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JO Holloszy, LB Oscai, IJ Don, PA Mole (1970)
Mitochondrial citric acid cycle and related enzymes: adaptive response to exerciseJ Clin Invest, 40
LJ Goodyear, BB Kahn (1998)
Exercise, glucose transport, and insulin sensitivityDiabetes Care, 9
K. Cusi, K. Maezono, K. Maezono, Abdullah Osman, M. Pendergrass, M. Pendergrass, M. Patti, T. Pratipanawatr, R. DeFronzo, C. Kahn, L. Mandarino (2000)
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.The Journal of clinical investigation, 105 3
Tatsuya Hayashi, M. Hirshman, Emily Kurth, W. Winder, L. Goodyear (1998)
Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose TransportDiabetes, 47
E. Ravussin, M. Valencia, J. Esparza, P. Bennett, L. Schulz (1994)
Effects of a Traditional Lifestyle on Obesity in Pima IndiansDiabetes Care, 17
R. Kawate, M. Yamakido, Y. Nishimoto, P. Bennett, R. Hamman, W. Knowler (1979)
Diabetes Mellitus and Its Vascular Complications in Japanese Migrants on the Island of HawaiiDiabetes Care, 2
O. Pedersen, J. Bak, P. Andersen, S. Lund, D. Moller, J. Flier, B. Kahn (1990)
Evidence Against Altered Expression of GLUT1 or GLUT4 in Skeletal Muscle of Patients With Obesity or NIDDMDiabetes, 39
D. King, G. Dalsky, M. Staten, W. Clutter, D. Houten, J. Holloszy (1987)
Insulin action and secretion in endurance-trained and untrained humans.Journal of applied physiology, 63 6
(1995)
Genetics , biochemistry , and molecular basis of variant human phenotypes
K. Gerbitz, K. Gempel, D. Brdiczka (1996)
Mitochondria and Diabetes: Genetic, Biochemical, and Clinical Implications of the Cellular Energy CircuitDiabetes, 45
K. Eriksson, F. Lindgärde (1991)
Prevention of Type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise The 6-year Malmö feasibility studyDiabetologia, 34
J. Lehman, P. Barger, A. Kovács, J. Saffitz, D. Medeiros, D. Kelly (2000)
Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis.The Journal of clinical investigation, 106 7
F. Hu, Ronald Sigal, J. Rich-Edwards, G. Colditz, C. Solomon, W. Willett, F. Speizer, J. Manson (1999)
Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study.JAMA, 282 15
R. Cortright, D. Muoio, G. Dohm (1997)
Skeletal muscle lipid metabolism: A frontier for new insights into fuel homeostasisJournal of Nutritional Biochemistry, 8
BF Hurley, PM Nemeth, WH Martin, JM Hagberg, GP Dalsky, JO Holloszy (1986)
Muscle triglyceride utilization during exercise: effect of trainingAnn N Y Acad Sci, 60
C. Bruce, A. Carey, J. Hawley, M. Febbraio (2003)
Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism.Diabetes, 52 9
J. Zierath (2002)
Invited review: Exercise training-induced changes in insulin signaling in skeletal muscle.Journal of applied physiology, 93 2
J. Tuomilehto, J. Lindström, J. Eriksson, T. Valle, H. Hämäläinen, P. Ilanne-Parikka, S. Keinänen-Kiukaanniemi, M. Laakso, A. Louheranta, M. Rastas, V. Salminen, S. Aunola, Z. Cepaitis, V. Moltchanov, M. Hakumäki, M. Mannelin, V. Martikkala, J. Sundvall, M. Uusitupa (2001)
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.The New England journal of medicine, 344 18
J. Regensteiner, T. Bauer, J. Reusch, S. Brandenburg, J. Sippel, Andria Vogelsong, Susan Smith, E. Wolfel, R. Eckel, W. Hiatt (1998)
Abnormal oxygen uptake kinetic responses in women with type II diabetes mellitus.Journal of applied physiology, 85 1
H. Yki-Järvinen, E. Helve, V. Koivisto (1987)
Hyperglycemia Decreases Glucose Uptake in Type I DiabetesDiabetes, 36
J. Helge, F. Dela (2003)
Effect of training on muscle triacylglycerol and structural lipids: a relation to insulin sensitivity?Diabetes, 52 8
G. Cooney, A. Thompson, S. Furler, Jiming Ye, E. Kraegen (2002)
Muscle Long‐Chain Acyl CoA Esters and Insulin ResistanceAnnals of the New York Academy of Sciences, 967
GI Shulman, DL Rothman, T Jue, P Stein, RA DeFronzo, RG Shulman (1990)
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non‐insulin‐dependent diabetes by 13C nuclear magnetic resonance spectroscopyExp Clin Endocrinol Diabetes, 322
Young-Bum Kim, S. Nikoulina, T. Ciaraldi, R. Henry, B. Kahn (1999)
Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes.The Journal of clinical investigation, 104 6
(1981)
Daily physical activity, work capacity and glucose tolerance in lean and obese normoglycaemic middleaged men
P. Schrauwen, M. Hesselink (2004)
Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes.Diabetes, 53 6
B Saltin (1973)
Metabolic fundamentals in exerciseTrends Enzyme Histochem Cytochem, 5
MD Michael, CR Kahn (2002)
Muscle MetabolismDiabetes
Paul Hogan, Tim Dall, Plamen, R E (1978)
American Diabetes AssociationDiabetes, 27
M. Charron, E. Katz, J. Zierath (1997)
Metabolic and molecular consequences of modifying GLUT4 expression in skeletal muscle.Biochemical Society transactions, 25 3
Mark Pereira, A. Kriska, M. Joswiak, G. Dowse, V. Collins, P. Zimmet, H. Gareeboo, P. Chitson, F. Hemraj, A. Purran, D. Fareed (1995)
Physical inactivity and glucose intolerance in the multiethnic island of Mauritius.Medicine and science in sports and exercise, 27 12
DA Hood, M Takahashi, MK Connor, D Freyssenet (2000)
Assembly of the cellular powerhouse: current issues in muscle mitochondrial biogenesisFASEB J, 28
(1996)
Diabetes 1996: Vital StatisticsDiabetes Care
D. Vavvas, A. Apazidis, A. Saha, J. Gamble, A. Patel, B. Kemp, L. Witters, N. Ruderman (1997)
Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle*The Journal of Biological Chemistry, 272
J. Holloszy (1967)
Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle.The Journal of biological chemistry, 242 9
J.T. Wang, L. Ho, K. Tang, L.M. Wang, Ydi Chen, G. Reaven (1989)
Effect of Habitual Physical Activity on Age‐Related Glucose IntoleranceJournal of the American Geriatrics Society, 37
Abraham Lee, P. Hansen, J. Holloszy (1995)
Wortmannin inhibits insulin‐stimulated but not contraction‐stimulated glucose transport activity in skeletal muscleFEBS Letters, 361
JO Holloszy, EF Coyle (1984)
Adaptations of skeletal muscle to endurance exercise and their metabolic consequencesJ Clin Invest, 56
H. Maegawa, Y. Shigeta, K. Egawa, M. Kobayashi (1991)
Impaired Autophosphorylation of Insulin Receptors From Abdominal Skeletal Muscles in Nonobese Subjects With NIDDMDiabetes, 40
GL Dohm (2002)
Invited review: Regulation of skeletal muscle GLUT‐4 expression by exerciseAm J Physiol, 93
PD Gollnick, B Saltin (1982)
Significance of skeletal muscle oxidative enzyme enhancement with endurance trainingJ Biol Chem, 2
JA Simoneau, DE Kelley (1997)
Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDMJ Biol Chem, 83
J Katoh, Y Hara, M Kurusu, J Miyaji, K Narutaki (1996)
Cardiorespiratory function as assessed by exercise testing in patients with non‐insulin‐dependent diabetes mellitusClin Physiol, 24
J. Katoh, Y. Hara, M. Kmvsu, J. Miyaji, K. Nabutaki (1996)
Cardiorespiratory Function as Assessed by Exercise Testing in Patients with Non-Insulin-Dependent Diabetes MellitusJournal of International Medical Research, 24
Richard Taylor, Parshu Ram, P. Zimmet, L. Raper, H. Ringrose (1984)
Physical activity and prevalence of diabetes in Melanesian and Indian men in FijiDiabetologia, 27
S Menzel (2002)
Genetic and molecular analyses of complex metabolic disorders: genetic linkageJ Appl Physiol, 967
B. Saltin, L. Rowell (1980)
Functional adaptations to physical activity and inactivity.Federation proceedings, 39 5
W. Garvey, L. Maianu, Jerry Hancock, A. Golichowski, A. Baron (1992)
Gene Expression of GLUT4 in Skeletal Muscle From Insulin-Resistant Patients With Obesity, IGT, GDM, and NIDDMDiabetes, 41
JJ Lehman, PM Barger, A Kovacs, JE Saffitz, DM Medeiros, DP Kelly (2000)
Peroxisome proliferator‐activated receptor γ coactivator‐1 promotes cardiac mitochondrial biogenesisExerc Sport Sci Rev, 106
M. Patti, A. Butte, Sarah Crunkhorn, K. Cusi, R. Berria, S. Kashyap, Y. Miyazaki, I. Kohane, M. Costello, Robert Saccone, E. Landaker, A. Goldfine, E. Mun, R. DeFronzo, J. Finlayson, C. Kahn, L. Mandarino (2003)
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1Proceedings of the National Academy of Sciences of the United States of America, 100
M. Pendergrass, J. Koval, C. Vogt, H. Yki-Jarvinen, P. Iozzo, R. Pipek, H. Ardehali, R. Printz, D. Granner, R. DeFronzo, L. Mandarino (1998)
Insulin-induced hexokinase II expression is reduced in obesity and NIDDM.Diabetes, 47 3
DO Clark (1997)
Physical activity efficacy and effectiveness among older adults and minoritiesObes Rev, 20
KJ Rodnick, WL Haskell, AL Swislocki, JE Foley, GM Reaven (1987)
Improved insulin action in muscle, liver, and adipose tissue in physically trained human subjectsDiabetes Care, 253
G. Cartee, A. Douen, T. Ramlal, A. Klip, J. Holloszy (1991)
Stimulation of glucose transport in skeletal muscle by hypoxia.Journal of applied physiology, 70 4
C. Bogardus, S. Lillioja, K. Stone, D. Mott (1984)
Correlation between muscle glycogen synthase activity and in vivo insulin action in man.The Journal of clinical investigation, 73 4
S. Lund, G. Holman, O. Schmitz, O. Pedersen (1995)
Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin.Proceedings of the National Academy of Sciences of the United States of America, 92 13
AL Beaudet, CR Scriver, WS Sly, D Valle (1995)
The Metabolic and Molecular Basis of Inherited DiseaseExerc Sport Sci Rev, 1
V. Hughes, M. Fiatarone, R. Fielding, B. Kahn, C. Ferrara, P. Shepherd, E. Fisher, R. Wolfe, D. Elahi, W. Evans (1993)
Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance.The American journal of physiology, 264 6 Pt 1
John Hawley (2002)
Proceedings of the Australian Physiological and Pharmacological Society Symposium: Integrative Physiology of Exercise ADAPTATIONS OF SKELETAL MUSCLE TO PROLONGED, INTENSE ENDURANCE TRAINING
AD Attie, CM Kendziorski (2003)
PGC‐1α at the crossroads of type 2 diabetesRev Physiol Biochem Pharmacol, 34
V. Mootha, C. Lindgren, K. Eriksson, A. Subramanian, S. Sihag, J. Lehár, P. Puigserver, E. Carlsson, M. Ridderstråle, E. Laurila, N. Houstis, M. Daly, N. Patterson, J. Mesirov, T. Golub, P. Tamayo, B. Spiegelman, E. Lander, J. Hirschhorn, D. Altshuler, L. Groop (2003)
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesNature Genetics, 34
E. Coyle (1984)
Adaptations of skeletal muscle to endurance exercise and their metabolic consequences.Journal of applied physiology: respiratory, environmental and exercise physiology, 56 4
R. Tunstall, K. Mehan, G. Wadley, G. Collier, A. Bonen, M. Hargreaves, D. Cameron-Smith (2002)
Exercise training increases lipid metabolism gene expression in human skeletal muscle.American journal of physiology. Endocrinology and metabolism, 283 1
L. Turcotte, E. Richter, B. Kiens (1992)
Increased plasma FFA uptake and oxidation during prolonged exercise in trained vs. untrained humans.The American journal of physiology, 262 6 Pt 1
(1999)
Effects of 7 days of exercise training on insulin action in morbidly obese men
H. Wallberg-Henriksson, J. Holloszy (1985)
Activation of glucose transport in diabetic muscle: responses to contraction and insulin.The American journal of physiology, 249 3 Pt 1
D. Clark (1997)
Physical Activity Efficacy and Effectiveness Among Older Adults and MinoritiesDiabetes Care, 20
Jan Henriksen, F. Alford, A. Handberg, A. Vaag, G. Ward, Anna Kalfas, H. Beck-Nielsen (1994)
Increased glucose effectiveness in normoglycemic but insulin-resistant relatives of patients with non-insulin-dependent diabetes mellitus. A novel compensatory mechanism.The Journal of clinical investigation, 94 3
ME Patti, AJ Butte, S Crunkhorn (2003)
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1Clin Exp Pharmacol Physiol, 100
M. Cruz-vidal, R. Costas, M. García-palmieri, P. Sorlie, E. Hertzmark (1979)
Factors Related to Diabetes Mellitus in Puerto Rican MenDiabetes, 28
Antonia Perez-Martin, E. Raynaud, J. Mercier (2001)
Insulin resistance and associated metabolic abnormalities in muscle: effects of exerciseObesity Reviews, 2
FW Booth, DB Thomason (1991)
Molecular and cellular adaptation of muscle in response to exercise: perspectives of various modelsJ Clin Invest, 71
A. Kriska (2003)
Can A Physically Active Lifestyle Prevent Type 2 Diabetes?Exercise and Sport Sciences Reviews, 31
MA Rodgers, C Yamamoto, DS King, JM Hagberg, AA Eshani, JO Holloszy (1988)
Improvements in glucose tolerance after 1 wk of exercise in patients with mild NIDDMArch Intern Med, 11
J Kang, RJ Robertson, JM Hagberg (1996)
Effect of exercise intensity on glucose and insulin metabolism in obese individuals and obese NIDDM patientsJ Appl Physiol, 19
Dang Qing
Effects of Diet and Exercise in Preventing NIDDM in People With Impaired Glucose Tolerance The
JA Houmard, CJ Tanner, CA Slentz, BD Duscha, JS McCartney, WE Kraus (2004)
The effect of the volume and intensity of exercise training on insulin sensitivityJ Biol Chem, 96
E. Henriksen, R. Bourey, K. Rodnick, L. Koranyi, M. Permutt, J. Holloszy (1990)
Glucose transporter protein content and glucose transport capacity in rat skeletal muscles.The American journal of physiology, 259 4 Pt 1
ZT Bloomgarden (1999)
American Diabetes Association Annual Meeting, 1998. Insulin resistance, exercise, and obesitySports Med, 22
J. Regensteiner, J. Sippel, Eric McFARLING, E. Wolfel, W. Hiatt (1995)
Effects of non-insulin-dependent diabetes on oxygen consumption during treadmill exercise.Medicine and science in sports and exercise, 27 6
(1999)
Effect of shortterm exercise training on insulin-stimulated PI 3-kinase activity in human skeletal muscle
A. Albright, M. Franz, G. Hornsby, A. Kriska, D. Marrero, I. Ullrich, L. Verity (2000)
American College of Sports Medicine position stand. Exercise and type 2 diabetes.Medicine and science in sports and exercise, 32 7
B. Kiens, Birgitta ESSEN-GUSTAVSSONt, Niels CHRISTENSENt, B. Saltin (1993)
Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training.The Journal of Physiology, 469
F Kanai, K Ito, M Todaka (1993)
Insulin‐stimulated GLUT4 translocation is relevant to the phosphorylation of IRS‐1 and the activity of PI3‐kinaseJ Clin Invest, 195
EW Kraegen, GJ Cooney, J Ye, AL Thompson (2001)
Triglycerides, fatty acids and insulin resistance‐hyperinsulinemiaJ Appl Physiol, 109
I. Irrcher, P. Adhihetty, Anna‐Maria Joseph, Vladimir Ljubicic, D. Hood (2003)
Regulation of Mitochondrial Biogenesis in Muscle by Endurance ExerciseSports Medicine, 33
C. Bruce, J. Hawley (2004)
Improvements in insulin resistance with aerobic exercise training: a lipocentric approach.Medicine and science in sports and exercise, 36 7
JG Regensteiner, J Sippel, ET McFarling, EE Wolfel, WR Hiatt (1995)
Effects of non‐insulin‐dependent diabetes on oxygen consumption during treadmill exerciseJ Clin Endocrin Metab, 27
K. Short, J. Vittone, Maureen Bigelow, D. Proctor, R. Rizza, Jill Coenen-Schimke, K. Nair (2003)
Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity.Diabetes, 52 8
L. Goodyear, B. Kahn (1998)
Exercise, glucose transport, and insulin sensitivity.Annual review of medicine, 49
Zhidan Wu, P. Puigserver, U. Andersson, Chenyu Zhang, G. Adelmant, V. Mootha, A. Troy, S. Cinti, B. Lowell, R. Scarpulla, B. Spiegelman (1999)
Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1Cell, 98
JG Eriksson (1999)
Exercise and the treatment of type 2 diabetes mellitus. An updateJ Appl Physiol, 27
M. Vukovich, P. Arciero, Wendy Kohrt, S. Racette, Polly Hansen, J. Holloszy (1996)
Changes in insulin action and GLUT-4 with 6 days of inactivity in endurance runners.Journal of applied physiology, 80 1
D Pette, HW Hofer (1980)
The constant proportion enzyme group concept in the selection of reference enzymes in metabolismProc Natl Acad Sci, 73
SK Gan, AD Kriketos, BA Ellis, CH Thompson, EE Kraegen, DJ Chisholm (2003)
Changes in Aerobic Capacity and Visceral Fat but not Myocyte Lipid Levels Predict Increased Insulin Action After Exercise in Overweight and Obese MenMed Sci Monit, 26
A. Attie, C. Kendziorski (2003)
PGC-1α at the crossroads of type 2 diabetesNature Genetics, 34
J. Simoneau, D. Kelley (1997)
Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM.Journal of applied physiology, 83 1
Marialice Kern (1990)
Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level.The Biochemical journal, 270 2
JE Henriksen, F Alford, A Handberg (1994)
Increased glucose effectiveness in normoglycemic but insulin‐resistant relatives of patients with non‐insulin‐dependent diabetes mellitus. A novel compensatory mechanismJ Biol Chem, 94
J. Hawley, J. Zierath (2004)
Integration of Metabolic and Mitogenic Signal Transduction in Skeletal MuscleExercise and Sport Sciences Reviews, 32
O Pinhas‐Hamiel, P Zeitler (1996)
Insulin resistance, obesity, and related disorders among black adolescentsN Engl J Med, 129
J. McGarry (2002)
Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes.Diabetes, 51 1
Z. Yan, S. Salmons, J. Jarvis, F. Booth (1995)
Increased muscle carnitine palmitoyltransferase II mRNA after increased contractile activity.The American journal of physiology, 268 2 Pt 1
L. Goodyear (2000)
AMP‐Activated Protein Kinase: A Critical Signaling Intermediary for Exercise‐Stimulated Glucose Transport?Exercise and Sport Sciences Reviews, 28
A. Kriska, Ronald Laporte, D. Pettitt, M. Charles, R. Nelson, L. Kuller, P. Bennett, W. Knowler (1993)
The association of physical activity with obesity, fat distribution and glucose intolerance in Pima IndiansDiabetologia, 36
R. Bonadonna, S. Prato, E. Bonora, M. Saccomani, G. Gulli, A. Natali, S. Frascerra, N. Pecori, E. Ferrannini, D. Bier, C. Cobelli, R. DeFronzo (1996)
Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM.Diabetes, 45 7
B Cheatham, CJ Vlahos, L Cheatham, L Wang, J Blenis, CR Kahn
Phosphatidylinositol 3‐kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocationJ Clin Invest, 14
GD Cartee, AG Douen, T Ramlal, A Klip, JO Holloszy (1991)
Stimulation of glucose transport in skeletal muscle by hypoxiaMol Cell Biol, 70
SN Blair, HW Kohl, NF Gordon, RS Paffenbarger (1992)
How much physical activity is good for health?Sports Med, 13
J. Kirwan, M. Jing (2002)
Modulation of Insulin Signaling in Human Skeletal Muscle in Response to ExerciseExercise and Sport Sciences Reviews, 30
C. Leibson, D. Williamson, L. Iii, P. Palumbo, Steven Smith, J. Ransom, Peter Schilling, K. Narayan, C. Leibson (2001)
Temporal trends in BMI among adults with diabetes.Diabetes care, 24 9
R. DeFronzo, E. Jacot, E. Jéquier, E. Maeder, J. Wahren, J. Felber (1981)
The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous CatheterizationDiabetes, 30
XR Pan, GW Li, YH Hu (1997)
Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes StudyExerc Sport Sci Rev, 20
K. Petersen, S. Dufour, D. Befroy, R. Garcia, G. Shulman (2004)
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.The New England journal of medicine, 350 7
GE Duncan, MG Perri, DW Theriaque, AD Hutson, RH Eckel, PW Stacpoole (2003)
Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adultsJ Clin Invest, 26
P Poirier, A Tremblay, T Broderick, C Catellier, G Tancrede, A Nadeau (2002)
Impact of moderate aerobic exercise training on insulin sensitivity in type 2 diabetic men treated with oral hypoglycemic agents: is insulin sensitivity enhanced only in nonobese subjects?Biochem Soc Trans, 8
S. Gan, A. Kriketos, B. Ellis, C. Thompson, E. Kraegen, D. Chisholm (2003)
Changes in aerobic capacity and visceral fat but not myocyte lipid levels predict increased insulin action after exercise in overweight and obese men.Diabetes care, 26 6
JT Wang, LT Ho, KT Tang, LM Wang, YD Chen, GM Reaven (1989)
Effect of habitual physical activity on age‐related glucose intoleranceN Engl J Med, 37
M Trovati, Q Carta, F Cavalot (1984)
Influence of physical training on blood glucose control, glucose tolerance, insulin secretion, and insulin action in non‐insulin‐dependent diabetic patientsExerc Sport Sci Rev, 7
GF Fletcher, SN Blair, J Blumenthal (1992)
Statement on exercise. Benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart associationFEBS Lett, 86
H Wallberg‐Henriksson, JO Holloszy (1985)
Activation of glucose transport in diabetic muscle: responses to contraction and insulinJ Biol Chem, 249
F. Dela, T. Ploug, A. Handberg, L. Petersen, J. Larsen, K. Mikines, H. Galbo (1994)
Physical Training Increases Muscle GLUT4 Protein and mRNA in Patients With NIDDMDiabetes, 43
P. MacLean, D. Zheng, L. Dohm (2000)
Muscle Glucose Transporter (GLUT 4) Gene Expression during ExerciseExercise and Sport Sciences Reviews, 28
K. Mikines, B. Sonne, B. Tronier, Henrik Galbo (1989)
Effects of training and detraining on dose-response relationship between glucose and insulin secretion.The American journal of physiology, 256 5 Pt 1
P. Gollnick, B. Saltin (1982)
Significance of skeletal muscle oxidative enzyme enhancement with endurance training.Clinical physiology, 2 1
JR Zierath (2002)
Invited review: Exercise training‐induced changes in insulin signalling in skeletal muscleBiochem J, 93
S Lund, GD Holman, O Schmitz, O Pedersen (1995)
Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulinBiochem Biophys Res Commun, 92
Ralph, A. DeFronzo, Roif Gunnarsson, Ola Bjorkman, Maggie Olason, J. Wahren (1985)
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.The Journal of clinical investigation, 76 1
J. Ivy (2002)
Exercise Training and Muscle Insulin Resistance: Cellular Adaptations
J. Eriksson, L. Koranyi, R. Bourey, C. Schalin-Jäntti, E. Widén, M. Mueckler, A. Permutt, L. Groop (1992)
Insulin resistance in Type 2 (non-insulin-dependent) diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter (GLUT-4) gene in human skeletal muscleDiabetologia, 35
A Kriska (2003)
Can a physically active lifestyle prevent type 2 diabetes?Clin Physiol Funct Imaging, 31
E. Richter, L. Garetto, M. Goodman, N. Ruderman (1984)
Enhanced muscle glucose metabolism after exercise: modulation by local factors.The American journal of physiology, 246 6 Pt 1
M Fluck, H Hoppeler (2003)
Molecular basis of skeletal muscle plasticity‐from gene to form and functionJ Appl Physiol, 146
L. Oscai, J. Holloszy (1971)
Biochemical adaptations in muscle. II. Response of mitochondrial adenosine triphosphatase, creatine phosphokinase, and adenylate kinase activities in skeletal muscle to exercise.The Journal of biological chemistry, 246 22
M Björnholm, Y Kawano, M Lehtihet, JR Zierath (1997)
Insulin receptor substrate‐1 phosphorylation and phosphatidylinositol 3‐kinase activity are decreased in skeletal muscle from NIDDM subjects following in vivo insulin stimulationDiabetologia, 46
J. Devlin, M. Hirshman, E. Horton, E. Horton (1987)
Enhanced Peripheral and Splanchnic Insulin Sensitivity in NIDDM Men After Single Bout of ExerciseDiabetes, 36
KF Peterson, S Dufour, D Befroy, R Garcia, GI Shulman (2004)
Impaired mitochondrial activity in the insulin‐resistant offspring of patients with type 2 diabetesNat Genet, 350
YB Kim, SE Nikoulina, TP Ciaraldi, RR Henry, BB Kahn (1999)
Normal insulin‐dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3‐kinase, in muscle in type 2 diabetesAm J Physiol, 104
M. Duchen (2004)
Roles of mitochondria in health and disease.Diabetes, 53 Suppl 1
J Cederholm, L Wibell (1985)
Glucose tolerance and physical activity in a health survey of middle‐aged subjectsDiabetes Care, 217
LJ Goodyear, F Giorgino, LA Sherman, J Carey, RJ Smith, GL Dohm (1995)
Insulin receptor phosphorylation, insulin receptor substrate‐1 phosphorylation, and phosphatidylinositol 3‐kinase activity are decreased in intact skeletal muscle strips from obese subjectsJ Appl Physiol, 95
M. Uusitupa, V. Lindi, A. Louheranta, T. Salopuro, J. Lindström, J. Tuomilehto (2003)
Long-term improvement in insulin sensitivity by changing lifestyles of people with impaired glucose tolerance: 4-year results from the Finnish Diabetes Prevention Study.Diabetes, 52 10
Z Yan, S Salmons, J Jarvis, FW Booth (1995)
Increased muscle carnitine palmitoyltransferase II mRNA after increased contractile activityN Engl J Med, 268
Samar Itani, N. Ruderman, Frank Schmieder, G. Boden (2002)
Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-αDiabetes, 51
B. Kiens, S. Kristiansen, P. Jensen, E. Richter, L. Turcotte (1997)
Membrane associated fatty acid binding protein (FABPpm) in human skeletal muscle is increased by endurance training.Biochemical and biophysical research communications, 231 2
A. Kriska, M. Pereira, R. Hanson, M. Courten, P. Zimmet, K. Alberti, P. Chitson, P. Bennett, K. Narayan, W. Knowler (2001)
Association of physical activity and serum insulin concentrations in two populations at high risk for type 2 diabetes but differing by BMI.Diabetes care, 24 7
P. Poirier, A. Tremblay, T. Broderick, C. Catellier, G. Tancrède, A. Nadeau (2002)
Impact of moderate aerobic exercise training on insulin sensitivity in type 2 diabetic men treated with oral hypoglycemic agents: is insulin sensitivity enhanced only in nonobese subjects?Medical science monitor : international medical journal of experimental and clinical research, 8 2
S. Menzel (2002)
Genetic and Molecular Analyses of Complex Metabolic Disorders: Genetic LinkageAnnals of the New York Academy of Sciences, 967
F. Giorgino (2002)
Defects in Intermediate Insulin Signaling in Skeletal Muscle: Phosphatidylinositol (Pi) 3-Kinase And Glucose Transport
CR Bruce, MJ Anderson, AL Carey (2003)
Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid statusBiochem Biophys Res Commun, 88
HA Koistinen, AV Chibalin, JR Zierath (2003)
Aberrant p38 mitogen‐activated protein kinase signalling in skeletal muscle from Type 2 diabetic patientsDiabetes Care, 46
CR Bruce, AD Kriketos, GJ Cooney, JA Hawley (2004)
Dissociation of muscle triglyceride content and insulin action after exercise training in patients with type 2 diabetesJ Appl Physiol, 47
E. Kraegen, G. Cooney, Jiming Ye, A. Thompson (2001)
Triglycerides, fatty acids and insulin resistance--hyperinsulinemia.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 109 4
JR Zierath, H Wallberg‐Henriksson (2002)
From receptor to effector: insulin signal transduction in skeletal muscle from type II diabetic patientsAm J Physiol, 967
A. Krook, R. Roth, X. Jiang, J. Zierath, H. Wallberg-Henriksson (1998)
Insulin-Stimulated Akt Kinase Activity Is Reduced in Skeletal Muscle From NIDDM SubjectsDiabetes, 47
M. Rogers, C. Yamamoto, D. King, J. Hagberg, A. Ehsani, J. Holloszy (1988)
Improvement in Glucose Tolerance After 1 Wk of Exercise in Patients With Mild NIDDMDiabetes Care, 11
H. Koistinen, D. Galuska, A. Chibalin, Jing Yang, J. Zierath, G. Holman, H. Wallberg-Henriksson (2003)
5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes.Diabetes, 52 5
J. Wojtaszewski, B. Hansen, Jon Gade, B. Kiens, J. Markuns, L. Goodyear, E. Richter (2000)
Insulin signaling and insulin sensitivity after exercise in human skeletal muscle.Diabetes, 49 3
K. Højlund, P. Staehr, B. Hansen, K. Green, D. Hardie, E. Richter, H. Beck-Nielsen, J. Wojtaszewski (2003)
Increased phosphorylation of skeletal muscle glycogen synthase at NH2-terminal sites during physiological hyperinsulinemia in type 2 diabetes.Diabetes, 52 6
D. Seals, J. Hagberg, W. Allen, B. Hurley, G. Dalsky, A. Ehsani, J. Holloszy (1984)
Glucose tolerance in young and older athletes and sedentary men.Journal of applied physiology: respiratory, environmental and exercise physiology, 56 6
FW Booth, MV Chakravarthy, SE Gordon, EE Spangenburg (2002)
Waging war on physical inactivity: using modern molecular ammunition against an ancient enemyDiabetes Care, 93
W. Knowler, E. Barrett-Connor, S. Fowler, R. Hamman, J. Lachin, Elizabeth Walker, David Nathan (2002)
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.The New England journal of medicine, 346 6
D. Roith, Y. Zick (2001)
Recent advances in our understanding of insulin action and insulin resistance.Diabetes care, 24 3
Jian-Ming RenS, Clay SemenkovichO, E. Gulve, Jiaping Gao, John Holloszfl (1994)
Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscle.The Journal of biological chemistry, 269 20
C Schmitz‐Peiffer (2002)
Protein kinase C and lipid‐induced insulin resistance in skeletal muscleMed Sci Sports, 967
FW Booth, MV Chakravarthy, EE Spangenburg (2002)
Exercise and gene expression: physiological regulation of the human genome through physical activityN Engl J Med, 543
JA Hawley, JR Zierath (2004)
Integration of metabolic and mitogenic signal transduction in skeletal muscleProc Natl Acad Sci, 32
H. King, P. Zimmet, L. Raper, B. Balkau (1984)
Risk factors for diabetes in three Pacific populations.American journal of epidemiology, 119 3
S. Schneider, L. Amorosa, A. Khachadurian, N. Ruderman (1984)
Studies on the mechanism of improved glucose control during regular exercise in Type 2 (non-insulin-dependent) diabetesDiabetologia, 26
J. Cederholm, L. Wibell (2009)
Glucose tolerance and physical activity in a health survey of middle-aged subjects.Acta medica Scandinavica, 217 4
Xiao-ren Pan, Guang-wei Li, Ying-hua Hu, Ji Wang, Wen–ying Yang, Zuo An, Ze-xi Hu, Juan Lin, Jian-zhong Xiao, H. Cao, Ping Liu, Xi Jiang, Yayun Jiang, Jin Wang, Hui-E Zheng, Hui Zhang, P. Bennett, B. Howard (1997)
Effects of Diet and Exercise in Preventing NIDDM in People With Impaired Glucose Tolerance: The Da Qing IGT and Diabetes StudyDiabetes Care, 20
F. Booth, D. Thomason (1991)
Molecular and cellular adaptation of muscle in response to exercise: perspectives of various models.Physiological reviews, 71 2
E. Gregg, R. Gerzoff, C. Caspersen, D. Williamson, K. Narayan (2003)
Relationship of walking to mortality among US adults with diabetes.Archives of internal medicine, 163 12
J. Bak, Uffe Jacobsen, Fritz Jorgensen, Oluf Pedersen (1989)
Insulin receptor function and glycogen synthase activity in skeletal muscle biopsies from patients with insulin-dependent diabetes mellitus: effects of physical training.The Journal of clinical endocrinology and metabolism, 69 1
D. Dunstan, P. Zimmet, T. Welborn, M. Courten, A. Cameron, R. Sicree, T. Dwyer, S. Colagiuri, D. Jolley, M. Knuiman, R. Atkins, J. Shaw (2002)
The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study.Diabetes care, 25 5
D. Hood (2001)
Invited Review: contractile activity-induced mitochondrial biogenesis in skeletal muscle.Journal of applied physiology, 90 3
E. Richter, L. Garetto, M. Goodman, N. Ruderman, E. Memorial (1982)
Muscle glucose metabolism following exercise in the rat: increased sensitivity to insulin.The Journal of clinical investigation, 69 4
EA Richter, LP Garetto, MN Goodman, NB Ruderman (1982)
Muscle glucose metabolism following exercise in the rat: increased sensitivity to insulinFEBS Lett, 69
F. Kanai, K. Ito, M. Todaka, H. Hayashi, S. Kamohara, K. Ishii, T. Okada, O. Hazeki, M. Ui, Y. Ebina (1993)
Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase.Biochemical and biophysical research communications, 195 2
M. Trovati, Q. Carta, F. Cavalot, S. Vitali, C. Banaudi, P. Lucchina, Franco Fiocchi, G. Emanuelli, G. Lenti (1984)
Influence of Physical Training on Blood Glucose Control, Glucose Tolerance, Insulin Secretion, and Insulin Action in Non-insulin-dependent Diabetic PatientsDiabetes Care, 7
J. Zierath (1995)
In vitro studies of human skeletal muscle: hormonal and metabolic regulation of glucose transport.Acta physiologica Scandinavica. Supplementum, 626
B. Cheatham, C. Vlahos, L. Cheatham, Lois Wang, J. Blenis, C. Kahn (1994)
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocationMolecular and Cellular Biology, 14
Lawrence Mandanno, Kimberly Wright, Larry Verity, Jeanne Nichols, Jo Bell, O. Kolterman, Henning Beck-Nielsen (1987)
Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolism.The Journal of clinical investigation, 80 3
C. Schmitz‐Peiffer (2002)
Protein Kinase C and Lipid‐Induced Insulin Resistance in Skeletal MuscleAnnals of the New York Academy of Sciences, 967
P. Molé, L. Oscai, J. Holloszy (1971)
Adaptation of muscle to exercise. Increase in levels of palmityl Coa synthetase, carnitine palmityltransferase, and palmityl Coa dehydrogenase, and in the capacity to oxidize fatty acids.The Journal of clinical investigation, 50 11
W. Garvey, L. Maianu, Ju-Hong Zhu, G. Brechtel-Hook, Penny Wallace, Alain Baron (1998)
Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance.The Journal of clinical investigation, 101 11
J. Friedman, W. Sherman, M. Reed, Charles Eiton, G. Dohm (1990)
Exercise training increases glucose transporter protein GLUT‐4 in skeletal muscle of obese Zucker (fa/fa) ratsFEBS Letters, 268
B. Goodpaster, A. Katsiaras, D. Kelley (2003)
Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity.Diabetes, 52 9
A Albright, M Franz, G Hornsby (2002)
American College of Sports Medicine Position stand: Exercise and type 2 diabetesDiabetes Care, 32
A Perez‐Martin, E Raynaud, J Mercier (2001)
Insulin resistance and associated metabolic abnormalities in muscle: effects of exerciseAnnu Rev Med, 2
A. Russell, J. Feilchenfeldt, Sylvia Schreiber, M. Praz, Antoinette Crettenand, C. Gobelet, C. Meier, D. Bell, A. Kralli, J. Giacobino, O. Deriaz (2003)
Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle.Diabetes, 52 12
D. Kelley, Jing He, Elizabeth Menshikova, V. Ritov (2002)
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes.Diabetes, 51 10
G. Dowse, H. Gareeboo, P. Zimmet, K. Alberti, J. Tuomilehto, D. Fareed, L. Brissonnette, C. Finch (1990)
High Prevalence of NIDDM and Impaired Glucose Tolerance in Indian, Creole, and Chinese MauritiansDiabetes, 39
(2004)
Diabetes Prevention Program Research Group
R Weiss, J Dziura, TS Burgert (2004)
Obesity and the metabolic syndrome in children and adolescentsN Engl J Med, 350
WC Knowler, E Barrett‐Connor, SE Fowler (2002)
Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metforminMed Sci Sports Exerc, 346
JM Ren, CF Semenkovich, EA Gulve, J Gao, JO Holloszy (1994)
Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin‐stimulated glycogen storage in muscleJ Clin Invest, 269
F. Booth, M. Chakravarthy, E. Spangenburg (2002)
Exercise and gene expression: physiological regulation of the human genome through physical activityThe Journal of Physiology, 543
G. Dohm (2002)
Invited review: Regulation of skeletal muscle GLUT-4 expression by exercise.Journal of applied physiology, 93 2
D. Kelley, M. Mokáň, L. Mandarino (1992)
Intracellular Defects in Glucose Metabolism in Obese Patients With NIDDMDiabetes, 41
(1992)
programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology
G. Shulman, D. Rothman, T. Jue, P. Stein, R. DeFronzo, R. Shulman (1990)
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.The New England journal of medicine, 322 4
K. Rodnick, W. Haskell, A. Swislocki, J. Foley, G. Reaven (1987)
Improved insulin action in muscle, liver, and adipose tissue in physically trained human subjects.The American journal of physiology, 253 5 Pt 1
EA Richter, LP Garetto, MN Goodman, NB Ruderman (1984)
Enhanced muscle glucose metabolism after exercise: modulation by local factorsExerc Sport Sci Rev, 246
S. Coort, D. Hasselbaink, D. Koonen, J. Willems, W. Coumans, A. Chabowski, G. Vusse, A. Bonen, J. Glatz, J. Luiken (2004)
Enhanced sarcolemmal FAT/CD36 content and triacylglycerol storage in cardiac myocytes from obese zucker rats.Diabetes, 53 7
LJ Mandarino, KS Wright, LS Verity (1987)
Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolismAnn N Y Acad Sci, 80
P. Zimmet, S. Faaiuso, J. Ainuu, S. Whitehouse, B. Milne, W. Deboer (1981)
The Prevalence of Diabetes in the Rural and Urban Polynesian Population of Western SamoaDiabetes, 30
S. Blair, Harold Kohl, N. Gordon, R. Paffenbarger (1992)
How much physical activity is good for health?Annual review of public health, 13
WT Garvey, L Maianu, JH Zhu, G Brechtel‐Hook, P Wallace, AD Baron (1998)
Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistanceAm J Physiol Endocrinol Metab, 101
VK Mootha, CM Lindgren, KF Eriksson (2003)
PGC‐1α‐responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesPhysiol Rev, 34
J. Ryder, Jing Yang, D. Galuska, J. Rincón, M. Björnholm, A. Krook, S. Lund, O. Pedersen, H. Wallberg-Henriksson, J. Zierath, G. Holman (2000)
Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients.Diabetes, 49 4
J. Dorrestijn, D. Ouwens, N. Berghe, J. Bos, J. Maassen (1996)
Expression of a dominant-negative Ras mutant does not affect stimulation of glucose uptake and glycogen synthesis by insulinDiabetologia, 39
J. Hirosumi, Gurol Tuncman, Lufen Chang, Cem Görgün, K. Uysal, K. Maeda, M. Karin, G. Hotamisligil (2002)
A central role for JNK in obesity and insulin resistanceNature, 420
M. Harris, K. Flegal, C. Cowie, M. Eberhardt, D. Goldstein, R. Little, H. Wiedmeyer, D. Byrd-Holt (1998)
Prevalence of Diabetes, Impaired Fasting Glucose, and Impaired Glucose Tolerance in U.S. Adults: The Third National Health and Nutrition Examination Survey, 1988–1994Diabetes Care, 21
DR Seals, JM Hagberg, WK Allen (1984)
Glucose tolerance in young and older athletes and sedentary menDiabetes Care, 56
J. Holloszy, L. Oscai, I. Don, P. Molé (1970)
Mitochondrial citric acid cycle and related enzymes: adaptive response to exercise.Biochemical and biophysical research communications, 40 6
B. Saltin (1973)
Metabolic fundamentals in exercise.Medicine and science in sports, 5 3
O. Pinhas‐Hamiel, P. Zeitler (1996)
Insulin resistance, obesity, and related disorders among black adolescents.The Journal of pediatrics, 129 3
F. Dela, J. Larsen, K. Mikines, T. Ploug, L. Petersen, H. Galbo (1995)
Insulin-Stimulated Muscle Glucose Clearance in Patients With NIDDM: Effects of One-Legged Physical TrainingDiabetes, 44
F. Booth, M. Chakravarthy, S. Gordon, E. Spangenburg (2002)
Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy.Journal of applied physiology, 93 1
J Tuomilehto, J Lindstrom, JG Eriksson (2001)
Finnish Diabetes Prevention Study Group. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose toleranceDiabetes Care, 344
J. Houmard, C. Tanner, C. Slentz, B. Duscha, Jennifer McCartney, W. Kraus (2004)
Effect of the volume and intensity of exercise training on insulin sensitivity.Journal of applied physiology, 96 1
E. Kraegen, G. Cooney, Jiming Ye, A. Thompson, S. Furler (2002)
Fatty Acids and Muscle Insulin Resistance
BL Nyomba, VM Ossowski, C Bogardus, DM Mott (1990)
Insulin‐sensitive tyrosine kinase: relationship with in vivo insulin action in humansJ Clin Exerc Physiol, 258
M. Michael, C. Kahn (2002)
Defects in Early Insulin Signaling in Skeletal Muscle
JH Warram, SS Rich, AS Krolewski (1995)
Joslin's Diabetes MellitusDiabetes Care
G. Duncan, M. Perri, D. Theriaque, A. Hutson, R. Eckel, P. Stacpoole (2003)
Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults.Diabetes care, 26 3
CR Bruce, JA Hawley (2004)
Improvements in insulin resistance with aerobic exercise training: a lipocentric approachJ Int Med Res, 36
Laurie Goodyear, Francesco Giorgino, L. Sherman, Julie Carey, Robert Smith, G. Dohm (1995)
Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.The Journal of clinical investigation, 95 5
MJ Charron, EB Katz, JR Zierath (1997)
Metabolic and molecular consequences of modifying GLUT4 expression in skeletal muscleJ Clin Invest, 25
K. Baar, A. Wende, T. Jones, Matthew Marison, L. Nolte, May Chen, D. Kelly, J. Holloszy (2002)
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC‐1The FASEB Journal, 16
K. West (1978)
Epidemiology of diabetes and its vascular lesions
J. Zierath, T. Tsao, A. Stenbit, J. Ryder, D. Galuska, M. Charron (1998)
Restoration of Hypoxia-stimulated Glucose Uptake in GLUT4-deficient Muscles by Muscle-specific GLUT4 Transgenic Complementation*The Journal of Biological Chemistry, 273
J. Eriksson (1999)
Exercise and the Treatment of Type 2 Diabetes MellitusSports Medicine, 27
H. Wallberg-Henriksson (1987)
Glucose transport into skeletal muscle. Influence of contractile activity, insulin, catecholamines and diabetes mellitus.Acta physiologica Scandinavica. Supplementum, 564
J. Zierath, H. Wallberg-Henriksson (2002)
From Receptor to Effector: Insulin Signal Transduction in Skeletal Muscle from Type II Diabetic PatientsAnnals of the New York Academy of Sciences, 967
A. Krook, I. Holm, Solveig Pettersson, H. Wallberg-Henriksson (2003)
Reduction of risk factors following lifestyle modification programme in subjects with type 2 (non‐insulin dependent) diabetes mellitusClinical Physiology and Functional Imaging, 23
B. Hurley, P. Nemeth, W. Martin, J. Hagberg, G. Dalsky, J. Holloszy (1986)
Muscle triglyceride utilization during exercise: effect of training.Journal of applied physiology, 60 2
JL Ivy, TW Zderic, DL Fogt (1999)
Prevention and treatment of non‐insulin‐dependent diabetes mellitusDiabetes, 27
MA Pereira, AM Kriska, ML Joswiak (1995)
Physical inactivity and glucose intolerance in the multiethnic island of MauritiusJ Physiol, 27
JR Zierath (1995)
In vitro studies of human skeletal muscle: hormonal and metabolic regulation of glucose transportJ Clin Endocrinol Metab, 626
KJ Mikines, B Sonne, B Tronier, H Galbo (1989)
Effects of training and detraining on dose‐response relationship between glucose and insulin secretionN Engl J Med, 256
J. McGarry (2001)
Dysregulation of Fatty Acid Metabolism in the Etiology of Type 2 Diabetes
Jie Kang, R. Robertson, J. Hagberg, D. Kelley, F. Goss, S. Dasilva, R. Suminski, A. Utter (1996)
Effect of Exercise Intensity on Glucose and Insulin Metabolism in Obese Individuals and Obese NIDDM PatientsDiabetes Care, 19
D. Hood, Mark Takahashi, M. Connor, D. Freyssenet (2000)
Assembly of the Cellular Powerhouse: Current Issues in Muscle Mitochondrial BiogenesisExercise and Sport Sciences Reviews, 28
J. Regensteiner, S. Shetterly, E. Mayer, R. Eckel, W. Haskell, J. Baxter, R. Hamman (1995)
Relationship Between Habitual Physical Activity and Insulin Area Among Individuals With Impaired Glucose Tolerance: The San Luis Valley Diabetes StudyDiabetes Care, 18
A. Krook, M. Björnholm, D. Galuska, X. Jiang, Roger Fahlman, Martin Myers, H. Wallberg-Henriksson, J. Zierath (2000)
Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients.Diabetes, 49 2
JO Holloszy (1967)
Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscleJ Appl Physiol, 242
K Cusi, K Maezono, A Osman (2000)
Insulin resistance differentially affects the PI 3‐kinase‐ and MAP kinase‐mediated signalling in human muscleAm J Physiol, 105
C. Bruce, Mitchell Anderson, A. Carey, D. Newman, A. Bonen, A. Kriketos, G. Cooney, J. Hawley (2003)
Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status.The Journal of clinical endocrinology and metabolism, 88 11
B. Nyomba, V. Ossowski, C. Bogardus, D. Mott (1990)
Insulin-sensitive tyrosine kinase: relationship with in vivo insulin action in humans.The American journal of physiology, 258 6 Pt 1
E. Henriksen (2002)
Invited review: Effects of acute exercise and exercise training on insulin resistance.Journal of applied physiology, 93 2
JA Hawley (2002)
Adaptations of skeletal muscle to prolonged, intense endurance trainingAm J Physiol, 29
D. Pette, H. Hofer (2008)
The constant proportion enzyme group concept in the selection of reference enzymes in metabolism.Ciba Foundation symposium, 73
M. Flück, H. Hoppeler (2003)
Molecular basis of skeletal muscle plasticity--from gene to form and function.Reviews of physiology, biochemistry and pharmacology, 146
G. Boden (1997)
Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDMDiabetes, 46
K Baar, AR Wende, TE Jones (2002)
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC‐1Nutr Biochem, 16
J. Manson, M. Stampfer, M. Stampfer, G. Colditz, G. Colditz, W. Willett, W. Willett, B. Rosner, B. Rosner, C. Hennekens, C. Hennekens, F. Speizer, E. Rimm, A. Krolewski (1991)
Physical activity and incidence of non-insulin-dependent diabetes mellitus in womenThe Lancet, 338
Tatsuya Hayashi, J. Wojtaszewski, L. Goodyear (1997)
Exercise regulation of glucose transport in skeletal muscle.The American journal of physiology, 273 6
FW Booth, KM Baldwin (1997)
Handbook of Physiology, Section 12, Exercise Regulation and Integration of Multiple SystemsExerc Sport Sci Rev
Z. Bloomgarden (1999)
American Diabetes Association Annual Meeting, 1998. Insulin resistance, exercise, and obesity.Diabetes care, 22 3
MI Harris, KM Flegal, CC Cowie (1998)
Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The third national health and nutrition examination survey, 1988–1994J Pediatr, 21
EW Gregg, RB Gerzoff, CJ Caspersen, DF Williamson, KM Narayan (2003)
Relationship of walking to mortality among US adults with diabetesExerc Sport Sci Rev, 163
During the past half‐century, there has been a dramatic increase in the incidence of obesity, insulin resistance and type 2 diabetes. A hallmark feature of these conditions is impaired glucose tolerance (IGT). Cross‐sectional and retrospective epidemiological studies have provided direct evidence that a lack of physical activity is strongly associated with IGT. Indeed, physical inactivity is an independent risk factor for insulin resistance and type 2 diabetes. The primary defect(s) in the development of whole‐body insulin resistance remain unclear. However, during the past decade significant progress has been made towards an understanding of the molecular basis underlying the beneficial effects of exercise training in stimulating the entry of glucose into insulin‐sensitive tissues. Accordingly, it is now well accepted that regular physical exercise offers an effective therapeutic intervention to improve insulin action in skeletal muscle in insulin‐resistant individuals. This review provides evidence that physical inactivity is significantly associated with IGT and directly contributes to the cascade of events that lead to the expression of the ‘exercise‐deficient phenotype’ associated with insulin resistance and type 2 diabetes. In contrast, exercise training will be shown to significantly reduce the risk of developing insulin resistance by improving glucose tolerance and insulin action in individuals predisposed to develop type 2 diabetes. Several putative mechanisms for enhanced glucose uptake after exercise training will be discussed. A determination of the underlying biological mechanisms that result from exercise training is essential in order to define the precise variations in physical activity that result in the most desired effects on targeted risk factors, and to aid in the development of such interventions. Copyright © 2004 John Wiley & Sons, Ltd.
Diabetes/Metabolism: Research and Reviews – Wiley
Published: Sep 1, 2004
Keywords: ; ; ; ; ; ;
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