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Recent Advances in the Molecular Biology of Dopamine Receptors

Recent Advances in the Molecular Biology of Dopamine Receptors The catecholamine dopamine plays a role i n the functi oning of numerous vertebrate and invertebrate organisms In mammals, dopamine affects a diverse array of processes, such as m otor control, cognition, emotion, neuroendocrine regulation, positive reinforcement, and cardiovascular regulation. Moreover, dopamine responsive systems have been implicated in se veral pathologic conditions, such as schizophrenia, tardive dyskinesia, Parkinson's disease, Tourette syndrome, hyperprolactinemia, and possibly Huntington's chorea. The quest to find new drugs to combat the symptoms of these conditions has led to the discovery of numerous synthetic agoni sts and antagoni sts for dopamine receptors. At the cellular and biochemical level, dopamine also exhibits a wide range of e ffects including stimulation and inhibition of adenylyl cyclase (Stoof & Kebabian 1984), stimulation of potassium channels (Sasaki & Sato 1 987), alterations of phosphotidyl­ inositol (Mahan et al 1 99 0) and arachidonic acid metabolism (Kanterman et al 1991; Piomelli et al 1991), changes in .neuronal firing rates (Walters et al 1987), and alterations of gene expressi on (Gerfen et alI990). Dopamine mediates these diverse effects through interactions with specific receptor proteins, and one of the challenges has been to i dentify these receptors and elucidate their properties. B http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Neuroscience Annual Reviews

Recent Advances in the Molecular Biology of Dopamine Receptors

Gingrich, J A; Caron, M G
Annual Review of Neuroscience , Volume 16 (1) – Mar 1, 1993
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References (31)

Publisher
Annual Reviews
Copyright
Copyright 1993 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0147-006X
eISSN
1545-4126
DOI
10.1146/annurev.ne.16.030193.001503
pmid
8460895
Publisher site
See Article on Publisher Site

Abstract

The catecholamine dopamine plays a role i n the functi oning of numerous vertebrate and invertebrate organisms In mammals, dopamine affects a diverse array of processes, such as m otor control, cognition, emotion, neuroendocrine regulation, positive reinforcement, and cardiovascular regulation. Moreover, dopamine responsive systems have been implicated in se veral pathologic conditions, such as schizophrenia, tardive dyskinesia, Parkinson's disease, Tourette syndrome, hyperprolactinemia, and possibly Huntington's chorea. The quest to find new drugs to combat the symptoms of these conditions has led to the discovery of numerous synthetic agoni sts and antagoni sts for dopamine receptors. At the cellular and biochemical level, dopamine also exhibits a wide range of e ffects including stimulation and inhibition of adenylyl cyclase (Stoof & Kebabian 1984), stimulation of potassium channels (Sasaki & Sato 1 987), alterations of phosphotidyl­ inositol (Mahan et al 1 99 0) and arachidonic acid metabolism (Kanterman et al 1991; Piomelli et al 1991), changes in .neuronal firing rates (Walters et al 1987), and alterations of gene expressi on (Gerfen et alI990). Dopamine mediates these diverse effects through interactions with specific receptor proteins, and one of the challenges has been to i dentify these receptors and elucidate their properties. B

Journal

Annual Review of Neuroscience – Annual Reviews

Published: Mar 1, 1993

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