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Recent evolution of clotting factor concentrates for hemophilia A and B. Transfusion Practices Committee

Recent evolution of clotting factor concentrates for hemophilia A and B. Transfusion Practices... KASPER, J.M. LUSHER, THE TRANSFUSION AND PRACTICES COMMITTEE such changes were incremental, requiring only amendments to licenses, while brand names remained the same. New brand names entered the vocabulary when additional fractionators entered the concentrate market. During the 198Os, however, changes in concentrates were major and relatively frequent and were due, for the most part, to efforts to prevent the transmission of bloodborne viral infections. Brand names were modified, usually by suffixes designating the method of purification or of virus inactivation. At times, multiple versions of one brand were on the market simultaneously. Only a few coagulation linguists could interpret the Babel of nomenclature. Confounding the perplexity, additional methods for screening donors were introduced and mandated at different times during the same epoch. A given brand might be manufactured from plasma screened by certain means one year, and by additional means the next year, with no change in brand name. Furthermore, nearly all concentrates had an outdate period of 2 years, and thus, concentrates made from plasma collected according to the standards of prior years often were on the market at the same time as concentrates made from plasma collected according to current standards. This report describes the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Wiley

Recent evolution of clotting factor concentrates for hemophilia A and B. Transfusion Practices Committee

Transfusion , Volume 33 (5) – May 1, 1993

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References (86)

Publisher
Wiley
Copyright
1993 AABB
ISSN
0041-1132
eISSN
1537-2995
DOI
10.1046/j.1537-2995.1993.33593255605.x
Publisher site
See Article on Publisher Site

Abstract

KASPER, J.M. LUSHER, THE TRANSFUSION AND PRACTICES COMMITTEE such changes were incremental, requiring only amendments to licenses, while brand names remained the same. New brand names entered the vocabulary when additional fractionators entered the concentrate market. During the 198Os, however, changes in concentrates were major and relatively frequent and were due, for the most part, to efforts to prevent the transmission of bloodborne viral infections. Brand names were modified, usually by suffixes designating the method of purification or of virus inactivation. At times, multiple versions of one brand were on the market simultaneously. Only a few coagulation linguists could interpret the Babel of nomenclature. Confounding the perplexity, additional methods for screening donors were introduced and mandated at different times during the same epoch. A given brand might be manufactured from plasma screened by certain means one year, and by additional means the next year, with no change in brand name. Furthermore, nearly all concentrates had an outdate period of 2 years, and thus, concentrates made from plasma collected according to the standards of prior years often were on the market at the same time as concentrates made from plasma collected according to current standards. This report describes the

Journal

TransfusionWiley

Published: May 1, 1993

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