Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Suppression of alcohol and saccharin preference in rats by a novel Ca 2+ channel inhibitor, Goe 5438

Suppression of alcohol and saccharin preference in rats by a novel Ca 2+ channel inhibitor, Goe 5438 213 107 107 2 3 Olgierd Pucilowski Amir H. Rezvani David S. Janowsky Skipper Bowles Center for Alcohol Studies and Department of Psychiatry University of North Carolina at Chapel Hill, School of Medicine 27599-7175 Chapel Hill NC USA Abstract The effect of the novel 1,4-dihydronaphthyridine Ca 2+ channel inhibitor Goe 5438 (CI-951) on voluntary ethanol consumption was examined in selectively bred alcohol-preferring (P) rats in a free choice two bottle preference test versus water. Intraperitoneally injected Goe 5438 dose-dependently (5, 10 or 20 µmol/kg, twice daily) inhibited ethanol and increased water intake over the 24 h period (injection day). The drug decreased ethanol preference, originally above 90%, by 6%, 19% and 45% at respective doses, on the injection day. That inhibitory effect of the highest dose of Goe 5438 on ethanol preference remained significant also on days 2 and 3 after injections (−51% and −18%, respectively). Goe 5438, in the highest dose, also tended to decrease granulated chow consumption during the injection day only. To further test whether the inhibition of ethanol preference is secondary to decrease in reinforcing properties of ethanol and not due to interference with satiety mechanisms, we compared the effect of two higher doses (10 and 20 µmol/kg, intraperitoneally, twice daily) of Goe 5438 on spontaneous preference for a non-caloric 0.04% saccharin solution in Sprague-Dawley rats. We observed a dose-dependent suppression of preference (by 44% and 58%, respectively) during the injection day, but not the subsequent 24 h period. However, Goe 5438 also significantly alleviated food pellet intake on the injection day. In conclusion, Goe 5438 produces potent and long-lasting inhibition of voluntary ethanol consumption, which may be secondary to attenuation of reinforcing properties of ethanol. Additionally, this particular Ca 2+ channel inhibitor appears to have mild anorectic properties which may be conducive to acute suppression of alcohol intake. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Suppression of alcohol and saccharin preference in rats by a novel Ca 2+ channel inhibitor, Goe 5438

Download PDF
6 pages

Loading next page...
 
/lp/springer-journals/suppression-of-alcohol-and-saccharin-preference-in-rats-by-a-novel-ca-nc3smawtJi

References (28)

Publisher
Springer Journals
Copyright
Copyright © 1992 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF02245174
Publisher site
See Article on Publisher Site

Abstract

213 107 107 2 3 Olgierd Pucilowski Amir H. Rezvani David S. Janowsky Skipper Bowles Center for Alcohol Studies and Department of Psychiatry University of North Carolina at Chapel Hill, School of Medicine 27599-7175 Chapel Hill NC USA Abstract The effect of the novel 1,4-dihydronaphthyridine Ca 2+ channel inhibitor Goe 5438 (CI-951) on voluntary ethanol consumption was examined in selectively bred alcohol-preferring (P) rats in a free choice two bottle preference test versus water. Intraperitoneally injected Goe 5438 dose-dependently (5, 10 or 20 µmol/kg, twice daily) inhibited ethanol and increased water intake over the 24 h period (injection day). The drug decreased ethanol preference, originally above 90%, by 6%, 19% and 45% at respective doses, on the injection day. That inhibitory effect of the highest dose of Goe 5438 on ethanol preference remained significant also on days 2 and 3 after injections (−51% and −18%, respectively). Goe 5438, in the highest dose, also tended to decrease granulated chow consumption during the injection day only. To further test whether the inhibition of ethanol preference is secondary to decrease in reinforcing properties of ethanol and not due to interference with satiety mechanisms, we compared the effect of two higher doses (10 and 20 µmol/kg, intraperitoneally, twice daily) of Goe 5438 on spontaneous preference for a non-caloric 0.04% saccharin solution in Sprague-Dawley rats. We observed a dose-dependent suppression of preference (by 44% and 58%, respectively) during the injection day, but not the subsequent 24 h period. However, Goe 5438 also significantly alleviated food pellet intake on the injection day. In conclusion, Goe 5438 produces potent and long-lasting inhibition of voluntary ethanol consumption, which may be secondary to attenuation of reinforcing properties of ethanol. Additionally, this particular Ca 2+ channel inhibitor appears to have mild anorectic properties which may be conducive to acute suppression of alcohol intake.

Journal

Psychopharmacology – Springer Journals

Published: Jun 1, 1992

There are no references for this article.