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Development of a Dog Microdialysis Model for Determining Synovial Fluid Pharmacokinetics of Anti-Arthritis Compounds Exemplified by Methotrexate

Development of a Dog Microdialysis Model for Determining Synovial Fluid Pharmacokinetics of... Purpose. The purpose of this study was to develop and validate an animal model of drug disposition in synovial fluid (SF) by comparing microdialysis with arthrocentesis using the anti-arthritic drug methotrexate (MTX). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Research Springer Journals

Development of a Dog Microdialysis Model for Determining Synovial Fluid Pharmacokinetics of Anti-Arthritis Compounds Exemplified by Methotrexate

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References (18)

Publisher
Springer Journals
Copyright
Copyright © 2003 by Plenum Publishing Corporation
Subject
Biomedicine; Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering
ISSN
0724-8741
eISSN
1573-904X
DOI
10.1023/A:1023246832321
Publisher site
See Article on Publisher Site

Abstract

Purpose. The purpose of this study was to develop and validate an animal model of drug disposition in synovial fluid (SF) by comparing microdialysis with arthrocentesis using the anti-arthritic drug methotrexate (MTX).

Journal

Pharmaceutical ResearchSpringer Journals

Published: Oct 7, 2004

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