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Age-related changes in sodium-dependent glucose transport in rat small intestine

Age-related changes in sodium-dependent glucose transport in rat small intestine FREEMAN, HUGH J., GARY A. QUAMME. Age-related changesin sodium-dependent in rat small intestine.Am. J. Physiol. 251 (Gastrointest. Liver Physiol. 14): G208-G217,1986.-Brush-border membranevesicleswere purified from jejunoileal segments rats ranging from 3 to 156 . The kinetics sodium-dependent co were studied under voltage-clamped, zero trans conditions over a widerange c&concentrations (0.005-1.5 mM). Initial uptake in brush-border membrane vesicles isolated from the proximal segment(50 cm from ligament Treitz) rats ~7-8 agedemonstrateda distinct curvilinear Hstee plot consistent with multiple- mechanisms.One system possessed apparent Vmax 10.6 t 0.5 an nmol. mg proI?= mil K, 630 t 18 PM. The second systemwascharacterized by Vmax 0.9 t 0.1 nmol . mgprot- . mine1 K, 12 t 1 PM. In contrast, the distal segment(50 cm to end small intestine) possessed only one sodiumdependentcarrier system. The apparent Vmax K, were 1.11 t 0.20 nmol mg protei mil 49 t 7 ,uM, respectively. Sodium-activation curves in the presence 0.3 0.03 mM were consistent with more than one sodiumion with both systems.In contrast, rats 12-13 old older possessed both sodium-dependent systems in the proximal early distal small intestine. The highcapacity system is more abundant in the proximal than the distal segment.These data suggestthat, under these specific conditions, there are http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Gastrointestinal and Liver Physiology The American Physiological Society

Age-related changes in sodium-dependent glucose transport in rat small intestine

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Publisher
The American Physiological Society
Copyright
Copyright © 1986 the American Physiological Society
ISSN
0193-1857
eISSN
1522-1547
Publisher site
See Article on Publisher Site

Abstract

FREEMAN, HUGH J., GARY A. QUAMME. Age-related changesin sodium-dependent in rat small intestine.Am. J. Physiol. 251 (Gastrointest. Liver Physiol. 14): G208-G217,1986.-Brush-border membranevesicleswere purified from jejunoileal segments rats ranging from 3 to 156 . The kinetics sodium-dependent co were studied under voltage-clamped, zero trans conditions over a widerange c&concentrations (0.005-1.5 mM). Initial uptake in brush-border membrane vesicles isolated from the proximal segment(50 cm from ligament Treitz) rats ~7-8 agedemonstrateda distinct curvilinear Hstee plot consistent with multiple- mechanisms.One system possessed apparent Vmax 10.6 t 0.5 an nmol. mg proI?= mil K, 630 t 18 PM. The second systemwascharacterized by Vmax 0.9 t 0.1 nmol . mgprot- . mine1 K, 12 t 1 PM. In contrast, the distal segment(50 cm to end small intestine) possessed only one sodiumdependentcarrier system. The apparent Vmax K, were 1.11 t 0.20 nmol mg protei mil 49 t 7 ,uM, respectively. Sodium-activation curves in the presence 0.3 0.03 mM were consistent with more than one sodiumion with both systems.In contrast, rats 12-13 old older possessed both sodium-dependent systems in the proximal early distal small intestine. The highcapacity system is more abundant in the proximal than the distal segment.These data suggestthat, under these specific conditions, there are

Journal

AJP - Gastrointestinal and Liver PhysiologyThe American Physiological Society

Published: Aug 1, 1986

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