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FREEMAN, HUGH J., GARY A. QUAMME. Age-related changesin sodium-dependent in rat small intestine.Am. J. Physiol. 251 (Gastrointest. Liver Physiol. 14): G208-G217,1986.-Brush-border membranevesicleswere purified from jejunoileal segments rats ranging from 3 to 156 . The kinetics sodium-dependent co were studied under voltage-clamped, zero trans conditions over a widerange c&concentrations (0.005-1.5 mM). Initial uptake in brush-border membrane vesicles isolated from the proximal segment(50 cm from ligament Treitz) rats ~7-8 agedemonstrateda distinct curvilinear Hstee plot consistent with multiple- mechanisms.One system possessed apparent Vmax 10.6 t 0.5 an nmol. mg proI?= mil K, 630 t 18 PM. The second systemwascharacterized by Vmax 0.9 t 0.1 nmol . mgprot- . mine1 K, 12 t 1 PM. In contrast, the distal segment(50 cm to end small intestine) possessed only one sodiumdependentcarrier system. The apparent Vmax K, were 1.11 t 0.20 nmol mg protei mil 49 t 7 ,uM, respectively. Sodium-activation curves in the presence 0.3 0.03 mM were consistent with more than one sodiumion with both systems.In contrast, rats 12-13 old older possessed both sodium-dependent systems in the proximal early distal small intestine. The highcapacity system is more abundant in the proximal than the distal segment.These data suggestthat, under these specific conditions, there are
AJP - Gastrointestinal and Liver Physiology – The American Physiological Society
Published: Aug 1, 1986
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