Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Growth factor profiles in intraperitoneal drainage fluid following colorectal surgery: Relationship to wound healing and surgery

Growth factor profiles in intraperitoneal drainage fluid following colorectal surgery:... Cytokines and growth factors are important at each stage of wound healing. This study aims to determine the changing profiles of these factors in intraperitoneal drainage, acute wound fluid, following colorectal surgery, and to correlate levels to wound healing and surgical outcomes. Acute wound fluid samples (n = 52 patients) were collected daily from postoperative day 1 until drain removal. Levels of cytokines (interleukins‐6 and ‐1β and tumor necrosis factor‐α) and epidermal growth factor, platelet‐derived growth factor, vascular endothelial derived growth factor, basic fibroblast growth factor, and transforming growth factor‐β1 were determined by enzyme‐linked immunosorbent assay. A significant negative correlation emerged between the levels of interleukin‐6, epidermal growth factor, platelet‐derived growth factor, and basic fibroblast growth factor and the postoperative day, e.g., basic fibroblast growth factor : day 1, 695, median (29–2,806, range) pg/ml; day 2, 249 (1–1,784); day 3, 94 (0–722); day 7, 22 (0–326) (p < 0.05, Spearman's correlation). Levels appeared to relate to the stage of wound healing. Several factors, in particular interleukin‐1β and tumor necrosis factor‐α levels, correlated with surgical outcomes such as the need for a defunctioning stoma and/or postoperative complications. Cytokines and growth factors are involved in normal wound healing, and their levels in acute wound fluid may act as markers of wound healing and surgical outcome. (WOUND REP REG 2003;11:261–267) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Wound Repair and Regeneration Wiley

Growth factor profiles in intraperitoneal drainage fluid following colorectal surgery: Relationship to wound healing and surgery

Download PDF
7 pages

Loading next page...
 
/lp/wiley/growth-factor-profiles-in-intraperitoneal-drainage-fluid-following-mEZD5zVXTj

References (17)

Publisher
Wiley
Copyright
Copyright © 2003 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1067-1927
eISSN
1524-475X
DOI
10.1046/j.1524-475X.2003.11405.x
Publisher site
See Article on Publisher Site

Abstract

Cytokines and growth factors are important at each stage of wound healing. This study aims to determine the changing profiles of these factors in intraperitoneal drainage, acute wound fluid, following colorectal surgery, and to correlate levels to wound healing and surgical outcomes. Acute wound fluid samples (n = 52 patients) were collected daily from postoperative day 1 until drain removal. Levels of cytokines (interleukins‐6 and ‐1β and tumor necrosis factor‐α) and epidermal growth factor, platelet‐derived growth factor, vascular endothelial derived growth factor, basic fibroblast growth factor, and transforming growth factor‐β1 were determined by enzyme‐linked immunosorbent assay. A significant negative correlation emerged between the levels of interleukin‐6, epidermal growth factor, platelet‐derived growth factor, and basic fibroblast growth factor and the postoperative day, e.g., basic fibroblast growth factor : day 1, 695, median (29–2,806, range) pg/ml; day 2, 249 (1–1,784); day 3, 94 (0–722); day 7, 22 (0–326) (p < 0.05, Spearman's correlation). Levels appeared to relate to the stage of wound healing. Several factors, in particular interleukin‐1β and tumor necrosis factor‐α levels, correlated with surgical outcomes such as the need for a defunctioning stoma and/or postoperative complications. Cytokines and growth factors are involved in normal wound healing, and their levels in acute wound fluid may act as markers of wound healing and surgical outcome. (WOUND REP REG 2003;11:261–267)

Journal

Wound Repair and Regeneration – Wiley

Published: Jul 1, 2003

There are no references for this article.