. Bliss, A. Fine (1999)
Single Synaptic Events Evoke NMDA Receptor–Mediated Release of Calcium from Internal Stores in Hippocampal Dendritic SpinesNeuron, 22
D. Hirsch, A. Stahl, H. Lodish (1998)
A family of fatty acid transporters conserved from mycobacterium to man.Proceedings of the National Academy of Sciences of the United States of America, 95 15
N. Stella, P. Schweitzer, D. Piomelli (1997)
A second endogenous cannabinoid that modulates long-term potentiationNature, 388
N. Ueda, K. Yamanaka, Shozo Yamamoto (2001)
Purification and Characterization of an Acid Amidase Selective for N-Palmitoylethanolamine, a Putative Endogenous Anti-inflammatory Substance*The Journal of Biological Chemistry, 276
M. Karlsson, J. Contreras, U. Hellman, H. Tornqvist, C. Holm (1997)
cDNA Cloning, Tissue Distribution, and Identification of the Catalytic Triad of Monoglyceride LipaseThe Journal of Biological Chemistry, 272
J. Walker, N. Strangman, Susan Huang (2001)
Cannabinoids and pain.Pain research & management, 6 2
(1999)
GRIFFIN G, SATIN LS, AND ABOOD ME
Peter Barnes (1992)
Modulation of neurotransmission in airways.Physiological reviews, 72 3
A. Watabe, H. Carlisle, T. O’Dell (2002)
Postsynaptic induction and presynaptic expression of group 1 mGluR-dependent LTD in the hippocampal CA1 region.Journal of neurophysiology, 87 3
N. Ueda, Y. Kurahashi, Shozo Yamamoto, T. Tokunaga (1995)
Partial Purification and Characterization of the Porcine Brain Enzyme Hydrolyzing and Synthesizing Anandamide (*)The Journal of Biological Chemistry, 270
U. Herzberg, E. Eliav, G. Bennett, I. Kopin (1997)
The analgesic effects of R(+)-WIN 55,212–2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic painNeuroscience Letters, 221
I. Llano, N. Leresche, A. Marty (1991)
Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currentsNeuron, 6
A. Farooqui, K. Rammohan, L. Horrocks (1989)
Isolation, Characterization, and Regulation of Diacylglycerol Lipases from the Bovine Brain aAnnals of the New York Academy of Sciences, 559
(1998)
AANONSEN L, AND HARGREAVES KM
A. Hohmann, M. Herkenham (2000)
Localization of cannabinoid CB(1) receptor mRNA in neuronal subpopulations of rat striatum: a double-label in situ hybridization study.Synapse, 37 1
A. Hampson, L. Bornheim, M. Scanziani, C. Yost, A. Gray, Bonnie Hansen, D. Leonoudakis, P. Bickler (1998)
Dual Effects of Anandamide on NMDA Receptor‐Mediated Responses and NeurotransmissionJournal of Neurochemistry, 70
(1998)
V, MELCK D, BISOGNO T, AND DE PETROCELLIS L
M. Sañudo‐Peña, J. Walker (1997)
Role of the subthalamic nucleus in cannabinoid actions in the substantia nigra of the rat.Journal of neurophysiology, 77 3
N. Buckley, Stefan Hansson, G. Harta, É. Mezey (1997)
Expression of the CB1 and CB2 receptor messenger RNAs during embryonic development in the ratNeuroscience, 82
P. Kujtan, P. Carlen, B. Kapur (1983)
delta 9-Tetrahydrocannabinol and cannabidiol: dose-dependent effects on evoked potentials in the hippocampal slice.Canadian journal of physiology and pharmacology, 61 4
(1998)
SELLATURAY S, AND RICE AS
T. Freund, G. Buzsáki (1998)
Interneurons of the hippocampusHippocampus, 6
N. Hájos, T. Freund (2002)
Pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibersNeuropharmacology, 43
A. Calignano, G. Rana, Massimiliano Beltramo, Alexandros Makriyannis, D. Piomelli (1997)
Potentiation of anandamide hypotension by the transport inhibitor, AM404.European journal of pharmacology, 337 1
TA Pitler, B. Alger (1992)
Postsynaptic spike firing reduces synaptic GABAA responses in hippocampal pyramidal cells, 12
(2000)
ISHII I, AND CHUN J
N. Hájos, I. Katona, S. Naiem, K. Mackie, C. Ledent, I. Módy, T. Freund (2000)
Cannabinoids inhibit hippocampal GABAergic transmission and network oscillationsEuropean Journal of Neuroscience, 12
P. Mailleux, J. Vanderhaeghen (1992)
Localization of cannabinoid receptor in the human developing and adult basal ganglia. Higher levels in the striatonigral neuronsNeuroscience Letters, 148
A. Giuffrida, L. Parsons, T. Kerr, F. Fonseca, M. Navarro, D. Piomelli (1999)
Dopamine activation of endogenous cannabinoid signaling in dorsal striatumNature Neuroscience, 2
B. Cravatt, Dan Giang, S. Mayfield, D. Boger, R. Lerner, N. Gilula (1996)
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amidesNature, 384
H. Wigström, B. Gustafsson (1983)
Facilitated induction of hippocampal long-lasting potentiation during blockade of inhibitionNature, 301
W. Devane, F. Dysarz, M. Johnson, L. Melvin, A. Howlett (1988)
Determination and characterization of a cannabinoid receptor in rat brain.Molecular pharmacology, 34 5
K. Mackie, Y. Lai, R. Westenbroek, R. Mitchell (1995)
Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor, 15
Takeshi Nakamura, K. Nakamura, N. Lasser‐Ross, J. Barbara, V. Sandler, W. Ross (2000)
Inositol 1,4,5-Trisphosphate (IP3)-Mediated Ca2+ Release Evoked by Metabotropic Agonists and Backpropagating Action Potentials in Hippocampal CA1 Pyramidal NeuronsThe Journal of Neuroscience, 20
Christopher Fowler, Ulrika Janson, Randolph Johnson, Göran Wahlström, Anders Stenström, Åke Norström, G. Tiger (1999)
Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen.Archives of biochemistry and biophysics, 362 2
A. Lysakowski, B. Wainer, G. Bruce, L. Hersh (1989)
An atlas of the regional and laminar distribution of choline acetyltransferase immunoreactivity in rat cerebral cortexNeuroscience, 28
M. Sañudo‐Peña, K. Tsou, J. Walker (1999)
Motor actions of cannabinoids in the basal ganglia output nuclei.Life sciences, 65 6-7
(2003)
CB1 receptor density and ENDOCANNABINOIDS IN SYNAPTIC SIGNALING 1061 Physiol Rev
L. Iversen, V. Chapman (2002)
Cannabinoids: a real prospect for pain relief?Current opinion in pharmacology, 2 1
T. Ohno-Shosaku, T. Maejima, M. Kano (2001)
Endogenous Cannabinoids Mediate Retrograde Signals from Depolarized Postsynaptic Neurons to Presynaptic TerminalsNeuron, 29
L. Murphy, R. Muñoz, B. Adrian, M. Villanúa (1998)
Function of Cannabinoid Receptors in the Neuroendocrine Regulation of Hormone SecretionNeurobiology of Disease, 5
David Evans, M. Johnson, A. Howlett (1992)
Ca2+ ‐Dependent Release from Rat Brain of Cannabinoid Receptor Binding ActivityJournal of Neurochemistry, 58
C. Ledent, O. Valverde, G. Cossu, F. Petitet, J. Aubert, F. Beslot, G. Böhme, A. Imperato, T. Pedrazzini, B. Roques, G. Vassart, W. Fratta, M. Parmentier (1999)
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.Science, 283 5400
D. Deutsch, S. Chin (1993)
Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist.Biochemical pharmacology, 46 5
K. Campbell, T. Foster, R. Hampson, S. Deadwyler (1986)
Effects of delta 9-tetrahydrocannabinol on sensory-evoked discharges of granule cells in the dentate gyrus of behaving rats.The Journal of pharmacology and experimental therapeutics, 239 3
J. O’Keefe (1979)
A review of the hippocampal place cellsProgress in Neurobiology, 13
A. Lichtman, E. Hawkins, G. Griffin, B. Cravatt (2002)
Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo.The Journal of pharmacology and experimental therapeutics, 302 1
(2001)
KATONA I, AND FREUND TF
E. Vizi (2000)
Role of high-affinity receptors and membrane transporters in nonsynaptic communication and drug action in the central nervous system.Pharmacological reviews, 52 1
(2002)
CARPENTER D, LESLIE FM, FREUND TF, KATONA I, SENSI SL, KATHURIA S, AND PIOMELLI D
N. Hájos, E. Papp, L. Acsády, Allan Levey, T. Freund (1997)
Distinct interneuron types express m2 muscarinic receptor immunoreactivity on their dendrites or axon terminals in the hippocampusNeuroscience, 82
C. Breivogel, G. Griffin, V. Marzo, B. Martin (2001)
Evidence for a new G protein-coupled cannabinoid receptor in mouse brain.Molecular pharmacology, 60 1
(2000)
MIYAUCHI H, PATRICELLI MP, AND CRAVATT BF
C. Fowler, S. Jacobsson (2002)
Cellular transport of anandamide, 2-arachidonoylglycerol and palmitoylethanolamide--targets for drug development?Prostaglandins, leukotrienes, and essential fatty acids, 66 2-3
J. O’Keefe, M. Recce (1993)
Phase relationship between hippocampal place units and the EEG theta rhythmHippocampus, 3
H. Cadas, S. Gaillet, M. Beltramo, L. Venance, D. Piomelli (1996)
Biosynthesis of an Endogenous Cannabinoid Precursor in Neurons and its Control by Calcium and cAMPThe Journal of Neuroscience, 16
F. Désarnaud, H. Cadas, D. Piomelli (1995)
Anandamide Amidohydrolase Activity in Rat Brain MicrosomesThe Journal of Biological Chemistry, 270
V. Marzo, C. Breivogel, Q. Tao, D. Bridgen, R. Razdan, A. Zimmer, A. Zimmer, B. Martin (2000)
Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain.Journal of neurochemistry, 75 6
J. Terranova, J. Michaud, G. Fur, P. Soubrié (1995)
Inhibition of long-term potentiation in rat hippocampal slices by anandamide and WIN55212-2: reversal by SR141716 A, a selective antagonist of CB1 cannabinoid receptorsNaunyn-Schmiedeberg's Archives of Pharmacology, 352
(2002)
AND O’DELL TJ
G. Nyiri, T. Freund, P. Somogyi (2001)
Input‐dependent synaptic targeting of α2‐subunit‐containing GABAA receptors in synapses of hippocampal pyramidal cells of the ratEuropean Journal of Neuroscience, 13
(1990)
BIDAUT-RUSSELL M, DEVANE WA, MELVIN LS, JOHNSON MR, AND HERKENHAM M
(2002)
BAO J, NOMIKOS GG, CARTER P, BYMASTER FP, LEESE AB, AND FELDER CC
T. Sugiura, S. Kondo, A. Sukagawa, Takashi Tonegawa, S. Nakane, A. Yamashita, K. Waku (1996)
Enzymatic synthesis of anandamide, an endogenous cannabinoid receptor ligand, through N-acylphosphatidylethanolamine pathway in testis: involvement of Ca(2+)-dependent transacylase and phosphodiesterase activities.Biochemical and biophysical research communications, 218 1
B. Manning, N. Merin, I. Meng, D. Amaral (2001)
Reduction in Opioid- and Cannabinoid-Induced Antinociception in Rhesus Monkeys after Bilateral Lesions of the Amygdaloid ComplexThe Journal of Neuroscience, 21
W. Chambers, C. Liu, G. McCouch, J. Yu (1973)
Reflexes involving triceps surae from the ankle joint of the cat.Experimental neurology, 39 3
D. Johnston, D. Hoffman, C. Colbert, J. Magee (1999)
Regulation of back-propagating action potentials in hippocampal neuronsCurrent Opinion in Neurobiology, 9
I. Wallmichrath, B. Szabo (2002)
Analysis of the effect of cannabinoids on GABAergic neurotransmission in the substantia nigra pars reticulataNaunyn-Schmiedeberg's Archives of Pharmacology, 365
M. Bracey, M. Hanson, K. Masuda, R. Stevens, B. Cravatt (2002)
Structural Adaptations in a Membrane Enzyme That Terminates Endocannabinoid SignalingScience, 298
J. Kiss, Á. Csáki, H. Bokor, M. Shanabrough, C. Léránth (2000)
The supramammillo-hippocampal and supramammillo-septal glutamatergic/aspartatergic projections in the rat: a combined [3H]d-aspartate autoradiographic and immunohistochemical studyNeuroscience, 97
D. Piomelli, M. Beltramo, S. Glasnapp, S. Lin, A. Goutopoulos, Xiang-Qun Xie, A. Makriyannis (1999)
Structural determinants for recognition and translocation by the anandamide transporter.Proceedings of the National Academy of Sciences of the United States of America, 96 10
B. Cravatt, O. Prospero-Garcia, G. Siuzdak, N. Gilula, S. Henriksen, D. Boger, R. Lerner (1995)
Chemical characterization of a family of brain lipids that induce sleep.Science, 268 5216
K. Kruszka, R. Gross (1994)
The ATP- and CoA-independent synthesis of arachidonoylethanolamide. A novel mechanism underlying the synthesis of the endogenous ligand of the cannabinoid receptor.The Journal of biological chemistry, 269 20
Y. Zilberter, Katharina Kaiser, B. Sakmann (1999)
Dendritic GABA Release Depresses Excitatory Transmission between Layer 2/3 Pyramidal and Bitufted Neurons in Rat NeocortexNeuron, 24
A. Hohmann, E. Briley, M. Herkenham (1999)
Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cordBrain Research, 822
C. Fowler, G. Tiger, A. Stenström (1997)
Ibuprofen inhibits rat brain deamidation of anandamide at pharmacologically relevant concentrations. Mode of inhibition and structure-activity relationship.The Journal of pharmacology and experimental therapeutics, 283 2
D. Evans, J. Lake, M. Johnson, A. Howlett (1994)
Endogenous cannabinoid receptor binding activity released from rat brain slices by depolarization.The Journal of pharmacology and experimental therapeutics, 268 3
Wei-Yi Ong, Ken Mackie (1999)
A light and electron microscopic study of the CB1 cannabinoid receptor in primate brainNeuroscience, 92
R. Lenz, J. Wagner, B. Alger (1998)
N‐ and L‐type calcium channel involvement in depolarization‐induced suppression of inhibition in rat hippocampal CA1 cellsThe Journal of Physiology, 512
S. Bröcher, A. Artola, W. Singer (1992)
Agonists of cholinergic and noradrenergic receptors facilitate synergistically the induction of long-term potentiation in slices of rat visual cortexBrain Research, 573
P. Huerta, J. Lisman (1993)
Heightened synaptic plasticity of hippocampal CA1 neurons during a Cholinergically induced rhythmic stateNature, 364
V. Natarajan, P. Schmid, P. Reddy, M. Zuzarte‐Augustin, H. Schmid (1983)
Biosynthesis of N‐Acylethanolamine Phospholipids by Dog Brain PreparationsJournal of Neurochemistry, 41
Y. Gaoni, R. Mechoulam (1964)
Isolation, Structure, and Partial Synthesis of an Active Constituent of HashishJournal of the American Chemical Society, 86
J. Larson, G. Lynch (1986)
Induction of synaptic potentiation in hippocampus by patterned stimulation involves two events.Science, 232 4753
L. Martin, Dong-Sheng Wei, B. Alger (2001)
Heterogeneous susceptibility of GABAA receptor‐mediated IPSCs to depolarization‐induced suppression of inhibition in rat hippocampusThe Journal of Physiology, 532
(1995)
PROSPERO-GARCIA O, SIUZDAK G, GILULA NB, HENRIKSEN SJ, BOGER DL, AND LERNER RA
Nephi Stella, D. Piomelli (2001)
Receptor-dependent formation of endogenous cannabinoids in cortical neurons.European journal of pharmacology, 425 3
W. Morishita, B. Alger (2000)
Differential effects of the group II mGluR agonist, DCG‐IV, on depolarization‐induced suppression of inhibition in hippocampal CA1 and CA3 neuronsHippocampus, 10
B. Koutek, G. Prestwich, A. Howlett, S. Chin, D. Salehani, Nima Akhavan, D. Deutsch (1994)
Inhibitors of arachidonoyl ethanolamide hydrolysis.The Journal of biological chemistry, 269 37
M. Keita, L. Frankel-Kohn, N. Bertrand, L. Lecanu, P. Monmaur (2000)
Acetylcholine release in the hippocampus of the urethane anaesthetised rat positively correlates with both peak theta frequency and relative power in the theta bandBrain Research, 887
Dan Giang, B. Cravatt (1997)
Molecular characterization of human and mouse fatty acid amide hydrolases.Proceedings of the National Academy of Sciences of the United States of America, 94 6
M. Kathmann, B. Weber, E. Schlicker (2000)
Cannabinoid CB1 receptor-mediated inhibition of acetylcholine release in the brain of NMRI, CD-1 and C57BL/6J miceNaunyn-Schmiedeberg's Archives of Pharmacology, 363
R. Maldonado, F. Fonseca (2002)
Cannabinoid Addiction: Behavioral Models and Neural CorrelatesThe Journal of Neuroscience, 22
(1997)
The cloned rat hydrolytic enzyme responsible for the breakdown of anandamide also catalyzes its formation via the condensation of arachidonic acid and ethanolamine
I. Lastres-Becker, H. Hansen, F. Berrendero, R. Miguel, A. Pérez‐Rosado, J. Manzanares, J. Ramos, J. Fernández-Ruiz (2002)
Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's diseaseSynapse, 44
M. Glass, M. Dragunow (1995)
Induction of the Krox 24 transcription factor in striosomes by a cannabinoid agonist.Neuroreport, 6 2
E. Acquas, A. Pisanu, P. Marrocu, S. Goldberg, G. Chiara (2001)
Delta9-tetrahydrocannabinol enhances cortical and hippocampal acetylcholine release in vivo: a microdialysis study.European journal of pharmacology, 419 2-3
Marco Diana, C. Levenes, K. Mackie, A. Marty (2002)
Short-Term Retrograde Inhibition of GABAergic Synaptic Currents in Rat Purkinje Cells Is Mediated by Endogenous CannabinoidsThe Journal of Neuroscience, 22
D. Smart, J. Jerman (2000)
Anandamide: an endogenous activator of the vanilloid receptor.Trends in pharmacological sciences, 21 4
M. López-Rodríguez, A. Viso, S. Ortega‐Gutiérrez, I. Lastres-Becker, S. González, J. Fernández-Ruiz, J. Ramos (2001)
Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.Journal of medicinal chemistry, 44 26
Nathalie Auclair, Satoru Otani, Philippe Soubrie, F. Crepel (2000)
Cannabinoids modulate synaptic strength and plasticity at glutamatergic synapses of rat prefrontal cortex pyramidal neurons.Journal of neurophysiology, 83 6
Z. Járai, J. Wagner, J. Wagner, K. Varga, K. Lake, D. Compton, B. Martin, A. Zimmer, T. Bonner, N. Buckley, É. Mezey, R. Razdan, A. Zimmer, G. Kunos (1999)
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.Proceedings of the National Academy of Sciences of the United States of America, 96 24
C. Breivogel, L. Sim, S. Childers (1997)
Regional differences in cannabinoid receptor/G-protein coupling in rat brain.The Journal of pharmacology and experimental therapeutics, 282 3
P. Isaacson, A. Doğan, S. Price, J. Spencer (1989)
Immunoproliferative small-intestinal disease. An immunohistochemical study.The American journal of surgical pathology, 13 12
R. Wilson, R. Nicoll (2001)
correction: Endogenous cannabinoids mediate retrograde signalling at hippocampal synapsesNature, 411
M. Caulfield, D. Brown (1992)
Cannabinoid receptor agonists inhibit Ca current in NG108–15 neuroblastoma cells via a Pertussis toxin‐sensitive mechanismBritish Journal of Pharmacology, 106
E. Gardner, Stanislav Vorel (1998)
Cannabinoid Transmission and Reward-Related EventsNeurobiology of Disease, 5
W. Martin, A. Hohmann, J. Walker, Michael Walker (1996)
Suppression of Noxious Stimulus-Evoked Activity in the Ventral Posterolateral Nucleus of the Thalamus by a Cannabinoid Agonist: Correlation between Electrophysiological and Antinociceptive EffectsThe Journal of Neuroscience, 16
(1975)
MCNAUGHTON N, JAMES DT, AND KELLY PH
J. Romero, J. Fernández-Ruiz, G. Vela, M. Ruiz‐Gayo, J. Fuentes, J. Ramos (1998)
Autoradiographic analysis of cannabinoid receptor binding and cannabinoid agonist-stimulated [35S]GTP gamma S binding in morphine-dependent mice.Drug and alcohol dependence, 50 3
D. Brindley, Janice Saxton, Hossain Shahidullah, Margaret Armstrong (1985)
Possible relationships between changes in body weight set-point and stress metabolism after treating rats chronically with D-fenfluramine. Effects of feeding rats acutely with fructose on the metabolism of corticosterone, glucose, fatty acids, glycerol and triacylglycerol.Biochemical pharmacology, 34 8
D. Selley, S. Stark, L. Sim, S. Childers (1996)
Cannabinoid receptor stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate binding in rat brain membranes.Life sciences, 59 8
Mark Segal (1974)
Central implantation of cannabinoids: induction of epileptiform discharges.European journal of pharmacology, 27 1
F. Beau, B. Alger (1998)
Transient suppression of GABAA-receptor-mediated IPSPs after epileptiform burst discharges in CA1 pyramidal cells.Journal of neurophysiology, 79 2
S. Cobb, E. Buhl, K. Halasy, O. Paulsen, P. Somogyi (1995)
Synchronization of neuronal activity in hippocampus by individual GABAergic interneuronsNature, 378
Takayuki Yoshida, K. Hashimoto, A. Zimmer, T. Maejima, K. Araishi, M. Kano (2002)
The Cannabinoid CB1 Receptor Mediates Retrograde Signals for Depolarization-Induced Suppression of Inhibition in Cerebellar Purkinje CellsThe Journal of Neuroscience, 22
(1996)
JIANG L, LAKE KD, VARGA K, ABOOD ME, AND KUNOS G
R. Luján, J. Roberts, R. Shigemoto, H. Ohishi, P. Somogyi (1997)
Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1α, mGluR2 and mGluR5, relative to neurotransmitter release sitesJournal of Chemical Neuroanatomy, 13
S. Deadwyler, R. Hampson, B. Bennett, Thomas Edwards, J. Mu, M. Pacheco, Susan Ward, Steven Childers (1993)
Cannabinoids modulate potassium current in cultured hippocampal neurons.Receptors & channels, 1 2
(1984)
J Neurochem
W. Twitchell, Sean Brown, K. Mackie (1997)
Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons.Journal of neurophysiology, 78 1
(2000)
EGERTOVA M, BRADBURY EJ, MCMAHON SB, RICE AS, AND ELPHICK MR
(1998)
CARTA G, AND MASCIA MS
A. King (1941)
Some factors governing the stability of oil-in-water emulsionsTransactions of The Faraday Society, 37
Raphael Mechoulam, L. Hanuš, Billy Martin (1994)
Search for endogenous ligands of the cannabinoid receptor.Biochemical pharmacology, 48 8
(2002)
LEVENES C, MACKIE K, AND MARTY A
B. Szabo, L. Dörner, C. Pfreundtner, W. Nörenberg, K. Starke (1998)
Inhibition of GABAergic inhibitory postsynaptic currents by cannabinoids in rat corpus striatumNeuroscience, 85
A. Hoffman, C. Lupica (2001)
Direct actions of cannabinoids on synaptic transmission in the nucleus accumbens: a comparison with opioids.Journal of neurophysiology, 85 1
B. Szabo, I. Wallmichrath, P. Mathonia, C. Pfreundtner (2000)
Cannabinoids inhibit excitatory neurotransmission in the substantia nigra pars reticulataNeuroscience, 97
J. Ahluwalia, L. Urbán, M. Capogna, S. Bevan, I. Nagy (2000)
Cannabinoid 1 receptors are expressed in nociceptive primary sensory neuronsNeuroscience, 100
W. Farquhar-Smith, M. Egertová, E. Bradbury, S. McMahon, A. Rice, M. Elphick (2000)
Cannabinoid CB1 Receptor Expression in Rat Spinal CordMolecular and Cellular Neuroscience, 15
A. Howlett, M. Bidaut‐Russell, W. Devane, L. Melvin, M.Ross Johnson, M. Herkenham (1990)
The cannabinoid receptor: biochemical, anatomical and behavioral characterizationTrends in Neurosciences, 13
C. Hillard, R. Harris, A. Bloom (1985)
Effects of the cannabinoids on physical properties of brain membranes and phospholipid vesicles: fluorescence studies.The Journal of pharmacology and experimental therapeutics, 232 3
D. Braida, M. Sala (2000)
Cannabinoid‐induced working memory impairment is reversed by a second generation cholinesterase inhibitor in ratsNeuroReport, 11
Jose Rodriguez, K. Mackie, V. Pickel (2001)
Ultrastructural Localization of the CB1 Cannabinoid Receptor in μ-Opioid Receptor Patches of the Rat Caudate Putamen NucleusThe Journal of Neuroscience, 21
G. Petersen, H. Hansen (1999)
N‐acylphosphatidylethanolamine‐hydrolysing phospholipase D lacks the ability to transphosphatidylateFEBS Letters, 455
J. Walker, Susan Huang, N. Strangman, Kang Tsou, M. Sañudo‐Peña (1999)
Pain modulation by release of the endogenous cannabinoid anandamide.Proceedings of the National Academy of Sciences of the United States of America, 96 21
Chiung‐Chun Huang, Yea-Lin Chen, Shiow-Win Lo, K. Hsu (2002)
Activation of cAMP-dependent protein kinase suppresses the presynaptic cannabinoid inhibition of glutamatergic transmission at corticostriatal synapses.Molecular pharmacology, 61 3
M. Beltramo, F. Fonseca, M. Navarro, A. Calignano, M. Gorriti, G. Grammatikopoulos, A. Sadile, A. Giuffrida, D. Piomelli (2000)
Reversal of Dopamine D2 Receptor Responses by an Anandamide Transport InhibitorThe Journal of Neuroscience, 20
A. Gifford, Yunjia Tang, S. Gatley, N. Volkow, R. Lan, A. Makriyannis (1997)
Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slicesNeuroscience Letters, 238
H. Schmid, P. Schmid, Viswanathan Natarajan (1990)
N-acylated glycerophospholipids and their derivatives.Progress in lipid research, 29 1
M. Kathmann, U. Bauer, E. Schlicker (1999)
CB1 receptor density and CB1 receptor-mediated functional effects in rat hippocampus are decreased by an intracerebroventricularly administered antisense oligodeoxynucleotideNaunyn-Schmiedeberg's Archives of Pharmacology, 360
Yuri Zilberter (2000)
Dendritic release of glutamate suppresses synaptic inhibition of pyramidal neurons in rat neocortexThe Journal of Physiology, 528
M. Herkenham, A. Lynn, Little, J. Mr, L. Melvin, deCosta Br, K. Rice (1990)
Cannabinoid receptor localization in brain.Proceedings of the National Academy of Sciences of the United States of America, 87 5
S. González, J. Romero, R. Miguel, I. Lastres-Becker, M. Villanúa, A. Makriyannis, J. Ramos, J. Fernández-Ruiz (1999)
Extrapyramidal and neuroendocrine effects of AM404, an inhibitor of the carrier-mediated transport of anandamide.Life sciences, 65 3
A. McDonald, F. Mascagni (2001)
Localization of the CB1 type cannabinoid receptor in the rat basolateral amygdala: high concentrations in a subpopulation of cholecystokinin-containing interneuronsNeuroscience, 107
F. Helmchen, K. Svoboda, W. Denk, D. Tank (1999)
In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neuronsNature Neuroscience, 2
E. Schlicker, J. Timm, J. Zentner, M. Göthert (1997)
Cannabinoid CB1 receptor-mediated inhibition of noradrenaline release in the human and guinea-pig hippocampusNaunyn-Schmiedeberg's Archives of Pharmacology, 356
V. Marzo, C. Breivogel, Q. Tao, D. Bridgen, R. Razdan, A. Zimmer, A. Zimmer, B. Martin (2000)
Levels, Metabolism, and Pharmacological Activity of Anandamide in CB1 Cannabinoid Receptor Knockout MiceJournal of Neurochemistry, 75
V. Natarajan, P. Schmid, P. Reddy, H. Schmid (1984)
Catabolism of N‐Acylethanolamine Phospholipids by Dog Brain PreparationsJournal of Neurochemistry, 42
C. Vaughan, I. McGregor, M. Christie (1999)
Cannabinoid receptor activation inhibits GABAergic neurotransmission in rostral ventromedial medulla neurons in vitroBritish Journal of Pharmacology, 127
M. Kathmann, B. Weber, A. Zimmer, E. Schlicker (2001)
Enhanced acetylcholine release in the hippocampus of cannabinoid CB1 receptor‐deficient miceBritish Journal of Pharmacology, 132
François Maingret, Amanda Patel, M. Lazdunski, E. Honoré (2001)
The endocannabinoid anandamide is a direct and selective blocker of the background K+ channel TASK‐1The EMBO Journal, 20
A. Al-Hayani, S. Davies (2000)
Cannabinoid receptor mediated inhibition of excitatory synaptic transmission in the rat hippocampal slice is developmentally regulatedBritish Journal of Pharmacology, 131
M. Rinaldi-Carmona, F. Barth, M. Héaulme, D. Shire, B. Calandra, C. Congy, Serge Martinez, J. Maruani, G. Néliat, D. Caput, P. Ferrara, P. Soubrié, J. Breliere, G. Fur (1994)
SR141716A, a potent and selective antagonist of the brain cannabinoid receptorFEBS Letters, 350
A. Jarrahian, S. Manna, W. Edgemond, W. Campbell, C. Hillard (2000)
Structure—Activity Relationships Among N‐Arachidonylethanolamine (Anandamide) Head Group Analogues for the Anandamide TransporterJournal of Neurochemistry, 74
I. Meng, B. Manning, W. Martin, H. Fields (1998)
An analgesia circuit activated by cannabinoidsNature, 395
A. Miller, J. Walker (1998)
Local effects of cannabinoids on spontaneous activity and evoked inhibition in the globus pallidus.European journal of pharmacology, 352 2-3
Diana Collins, R. Pertwee, Stephen Davies (1994)
The action of synthetic cannabinoids on the induction of long-term potentiation in the rat hippocampal slice.European journal of pharmacology, 259 3
A. Farooqui, W. Taylor, L. Horrocks (1986)
Characterization and solubilization of membrane bound diacylglycerol lipases from bovine brain.The International journal of biochemistry, 18 11
N. Ueda, K. Yamanaka, Y. Terasawa, S. Yamamoto (1999)
An acid amidase hydrolyzing anandamide as an endogenous ligand for cannabinoid receptorsFEBS Letters, 454
C. Levenes, H. Daniel, P. Soubrié, F. Crépel (1998)
Cannabinoids decrease excitatory synaptic transmission and impair long‐term depression in rat cerebellar Purkinje cellsThe Journal of Physiology, 510
Chiara Salio, J. Fischer, M. Franzoni, M. Conrath (2002)
Pre- and postsynaptic localizations of the CB1 cannabinoid receptor in the dorsal horn of the rat spinal cordNeuroscience, 110
J. Romero, C. Hillard, M. Calero, A. Rábano (2002)
Fatty acid amide hydrolase localization in the human central nervous system: an immunohistochemical study.Brain research. Molecular brain research, 100 1-2
M. Beltramo, Emmanuelle Tomaso, D. Piomelli (1997)
Inhibition of anandamide hydrolysis in rat brain tissue by (E)‐6‐(bromomethylene) tetrahydro‐3‐(1‐naphthalenyl)‐2H‐pyran‐2‐oneFEBS Letters, 403
A. Gifford, C. Ashby (1996)
Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A.The Journal of pharmacology and experimental therapeutics, 277 3
F. Helmchen, K. Imoto, B. Sakmann (1996)
Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons.Biophysical journal, 70 2
E. Papp, X. Leinekugel, D. Henze, J. Lee, G. Buzsáki (2001)
The apical shaft of CA1 pyramidal cells is under GABAergic interneuronal controlNeuroscience, 102
S. Sagratella, A. Carolis, V. Longo (1986)
EEG interaction between delta 8-tetrahydrocannabinol and some sedative-anxiolytic drugs. Is the anxiogenic effect of Cannabis related to an action on the GABAergic system?Advances in biochemical psychopharmacology, 41
Y. Kurahashi, Natsuo Ueda, Hiroshi Suzuki, Mitsujiro Suzuki, Shozo Yamamoto (1997)
Reversible hydrolysis and synthesis of anandamide demonstrated by recombinant rat fatty-acid amide hydrolase.Biochemical and biophysical research communications, 237 3
P. Delmas, N. Wanaverbecq, F. Abogadie, M. Mistry, D. Brown (2002)
Signaling Microdomains Define the Specificity of Receptor-Mediated InsP3 Pathways in NeuronsNeuron, 34
P. Zygmunt, J. Petersson, D. Andersson, H. Chuang, M. Sørgård, V. Marzo, D. Julius, E. Högestätt (1999)
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamideNature, 400
D. Boger, Haruhiko Sato, Aaron Lerner, Michael Hedrick, R. Fecik, H. Miyauchi, Gordon Wilkie, B. Austin, M. Patricelli, B. Cravatt (2000)
Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide.Proceedings of the National Academy of Sciences of the United States of America, 97 10
(2002)
E, FERNANDEZ-RUIZ J, ORTEGA-GUTIERREZ S, VISO A, LOPEZRODRIGUEZ ML, AND RAMOS JA
(1997)
MOUGINOT D, AND PITTMAN QJ
V. Marzo, A. Fontana, H. Cadas, S. Schinelli, G. Cimino, J. Schwartz, D. Piomelli (1994)
Formation and inactivation of endogenous cannabinoid anandamide in central neuronsNature, 372
N. Abumrad, C. Coburn, A. Ibrahimi (1999)
Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm.Biochimica et biophysica acta, 1441 1
(2000)
FRANKEL-KOHN L, BERTRAND N, LECANU L, AND MONMAUR P
J. Diamond (2001)
Neuronal Glutamate Transporters Limit Activation of NMDA Receptors by Neurotransmitter Spillover on CA1 Pyramidal CellsThe Journal of Neuroscience, 21
Manuel Megías, Z. Emri, T. Freund, A. Gulyás (2001)
Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cellsNeuroscience, 102
G. Buzsáki (1986)
Hippocampal sharp waves: Their origin and significanceBrain Research, 398
Chiung‐Chun Huang, Shiow-Win Lo, K. Hsu (2001)
Presynaptic mechanisms underlying cannabinoid inhibition of excitatory synaptic transmission in rat striatal neuronsThe Journal of Physiology, 532
L. Hanuš, S. Abu-Lafi, E. Fride, A. Breuer, Z. Vogel, D. Shalev, I. Kustanovich, R. Mechoulam (2001)
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptorProceedings of the National Academy of Sciences of the United States of America, 98
L. Matsuda, S. Lolait, M. Brownstein, A. Young, T. Bonner (1990)
Structure of a cannabinoid receptor and functional expression of the cloned cDNANature, 346
A. Gifford, M. Bruneus, S. Gatley, N. Volkow (2000)
Cannabinoid receptor‐mediated inhibition of acetylcholine release from hippocampal and cortical synaptosomesBritish Journal of Pharmacology, 131
A. Baude, Z. Nusser, J. Roberts, E. Mulvihill, R. Mcllhinney, P. Somogyi (1993)
The metabotropic glutamate receptor (mGluRlα) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reactionNeuron, 11
I. Katona, B. Sperlágh, Z. Maglóczky, E. Sántha, A. Köfalvi, S. Czirják, K. Mackie, E. Vizi, T. Freund (2000)
GABAergic interneurons are the targets of cannabinoid actions in the human hippocampusNeuroscience, 100
R. Miles, K. Tóth, A. Gulyás, N. Hájos, T. Freund (1996)
Differences between Somatic and Dendritic Inhibition in the HippocampusNeuron, 16
Christopher Vaughan, Mark Connor, Elena Bagley, M. Christie (2000)
Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitro.Molecular pharmacology, 57 2
(1992)
HANUS L, BREUER A, PERTWEE RG, STEVENSON LA, GRIFFIN G, GIBSON D, MANDELBAUM A, ETINGER A, AND MECHOULAM R
S. Deadwyler, R. Hampson, J. Mu, A. Whyte, S. Childers (1995)
Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process.The Journal of pharmacology and experimental therapeutics, 273 2
J. Power, P. Sah (2002)
Nuclear Calcium Signaling Evoked by Cholinergic Stimulation in Hippocampal CA1 Pyramidal NeuronsThe Journal of Neuroscience, 22
C. Hillard, D. Wilkison, W. Edgemond, William Campbell (1995)
Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain.Biochimica et biophysica acta, 1257 3
P. Vincent, Alain Marty (1993)
Neighboring cerebellar purkinje cells communicate via retrograde inhibition of common presynaptic interneuronsNeuron, 11
J. Romero, F. Berrendero, L. Garcı́a-Gil, P. Cruz, J. Ramos, J. Fernández-Ruiz (1998)
Loss of cannabinoid receptor binding and messenger RNA levels and cannabinoid agonist-stimulated [35s]guanylyl-5′-O-(thio)-triphosphate binding in the basal ganglia of aged ratsNeuroscience, 84
V. Adipudi, V. Reddy (1994)
Effect of chronic lithium chloride on membrane adenosine triphosphatases in certain postural muscles of rats.European journal of pharmacology, 259 1
M. Matsuzaki, G. Casella, M. Ratner (1987)
Δ9-Tetrahydrocannabinol: EEG changes, bradycardia and hypothermia in the rhesus monkeyBrain Research Bulletin, 19
L. Hanuš, A. Gopher, S. Almog, R. Mechoulam (1993)
Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor.Journal of medicinal chemistry, 36 20
Anatol Kreitzer, W. Regehr (2001)
Retrograde Inhibition of Presynaptic Calcium Influx by Endogenous Cannabinoids at Excitatory Synapses onto Purkinje CellsNeuron, 29
K. Katayama, N. Ueda, I. Katoh, S. Yamamoto (1999)
Equilibrium in the hydrolysis and synthesis of cannabimimetic anandamide demonstrated by a purified enzyme.Biochimica et biophysica acta, 1440 2-3
(2002)
RONESI J, AND LOVINGER DM
D. Deutsch, S. Lin, W. Hill, K. Morse, D. Salehani, G. Arreaza, R. Omeir, A. Makriyannis (1997)
Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor.Biochemical and biophysical research communications, 231 1
J. Wagner, B. Alger (1996)
Increased neuronal excitability during depolarization‐induced suppression of inhibition in rat hippocampus.The Journal of Physiology, 495
T. Westlake, A. Howlett, T. Bonner, L. Matsuda, M. Herkenham (1994)
Cannabinoid receptor binding and messenger RNA expression in human brain: An in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimer's brainsNeuroscience, 63
Michaela Egertovä, Dan Giang, B. Cravatt, M. Elphick (1998)
A new perspective on cannabinoid signalling: complimentary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain.Proceedings of the Royal Society of London. Series B: Biological Sciences, 265
A. Porcella, G. Gessa, L. Pani (1998)
Δ9‐Tetrahydrocannabinol increases sequence‐specific AP‐1 DNA‐binding activity and Fos‐related antigens in the rat brainEuropean Journal of Neuroscience, 10
Masako Kobayashi, M. Ohno, S. Shibata, Tsuneyuki Yamamoto, Shigenori Watanabe (1997)
Concurrent blockade of β-adrenergic and muscarinic receptors suppresses synergistically long-term potentiation of population spikes in the rat hippocampal CA1 regionBrain Research, 777
K. Tóth, T. Freund, R. Miles (1997)
Disinhibition of rat hippocampal pyramidal cells by GABAergic afferents from the septum.The Journal of Physiology, 500
(1985)
SAXTON J, SHAHIDULLAH H, AND ARMSTRONG M
Gaynor Paton, R. Pertwee, S. Davies (1998)
Correlation between cannabinoid mediated effects on paired pulse depression and induction of long term potentiation in the rat hippocampal sliceNeuropharmacology, 37
A. Zimmer, A. Zimmer, A. Hohmann, M. Herkenham, T. Bonner (1999)
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.Proceedings of the National Academy of Sciences of the United States of America, 96 10
R. Mechoulam, S. Ben-Shabat, L. Hanuš, M. Ligumsky, N. Kaminski, A. Schatz, A. Gopher, S. Almog, B. Martin, D. Compton, R. Pertwee, G. Griffin, M. Bayewitch, J. Barg, Z. Vogel (1995)
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.Biochemical pharmacology, 50 1
W. Devane, J. Axelrod (1994)
Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes.Proceedings of the National Academy of Sciences of the United States of America, 91 14
C. Breivogel, D. Selley, S. Childers (1998)
Cannabinoid Receptor Agonist Efficacy for Stimulating [35S]GTPγS Binding to Rat Cerebellar Membranes Correlates with Agonist-induced Decreases in GDP Affinity*The Journal of Biological Chemistry, 273
(2001)
V, LASTRES-BECKER I, BISOGNO T, DE PETROCELLIS L, MILONE A, DAVIS JB, AND FERNANDEZ-RUIZ JJ
D. Piomelli, A. Giuffrida, A. Calignano, F. Fonseca (2000)
The endocannabinoid system as a target for therapeutic drugs.Trends in pharmacological sciences, 21 6
A. Szallasi, P. Blumberg (1999)
Vanilloid (Capsaicin) receptors and mechanisms.Pharmacological reviews, 51 2
(2001)
RAKHSHAN F, DEUTSCH DG, AND BARKER EL
W. Morishita, S. Kirov, B. Alger (1998)
Evidence for Metabotropic Glutamate Receptor Activation in the Induction of Depolarization-Induced Suppression of Inhibition in Hippocampal CA1The Journal of Neuroscience, 18
E. Finch, G. Augustine (1998)
Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendritesNature, 396
(1994)
V, FONTANA A, CADAS H, SCHINELLI S, CIMINO G, SCHWARTZ JC, AND PIOMELLI D
L. Ferraro, M. Tomasini, T. Cassano, B. Bebe, A. Siniscalchi, W. O’Connor, Pamela Magee, S. Tanganelli, V. Cuomo, T. Antonelli (2001)
Cannabinoid receptor agonist WIN 55,212‐2 inhibits rat cortical dialysate γ‐aminobutyric acid levelsJournal of Neuroscience Research, 66
B. Wintroub, C. Kaempfer, N. Schechter, D. Proud (1986)
Identification and Partial Characterization
Martin Deahl (1991)
Cannabis and memory loss.British journal of addiction, 86 3
C. Hillard, W. Edgemond, A. Jarrahian, W. Campbell (1997)
Accumulation of N‐Arachidonoylethanolamine (Anandamide) into Cerebellar Granule Cells Occurs via Facilitated DiffusionJournal of Neurochemistry, 69
(1994)
and CoA-independent synthesis of arachidonoylethanolamide
M. Tognetto, S. Amadesi, S. Harrison, C. Créminon, M. Trevisani, Mirko Carreras, M. Matera, P. Geppetti, A. Bianchi (2001)
Anandamide Excites Central Terminals of Dorsal Root Ganglion Neurons via Vanilloid Receptor-1 ActivationThe Journal of Neuroscience, 21
V. Natarajan, P. Schmid, H. Schmid (1986)
N-acylethanolamine phospholipid metabolism in normal and ischemic rat brain.Biochimica et biophysica acta, 878 1
M. Buonamici, G. Young, N. Khazan (1982)
Effects of acute delta 9-THC administration on EEG and EEG power spectra in the rat.Neuropharmacology, 21 8
C. Hillard, S. Manna, M. Greenberg, R. Dicamelli, R. Ross, L. Stevenson, Vicki Murphy, R. Pertwee, W. Campbell (1999)
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1).The Journal of pharmacology and experimental therapeutics, 289 3
E. Valjent, C. Pagès, M. Rogard, M. Besson, R. Maldonado, J. Caboche (2001)
Δ9‐tetrahydrocannabinol‐induced MAPK/ERK and Elk‐1 activation in vivo depends on dopaminergic transmissionEuropean Journal of Neuroscience, 14
C. Heyser, R. Hampson, S. Deadwyler (1993)
Effects of delta-9-tetrahydrocannabinol on delayed match to sample performance in rats: alterations in short-term memory associated with changes in task specific firing of hippocampal cells.The Journal of pharmacology and experimental therapeutics, 264 1
(2001)
HO W, HILLARD CJ, MACKIE K, DAVISON JS, AND SHARKEY KA
D. Piomelli (1993)
Arachidonic Acid in Cell SignalingCurrent opinion in cell biology, 5 2
(1999)
PETERSSON J, ANDERSSON DA, CHUANG H, SORGARD M, DI MARZO V, JULIUS D, AND HOGESTATT ED
Veronique Morisset, L. Urbán (2001)
Cannabinoid-induced presynaptic inhibition of glutamatergic EPSCs in substantia gelatinosa neurons of the rat spinal cord.Journal of neurophysiology, 86 1
M. Glitsch, I. Llano, A. Marty (1996)
Glutamate as a candidate retrograde messenger at interneurone‐Purkinje cell synapses of rat cerebellum.The Journal of Physiology, 497
S. Galiègue, S. Mary, J. Marchand, D. Dussossoy, D. Carrière, P. Carayon, M. Bouaboula, D. Shire, G. Fur, P. Casellas (1995)
Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations.European journal of biochemistry, 232 1
Rachel Wilson, R. Nicoll (2001)
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapsesNature, 410
M. Beinfeld, Kelly Connolly (2001)
Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoidsNeuroscience Letters, 301
D. Lawrence, E. Gill (1975)
The effects of delta1-tetrahydrocannabinol and other cannabinoids on spin-labeled liposomes and their relationship to mechanisms of general anesthesia.Molecular pharmacology, 11 5
G. Edwards (1975)
MarihuanaNature, 254
A. Trendelenburg, S. Cox, V. Schelb, W. Klebroff, L. Khairallah, K. Starke (2000)
Modulation of 3H‐noradrenaline release by presynaptic opioid, cannabinoid and bradykinin receptors and β‐adrenoceptors in mouse tissuesBritish Journal of Pharmacology, 130
A. Hohmann, M. Herkenham (1999)
Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization studyNeuroscience, 90
Thien Dinh, D. Carpenter, F. Leslie, T. Freund, I. Katona, S. Sensi, S. Kathuria, D. Piomelli (2002)
Brain monoglyceride lipase participating in endocannabinoid inactivationProceedings of the National Academy of Sciences of the United States of America, 99
Rachel Wilson, G. Kunos, R. Nicoll (2001)
Presynaptic Specificity of Endocannabinoid Signaling in the HippocampusNeuron, 31
K. Monory, E. Tzavara, Jinette Lexime, C. Ledent, M. Parmentier, A. Borsodi, J. Hanoune (2002)
Novel, not adenylyl cyclase-coupled cannabinoid binding site in cerebellum of mice.Biochemical and biophysical research communications, 292 1
F. Fezza, T. Bisogno, Alberto Minassi, G. Appendino, R. Mechoulam, V. Marzo (2002)
Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissuesFEBS Letters, 513
D. Stump, R. Weisiger, P. Berk (1995)
Expression cloning and characterization of a novel adipocyte long chain fatty acid transport proteinHepatology
E. Fride, R. Mechoulam (1993)
Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent.European journal of pharmacology, 231 2
(2001)
HIRASE H, LEINEKUGEL X, HENZE DA, AND BUZSAKI G
Freund, Tamás F., István Katona, and Daniele Piomelli. Role of Endogenous Cannabinoids in Synaptic Signaling. Physiol Rev 83: 1017–1066, 2003; 10.1152/physrev.00004.2003.—Research of cannabinoid actions was boosted in the 1990s by remarkable discoveries including identification of endogenous compounds with cannabimimetic activity (endocannabinoids) and the cloning of their molecular targets, the CB 1 and CB 2 receptors. Although the existence of an endogenous cannabinoid signaling system has been established for a decade, its physiological roles have just begun to unfold. In addition, the behavioral effects of exogenous cannabinoids such as delta-9-tetrahydrocannabinol, the major active compound of hashish and marijuana, await explanation at the cellular and network levels. Recent physiological, pharmacological, and high-resolution anatomical studies provided evidence that the major physiological effect of cannabinoids is the regulation of neurotransmitter release via activation of presynaptic CB 1 receptors located on distinct types of axon terminals throughout the brain. Subsequent discoveries shed light on the functional consequences of this localization by demonstrating the involvement of endocannabinoids in retrograde signaling at GABAergic and glutamatergic synapses. In this review, we aim to synthesize recent progress in our understanding of the physiological roles of endocannabinoids in the brain. First, the synthetic pathways of endocannabinoids are discussed, along with the putative mechanisms of their release, uptake, and degradation. The fine-grain anatomical distribution of the neuronal cannabinoid receptor CB 1 is described in most brain areas, emphasizing its general presynaptic localization and role in controlling neurotransmitter release. Finally, the possible functions of endocannabinoids as retrograde synaptic signal molecules are discussed in relation to synaptic plasticity and network activity patterns. Address for reprint requests and other correspondence: T. F. Freund, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest 8, Szigony u.43, H-1083 Hungary (E-mail: freund@koki.hu ).
Physiological Reviews – The American Physiological Society
Published: Jul 1, 2003
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