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Lentiviral nuclear import: a complex interplay between virus and host

Lentiviral nuclear import: a complex interplay between virus and host Although the capacity to infect non‐dividing cells is a hallmark of lentiviruses, nuclear import is still barely understood. More than 100 research papers have been dedicated to this topic during the last 15 years, yet, more questions have been raised than answers. The signal‐facilitating translocation of the viral preintegration complex (PIC) through the nuclear pore complex (NPC) remains unknown. It is clear, however, that nuclear import is the result of a complex interplay between viral and cellular components. In this review, we discuss the current knowledge on nuclear import. We focus on the controversies and pitfalls and discuss the interplay between virus and host. BioEssays 29:441–451, 2007. © 2007 Wiley Periodicals, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioEssays Wiley

Lentiviral nuclear import: a complex interplay between virus and host

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References (114)

Publisher
Wiley
Copyright
Copyright © 2007 Wiley Periodicals, Inc.
ISSN
0265-9247
eISSN
1521-1878
DOI
10.1002/bies.20561
pmid
17450594
Publisher site
See Article on Publisher Site

Abstract

Although the capacity to infect non‐dividing cells is a hallmark of lentiviruses, nuclear import is still barely understood. More than 100 research papers have been dedicated to this topic during the last 15 years, yet, more questions have been raised than answers. The signal‐facilitating translocation of the viral preintegration complex (PIC) through the nuclear pore complex (NPC) remains unknown. It is clear, however, that nuclear import is the result of a complex interplay between viral and cellular components. In this review, we discuss the current knowledge on nuclear import. We focus on the controversies and pitfalls and discuss the interplay between virus and host. BioEssays 29:441–451, 2007. © 2007 Wiley Periodicals, Inc.

Journal

BioEssaysWiley

Published: May 1, 2007

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