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Red Cross Blood Bank, Amsterdam. 0-L. Choo, PhD, Senior Scientist, Chiron Corporation, Emeryvil le, Cali fornia
(1990)
Schaasberg Y, e t a l . I n f e c t i v i t y o f b lood seropos i t i ve f o r hepa t i t s C v i r u s ant ibodies
Epidemiology and Prevention o f Transmissible Diseases
Han Han, Shyamala Shyamala, Richman Richman (1991)
Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5′ untranslated region and poly(A) tails at the 3′ endProc Natl Acad Sci U S A, 88
Poel Poel, Reesink Reesink, Schaasberg Schaasberg (1990)
Infectivity of blood seropositive for hepatits C virus antibodiesLancet, 335
(1990)
Risk factors f o r acute non-A, non-B ion
PhD, Director o f I m n o c h e m i s t r y , Chiron Corporat i on
(1991)
C v i r a l RNA: i d e n t i f i c a t i o n o f conserved sequences i n the 5' untranslated region and poly(A) t a i l s a t the 3' end
PhD, Senior S c i e n t i s t , Central Laboratory o f The Netherlands Red Cross Blood Transfusion Service
(1988)
Non-A, non-B posttransfusion h e p a t i t i s i n open heart surgery patients i n The Netherlands: preliminary r e s u l t s o f a prospective study
Alter Alter, Hadler Hadler, Judson Judson (1990)
Risk factors for acute non‐A, non‐B hepatitis in the United States and association with hepatitis C virus infectionJAMA, 264
Mimms Mimms, Vallari Vallari, Ducharme Ducharme (1990)
Specificity of anti‐HCV ELISA assessed by reactivity to three immunodominant HCV regionsLancet, 336
(1990)
Enhanced de tec t ion by PCR o f h e p a t i t i s C v i r u s RNA
Poel Poel, Cuypers Cuypers, Reesink Reesink (1991)
Confirmation of hepatitis C virus infection by new four‐antigen recombinant immunoblot assyLancet, 337
Risk factors of parenteral and nonparenteral exposure to hepatitis C virus (HCV) infection were studied in 125 blood donors in The Netherlands who were positive for anti‐HCV on enzyme‐linked immunosorbent assay (ELISA). Risk factors were related to confirmatory test results of four‐antigen recombinant immunoblot assay (4‐RIBA) and polymerase chain reaction (PCR) of the HCV 5′ untranslated region. Twelve (10%) of the 125 anti‐HCV C100 ELISA‐positive blood donors were 4‐RIBA positive. Eleven (92%) of 12 4‐RIBA‐positive blood donors were PCR positive, and all 113 remaining 4‐RIBA‐negative or ‐indeterminate donors were PCR negative. Eleven (92%) of 12 4‐RIBA‐positive blood donors had a risk factor of parenteral exposure, as compared to 17 (15%) of 113 4‐RIBA‐negative or ‐indeterminate donors. The prevalence of confirmed HCV infection among Amsterdam blood donors is calculated at 0.04 percent; parenteral exposure appears to be the major risk factor for HCV infection.
Transfusion – Wiley
Published: Oct 1, 1991
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