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- Publisher
- Rockefeller University Press
- Copyright
- © 1996 Rockefeller University Press
- ISSN
- 0022-1007
- eISSN
- 1540-9538
- DOI
- 10.1084/jem.183.4.1377
- Publisher site
- See Article on Publisher Site
Abstract
Naive and memory B cells were isolated from human tonsils and examined for expression of APO-1/Fas and for their sensitivity to the APO-1-dependent apoptosis. APO-1 was found to be constitutively expressed on memory but not on naive B cells. The susceptibility of both cell types to the APO-1 apoptotic pathway was acquired upon CD40 triggering and was correlated with increased expression of the APO-1 receptor. Both naive and memory B cells were protected from the APO-1-mediated death signal after dual ligation of the Ag receptor adn CD40. Our findings suggest that the APO-1 pathway controls the specificity of B cell responses to T-dependent Ags and that occupancy of the Ag receptor dictates the outcome of APO-1-ligation on B cell survival.
Journal
The Journal of Experimental Medicine – Rockefeller University Press
Published: Apr 1, 1996