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A. Lewin, L. Schnipper, C. Crumpacker (1980)
Photodynamic Inactivation of Herpes Simplex Virus by Hematoporphyrin Derivative and LightProceedings of the Society for Experimental Biology and Medicine, 163
H. Alter, P. Morel, Burton Dorman, G. Smith, R. Creagan, G. Wiesehahn, L. Corash, H. Popper, J. Eichberg (1988)
PHOTOCHEMICAL DECONTAMINATION OF BLOOD COMPONENTS CONTAINING HEPATITIS B AND NON-A, NON-B VIRUSThe Lancet, 332
(1987)
Preliminary studics on a more cffcctive phototoxic agent than hcmatoporphyrin
Y. Tano (1977)
Photodynamic Inactivation of Herpes Simplex VirusJapanese Journal of Ophthalmology, 21
J. Matthews, J. Newman, F. Sogandares-Bernal, M. Judy, H. Skiles, J. Leveson, A. Marengo-Rowe, T. Chanh (1988)
Photodynamic therapy of viral contaminants with potential for blood banking applicationsTransfusion, 28
(1989)
Inactivation of Friend erythrolcukemia virus and Fricnd virus - transformed cells by meroeyanine 540 - mediated pho - tosensitization
520 West 6th Avenue
(1989)
In - activation and mutagcnesis of herpes virus by photodynamic treat - mcnt with therapeutic dyes
A. Richter, E. Sternberg, E. Waterfield, D. Dolphin, J. Levy (1989)
Characterization Of Benzoporphyrin Derivative, A New Photosensitizer, 0997
(1989)
Dyc uptake methods of assessing viral cytophotogen - icity and thcir application to Interferon assays
Chanh Chanh, Allan Allan, Mathews Mathews (1989)
Photodynamic inactivation of simian immunodeficiency virusJ Virol Methods, 26
L. Corash, L. Lin, G. Wiesehahn (1992)
Use of 8-methoxypsoralen and long wavelength ultraviolet radiation for decontamination of platelet concentrates.Blood cells, 18 1
A model has been developed to demonstrate the use of photodynamic treatment (PDT) to eradicate viral contaminants from donated blood and blood products. Whole blood, spiked with vesicular stomatitis virus (VSV), was treated with the photosensitizer benzoporphyrin derivative‐monoacid ring A (BPD‐MA). After light activation of BPD‐MA, a neutral red dye uptake assay was carried out to determine virus inactivation. Various drug incubation times and light intensities were tested as well as red cell lysis and distribution of VSV in blood. At BPD‐MA concentrations between 2 and 4 μg per mL in whole blood, up to 107 VSV were inactivated. Several photosensitizers were also tested with this model to determine their relative efficacy in viral inactivation.
Transfusion – Wiley
Published: Jul 8, 1990
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