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Expression of superoxide dismutase messenger RNA in adult rat brain cholinergic neurons

Expression of superoxide dismutase messenger RNA in adult rat brain cholinergic neurons Superoxide dismutase (SOD) protects cells exposed to an excess of the free radical nitric oxide, by preventing the formation of peroxynitrite. Certain central cholinergic neurons express constitutive nitric oxide synthase (nNOS), and presumably they are at risk from peroxynitrite intoxication. Immunocytochemistry for choline acetyltransferase (ChAT) was combined with in situ hybridization histochemistry (ISHH) to examine whether brain cholinergic populations differ with respect to their expression of the messenger RNA molecules (mRNAs) for the manganese-dependent (Mn-SOD) and copper/zinc-dependent superoxide dismutases (Cu/Zn-SOD). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Molecular Neuroscience Springer Journals

Expression of superoxide dismutase messenger RNA in adult rat brain cholinergic neurons

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References (54)

Publisher
Springer Journals
Copyright
Copyright © 1999 by Humana Press Inc
Subject
Biomedicine; Neurosciences; Neurology
ISSN
0895-8696
eISSN
1559-1166
DOI
10.1385/JMN:12:1:1
pmid
10636466
Publisher site
See Article on Publisher Site

Abstract

Superoxide dismutase (SOD) protects cells exposed to an excess of the free radical nitric oxide, by preventing the formation of peroxynitrite. Certain central cholinergic neurons express constitutive nitric oxide synthase (nNOS), and presumably they are at risk from peroxynitrite intoxication. Immunocytochemistry for choline acetyltransferase (ChAT) was combined with in situ hybridization histochemistry (ISHH) to examine whether brain cholinergic populations differ with respect to their expression of the messenger RNA molecules (mRNAs) for the manganese-dependent (Mn-SOD) and copper/zinc-dependent superoxide dismutases (Cu/Zn-SOD).

Journal

Journal of Molecular NeuroscienceSpringer Journals

Published: May 24, 2007

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