Access the full text.
Sign up today, get DeepDyve free for 14 days.
B. Lewin (1971)
Cells in ChargeNature, 232
A. Pierce, P. Risdall, B. Shaw (1964)
Absorption of orally administered insulin by the newly born calfThe Journal of Physiology, 171
B. Poole, M. Wibo (1973)
Protein degradation in cultured cells. The effect of fresh medium, fluoride, and iodoacetate on the digestion of cellular protein of rat fibroblasts.The Journal of biological chemistry, 248 17
M. Bradley (1977)
Regulation of protein degradation in normal and transformed human cells. Effects of growth state, medium composition, and viral transformation.The Journal of biological chemistry, 252 15
J. Rosenzweig, J. Havránková, M. Lesniak, M. Brownstein, J. Roth (1980)
Insulin is ubiquitous in extrapancreatic tissues of rats and humans.Proceedings of the National Academy of Sciences of the United States of America, 77 1
F. Ballard, S. Wong, S. Knowles, N. Partridge, T. Martin, C. Wood, J. Gunn (1980)
Insulin inhibition of protein degradation in cell monolayersJournal of Cellular Physiology, 105
Yukio Hirata, George Moore, Christine Bertagana, D Orth (1980)
Plasma concentrations of immunoreactive human epidermal growth factor (urogastrone) in man.The Journal of clinical endocrinology and metabolism, 50 3
L. Castor (1977)
Responses of protein synthesis and degradation in growth control of WI‐38 cellsJournal of Cellular Physiology, 92
(1951)
Protein measured with the Folin phenol reagent
J. Amenta, M. Sargus, F. Baccino (1977)
Effect of microtubular or translational inhibitors on general cell protein degradation. Evidence for a dual catabolic pathway.The Biochemical journal, 168 2
M. Klagsbrun (1980)
Bovine colostrum supports the serum-free proliferation of epithelial cells but not of fibroblasts in long-term cultureThe Journal of Cell Biology, 84
G. Carpenter (1980)
Epidermal growth factor is a major growth-promoting agent in human milk.Science, 210 4466
M. Klagsbrun (1978)
Human milk stimulates DNA synthesis and cellular proliferation in cultured fibroblasts.Proceedings of the National Academy of Sciences of the United States of America, 75 10
J. Gunn, M. Clark, S. Knowles, M. Hopgood, F. Ballard (1977)
Reduced rates of proteolysis in transformed cellsNature, 266
J. Gunn, F. Ballard, R. Hanson (1976)
Infulence of hormones and medium composition on the degradation of phosphoenolpyruvate carboxykinase (GTP) and total protein in Reuber H35 cells.The Journal of biological chemistry, 251 12
Nicola Partridge, Daine Alcorn, V. Michelangeli, B. Kemp, Graeme Ryan, T. Martin (1981)
Functional properties of hormonally responsive cultured normal and malignant rat osteoblastic cells.Endocrinology, 108 1
L. Engel, N. Young (1978)
Human breast carcinoma cells in continuous culture: a review.Cancer research, 38 11 Pt 2
F. Ballard, S. Knowles, Susanna Wong, J. Bodner, C. Wood, J. Gunn (1980)
Inhibition of protein breakdown in cultured cells is a consistent response to growth factorsFEBS Letters, 114
S. Cevreska, V. Kovacev, M. Stankovski, E. Kalamaras (1975)
The presence of immunologically reactive insulin in milk of women, during the first week of lactation and its relation to changes in plasma insulin concentration.Godisen zbornik na Medicinskiot fakultet vo Skopje, 21
N. Beck, H. Tucker (1978)
Mammary Arterial and Venous Concentrations of Serum Insulin in Lactating Dairy Cows 1Proceedings of the Society for Experimental Biology and Medicine, 159
O. Koldovský (1978)
Digestion and Absorption
R. Smith, W. Hansel, C. Coppock (1976)
Plasma growth hormone and insulin during early lactation in cows fed silage based diets.Journal of dairy science, 59 2
J. Koprowski, H. Tucker (1973)
Bovine serum growth hormone, corticoids and insulin during lactation.Endocrinology, 93 3
A. Hershko, P. Mamont, R. Shields, G. Tomkins (1971)
"Pleiotypic response".Nature: New biology, 232 33
D. Kelley, J. Becker, V. Potter (1978)
Effect of insulin, dexamethasone, and glucagon on the amino acid transport ability of four rat hepatoma cell lines and rat hepatocytes in culture.Cancer research, 38 12
R. Starkey, D. Orth (1977)
Radioimmunoassay of human epidermal growth factor (urogastrone).The Journal of clinical endocrinology and metabolism, 45 6
10.1002/jcp.1041100305.abs Protein degradation in ten mammalian cell lines is markedly inhibited by small amounts of bovine colostrum. This response is consistent with the growth‐promoting activity of colostrum that has been reported previously. Fractionation of colostrum on DEAE cellulose showed that most of the inhibitory activity against protein breakdown in H35 cells coeluted with insulin. Insulin concentrations in different batches of bovine colostrum ranged from 0.67 nM to 5.7 nM, approximately 100‐fold higher than in blood. The sensitivity of protein breakdown in H35 or MH1C1 hepatoma lines to these colostrum samples was proportional to their insulin concentrations and could largely be accounted for by the amount of insulin present. Removal of insulin from colostrum by means of a protein A‐anti‐insulin antibody affinity column was accompanied by a loss of the ability of colostrum to inhibit protein breakdown in H35 or MH1C1 cells. However, in IMR90 fibroblasts, a cell line with a similar sensitivity to colostrum as the two hepatomas but very insensitive to insulin, protein breakdown was still inhibited by the insulin‐free colostrum. These results suggest that, whereas the effect of bovine colostrum in H35 or MH1C1 cells is actually a response to insulin, different growth factors in colostrum account for the inhibition of protein breakdown in other cell lines.
Journal of Cellular Physiology – Wiley
Published: Mar 1, 1982
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.