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G. Imokawa, S. Akasaki, M. Hattori, N. Yoshizuka (1986)
Selective recovery of deranged water-holding properties by stratum corneum lipids.The Journal of investigative dermatology, 87 6
Grubauer (1989)
89J Lipid Res, 30
Elias (1983)
44J Invest Dermatol, 80
Monger (1988)
603J Lipid Res, 29
Alberts Alberts, Chen Chen, Kuron Kuron (1980)
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl‐coenzyme A reductase and a cholesterol‐lowering agentProc Natl Acad Sci U SA, 77
P. Elias, B. Brown (1978)
The mammalian cutaneous permeability barrier: defective barrier function is essential fatty acid deficiency correlates with abnormal intercellular lipid deposition.Laboratory investigation; a journal of technical methods and pathology, 39 6
Houtsmuller Houtsmuller, Beek Beek (1981)
Effects of topical application of fatty acids in essential fatty acid deficiencyProgr Lipid Res, 20
Z. Beg, J. Stonik, H. Brewer (1978)
3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation.Proceedings of the National Academy of Sciences of the United States of America, 75 8
A. Finkelstein, A. Cass (1967)
Effect of Cholesterol on the Water Permeability of Thin Lipid MembranesNature, 216
Urs. Siegenthaler, A. Laine, L. Polák (1983)
Studies on contact sensitivity to chromium in the guinea pig. The role of valence in the formation of the antigenic determinant.The Journal of investigative dermatology, 80 1
Elias (1981)
95Arch Dermatol Res, 270
W. Holleran, M. Williams, W. Gao, P. Elias (1990)
Serine-palmitoyl transferase activity in cultured human keratinocytes.Journal of lipid research, 31 9
U. Houtsmuller, A. Beek (1981)
Effects of topical application of fatty acids.Progress in lipid research, 20
Menon (1985)
418J Lipid Res, 26
Holleran (1990)
1655J Lipid Res, 31
N. Lowe, R. Stoughton (1977)
Essential fatty acid deficient hairless mouse: a model of chronic epidermal hyperproliferationBritish Journal of Dermatology, 96
G. Grubauer, K. Feingold, P. Elias (1987)
Relationship of epidermal lipogenesis to cutaneous barrier function.Journal of lipid research, 28 6
E. Proksch, P. Elias, K. Feingold (1991)
Localization and regulation of epidermal 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity by barrier requirements.Biochimica et biophysica acta, 1083 1
C. Prottey (1976)
ESSENTIAL FATTY ACIDS AND THE SKINBritish Journal of Dermatology, 94
P. Wertz, E. Cho, D. Downing (1983)
Effect of essential fatty acid deficiency on the epidermal sphingolipids of the rat.Biochimica et biophysica acta, 753 3
(1985)
Wenig KH. Effect of plastic-foilsimultaneous assessment of irritancy and efficiency of skin care occlusion on psorialic lesions
B. Melnik, J. Hollmann, G. Plewig (1988)
Decreased stratum corneum cerarnides in atopic individuals—a pathobiochemical factor in xerosis?British Journal of Dermatology, 119
P. Elias, B. Brown, P. Fritsch, J. Goerke, G. Gray, R. White (1979)
Localization and composition of lipids in neonatal mouse stratum granulosum and stratum corneum.The Journal of investigative dermatology, 73 5
R. Williams, E. Wang, A. Merrill (1984)
Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes.Archives of biochemistry and biophysics, 228 1
Gray (1975)
434J Lipid Res, 16
Kennelly Kennelly, Rodwell Rodwell (1985)
Regulation of 3‐hydroxy‐J‐methylglutaryl coenzyme A reductase by reversible phosphorylation‐dephosphorylationJ Lpid Res, 26
P. Elias, K. Feingold (1988)
Lipid‐Related Barriers and Gradients in the Epidermis aAnnals of the New York Academy of Sciences, 548
Elias (1983)
342
Ehrhardt Proksch, K. Feingold, Peter Elias (1992)
Epidermal HMG CoA reductase activity in essential fatty acid deficiency: barrier requirements rather than eicosanoid generation regulate cholesterol synthesis.The Journal of investigative dermatology, 99 2
U. Houtsmuller (1981)
Columbinic acid, a new type of essential fatty acid.Progress in lipid research, 20
EIias (1978)
574Lab Invest, 39
Petzold (1970)
160Arch Klin Exp Dermatol, 238
P. Elias, M. Williams (1985)
Neutral lipid storage disease with ichthyosis. Defective lamellar body contents and intracellular dispersion.Archives of dermatology, 121 8
K. Feingold, M. Wiley, G. MacRae, S. Lear, A. Moser, G. Zsigmond, M. Siperstein (1983)
De novo sterologenesis in the intact rat.Metabolism: clinical and experimental, 32 1
Elias Elias, Feingold Feingold (1988)
Lipid related barriers and gradients in the epidermis. Endocrine, metabolic and immunologic functions of keratinocytesAnn NY Acad Sci, 548
Lampe Lampe, Burlingame Burlingame (1983)
Whitney J et al . Human stratum corneum lipids: characterization and regional variationsJ Lipid Res, 24
P. Dykes, R. Marks, M. Davies, D. Reynolds (1978)
Epidermal metabolism in heredopathia atactica polyneuritiformis (Refsum's disease).The Journal of investigative dermatology, 70 3
Pitz (1985)
209
P. Elias, D. Friend (1975)
The permeability barrier in mammalian epidermisThe Journal of Cell Biology, 65
M. Koone, W. Rizzo, P. Elias, M. Williams, V. Lightner, S. Pinnell (1990)
Ichthyosis, mental retardation, and asymptomatic spasticity. A new neurocutaneous syndrome with normal fatty alcohol:NAD+ oxidoreductase activity.Archives of dermatology, 126 11
K. Feingold, K. Feingold, Barbara Brown, Barbara Brown, Steven Lear, Steven Lear, A. Moser, A. Moser, Peter Elias, Peter Elias (1983)
Localization of de novo sterologenesis in mammalian skin.The Journal of investigative dermatology, 81 4
Hermann Pinkus (1951)
Examination of the epidermis by the strip method of removing horny layers. I. Observations on thickness of the horny layer, and on mitotic activity after stripping.The Journal of investigative dermatology, 16 6
Gerhard Grubauer, K. Feingold, Ronald Harris, Peter Elias (1989)
Lipid content and lipid type as determinants of the epidermal permeability barrier.Journal of lipid research, 30 1
W. Holleran, K. Feingold, M. Man, W. Gao, J. Lee, P. Elias (1991)
Regulation of epidermal sphingolipid synthesis by permeability barrier function.Journal of lipid research, 32 7
Hamanaka Hamanaka, Asagami Asagami, Suzuki Suzuki (1989)
Structure detennination of glucosyl β 1‐N‐(ω‐O‐linoleoyl)‐acylsphtngosines of human epidermisJ Biochem, 105
P. Wertz, D. Downing, R. Freinkel, T. Traczyk (1984)
Sphingolipids of the stratum corneum and lamellar granules of fetal rat epidermis.The Journal of investigative dermatology, 83 3
Grubauer (1987)
746J Lipid Res, 28
D. Monger, M. Williams, K. Feingold, B. Brown, P. Elias (1988)
Localization of sites of lipid biosynthesis in mammalian epidermis.Journal of lipid research, 29 5
P. Bondy (1988)
Endocrine, Metabolic and Immunologic Functions of KeratinocytesThe Yale Journal of Biology and Medicine, 62
Holleran (1991)
151J Lipid Res, 32
Donald Downing, Mary Stewart, Philip Wertz, Sabin Colton, William Abraham, John Strauss (1987)
Skin lipids: an update.The Journal of investigative dermatology, 88 3 Suppl
W. Holleran, M. Man, Wenge Gao, G. Menon, P. Elias, K. Feingold (1991)
Sphingolipids are required for mammalian epidermal barrier function. Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation.The Journal of clinical investigation, 88 4
G. Menon, K. Feingold, A. Moser, B. Brown, P. Elias (1985)
De novo sterologenesis in the skin. II. Regulation by cutaneous barrier requirements.Journal of lipid research, 26 4
Ziboh (1972)
458J Lipid Res, 13
S. Friedman (1987)
Management of psoriasis vulgaris with a hydrocolloid occlusive dressing.Archives of dermatology, 123 8
P. Braun*, P. Morell, N. Radin (1970)
Synthesis of C18- and C20-dihydrosphingosines, ketodihydrosphingosines, and ceramides by microsomal preparations from mouse brain.The Journal of biological chemistry, 245 2
Petzold Petzold, Braun‐Falco Braun‐Falco, Wenig Wenig (1970)
Effect of plastic‐foil‐occlusion on psoriatic lesionsArch Klin Exp Dermatol, 238
S. Hamanaka, C. Asagami, M. Suzuki, F. Inagaki, A. Suzuki (1989)
Structure determination of glucosyl beta 1-N-(omega-O-linoleoyl)-acylsphingosines of human epidermis.Journal of biochemistry, 105 5
Elias Pm, Brownlie Be (1978)
The mammalian cutaneous permeability barrier: defective barrier function is essential fatty acid deficiency correlates with abnormal intercellular lipid deposition.Laboratory Investigation, 39
G. Gray, H. Yardley (1975)
Lipid compositions of cells isolated from pig, human, and rat epidermis.Journal of lipid research, 16 6
(1987)
Decreased stratum comeum occlusive dressing
Abraham Abraham, Wertz Wertz, Downing Downing (1985)
Linoleate‐rich acylglucosyl‐ceramides of pig epidermis: structure determination by proton magnetic resonanceJ Lipid Res, 26
(1983)
The special role of stratum corneum; stratum corneum structure. In; Dermalahcm in General Merfifinf (Fitzpatrick TB
R. Ghadially, M. Williams, S. Hou, P. Elias (1992)
Membrane structural abnormalities in the stratum corneum of the autosomal recessive ichthyoses.The Journal of investigative dermatology, 99 6
L. Schäfer, K. Kragballe (1991)
Abnormalities in epidermal lipid metabolism in patients with atopic dermatitis.The Journal of investigative dermatology, 96 1
P. Elias, B. Brown, V. Ziboh (1980)
The permeability barrier in essential fatty acid deficiency: evidence for a direct role for linoleic acid in barrier function.The Journal of investigative dermatology, 74 4
P. Bowser, D. Nugteren, R. White, U. Houtsmuller, C. Prottey (1985)
Identification, isolation and characterization of epidermal lipids containing linoleic acid.Biochimica et biophysica acta, 834 3
P. Elias (1983)
Epidermal lipids, barrier function, and desquamation.The Journal of investigative dermatology, 80 Suppl
Grubauer (1989)
323J Lipid Res, 30
K. Feingold, M. Man, E. Proksch, G. Menon, B. Brown, P. Elias (1991)
The lovastatin-treated rodent: a new model of barrier disruption and epidermal hyperplasia.The Journal of investigative dermatology, 96 2
Kennelly (1985)
903J Lpid Res, 26
E. Proksch, P. Elias, K. Feingold (1990)
Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in murine epidermis. Modulation of enzyme content and activation state by barrier requirements.The Journal of clinical investigation, 85 3
Gerhard Grubauer, P. Elias, K. Feingold (1989)
Transepidermal water loss: the signal for recovery of barrier structure and function.Journal of lipid research, 30 3
M. Lampe, A. Burlingame, J. Whitney, M. Williams, B. Brown, E. Roitman, P. Elias (1983)
Human stratum corneum lipids: characterization and regional variations.Journal of lipid research, 24 2
E. Proksch, K. Feingold, M. Man, P. Elias (1991)
Barrier function regulates epidermal DNA synthesis.The Journal of clinical investigation, 87 5
R. Chapkin, V. Ziboh (1984)
Inability of skin enzyme preparations to biosynthesize arachidonic acid from linoleic acid.Biochemical and biophysical research communications, 124 3
V. Ziboh, S. Hsia (1972)
Effects of prostaglandin E2 on rat skin: inhibition of sterol ester biosynthesis and clearing of scaly lesions in essential fatty acid deficiencyJournal of Lipid Research, 13
PM Elias (1981)
Lipid sand the epidermal permeability barrier, 270
P. Elias, P. Fritsch, M. Dahl, K. Wolff (1975)
Staphylococcal toxic epidermal necrolysis: pathogenesis and studies on the subcellular site of action of exfoliatin.The Journal of investigative dermatology, 65 6
Abraham (1985)
761J Lipid Res, 26
Lampe (1983)
120J Lipid Res, 24
A. Alberts, J. Chen, G. Kuron, V. Hunt, J. Huff, C. Hoffman, J. Rothrock, M. Lopez, H. Joshua, E. Harris, A. Patchett, R. Monaghan, S. Currie, E. Stapley, G. Albers-Schonberg, O. Hensens, J. Hirshfield, K. Hoogsteen, J. Liesch, J. Springer (1980)
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.Proceedings of the National Academy of Sciences of the United States of America, 77 7
G. Imokawa, Yutaka Mishima (1979)
Cumulative effect of surfactants on cutaneous horny layers: Adsorption onto human keratin layers in vivoContact Dermatitis, 5
K. Feingold, M. Man, G. Menon, S. Cho, B. Brown, P. Elias (1990)
Cholesterol synthesis is required for cutaneous barrier function in mice.The Journal of clinical investigation, 86 5
Summary The stratum corneum, the permeability barrier between the internal milieu and the environment, is composed of fibrous protein‐enriched corneocytes and a lipid‐enriched intercellular matrix. The lipids are a mixture of sphingolipids, cholesterol and free fatty acids, which form intercellular membrane bilayers. Lipid synthesis occurs in the keratinocytes in all nucleated layers of the epidermis, and the newly synthesized lipids are delivered by lamellar bodies to the interstices of the stratum corneum during epidermal differentiation. Disruption of barrier function by topical acetone treatment results in an increase in the synthesis of free fatty acids, sphingolipids and cholesterol in the living layers of the epidermis, leading to barrier repair. Cholesterol and sphingolipid synthesis are regulated by the rate‐limiting enzymes HMG CoA reductase and serine palmitoyi transferase (SPT). respectively. Acute barrier disruption leads to an increase in both enzymes, but with a different time curve: increase in HMG CoA reductase activity begins at 1.5 h, whereas the increase in SPT activity occurs 6 h after barrier impairment. Topical application of HMG CoA reductase or SPT inhibitors after acetone treatment delays barrier repair, providing further evidence for a role of cholesterol and sphingolipids in epidermal barrier function. Repeated application of lovastatin to untreated skin results in disturbed barrier function accompanied by increased DNA synthesis and epidermal hyperplasia. Therefore, we have examined the specific relationship between barrier function and epidermal DNA synthesis. After acute and chronic disturbances not only lipid, but also DNA synthesis, is stimulated. Thus, stimulation of DNA synthesis leading to epidermal hyperplasia may be a second mechanism by which the epidermis repairs defects in barrier function. The link between barrier function and both lipid and DNA synthesis is supported further by occlusion studies. Artificial barrier repair by latex occlusion prevents an increase in both lipid and DNA synthesis. In addition, increased epidermal lipid and DNA synthesis in essential fatty‐acid deficiency can be reversed by topical applications of the n‐6 unsaturated fatty acids, linoleic or columbinic acid. These studies may be of relevance in understanding the pathogenesis of hyperproliferative skin diseases, such as ichthyosis, psoriasis, atopic dermatitis, and irritant contact dermatitis.
British Journal of Dermatology – Wiley
Published: May 1, 1993
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