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- Publisher
- Springer Journals
- Copyright
- Copyright © 2004 by Nature Publishing Group
- Subject
- Life Sciences; Life Sciences, general; Cell Biology; Cancer Research; Developmental Biology; Stem Cells
- ISSN
- 1465-7392
- eISSN
- 1476-4679
- DOI
- 10.1038/ncb1095
- Publisher site
- See Article on Publisher Site
Abstract
Humans and animals undergo ageing, and although their primary cells undergo cellular senescence in culture, the relationship between these two processes is unclear 1,2 . Here we show that γ-H2AX foci (γ-foci), which reveal DNA double-strand breaks (DSBs) 3,4 , accumulate in senescing human cell cultures and in ageing mice. They colocalize with DSB repair factors, but not significantly with telomeres. These cryptogenic γ-foci remain after repair of radiation-induced γ-foci, suggesting that they may represent DNA lesions with unrepairable DSBs. Thus, we conclude that accumulation of unrepairable DSBs may have a causal role in mammalian ageing.
Journal
Nature Cell Biology – Springer Journals
Published: Feb 2, 2004