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D. Wayner, G. Burton, K. Ingold, L. Barclay, S. Locke (1987)
The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma.Biochimica et biophysica acta, 924 3
B. Frei, L. England, B. Ames (1989)
Ascorbate is an outstanding antioxidant in human blood plasma.Proceedings of the National Academy of Sciences of the United States of America, 86 16
D. Steinberg, S. Parthasarathy, T. Carew, J. Khoo, J. Witztum (1989)
Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.The New England journal of medicine, 320 14
Tolonen Tolonen, Sarna Sarna, Halme Halme (1988)
Antioxidant supplementation decreases TBA reactants in serum elderlyBiol Trace Elem Res, 17
S. Glantz (1981)
Primer of biostatistics : statistical software program version 6.0
Tolonen Tolonen, Halme Halme, Sarna Sarna (1985)
Vitamin E and selenium supplementation in geriatric patientsBiol Trace Elem Res, 7
Eduardo Ehrenwald, G. Chisolm, Paul Fox (1994)
Intact human ceruloplasmin oxidatively modifies low density lipoprotein.The Journal of clinical investigation, 93 4
(1992)
Nutrition in the Elderly: The Boston Nutrition Survey
Hans Nohl (1993)
Involvement of free radicals in ageing: a consequence or cause of senescence.British medical bulletin, 49 3
E. Niki (1987)
Interaction of ascorbate and alpha-tocopherol.Annals of the New York Academy of Sciences, 498
Dillard Dillard, Tappel Tappel (1984)
Fluorescent products of lipid peroxidationMethods Enzymol, 105
B. Lee, S. Chua, H. Ong, C. Ong (1992)
High-performance liquid chromatographic method for routine determination of vitamins A and E and β-carotene in plasmaJournal of Chromatography B: Biomedical Sciences and Applications, 581
C. Dillard, A. Tappel (1984)
[41] Fluorescent damage products of lipid peroxidationMethods in Enzymology, 105
R. Sohal (1993)
The free radical hypothesis of aging: An appraisal of the current statusAging Clinical and Experimental Research, 5
J. Morley (1992)
THE RESURGENCE OF FREE RADICALSJournal of the American Geriatrics Society, 40
A. Reunanen, P. Knekt, R. Aaran (1992)
Serum ceruloplasmin level and the risk of myocardial infarction and stroke.American journal of epidemiology, 136 9
E. Niki (1987)
Interaction of Ascorbate and α‐TocopherolAnnals of the New York Academy of Sciences, 498
V. Samokyszyn, D. Miller, D. Reif, S. Aust (1989)
Inhibition of superoxide and ferritin-dependent lipid peroxidation by ceruloplasmin.The Journal of biological chemistry, 264 1
R. Russell, P. Suter (1993)
Vitamin requirements of elderly people: an update.The American journal of clinical nutrition, 58 1
J. Smith, A. Wickiser, L. Korth, A. Grandjean, A. Schaefer (1984)
Nutritional status of an institutionalized aged population.Journal of the American College of Nutrition, 3 1
B. Day, D. Williams, C. Marsh (1979)
A rapid manual method for routine assay of ascorbic acid in serum and plasma.Clinical biochemistry, 12 1
H. Baker, O. Frank, I. Thind, Seymour Jaslow, D. Louria (1979)
Vitamin Profiles in Elderly Persons Living at Home or in Nursing Homes, versus Profile in Healthy Young SubjectsJournal of the American Geriatrics Society, 27
F. Fukuda, M. Kitada, T. Horie, S. Awazu (1992)
Evaluation of adriamycin-induced lipid peroxidation.Biochemical pharmacology, 44 4
M. Hunter, J. Mohamed (1986)
Plasma antioxidants and lipid peroxidation products in Duchenne muscular dystrophy.Clinica chimica acta; international journal of clinical chemistry, 155 2
M. Wartanowicz, B. Panczenko-Kresowska, Ś. Ziemlański, M. Kowalska, G. Okolska (1984)
The effect of alpha-tocopherol and ascorbic acid on the serum lipid peroxide level in elderly people.Annals of nutrition & metabolism, 28 3
Wayner Wayner, Burton Burton, Ingold Ingold (1987)
The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical‐trapping antioxidant activity of human blood plasmaBiochem Biophys Acta, 924
M. Wartanowicz, B. Panczenko-Kresowska, Ś. Ziemlański, M. Kowalska, G. Okolska (1984)
The Effect of α-Tocopherol and Ascorbic Acid on the Serum Lipid Peroxide Level in Elderly PeopleAnnals of Nutrition and Metabolism, 28
J. Maciejko, S. Levinson, L. Markyvech, M. Smith, R. Blevins (1987)
New assay of apolipoproteins A-I and B by rate nephelometry evaluated.Clinical chemistry, 33 11
Sohal (1993)
The free radical hypothesis of aging: An appraisal of the current statusAging Milano, 5
D. Harman (1993)
Free Radical Involvement in AgingDrugs & Aging, 3
B. Halliwell, J. Gutteridge (1985)
Free radicals in biology and medicine
OBJECTIVE: It has recently been proposed that increased oxidative stress may play a role in the aging process and age‐associated degenerative diseases. DESIGN AND MEASUREMENTS: A cross‐sectional study was carried out to assess the relationship of circulating antioxidants, namely vitamins E and C, β‐carotene, proteic thiols (P‐SH) and ceruloplasmin, and of lipid peroxides, with both aging and aging with disability, i.e., unsuccessful aging. PARTICIPANTS: One hundred healthy free living and 62 disabled octo‐nonagenarians and 91 healthy adults were enrolled in the study. RESULTS: Free living and disabled older adults had lower antioxidant and higher lipid peroxide levels than healthy adults, as well as the disabled older adults compared with free living older persons. Using logistic regression, we observed that plasma concentrations of vitamins E and C, P‐SH, and lipid peroxides were independently associated with either aging or aging with disability, apparently representing biochemical indicators of patient status. In particular, aging and unsuccessful aging were associated with higher levels of lipid peroxides independently of circulating levels of vitamins C and E, suggesting that the increased oxidative stress was not merely an effect of a lower dietary intake of antioxidants. Serum ceruloplasmin was significantly higher in free living older adults than in healthy adults, and in the disabled compared with free living octo‐nonagenarians. CONCLUSIONS: Our findings are consistent with the presence of systemic oxidant load in older adults, and this phenomenon is far more evident in unsuccessful aging.
Journal of American Geriatrics Society – Wiley
Published: Jul 1, 1996
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