Access the full text.
Sign up today, get DeepDyve free for 14 days.
H. Zaaijer, M. Koppelman, C. Farrington (2004)
Parvovirus B19 viraemia in Dutch blood donorsEpidemiology and Infection, 132
I. Thomas, M. Giambattista, C. Gérard, E. Mathys, V. Hougardy, B. Latour, T. Branckaert, Ruth Laub (2003)
Prevalence of human erythrovirus B19 DNA in healthy Belgian blood donors and correlation with specific antibodies against structural and non‐structural viral proteinsVox Sanguinis, 84
P. Mortimer, N. Luban, J. Kelleher, B. Cohen (1983)
TRANSMISSION OF SERUM PARVOVIRUS-LIKE VIRUS BY CLOTTING-FACTOR CONCENTRATESThe Lancet, 322
S. Stramer, S. Glynn, S. Kleinman, D. Strong, S. Caglioti, D. Wright, R. Dodd, M. Busch (2004)
Detection of HIV-1 and HCV infections among antibody-negative blood donors by nucleic acid-amplification testing.The New England journal of medicine, 351 8
A. Plentz, J. Hahn, A. Knöll, E. Holler, W. Jilg, S. Modrow (2005)
Exposure of hematologic patients to parvovirus B19 as a contaminant of blood cell preparations and blood productsTransfusion, 45
A. Corcoran, S. Doyle (2004)
Advances in the biology, diagnosis and host-pathogen interactions of parvovirus B19.Journal of medical microbiology, 53 Pt 6
Walter Hitzler, Stefan Runkel (2002)
Prevalence of human parvovirus B19 in blood donors as determined by a haemagglutination assay and verified by the polymerase chain reactionVox Sanguinis, 82
A. Zanella, F. Rossi, C. Cesana, A. Foresti, F. Nador, A. Binda, G. Lunghi, M. Cappellini, M. Furione, G. Sirchia (1995)
Transfusion‐transmitted human parvovirus B19 infection in a thalassemic patientTransfusion, 35
(1992)
Human parvovirus B19 infection in hemophiliacs first infused with two high-purity, virally attenuated factor VIII concentrates
(2001)
Parvovirus B19 and HAV screening of whole blood donations [abstract]. Transfusion 2001;41S:28S
M. Musiani, E. Manaresi, G. Gallinella, M. Cricca, M. Zerbini (2005)
Recurrent erythema in patients with long-term parvovirus B19 infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 40 12
(1985)
Experimental PARVOVIRUS B19 DNA LEVELS IN BLOOD DONORS Volume 47, October 2007 TRANSFUSION 1763 parvovirus infection in humans
Steven Kleinman, S. Glynn, M. Higgins, D. Triulzi, James Smith, C. Nass, G. Garratty, Edward Murphy, German Leparc, George Schreiber, Melissa King, Mary Chamberland, G. Nemo (2005)
The RADAR repository: a resource for studies of infectious agents and their transmissibility by transfusionTransfusion, 45
Chuan-ging Wu, B. Mason, J. Jong, D. Erdman, Laurel Mckernan, Meredith Oakley, M. Soucie, B. Evatt, M. Yu (2005)
Parvovirus B19 transmission by a high‐purity factor VIII concentrateTransfusion, 45
(2002)
Development of a parvovirus B19 nucleic acid quantitative confirmatory assay for use in blood donor screening [abstract]. Transfusion 2002;42S:90S
S. Doyle, A. Corcoran (2006)
The immune response to parvovirus B19 exposure in previously seronegative and seropositive individuals.The Journal of infectious diseases, 194 2
J. Lefrère, A. Servant‐Delmas, D. Candotti, M. Mariotti, I. Thomas, Y. Brossard, F. Lefrère, R. Girot, J. Allain, S. Laperche (2005)
Persistent B19 infection in immunocompetent individuals: implications for transfusion safety.Blood, 106 8
M. Anderson, P. Higgins, L. Davis, J. Willman, S. Jones, I. Kidd, J. Pattison, D. Tyrrell (1985)
Experimental Parvoviral Infection in HumansThe Journal of Infectious Diseases, 152
P. Cassinotti, G. Siegl (2000)
Quantitative Evidence for Persistence of Human Parvovirus B19 DNA in an Immunocompetent IndividualEuropean Journal of Clinical Microbiology and Infectious Diseases, 19
Jonathan Samet, N. Benowitz (2002)
From the Food and Drug Administration.JAMA, 287 22
Y. Yoto, T. Kudoh, K. Haseyama, N. Suzuki, Takanori Oda, T. Katoh, Tsuneo Takahashi, Sadami Sekiguchi, Shunzo Chiba (1995)
Incidence of human parvovirus B19 DNA detection in blood donorsBritish Journal of Haematology, 91
D. Candotti, N. Etiz, Armen Parsyan, J. Allain (2004)
Identification and Characterization of Persistent Human Erythrovirus Infection in Blood Donor SamplesJournal of Virology, 78
Application of nucleic acid testing to blood borne pathogens and emerging technologies. OBRR/CBER/FDA Workshop
Shyamala Shyamala, Madriaga Madriaga, Cotrell Cotrell, Pichuantes Pichuantes, Chien Chien, Phelps Phelps (2002)
Development of a parvovirus B19 nucleic acid quantitative confirmatory assay for use in blood donor screening (abstract)Transfusion, 42S
Stramer Stramer, Dodd Dodd, Smith Smith (2001)
Parvovirus B19 and HAV screening of whole blood donations (abstract)Transfusion, 41S
P. Norja, K. Hokynar, L. Aaltonen, Renwei Chen, A. Ranki, E. Partio, O. Kiviluoto, I. Davidkin, T. Leivo, A. Eis-Hübinger, B. Schneider, H. Fischer, R. Tolba, O. Vapalahti, A. Vaheri, M. Söderlund-Venermo, K. Hedman (2006)
Bioportfolio: lifelong persistence of variant and prototypic erythrovirus DNA genomes in human tissue.Proceedings of the National Academy of Sciences of the United States of America, 103 19
Armen Parsyan, Emmanuel Addo-Yobo, S. Owusu-Ofori, Henrietta Akpene, F. Sarkodie, J. Allain (2006)
Effects of transfusion on human erythrovirus B19‐susceptible or ‐infected pediatric recipients in a genotype 3–endemic areaTransfusion, 46
J. Jordan, B. Tiangco, J. Kiss, W. Koch (1998)
Human Parvovirus B19: Prevalence of Viral DNA in Volunteer Blood Donors and Clinical Outcomes of Transfusion RecipientsVox Sanguinis, 75
M. Koppelman, H. Cuypers, T. Emrich, H. Zaaijer (2004)
Quantitative real‐time detection of parvovirus B19 DNA in plasmaTransfusion, 44
BJ Cohen, S. Beard, WA Knowles, J. Ellis, D. Joske, J. Goldman, P. Hewitt, K. Ward (1997)
Chronic anemia due to parvovirus B19 infection in a bone marrow transplant patient after platelet transfusionTransfusion, 37
Jordan Jordan, Tiangco Tiangco, Kiss Kiss, Koch Koch (1998)
Prevalence of human parvovirus B19 DNA in a blood donor populationVox Sang, 75
BACKGROUND: Blood donor parvovirus B19 DNA prevalence with sensitive nucleic acid test assays has recently been demonstrated to be higher than that found with assays designed to detect high viral titers in the plasma manufacturing sector. STUDY DESIGN AND METHODS: Stored plasma aliquots from 5020 donations collected between 2000 and 2003 at seven US blood centers were tested. Testing was performed with a real‐time B19 DNA polymerase chain reaction (PCR; TaqMan, Applied Biosystems) assay with a 50 percent limit of detection (LOD) of 1.6 IU per mL (95% confidence interval (CI), 1.2‐2.1 IU/mL) and a 95 percent LOD of 16.5 IU per mL (95% CI, 10.6‐33.9 IU/mL). Confirmation and quantitation of B19 DNA was accomplished by retesting of two additional subaliquots. Confirmed‐positive specimens were tested for the presence of anti‐B19 immunoglobulin M (IgM) and IgG with FDA‐licensed assays. RESULTS: B19 DNA prevalence was 0.88 percent (95% CI, 0.64%‐1.2%). Among the 23 donations with B19 DNA titers of at least 20 IU per mL, the median DNA concentration was 105 IU per mL with an interquartile range of 42 to 481 IU per mL; the highest value was 1869 IU per mL. All B19 DNA–positive donations were positive for the presence of IgG and 10 (23%) were also positive for the presence of IgM; IgM seropositivity was associated with increasing DNA levels (p = 0.0013). CONCLUSION: Low‐level B19 DNA was detected in nearly 1 percent of donations. The 23 percent of DNA‐positive donations with both IgM and IgG B19 antibody most likely represent acute resolving infection, whereas those with IgG but no IgM are most consistent with a more chronic and possibly persistent phase of B19 infection.
Transfusion – Wiley
Published: Oct 1, 2007
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.