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Glycine minimizes reperfusion injury in a low-flow, reflow liver perfusion model in the rat

Glycine minimizes reperfusion injury in a low-flow, reflow liver perfusion model in the rat 27599-7365 artery endothelial cells and calcium- and hydrogen peroxide-induced venous endothelial cell death were reduced by (28, 30). also diminished hypoxic and cold ischemic to perfused dog and rabbit kidneys (20,26), and addition of to organ cold storage or rinse solutions reduced rat liver graft and increased survival after transplantation, most likely by decreasing nonparenchymal cell (1, 10). Furthermore, addition of hepatamine, which contains 9 g of per liter, to media decreased lactic acid dehydrogenase release (10). The cytoprotective effect of is shared by a small number of amino acids with similar structures, such as D- and L-alanine. Surprisingly, strychnine, which antagonizes many actions of in the central nervous system, mimicked the cytoprotective properties of in renal proximal tubules (22); however, storage of liver grafts in solutions containing did not improve survival in dogs (lo), and Marsh et al. (21) did not observe protection in suspended hepatocytes against caused by calcium ionophores or oxidative stress. Therefore, whether glytine has a protective effect on liver induced by hypoxia-reoxygenation remains unclear. Accordingly, the purpose of this study was to investigate the effect of on of rat livers in a low-flow, reflow liver perfusion model. In this model, livers are perfused http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Gastrointestinal and Liver Physiology The American Physiological Society

Glycine minimizes reperfusion injury in a low-flow, reflow liver perfusion model in the rat

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Publisher
The American Physiological Society
Copyright
Copyright © 1996 the American Physiological Society
ISSN
0193-1857
eISSN
1522-1547
Publisher site
See Article on Publisher Site

Abstract

27599-7365 artery endothelial cells and calcium- and hydrogen peroxide-induced venous endothelial cell death were reduced by (28, 30). also diminished hypoxic and cold ischemic to perfused dog and rabbit kidneys (20,26), and addition of to organ cold storage or rinse solutions reduced rat liver graft and increased survival after transplantation, most likely by decreasing nonparenchymal cell (1, 10). Furthermore, addition of hepatamine, which contains 9 g of per liter, to media decreased lactic acid dehydrogenase release (10). The cytoprotective effect of is shared by a small number of amino acids with similar structures, such as D- and L-alanine. Surprisingly, strychnine, which antagonizes many actions of in the central nervous system, mimicked the cytoprotective properties of in renal proximal tubules (22); however, storage of liver grafts in solutions containing did not improve survival in dogs (lo), and Marsh et al. (21) did not observe protection in suspended hepatocytes against caused by calcium ionophores or oxidative stress. Therefore, whether glytine has a protective effect on liver induced by hypoxia-reoxygenation remains unclear. Accordingly, the purpose of this study was to investigate the effect of on of rat livers in a low-flow, reflow liver perfusion model. In this model, livers are perfused

Journal

AJP - Gastrointestinal and Liver PhysiologyThe American Physiological Society

Published: Feb 1, 1996

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