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Absence of central effects in man of the benzodiazepine antagonist Ro 15-1788

Absence of central effects in man of the benzodiazepine antagonist Ro 15-1788 213 80 80 2 2 Austin Darragh Ronan Lambe Ciaran O'Boyle Marie Kenny Ian Brick Institute of Clinical Pharmacology P.O. Box 469 Dublin 8 Ireland Psychosomatic Unit, Department of Psychiatry University College Dublin 4 Ireland Abstract The benzodiazepines are typified by a profile of side effects which includes drowsiness, ataxia and incoordination. Ro 15-1788, an imidazodiazepine derivative, exhibits marked antagonism of the behavioural and biochemical effects of the benzodiazepines in animals and man. It is devoid of any behavioural activity in animals, except at very high doses. In the present study the effects of single rising oral doses of Ro 15-1788 on cognitive, psychomotor and subjective function in man have been assessed using a battery of psychometric tests designed to identify the sedative action of the benzodiazepines. At all doses up to 600 mg, Ro 15-1788 demonstrated none of the classical behavioural effects of the benzodiazepines. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Absence of central effects in man of the benzodiazepine antagonist Ro 15-1788

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References (39)

Publisher
Springer Journals
Copyright
Copyright © 1983 by Springer-Verlag GmbH & Co. KG
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00427969
Publisher site
See Article on Publisher Site

Abstract

213 80 80 2 2 Austin Darragh Ronan Lambe Ciaran O'Boyle Marie Kenny Ian Brick Institute of Clinical Pharmacology P.O. Box 469 Dublin 8 Ireland Psychosomatic Unit, Department of Psychiatry University College Dublin 4 Ireland Abstract The benzodiazepines are typified by a profile of side effects which includes drowsiness, ataxia and incoordination. Ro 15-1788, an imidazodiazepine derivative, exhibits marked antagonism of the behavioural and biochemical effects of the benzodiazepines in animals and man. It is devoid of any behavioural activity in animals, except at very high doses. In the present study the effects of single rising oral doses of Ro 15-1788 on cognitive, psychomotor and subjective function in man have been assessed using a battery of psychometric tests designed to identify the sedative action of the benzodiazepines. At all doses up to 600 mg, Ro 15-1788 demonstrated none of the classical behavioural effects of the benzodiazepines.

Journal

PsychopharmacologySpringer Journals

Published: May 1, 1983

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